Effect of Vitamin D Supplementation in Improving Pregnancy Rates in Infertile Women with PCOS
Open accessAbstract
Polycystic ovarian condition (PCOS) is the most well-known endocrine problem that influences ladies in the youngster bearing period. The point of the current examination was to contemplate the impact of nutrient D supplementation in nutrient D inadequate PCOS ladies, as respects the clinical pregnancy and ovulation rates. Patient and techniques : This is a Randomized controlled clinical preliminary investigation included 100 nutrient D inadequate/lacking fruitless ladies with an analysis of PCOS. Serum 25-OH-VD levels were estimated and ladies were haphazardly partitioned into Vitamin D and placepo gatherings. Following 3 months of metformin ± nutrient D supplementation, all included ladies got ovulation enlistment by letrozole 2.5 mg. Sequential trans vaginal ultrasound was performed and evaluated. Results: Following nutrient D3 supplementation, the rate of continuous pregnancy demonstrated genuinely huge expansion in nutrient D gathering contrasted with fake treatment group(39.1% and 18.4%% separately) P = 0.025. Likewise measurably critical expansion in ovulation after the enlistment cycles in vit D gathering contrasted with the fake treatment gathering (p = 0.001, 0.001 and 0.045) through three continuous acceptance cycles . End: In subfertile ladies with PCOS, Vitamin D supplementation may have a possible adjuvant part to standard enlistment of ovulation regimens.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vitamin D administration led to improved fertility and ovulation rates in women with PCOS whose vitamin D is insufficient.
“A study has shown that the administration of vitamin D led to improved fertility and ovulation rates in women with PCOS whose vitamins are insufficient [67].”
Cites
Holick, M. F., Binkley, N., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., & Weaver, C. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0385 · Cited by 10,556 · see citing works
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924 · see citing works
March, W. A., Moore, V. M., Willson, K. J., Phillips, D. I. W., Norman, R. J., & Davies, M. J. (2010) · Human Reproduction · doi:10.1093/humrep/dep399 · Cited by 1,799 · see citing works
“Activation” of vitamin D by the liver
Ponchon, G., Kennan, A. L., & DeLuca, H. F. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106168 · Cited by 389 · see citing works
Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome
Yıldızhan, R., Kurdoğlu, M., Adalı, E., Kolusarı, A., Yıldızhan, B., Şahin, H. G., & Kamacı, M. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-0958-7 · Cited by 231 · see citing works
The Effects of Calcium-Vitamin D and Metformin on Polycystic Ovary Syndrome: A Pilot Study
Rashidi, B. H., Haghollahi, F., Shariat, M., & Zayerii, F. (2009) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/s1028-4559(09)60275-8 · Cited by 151 · see citing works
The effects of old, new and emerging medicines on metabolic aberrations in PCOS
Bargiota, Α., & Diamanti‐Kandarakis, E. (2012) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018812437355 · Cited by 118 · see citing works
Role of vitamin D in female Reproduction
Shahrokhi, S. Z., Ghaffari, F., & Kazerouni, F. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.12.040 · Cited by 104 · see citing works
Pal, L., Zhang, H., Williams, J. W., Santoro, N. F., Diamond, M. P., Schlaff, W. D., Coutifaris, C., Carson, S. A., Steinkampf, M. P., Carr, B. R., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4352 · Cited by 103 · see citing works
Serum Vitamin D Concentrations and Unexplained Elevation in ALT Among US Adults
Liangpunsakul, S., & Chalasani, N. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1707-x · Cited by 73 · see citing works
Abedi, S., Taebi, M., & Esfahani, M. H. N. (2019) · Europe PMC (PubMed Central) · doi:10.22074/ijfs.2019.5470 · Cited by 29 · see citing works
Rasheedy, R., Sammour, H. M., Elkholy, A. G., & Salim, Y. (2020) · Endocrine · doi:10.1007/s12020-020-02315-3 · Cited by 20 · see citing works
(2008) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9781439807224.008 · Cited by 9 · see citing works
Serum Vitamin D Concentrations and Unexplained Elevation in ALT Among US Adults
Boucher, B. J. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1768-x · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Muhammed Saeed, A. A., Noreen, S., Awlqadr, F. H., Farooq, M. I., Qadeer, M., Rai, N., Farag, H. A., & Saeed, M. N. (2025) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-025-00899-y · Cited by 29 · see citing works
“A study has shown that the administration of vitamin D led to improved fertility and ovulation rates in women with PCOS whose vitamins are insufficient [67].”
Rehman, R., Naz, S., Khan, H. N., Sheikh, A., Azhar, A., Ashraf, M., Afzal, S., & Khan, A. H. (2023) · Research Square · doi:10.21203/rs.3.pex-2199/v1 · Cited by 1 · see citing works
Khan, A. H., Khan, U. I., Khan, H. N., Zahid, N., & Rehman, R. (2024) · Research Square · doi:10.21203/rs.3.pex-2558/v1 · Cited by 1 · see citing works
- Authors
- Nosseir, M. A., Sadek, A. M., Awad, S. H., & Edris, T. I.
- Affiliations
- Benha University (EG)
- Venue
- Benha Journal of Applied Sciences
- Published
- 2021-04-01
- Volume
- 6
- Issue
- 2
- Pages
- 267-272
- ISSN
- 2356-9751 (ISSN-L)
- 2356-976X
- OpenAlex
- W3164981385
- Cited by
- 3
- References
- 14
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Benha Journal of Applied Sciences (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- vitamin D supplementation, polycystic ovary syndrome, female infertility, clinical pregnancy rate, ovulation induction, letrozole, metformin, 25-hydroxyvitamin D, vitamin D deficiency, assisted reproduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
