Treatment-resistant depression: therapeutic trends, challenges, and future directions

Al-harbi·2012·Patient Preference and Adherence

DOI 10.2147/ppa.s29716

Cited by (794)

Items 301–400 of 794

An effective brain connectivity technique to predict repetitive transcranial magnetic stimulation outcome for major depressive disorder patients using EEG signals
Behrouz Nobakhsh, Ahmad Shalbaf, Reza Rostami, Reza Kazemi, Erfan Rezaei, Reza Shalbaf · 2022 · Physical and Engineering Sciences in Medicine
Prediction of treatment outcome for repetitive transcranial magnetic stimulation in major depressive disorder using connectivity measures and ensemble of pre-trained deep learning models
Mohsen Sadat Shahabi, Behrooz Nobakhsh, Ahmad Shalbaf, Reza Rostami, Reza Kazemi · 2023 · Biomedical Signal Processing and Control
Efficacy and tolerability of monoamine oxidase inhibitors for the treatment of depressive episodes in mood disorders: A systematic review and network meta‐analysis
Anna Giménez‐Palomo, Anjli K. Chamdal, Natalie Gottlieb, Mojtaba Lotfaliany, Tahir Jokinen, Eslam M. Bastawy, Katherine Adlington, Nawal Benachar, Seetal Dodd, Isabella Pacchiarotti et al. · 2024 · Acta Psychiatrica Scandinavica
Synergistic antidepressant-like effect of capsaicin and citalopram reduces the side effects of citalopram on anxiety and working memory in rats
Irving Aguilar-Martínez, Miriam E. Reyes-Méndez, J. M. Herrera-Zamora, Fernando Osuna‐López, A. Virgen-Ortíz, N. Mendoza-Muñoz, J. Góngora-Alfaro, Eloy G. Moreno-Galindo, Javier Alamilla · 2020 · Psychopharmacology
Neuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression
Wing-Shan Yu, So-hyun Kwon, S. K. Agadagba, L. Chan, Kah-Hui Wong, L. Lim · 2021 · Cells
High-resolution virtual brain modeling personalizes deep brain stimulation for treatment-resistant depression: Spatiotemporal response characteristics following stimulation of neural fiber pathways
Sora An, Jan Fousek, Zelma H. T. Kiss, Filomeno Cortese, Gwen van der Wijk, Laina Beth McAusland, Rajamannar Ramasubbu, Viktor Jirsa, Andrea B. Protzner · 2021 · NeuroImage
Chronic orexin-1 receptor blockage attenuates depressive behaviors and provokes PSD-95 expression in a rat model of depression
Batoul Mirbolouk, Kambiz Rohampour, Mohammad Rostampour, Adele Jafari, Behrooz Khakpour-Taleghani · 2022 · Behavioural Brain Research
Proteomic Markers for Depression
Lícia C. Silva-Costa, Pamela T. Carlson, Paul C. Guest, Valéria de Almeida, Daniel Martins‐de‐Souza · 2019 · Advances in experimental medicine and biology
Chronic Mild Stress and Venlafaxine Treatment Were Associated with Altered Expression Level and Methylation Status of New Candidate Inflammatory Genes in PBMCs and Brain Structures of Wistar Rats
Katarzyna I. Białek, Piotr Lech Czarny, Paulina Wigner, Ewelina Synowiec, Gabriela Barszczewska-Pietraszek, Michał Bijak, Janusz Szemraj, Monika Niemczyk, Katarzyna Tota-Glowczyk, Mariusz Papp et al. · 2021 · Genes
Feasibility, engagement, and preliminary clinical outcomes of a digital biodata-driven intervention for anxiety and depression
Charalampos Tsirmpas, Dimitrios Andrikopoulos, Panagiotis Fatouros, Georgios Eleftheriou, Joaquin A. Anguera, Konstantinos A. Kontoangelos, Charalabos Papageorgiou · 2022 · Frontiers in Digital Health
The implication of a diversity of non-neuronal cells in disorders affecting brain networks
Micaël Carrier, Kira Dolhan, Bianca Caroline Bobotis, Michèle Desjardins, Marie‐Ève Tremblay · 2022 · Frontiers in Cellular Neuroscience
Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats
Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M. Kogan, Aron Weller · 2023 · International Journal of Molecular Sciences
Do Mental Health Changes in Nature Co-occur with Changes in Heartrate Variability and Executive Functioning? A Systematic Review
