Gross and fine motor function in fibromyalgia and chronic fatigue syndrome
Open accessAbstract
Purpose: This paper aimed to investigate motor proficiency in fine and gross motor function, with a focus on reaction time (RT) and movement skill, in patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS) compared to healthy controls (HC). Methods: A total of 60 individuals (20 CFS, 20 FM, and 20 HC), age 19–49 years, participated in this study. Gross motor function in the lower extremity was assessed using a RT task during gait initiation in response to an auditory trigger. Fine motor function in the upper extremity was measured during a precision task (the Purdue Pegboard test) where the number of pins inserted within 30 s was counted. Results: No significant differences were found between FM and CFS in any parameters. FM and CFS groups had significantly longer RT than HC in the gait initiation ( p =0.001, and p =0.004 respectively). In the Purdue Pegboard test, 20% in the FM group, 15% in the CFS groups, and 0% of HC group, scored below the threshold of the accepted performance. However, there were no significant differences between FM, CFS, and HC in this task ( p =0.12). Conclusion: Compared to controls, both CFS and FM groups displayed significantly longer RT in the gait initiation task. Generally, FM patients showed the worst results in both tests, although no group differences were found in fine motor control, according to the Purdue Pegboard test. Keywords: fatigue syndrome, chronic, musculoskeletal diseases, gait initiation, Purdue Pegboard, reaction time
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FM was associated with an increased BMI, which was positively correlated with decreased reaction time during gait initiation.
“FM was associated with an increased BMI, which was positively correlated with decreased reaction time during gait initiation.2”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Discussion says the FM group had the highest BMI, but the between-group BMI difference was not significant. It reports a positive correlation between weight—not BMI—and reaction time during gait initiation; the Results report longer, not decreased, reaction times for FM compared with healthy controls. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredFibromyalgia is a disabling chronic pain syndrome characterized by multiple symptoms, including medically unexplained widespread pain, fatigue, cognitive, mood and sleep disorders.
“Fibromyalgia (FM) is a disabling chronic pain syndrome characterized by multiple symptoms, including medically unexplained widespread pain, fatigue, cognitive, mood and sleep disorders.1–11”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Introduction describes fibromyalgia as characterized by chronic widespread pain, reports cognitive complaints, and notes substantial symptom overlap with chronic fatigue syndrome. The Discussion says newer diagnostic criteria include fatigue and cognition. The passages do not describe mood or sleep disorders as features of fibromyalgia, or characterize its pain as medically unexplained. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHigh BMI and inactivity may exacerbate motor deficits and perpetuate the cycle of disability.
“High BMI and inactivity may exacerbate motor deficits and perpetuate the cycle of disability.2,17”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Discussion (page not provided) says high BMI may impair fine and gross motor skills and that low physical activity may adversely affect motor proficiency in patients with fibromyalgia or chronic fatigue syndrome. It also links avoidance of pain and fatigue to inactivity and deconditioning, but does not establish that these factors perpetuate a cycle of disability. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPatients with FM present with slower gait speed, reduced stride length, delayed gait initiation, altered postural sway, and altered muscle activation patterns during walking.
“Patients with FM present with slower gait speed, reduced stride length, delayed gait initiation, altered postural sway,2,21 and altered muscle activation patterns during walking.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Results (Gait initiation; page not provided) report significantly longer gait-initiation reaction times in patients with FM than in healthy controls. The Introduction also reports reduced gait velocity in FM. Our copy does not establish reduced stride length or altered postural sway; the separately cited muscle-activation clause is not necessary to this verdict. (LLM, conf=0.84)
Experimental — accuracy not yet measuredLow levels of physical activity were correlated with poor motor control, lower movement velocity, and a higher body mass index (BMI), which are typical in FM populations.
“Low levels of physical activity were correlated with poor motor control, lower movement velocity, and a higher body mass index (BMI), which are typical in FM populations.”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Discussion says low physical activity is common in FM and may be correlated with poor motor control and lower movement velocity. It also says high BMI is common in FM, but does not establish a correlation between BMI and physical activity. The claim presents the tentative motor-control association as an established correlation. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Deficits in fine motor tasks, such as manual dexterity, reflect broader impairments in sensorimotor integration but may also be associated with dopamine dysregulation.
“Deficits in fine motor tasks, such as manual dexterity, reflect broader impairments in sensorimotor integration2 but may also be associated with dopamine dysregulation.25”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Introduction reports prior findings of manual-dexterity deficits in fibromyalgia, and the Discussion describes sensory–motor processing deficits in fibromyalgia and chronic fatigue syndrome. But the Discussion presents their connection to poor motor function as a possible explanation, especially for gross motor function; this study found no statistically significant difference in fine-motor performance. Dopamine dysregulation is attached to a different citation and is not assessed here. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe literature is mixed in implicating obesity concerning motor control and postural stability.
