The DOI matches its Crossref record; 129 of the 130 references it cites were found in a registry or an index.
Canine neosporosis: perspectives on pathogenesis and management
Open accessAbstract
Abstract: Canine neosporosis is a worldwide disease caused by the obligate intracellular parasite protozoan Neospora caninum , manifesting mainly neurological symptoms. N. caninum has a heteroxenous life cycle and affects a wide range of warm-blooded animals. The domestic and wild canids are the definitive host of the parasite. They shed oocysts after ingestion of tissue cysts from infected intermediate hosts (ovine, equine, bovine, canine, and many other species), containing bradyzoites, or oocyst-contaminated water and food. The presence of dogs in farms is considered a risk factor for production animals. A wide range of diagnostic methods are currently available, but the most used is serology, ie, indirect fluorescent antibody test specific to the antibody detection in blood serum samples. No vaccine is available, but control strategies should be focused on the vertical and horizontal transmission of the parasite, ie, avoid feeding dogs with raw or undercooked meat, and taking care with water for human and animal consumption. No medicines to control the transplacental transmission are available yet. Keywords: neosporosis, Neospora caninum , pathogenesis, management, dogs
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“Several helminths and protozoa have been proposed as potential pathogenic risks for raw‐fed cats and dogs and/or for in‐contact owners and livestock.”
From Raw diets for dogs and cats: a review, with particular reference to microbiological hazards. (2019) · cites this paper as Silva & Machado 2016
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Citations
Cites
Pathologic basis of veterinary disease
McGavin, M. D., & Zachary, J. F. (2007) · Elsevier eBooks · Cited by 1,488
Epidemiology and Control of Neosporosis and Neospora caninum
Dubey, J. P., Schares, G., & Ortega‐Mora, L. M. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00031-06 · Cited by 1,056 · cited 2×
“Vertical transmission happens during terminal stages of gestation (transplacental transmission with fetal infection) or postnatally, by the transmission of tachyzoites via milk (transmammary transmission).(3,52) In horizontal transmission, the infection occurs postnatally after ingestion of water containing sporulated…”
Dogs are definitive hosts of Neospora caninum.
McAllister, M. Μ., Dubey, J. P., Lindsay, D. S., Jolley, W. R., Wills, R. A., & McGuire, A. M. (1998) · PubMed · Cited by 996
A review of Neospora caninum and neosporosis
Dubey, J. P., & Lindsay, D. S. (1996) · Veterinary Parasitology · doi:10.1016/s0304-4017(96)01035-7 · Cited by 970 · cited 1×
“The parasite can be transmitted multiple times from the infected female dog to her offspring, because no preventive treatment is available.(12) Dogs should never have access to bovine placental materials, dead calves, fetal membranes, aborted fetuses, or raw/ undercooked meat, and should be prevented from defecating a…”
Newly recognized fatal protozoan disease of dogs
Dubey, J. P., Carpenter, J. L., Speer, C. A., Topper, M. J., & Uggla, A. (1988) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1988.192.09.1269 · Cited by 828 · cited 2×
“Articular deformation and joint curvature (genu recurvatum) can occur in some puppies,(30) followed by cervical weakness, dysphagia, megaesophagus, and death.(8,25,26) Dogs remain”
Review of Neospora caninum and neosporosis in animals
Dubey, J. P. (2003) · Korean Journal of Parasitology · doi:10.3347/kjp.2003.41.1.1 · Cited by 828 · cited 4×
“10,85 No breed predisposition or differential sex susceptibility to neosporosis in dogs is known, 33 but age can be a risk factor.”
InfluentialNeosporosis in animals—The last five years
Dubey, J. P., & Schares, G. (2011) · Veterinary Parasitology · doi:10.1016/j.vetpar.2011.05.031 · Cited by 699 · cited 3×
“caninum in sheep is less clear when compared with cattle.(6) In Norway, Bjerkås et al(7) diagnosed a disease similar to toxoplasmosis, another”
InfluentialCoyotes (Canis latrans) are definitive hosts of Neospora caninum
Gondim, L. F. P., McAllister, M. Μ., Pitt, W. C., & Zemlicka, D. E. (2004) · International Journal for Parasitology · doi:10.1016/j.ijpara.2004.01.001 · Cited by 569 · cited 1×
“9 McAllister et al 10 defined the domestic dog ( Canis lupus familiaris ) as the definitive host of N. caninum , and Gondim et al 2 reported the coyote ( C. latrans ) as a wild definitive host of the parasite by confirming the sexual stage of the parasite, and oocysts being shed in feces.”
