Clinical characteristics of dermatomyosits/polymyositis associated interstitial lung disease according to the autoantibody
Open accessAbstract
BACKGROUND: Dermatomyositis (DM) and polymyositis (PM) often have association with interstitial lung disease (ILD) which have disease specific autoantibody. METHODOLOGY: We reviewed medical records of DM/PM associated ILD from January 2000 to December 2017 according to the autoantibody. RESULT: We identified 52 patients, of whom 30 were antibody negative, 18 had anti aminoacyl-tRNA synthetases (ARS) antibodies and 4 had anti melanoma differentiation-associated gene (MDA)-5 antibody. In high resolution computed tomography (HRCT) of the chest, area of ground glass opacity (GGO), consolidation, and lung tip consolidation were more extensive in anti MDA-5 antibody positive patients (p=0.051, p=0.026, and p=0.027, respectively). Among laboratory findings, GOT had strong correlations with CPK (r=0.889, p < 0.001), and LDH (r=0.910, p < 0.001). Among roentgenographic findings, there were moderate correlations between GGO and consolidation (r=0.668, p < 0.001), and between reticular shadow and traction bronchiectasis (p=0.633, p < 0.001). ILD patients with anti MDA-5 antibodies had decreased survival (1.00 vs 84.3, 22.9 months, p < 0.001). CONCLUSION: ILD patients with anti ARS antibody had intense inflammation, but reversible fibrosis and good prognosis. On the other hand, anti MDA-5 antibody positive ILD patients had shorter survival. Extent of parenchymal shadow and serum GOT were useful indicator of disease activity of PM/DM associated ILD patients in our cohort. J. Med. Invest. 65:251-257, August, 2018.
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Some studies have shown no notable effects of anti-fibrotic agents on wounds, anastomosis, or bleeding.
“some studies have shown no notable effects of anti-fibrotic agents on wounds, anastomosis, or bleeding [51-53].”
From Indications for Lung Transplantation and Patient Selection (2022) · cites this paper as [52]
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- Authors
- Kishaba, T., McGill, R., Nei, Y., Ibuki, S., Momose, M., Nishiyama, K., Nagano, H., & Yamashiro, S.
- Affiliations
- Okinawa Prefectural Chubu Hospital (JP)
- University of Chicago (US)
- Kyoto University (JP)
- Venue
- The Journal of Medical Investigation
- Published
- 2018
- Volume
- 65
- Issue
- 3.4
- Pages
- 251-257
- ISSN
- 1343-1420 (ISSN-L)
- 1349-6867
- OpenAlex
- W2894769425
- Cited by
- 24
- References
- 25
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- The Journal of Medical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- dermatomyositis, polymyositis, interstitial lung disease, anti-MDA5 antibodies, autoantibody classification, ground-glass opacities, lung consolidation, serum GOT, creatine kinase, lactate dehydrogenase, survival, disease activity markers
- MeSH terms
- Interferon-Induced Helicase, IFIH1, Adolescent, Adult, Aged, Aged, 80 and over, Amino Acyl-tRNA Synthetases, Antibody Specificity, Autoantibodies, Dermatomyositis, Female, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Polymyositis, Lung Diseases, Interstitial, Young Adult
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