“However, the literature is mixed in implicating obesity concerning motor control and postural stability.2,17,30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Discussion (page not provided) reports mixed associations across motor tasks: weight correlated with reaction time during gait initiation but not with Purdue Pegboard scores. It also notes indications that high BMI adversely affects motor skills. The paper does not establish that the literature is mixed specifically about obesity and postural stability; its own comparison concerns weight and motor performance in fibromyalgia and chronic fatigue syndrome groups. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSevere fatigue impacts depression, pain perception, physical functioning, and exercise adherence in fibromyalgia.
“More than 80% of people with FM experience poor sleep quality with severe fatigue impacting depression,3 pain perception, physical functioning10 and exercise adherence.2,17,21”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Discussion (page unavailable) suggests that avoiding aggravation of pain and fatigue contributes to low physical activity in fibromyalgia, and reports reduced motor performance. It does not establish that severe fatigue affects depression or pain perception, or measure exercise adherence; avoiding activity is not the same as adherence to an exercise program. (LLM, conf=0.83)
Experimental — accuracy not yet measuredAn integrative strategy combining pain-coping skills with tailored, enjoyable exercise that includes sensory and motor challenges holds promise in managing fibromyalgia.
“An integrative strategy combining pain-coping skills, enhanced with tailored, enjoyable exercise that includes sensory and motor challenges specifically designed to improve confidence in movement and enhance activity participation, holds promise in managing FM.2,17,30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Discussion (page unavailable) suggests that patients with fibromyalgia may benefit from exercise therapy including sensory–motor challenges. It does not describe combining that exercise with pain-coping skills, making it tailored and enjoyable, or using it to improve confidence in movement and activity participation. (LLM, conf=0.87)
Experimental — accuracy not yet measuredLonger response times in reaction time tasks were observed in FM, along with reduced psychomotor function, resulting in slower movement initiation and lower movement speed, especially in tasks with higher cognitive demands.
“Longer response times in reaction time tasks were observed in FM, along with reduced psychomotor function, resulting in slower movement initiation and lower movement speed, especially in tasks with higher cognitive demands.2”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
A high BMI has been associated with negative consequences for both fine and gross motor skills.
“A high BMI has been associated with negative consequences for both fine and gross motor skills.2”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
Pain can trigger inhibitory mechanisms in affected and surrounding muscles, contributing to decreased motor output.
“Pain can trigger inhibitory mechanisms in affected and surrounding muscles, contributing to decreased motor output.2”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
More than 80% of people with fibromyalgia experience poor sleep quality with severe fatigue.
“More than 80% of people with FM experience poor sleep quality with severe fatigue impacting depression,3 pain perception, physical functioning10 and exercise adherence.2,17,21”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [2]
The Introduction discusses overlapping symptoms of fibromyalgia and chronic fatigue syndrome, and the Methods report fatigue ratings, but neither gives a prevalence of poor sleep or links it to severe fatigue. Searches for the 80% figure and sleep quality found no passage addressing the quoted claim. In the full citing sentence, this source’s citation is attached to physical functioning rather than to the prevalence figure. (LLM, conf=0.77)
Experimental — accuracy not yet measured
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Cites
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Flagged first, then by citations
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Cited by
Sorted by citations
A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment
Quodling, N., Hoffman, N., Carrick, F., & Jemni, M. (2025) · Journal of Pain Research · doi:10.2147/jpr.s543775 · Cited by 5 · see citing works
- Authors
- Rasouli, O., Fors, E., Borchgrevink, P., Öhberg, F., & Stensdotter, A.-K.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Umeå University (SE)
- Corresponding author
- Rasouli, Omid
- Venue
- Journal of Pain Research
- Publisher
- Informa UK Limited
- Published
- 2017-02
- Volume
- Volume 10
- Pages
- 303-309
- ISSN
- 1178-7090 (ISSN-L)
- PMC
- PMC5304994
- OpenAlex
- W2587100346
- Cited by
- 19
- References
- 4
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Pain Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- BIBSYS Brage (BIBSYS (Norway)) (acceptedVersion, cc-by-nc)
- DiVA at Umeå University (Umeå University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- fibromyalgia, chronic fatigue syndrome, gross motor function, fine motor function, reaction time, gait initiation, Purdue Pegboard Test, motor competence, lower extremity, upper limb
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