Unidentified cyst-forming Sporozoon causing encephalomyelitis and myositis in dogs
Bjerk�s, I., Mohn, S. F., & PRESTHUS, J. (1984) · Parasitology Research · doi:10.1007/bf00942230 · Cited by 477 · cited 2×
“and described the disease caused by a protozoan infecting a puppy with clinical signs similar to those reported by Bjerkas et al.(7) Afterwards, this protozoan was recognized”
Recent advances in Neospora and neosporosis
Dubey, J. P. (1999) · Veterinary Parasitology · doi:10.1016/s0304-4017(99)00044-8 · Cited by 414 · cited 1×
“caninum can produce necrotic lesions, which are detectable in a few days; it causes cell death by the active multiplication of the tachyzoites, and can induce neuromuscular diseases in dogs and other species by the destruction of a large number of neuronal cells, ie, cranial and spinal nerves, which affect the nerve-i…”
Background
Research works printed but not linked: 4
- [20]Sykes JE Neosporosis Sykes JE Canine and Feline Infectious Diseases 1 1st ed St Louis Elsevier 2014 704 712
- [27]Dubey JP Lindsay DS Neosporosis Parasitol Today 1993 9 12 452 458 15463690
- [39]Almería S Neospora caninum and wildlife ISRN Parasitol 2013 2013 947347 27335866 PMC4890850
- [122]Ramamoorthy S Lindsay DS Schurig GG Vaccination with γ-irradiated Neospora caninum tachyzoites protects mice against acute challenge with N. caninum J Eukaryot Microbiol 2006 53 2 151 156 16579818
Cited by
Sorted by citations
Raw diets for dogs and cats: a review, with particular reference to microbiological hazards.
Davies, R. H., Lawes, J. R., & Wales, A. D. (2019) · Journal of Small Animal Practice · doi:10.1111/jsap.13000 · Cited by 195
“…caninum, Sarcocystis species, Toxoplasma gondii, Isospora species, Cryptosporidium parvum, Giardia, Echinococcus granulosus, Echinococcus multilocularis, Taenia hydatigena, Taenia ovis and Trichinella species (LeJeune & Hancock 2001, Macpherson 2005, Silva & Machado 2016, van Bree et al. 2018).”
BackgroundNeospora caninum, A potential cause of reproductive failure in dairy cows from Northern Greece
Lefkaditis, M., Mpairamoglou, R., Sossidou, A., Spanoudis, K., & Tsakiroglou, M. (2019) · Veterinary Parasitology Regional Studies and Reports · doi:10.1016/j.vprsr.2019.100365 · Cited by 31
“While this disease has a considerable impact on reproduction in cattle, in adult and older dogs appears to be asymptomatic (Silva and Machado, 2016; Kul et al., 2015; Lindsay et al., 1999a).”
Wei, X., An, Q., Xue, N.-Y., Chen, Y., Chen, Y., Zhang, Y., Zhao, Q., & Wang, C.-R. (2022) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2022.105620 · Cited by 30
Effects of Neospora caninum on reproductive parameters in dairy cows from a closed herd in Brazil
de Barros, L. D., Bogado, A. L. G., Furlan, D., Jardim, A. D. M., Okano, W., da Silva, L. C., Pereira, C. E. S., Bronkhorst, D. E., Cardim, S. T., & Garcia, J. L. (2020) · Veterinary Parasitology Regional Studies and Reports · doi:10.1016/j.vprsr.2020.100524 · Cited by 19
Didiano, A., Monti, P., Taeymans, O., & Cherubini, G. B. (2020) · Veterinary Record Case Reports · doi:10.1136/vetreccr-2019-000905 · Cited by 18
Metadata
- Authors
- Silva, R., & Machado, G.
- ORCID
- Machado, Gustavo
- Venue
- Veterinary Medicine: Research and Reports
- Publisher
- Informa UK Limited
- Published
- 2016-04
- Volume
- 7
- Pages
- 59
- ISSN
- 2230-2034 (ISSN-L)
- PMC
- PMC6055790
- OpenAlex
- W2343809509
- Cited by
- 62
- References
- 130
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 12 · 2023: 9 · 2022: 4 · 2021: 11 · 2020: 10 · 2019: 6 · 2018: 1 · 2016: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Veterinary Medicine Research and Reports (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Toxoplasma gondii Research Studies
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Coccidia and coccidiosis research
- Keywords
- canine neosporosis, Neospora caninum, pathogenesis, disease management, neurological symptoms, heteroxenous life cycle, definitive host, intermediate hosts, bradyzoites, serological diagnosis, indirect fluorescent antibody test, transplacental transmission, vertical transmission, horizontal transmission, water pollution
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