Sara B. LoTemplio, Joanna E. Bettmann, Emily E. Scott, Ellison Blumenthal · 2023 · Current Environmental Health Reports
Addressing depression in older adults with Alzheimer’s through cognitive behavioral therapy: systematic review and meta-analysis
Ana María González-Martín, Agustín Aibar‐Almazán, Yulieth Rivas-Campo, Noelia Rodríguez Sobrino, Yolanda Castellote‐Caballero · 2023 · Frontiers in Aging Neuroscience
Liquid Biopsy-Based Detection and Response Prediction for Depression
Seungmin Kim, Youbin Kang, Hyunku Shin, Eun Byul Lee, Byung‐Joo Ham, Yeonho Choi · 2024 · ACS Nano
The Potential of Selected Plants and Their Biologically Active Molecules in the Treatment of Depression and Anxiety Disorders
Nicol Urbanská, Tolulope Joshua Ashaolu, Simona Mattova, Patrik Simko, Terézia Kisková · 2025 · International Journal of Molecular Sciences
Economic burden of treatment-resistant depression in privately insured US patients with co-occurring anxiety disorder and/or substance use disorder
Maryia Zhdanava, Harsh Kuvadia, Kruti Joshi, Ella Daly, Dominic Pilon, Carmine Rossi, Laura Morrison, Patrick Lefèbvre, Craig J. Nelson · 2020 · Current Medical Research and Opinion
Examining determinants of seeking help for depression: implications for effective health promotion messages
Jennifer A. Lueck · 2017 · Journal of Communications In Healthcare
Treatment resistant depression incidence and prevalence using the French nationwide claims database
Pauline Bosco‐Lévy, Angela Grelaud, Patrick Blin, Bernard Astruc, Bruno Falissard, Pierre‐Michel Llorca, Marie‐Agnès Bernard, R. Lassalle, Nicholas D Moore, Cécile Droz‐Perroteau · 2020 · Pharmacoepidemiology and Drug Safety
The HPA axis and kynurenine pathway: exploring the role of stress and neuroinflammation in treatment-resistant depression
Madhura M Bose, Anusha Govindula, Madhavan Nampoothiri, Devinder S Arora, Jayesh Mudgal · 2025 · Pharmacological Reports
Efficacy and safety of Buyang Huanwu Decoction in the treatment of post-stroke depression: A systematic review and meta-analysis of 15 randomized controlled trials
Kun Zhen, Hongshuo Shi, Xuecheng Zhang, Xiangyi Liu, Wen-Wen Li, Guo-Min Si, Hong-Ling Jia, D. Guo · 2022 · Frontiers in Neurology
tDCS efficacy and utility of anhedonia and rumination as clinical predictors of response to tDCS in major depressive disorder (MDD)
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri, Samaneh Khazaei, Houshang Garavand · 2023 · Journal of Affective Disorders
A Preliminary Analysis of the Clinical Effectiveness of Audiologist-Delivered Cognitive Behavioral Therapy Delivered via Video Calls for Rehabilitation of Misophonia, Hyperacusis, and Tinnitus
Hashir Aazh, Anahita Najjari, Brian C. J. Moore · 2024 · American Journal of Audiology
SUMOylation and Major Depressive Disorder
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong‐Hyung Cho, Hyun‐Shik Lee, Hong‐Yeoul Ryu · 2022 · International Journal of Molecular Sciences
Astrocyte Activation is A Potential Mechanism Underlying Depressed Mood and Apathy in People with HIV
Ronald J. Ellis · 2022 · Journal of Neurology and Psychology
D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels
Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, Wanjun Chen et al. · 2023 · Translational Psychiatry
Discovery and validation of protein biomarkers for monitoring the effectiveness of drug treatment for major depressive disorder
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee‐Gyoo Kang · 2023 · Journal of Psychiatric Research
Enrichment of pathogenic variants in genes associated with inborn errors of metabolism in psychiatric populations
Venuja Sriretnakumar, Ricardo Harripaul, John B. Vincent, James L. Kennedy, Joyce So · 2018 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
