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Cited by 19Skin Protection and AgingDrug-Induced Adverse ReactionsPharmaceutical Practices and Patient Outcomes

Photosensitivity reactions in the elderly population: questionnaire-based survey and literature review

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Korzeniowska, Katarzyna, Cieślewicz, Artur, Chmara, Ewa, Jabłecka, Anna, Pawlaczyk, Mariola·2019·Therapeutics and Clinical Risk Management
DOI 10.2147/tcrm.s215308PMC PMC6748316
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Abstract

PURPOSE: Older people are at risk of developing adverse drug reactions, including photosensitivity reactions. Therefore, the aim of the study was to assess the use of potentially photosensitizing medications and photoprotection in the elderly population. PATIENTS AND METHODS: Three hundred and fifty-six respondents (223 [63%] women and 133 [37%] men) aged ≥65 years filled in the original questionnaire concerning photosensitivity reactions to drugs. The diagnosis of drug-induced photosensitivity was based on medical history and clinical examination. RESULTS AND CONCLUSION: We found that drugs potentially causing phototoxic/photoallergic reactions comprised more than one fifth of all drugs used by the participants. The most numerous group was patients treated with 3-5 drugs potentially causing phototoxic/photoallergic reactions simultaneously. Of all drugs, ketoprofen was found to cause the highest number of photosensitivity reactions. Cutaneous adverse reactions were also observed for hydrochlorothiazide, atorvastatin, simvastatin, telmisartan, and metformin. Moreover, it was found that the incidence of photosensitivity reactions can be significantly reduced by using proper photoprotection.

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  • Individual responses to phototoxic chemicals are influenced by several parameters, including absorption, metabolism and light penetration into the skin.

    “Individual responses to phototoxic chemicals are influenced by several parameters, including absorption, metabolism and light penetration into the skin”

    From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Korzeniowska et al. 2019

    The Introduction (page unavailable) says phototoxic reactions require a large drug dose and exposure to light, supporting the general point that responses depend on more than the chemical alone. It does not identify absorption, metabolism, or light penetration into the skin as factors influencing individual responses; searches for those terms found no such passage. (LLM, conf=0.76)

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Authors
Korzeniowska, K., Cieślewicz, A., Chmara, E., Jabłecka, A., & Pawlaczyk, M.
Affiliations
Poznan University of Medical Sciences (PL)
Corresponding author
Cieślewicz, Artur
ORCID
Venue
Therapeutics and Clinical Risk Management
Publisher
Informa UK Limited
Published
2019-09
Volume
Volume 15
Pages
1111-1119
ISSN
  • 1176-6336 (ISSN-L)
  • 1178-203X
DOI
10.2147/tcrm.s215308
PMC
PMC6748316
OpenAlex
W2972347091
Cited by
19
References
0
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2012: 1
FWCI
1.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Therapeutics and Clinical Risk Management (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
photosensitivity reactions, drug-induced photosensitivity, phototoxicity, photoallergic reactions, older adults, photoprotection, ketoprofen, hydrochlorothiazide, statins, metformin, adverse drug reactions, polypharmacy

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