The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
The role of the NLRP3 inflammasome in gout
Open accessAbstract
Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Recent studies suggest that orchestration of the MSU-induced inflammatory response is dependent on the proinflammatory cytokine IL-1β, underlined by promising results in early IL-1 inhibitor trials in gout patients. This IL-1-dependent innate inflammatory phenotype, which is observed in a number of diseases in addition to gout, is now understood to rely on the formation of the macromolecular NLRP3 inflammasome complex in response to the MSU 'danger signal'. This review focuses on our current understanding of the NLRP3 inflammasome and its critical role in MSU-crystal induced inflammatory gout attacks. It also discusses the management of treatment-resistant acute and chronic tophaceous gout with IL-1 inhibitors; early clinical studies of rilonacept (IL-1 Trap), canakinumab (monoclonal anti-IL-1β antibody), and anakinra have all demonstrated treatment efficacy in such patients.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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“76,77 Late-stage human melanoma cells exhibit autoinflammatory characteristics, spontaneously secreting active IL-1 β due to constitutive assembly and activation of NLRP3.”
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Cryopyrin activates the inflammasome in response to toxins and ATP
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The NALP3 inflammasome is involved in the innate immune response to amyloid-β
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Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., Jing, T., Yao, Y., Qiu, Z., Wang, Z., et al. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00462-9 · Cited by 492
Koushki, K., Shahbaz, S. K., Mashayekhi, K., Sadeghi, M., Zayeri, Z. D., Taba, M. Y., Banach, M., Al-Rasadi, K., Johnston, T. P., & Sahebkar, A. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08791-9 · Cited by 382
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Metadata
- Authors
- McDermott, M., Kingsbury, S., & Conaghan
- Venue
- Journal of Inflammation Research
- Publisher
- Informa UK Limited
- Published
- 2011-03
- Volume
- 4
- Pages
- 39
- ISSN
- 1178-7031 (ISSN-L)
- OpenAlex
- W2126158243
- Cited by
- 219
- References
- 24
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- gold
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