Perceived mechanisms of change in therapeutic yoga targeting psychological distress
Rebecca A. Harvey, Panoraia Andriopoulou, Sarah Grogan · 2019 · Journal of Bodywork and Movement Therapies
The role of GABA, glutamate, and Glx levels in treatment of major depressive disorder: A systematic review and meta-analysis
Kate Godfrey, Hannah M. Douglass, David Erritzøe, Suresh D Muthukumaraswamy, David Nutt, Rachael L. Sumner · 2025 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
Analysis of the prescribing pattern of antidepressants and the side effects in depression patients
SepidehKhatib Ara · 2022 · Journal of Family Medicine and Primary Care
Therapeutic Protocols Using Ketamine and Esketamine for Depressive Disorders: A Systematic Review
JULIA MURIEL KUTNO FREIND, Fernando R. Beserra, Bruno S. Menezes, Daniel C. Mograbi · 2023 · Journal of Psychoactive Drugs
Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress
Kevin T. Krupp, Jazmine D. W. Yaeger, Leighton J. Ledesma, Miyuraj Harishchandra Hikkaduwa Withanage, Jason Gale, Chase B. Howe, Trevor J. Allen, Monica Sathyanesan, Samuel Sathyanesan Newton, Cliff H. Summers · 2024 · Neuropharmacology
Cost-effectiveness and threshold analysis of deep brain stimulation vs. treatment-as-usual for treatment-resistant depression
Katherine E. Kabotyanski, Ricardo Andres Najera, Garrett P. Banks, Himanshu Sharma, Nicole R. Provenza, Benjamin Y. Hayden, Sanjay J. Mathew, Sameer Anil Sheth · 2024 · Translational Psychiatry
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew D. B. Claydon, James Rucker, Emma S. J. Robinson · 2024 · British Journal of Pharmacology
Predicting the treatment outcomes of major depressive disorder interventions with baseline resting-state functional connectivity: a meta-analysis
Yanyao Zhou, Na Dong, Li-Jun Lei, Dorita H. F. Chang, Charlene L.M. Lam · 2025 · BMC Psychiatry
Evaluation of the Antidepressant-like Activity of the Crude Extract and Solvent Fractions of Rosa Abyssinica Lindley (Rosaceae) Using Rodent Models of Depression
Netsanet Fekadu, Workineh Shibeshi · 2016 · Clinical and Experimental Pharmacology
Predicting Incident Treatment-Resistant Depression: A Model Designed for Health Systems of Care
Joshua N. Liberman, Tigwa Davis, JA Pesa, Wing Chow, J. Verbanac, Sara Heverly-Fitt, Charles R. Ruetsch · 2020 · Journal of Managed Care & Specialty Pharmacy
Self-reported review of the value of esketamine in patients with treatment-resistant depression: Understanding the patient experience in the STRIVE Study
H. Lynn Starr, Jill E. Abell, Allyson Larish, Sandy Lewis, Carla DeMuro, Jagadish P. Gogate, Carol Jamieson, Ella Daly, Naim Zaki, Michelle L. Kramer · 2020 · Psychiatry Research
Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological and clinical activities
T.L. Olatunji, Frances Siebert, Ademola Emmanuel Adetunji, Brian Herbert Harvey, Johané Gericke, Josias Hendrik Hamman, Frank van der Kooy · 2021 · Journal of Ethnopharmacology
Frequency analysis of symptomatic worsening following ketamine infusions for treatment resistant depression in a real-world sample: Results from the canadian rapid treatment center of excellence
Joshua D. Di Vincenzo, Orly Lipsitz, Nelson B. Rodrigues, Brett D. M. Jones, Hartej Gill, Yena L. Lee, Leanna M.W. Lui, Kayla M. Teopiz, Roger Ho, Kangguang Lin et al. · 2021 · Psychiatry Research
Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status
Karen A. Scott, Annette D. de Kloet, Michael D. Smeltzer, Eric G. Krause, Jonathan N. Flak, Susan J. Melhorn, Michelle T. Foster, Kellie L. Tamashiro, Randall R. Sakai · 2017 · Physiology & Behavior
A Bayesian approach to joint modeling of matrix‐valued imaging data and treatment outcome with applications to depression studies
Bei Jiang, Eva Petkova, Thaddeus Tarpey, Robert Todd Ogden · 2019 · Biometrics
Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function
Tim L. Emmerzaal, Leah Jacobs, Bram Geenen, Vivienne G. M. Verweij, Éva Morava, Richard J. Rodenburg, Tamás Kozicz · 2020 · European Journal of Neuroscience
Temporal multi-step predictive modeling of remission in major depressive disorder using early stage treatment data; STAR*D based machine learning approach
Haitham Salem, Tung Huynh, Natasha Topolski, Benson Mwangi, Madhukar H. Trivedi, Jair C. Soares, Augustus John Rush, Sudhakar Selvaraj · 2022 · Journal of Affective Disorders
Single-Nucleotide Polymorphisms in Genes Maintaining the Stability of Mitochondrial DNA Affect the Occurrence, Onset, Severity and Treatment of Major Depressive Disorder
Piotr Lech Czarny, Sylwia Ziółkowska, Łukasz Kołodziej, Cezary W. Watała, Paulina Wigner, Katarzyna Maria Bliźniewska-Kowalska, Katarzyna Wachowska, Małgorzata Gałecka, Ewelina Synowiec, Piotr Gałecki et al. · 2023 · International Journal of Molecular Sciences
Major challenges in youth psychopathology: treatment-resistant depression. A narrative review
Giulia Menculini, Gianmarco Cinesi, Francesca Scopetta, Matteo Cardelli, Guido Caramanico, Pierfrancesco Maria Balducci, Filippo De Giorgi, Patrizia Moretti, Alfonso Antonio Vincenzo Tortorella · 2024 · Frontiers in Psychiatry
Functional connectivity analyses of individual hippocampal subregions in major depressive disorder with electroconvulsive therapy
Hui Sun, Dundi Xu, Qinyao Sun, Tongjian Bai, Kai Wang, Jiaojian Wang, Jiang Zhang, Yanghua Tian · 2024 · Psychoradiology
Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults
Alexandra-Eleftheria Menni, Helen Theodorou, Georgios Tzikos, Ioannis M. Theodorou, Eleni Semertzidou, Veroniki Stelmach, Anne D. Shrewsbury, George Stavrou, Katerina E. Kotzampassi · 2025 · Nutrients
Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors
Jian Wei Jiang, Jun Ju, Liang Luo, Ze Song, Huanquan Liao, Xiuyan Yang, Shoupeng Wei, Dilong Wang, Zhu Wenhui, Jinlong Chang et al. · 2022 · Frontiers in Pharmacology
Review of Herbal Medicines for the Treatment of Depression
Siqi Peng, Yalan Zhou, Lu Monroe Meng, Qingzhong Wang · 2022 · Natural Product Communications
Oscillatory network markers of subcallosal cingulate deep brain stimulation for depression
Maximilian Scherer, Irene E. Harmsen, Nardin Samuel, Gavin J.B. Elias, Jürgen Germann, Alexandre Boutet, C. E. MacLeod, Peter Giacobbe, Nathan Christopher Rowland, Andrés M. Lozano et al. · 2023 · Brain stimulation
Clinical utility of pharmacogenetics-guided treatment of depression and anxiety
Joseph R. Boland, Brenna C. Duffy, Nicole M. Myer · 2017 · Personalized Medicine in Psychiatry
GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity
Qianqian Sun, Fan Yuan, Ruixue Yuan, Decheng Ren, Yuhao Zhu, Yan Bi, Jiaxin Hu, Zhenming Guo, Fei Xu, Weibo Niu et al. · 2019 · Medicine
Phenotypic analysis of 23andMe survey data: Treatment-resistant depression from participants’ perspective
Qingqin S. Li, Chao Tian, Matthew H. McIntyre, Yu Sun, David A. Hinds, Vaibhav A. Narayan · 2019 · Psychiatry Research
The Use of Neuro-Linguistic Programming as an Educational-Therapeutic Programme: Two Case Studies
Meisam Savarledavar, Garry Kuan · 2017 · Education in Medicine Journal
A comparative study of the effect of electroconvulsive therapy and transcranial direct current stimulation in the treatment of persons suffering from treatment‐resistant depression
Ramasubramanian, Vikhram, Mathumathi, S., Rajendhiran, Gopi, Bijulakshmi, P., Kannan, M. · 2022 · Industrial Psychiatry Journal
Merging the Multi-Target Effects of Kleeb Bua Daeng, a Thai Traditional Herbal Formula in Unpredictable Chronic Mild Stress-Induced Depression
Maneenet, Juthamart, Monthakantirat, Orawan, Daodee, Supawadee, Boonyarat, Chantana, Chotritthirong, Yutthana, Kwankhao, Pakakrong, Pitiporn, Supaporn, Awale, Suresh, Chulikhit, Yaowared · 2021 · Pharmaceuticals
The Effectiveness of Emotional Freedom Techniques for Depressive Symptoms: A Meta-Analysis
Ji‐Woo Seok, Jaeuk U. Kim · 2024 · Journal of Clinical Medicine
Comorbid anxiety, loneliness, and chronic pain as predictors of intervention outcomes for subclinical depressive symptoms in older adults: evidence from a large community-based study in Hong Kong
Stephanie Ming Yin Wong, Dara Kiu Yi Leung, Tianyin Liu, Zuna Loong Yee Ng, Gloria Hoi Yan Wong, Wai Chi Chan, Terry Yat Sang Lum · 2024 · BMC Psychiatry
Navigating the depths: A comprehensive narrative review on depression in people with epilepsy
Norah A. AlKhaldi · 2024 · Heliyon
Examining the needs, outcomes and current treatment pathways of 2461 people with treatment-resistant depression: mixed-methods study
Kiranpreet Gill, Danielle Hett, Max Carlish, Rebekah Amos, Ali Khatibi, Isabel Morales‐Muñoz, Steven Marwaha · 2025 · The British Journal of Psychiatry
Acupuncture Treatment for Social Defeat Stress
Jun Kawanokuchi, Ken Takagi, Nobuyuki Tanahashi, Teruhisa Yamamoto, Nobuyuki Nagaoka, Torao Ishida, Ning Ma · 2021 · Frontiers in Behavioral Neuroscience
The Cannabis-Induced Epigenetic Regulation of Genes Associated with Major Depressive Disorder
Guldar Sayed Mohammad, Sâmia R.L. Joca, Anna Starnawska · 2022 · Genes
P11 (S100A10) as a potential predictor of ketamine response in patients with SSRI-resistant depression
Emma R. Veldman, Dejan Mamula, Haitang Jiang, Mikael Tiger, Carl Johan Ekman, Johan Lundberg, Per Svenningsson · 2021 · Journal of Affective Disorders
Exploring real-world evidence to uncover unknown drug benefits and support the discovery of new treatment targets for depressive and bipolar disorders
Rachel E. Teneralli, David M. Kern, M. Soledad Cepeda, James P. Gilbert, Wayne Curtis Drevets · 2021 · Journal of Affective Disorders
Synthesis and biological evaluation of 1-(4-(piperazin-1-yl)phenyl)pyridin-2(1H)-one derivatives as potential SSRIs
Tengfei Xu, Ya‐Ping Xue, Jie-Lian Lu, Chuanfei Jin · 2021 · European Journal of Medicinal Chemistry
Mindfulness skills and experiential avoidance as therapeutic mechanisms for treatment-resistant depression through mindfulness-based cognitive therapy and lifestyle modification
Garcia-Toro, Mauro, Aguilar-Latorre, Alejandra, Garcia, Aurora, Navarro-Guzmán, Capilla, Gervilla, Elena, Seguí, Andrea, Gazquez, Francisco, Marino, Jose Antonio, Gomez-Juanes, Rocío, Serrano-Ripoll, María J. et al. · 2023 · Frontiers in Psychology
Cost-Utility Analysis of Esketamine for Patients with Treatment-Resistant Depression in Italy
Carla Rognoni, Camilla Falivena, Francesco Costa, Patrizio Armeni · 2023 · PharmacoEconomics
Stem cell-derived brain organoids for controlled studies of transcranial neuromodulation
Jan Kubanek, Matthew Wilson, Richard D. Rabbitt, Celeste J. Armstrong, Alexander J. Farley, H. M. Arif Ullah, Alex Shcheglovitov · 2023 · Heliyon
Anti-Neuroinflammatory Effects of a Macrocyclic Peptide-Peptoid Hybrid in Lipopolysaccharide-Stimulated BV2 Microglial Cells
Lu Sun, Soraya Wilke Saliba, Matthias Apweiler, Kamil Akmermer, Claudine Herlan, Christoph W. Grathwol, Antônio Carlos Pinheiro de Oliveira, Claus Normann, Nicole Jung, Stefan Bräse et al. · 2024 · International Journal of Molecular Sciences
Vitamin-mediated interaction between the gut microbiome and mitochondria in depression: A systematic review-based integrated perspective
Ellen Bisle, Suchithra Varadarajan, Iris‐Tatjana Kolassa · 2024 · Brain Behavior & Immunity - Health
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Sarah Ali, Yogesh Dwivedi · 2024 · Molecular Neurobiology
Longitudinal trajectories of symptom change during antidepressant treatment among managed care patients with depression and anxiety
Judith Cukor, Zhenxing Xu, Veer Vekaria, Fei Wang, Mark Olfson, Samprit Banerjee, Gregory E. Simon, George S. Alexopoulos, Jyotishman Pathak · 2024 · npj Mental Health Research
Depressive disorders: systematic review of approved psychiatric medications (2009-April 2025) and pipeline phase 3 medications
Waguih William IsHak, Drew Hirsch, Sabrina Renteria, Jayant Totlani, Nathalie Murphy, Tiffany Y. Chang, Rasha Abdelsalam, Mohamed Salem, Ashley Meyer, Shirley Keerthana et al. · 2025 · BMC Psychiatry
The effects of perinatal fluoxetine exposure on emotionality behaviours and cortical and hippocampal glutamatergic receptors in female Sprague-Dawley and Wistar-Kyoto rats
Samuel J. Millard, Jeremy Stephen Lum, Francesca Fernandez, Katrina Weston–Green, Kelly Anne Newell · 2020 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
The role of ventral tegmental area orexinergic afferents in depressive-like behavior in a chronic unpredictable mild stress (CUMS) mouse model
Yunyun Song, Jiannan Li, Huiming Li, Min Cai, Danmin Miao · 2021 · Biochemical and Biophysical Research Communications
Descriptive analysis of the economic burden of treatment resistance in a major depressive episode
Qian Cai, John J. Sheehan, Bingcao Wu, Larry D Alphs, Nancy Connolly, Carmela J. Benson · 2019 · Current Medical Research and Opinion
Reducing suicidal ideation by biofeedback-guided respiration – heart rate coherence
Herbert Franz Jelinek, Ahsan Habib Khandoker · 2020 · Digital Psychiatry
Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression
Shami Kanekar, Chandni S. Sheth, Hendrick Ombach, Jadeda Brown, Michael D. Hoffman, Robert Ettaro, Perry Franklin Renshaw · 2021 · Psychopharmacology
A narrative review on invasive brain stimulation for treatment-resistant depression
Manoj P. Dandekar, Alexandre Paim Díaz, Ziaur Rahman, Ritele Hernandez da Silva, Ziad H. Nahas, Scott T. Aaronson, Sudhakar Selvaraj, Albert J. Fenoy, Marsal Sanches, Jair C. Soares et al. · 2021 · Brazilian Journal of Psychiatry
Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy
Claudia Pisanu, Erika Vitali, Anna Meloni, Donatella Congiu, Giovanni Severino, Raffaella Ardau, Caterina Chillotti, Luigi Trabucchi, Marco Bortolomasi, Massimo Gennarelli et al. · 2021 · Journal of Personalized Medicine
Physical activity in the treatment-resistance depression and non-remitted depression: a systematic review of randomized controlled trials
José Etxaniz‐Oses, Nagore Iriarte‐Yoller, Mikel Tous‐Espelosin, Sara Maldonado‐Martín · 2023 · F1000Research
Multiple cellular targets involved in the antidepressant-like effect of glutathione
Alcir Luiz Dafré, Juliana M. Rosa, Ana Lúcia S. Rodrigues, Mauricio Peña Cunha · 2020 · Chemico-Biological Interactions
Self-blame-selective hyper-connectivity between anterior temporal and subgenual cortices predicts prognosis in major depressive disorder
Fennema, Diede, Barker, Gareth J., O'Daly, Owen, Duan, Suqian, Carr, Ewan, Goldsmith, Kimberley, Young, Allan H., Moll, Jorge, Zahn, Roland · 2023 · NeuroImage: Clinical
A Low-Intensity Internet-Based Intervention Focused on the Promotion of Positive Affect for the Treatment of Depression in Spanish Primary Care: Secondary Analysis of a Randomized Controlled Trial
Vara, Mª Dolores, Mira, Adriana, Miragall, Marta, García-Palacios, Azucena, Botella, Cristina, Gili, Margalida, Riera-Serra, Pau, García-Campayo, Javier, Mayoral-Cleries, Fermín, Baños, Rosa Mª · 2020 · International Journal of Environmental Research and Public Health
Treating Treatment-resistant Depression with Esketamine Nasal Spray When All Therapeutic Options Have Been Exhausted: Clinical Experience from a Spanish Cohort of Expanded Use
Júlia Vendrell-Serres, Óscar Soto-Angona, Amanda Rodríguez‐Urrutia, Benedetta Inzoli, A González, Josep Antoni Ramos‐Quiroga · 2023 · Clinical Psychopharmacology and Neuroscience
Application of graph frequency attention convolutional neural networks in depression treatment response
Zihe Lu, Jialin Wang, Fengqin Wang, Zhoumin Wu · 2023 · Frontiers in Psychiatry
Safety and efficacy of repetitive stimulation of the left dorsolateral prefrontal cortex using transcranial focused ultrasound in treatment-resistant depressed patients: A non-inferiority randomized controlled trial protocol
Gustavo dos Santos Alves Maria, Natália Silva Dias, Rodrigo Nicolato, Jonas Jardim de Paula, Maria Aparecida Camargos Bicalho, Renan Souza Cunha, Luciana Costa Silva, Débora Marques de Miranda, Bernardo de Mattos Viana, Marco Aurélio Romano‐Silva · 2024 · Asian Journal of Psychiatry
Exploring the incidence of inadequate response to antidepressants in the primary care of depression
Abigail B. Abrahams, Amy C. Beckenstrom, Michael D Browning, Rebecca Dias, Guy M. Goodwin, Philip A. P. M. Gorwood, Jonathan Kingslake, Richard Keith Morriss, Andreas Reif, Henricus Gerardus Ruhé et al. · 2024 · European Neuropsychopharmacology
Association between the functional brain network and antidepressant responsiveness in patients with major depressive disorders: a resting-state EEG study
Kang‐Min Choi, Hyeon-Ho Hwang, Chaeyeon Yang, Bori Jung, Chang‐Hwan Im, Seung‐Hwan Lee · 2025 · Psychological Medicine
Environmental determinants of ketamine’s prohedonic and antianhedonic efficacy: Persistence of enhanced reward responsiveness is modulated by chronic stress
Amaya R. Jenkins, Daniela Betiana Radl, Thomas J. Kornecook, Diego A. Pizzagalli, Jack Bergman, Derek L. Buhl, Patricio O’Donnell, Brian D. Kangas · 2025 · Journal of Pharmacology and Experimental Therapeutics
Exploring depression treatment response by using polygenic risk scoring across diverse populations
Sandra Lapinska, Aditya Pimplaskar, Zhuozheng Shi, Yi Ding, Clara Frydman-Gani, Kangcheng Hou, Vidhya Venkateswaran, Kristin M. Boulier, Loes M. Olde Loohuis, Bogdan Paşaniuc · 2025 · The American Journal of Human Genetics
The Effects of Psychotherapy on Single and Repeated Ketamine Infusion(s) Therapy for Treatment-Resistant Depression: The Convergence of Molecular and Psychological Treatment
Sofia Sakopoulos, McWelling Todman · 2025 · International Journal of Molecular Sciences
The Genetics of Major Depression: Perspectives on the State of Research and Opportunities for Precision Medicine
R. Peterson · 2021 · Psychiatric annals
Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological, pre-clinical and clinical activities
T.L. Olatunji, Frances Siebert, Ademola Emmanuel Adetunji, Brian Herbert Harvey, Johané Gericke, Josias Hendrik Hamman, Frank van der Kooy · 2021 · Journal of Ethnopharmacology
The Use of Kinesthetic Empathy with Adults Living with Treatment Resistant Depression: A Survey Study
Neha Christopher, Jeanette Tamplin · 2022 · American Journal of Dance Therapy
Lactobacillus reuteri ATG-F4 Alleviates Chronic Stress-induced Anhedonia by Modulating the Prefrontal Serotonergic System
Jiyun Lee, Eum-Ji Kim, Gun-Seok Park, Jeongseop Kim, Taeeun Kim, Yoo Jin Lee, Juyi Park, Jihee Kang, Ja Wook Koo, Tae-Yong Choi · 2023 · Experimental Neurobiology
Sildenafil, alone and in combination with imipramine or escitalopram, display antidepressant-like effects in an adrenocorticotropic hormone-induced (ACTH) rodent model of treatment-resistant depression
Juandré Lambertus Bernardus Saayman, Brian Herbert Harvey, Gregers Wegener, Christiaan Beyers Brink · 2024 · European Journal of Pharmacology
Remission of treatment-resistant depression with tardive akathisia with electroconvulsive therapy
Thanos Emmanuel · 2019 · BMJ Case Reports