The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effects of Chronic Stress on Penile Corpus Cavernosum of Rats
Abstract
Abstract: The objective of this study was to investigate structural changes in the penile corpus cavernosum of prepubertal chronically stressed rats. Eight Wistar rats were assigned into the stress group (SG) and were submitted to 2 hours of tube restraint daily, from the fourth to the ninth week of life. Another 7 rats were used as the control group (CG). All animals were weighed weekly. At day 64, animals were sacrificed by anesthetic overdose, blood was collected for testosterone concentration by radioimmunoassay, and penis and adrenal were collected. Adrenal mass index and testosterone serum levels were used to assess the efficacy of the stress stimulus. The surface density of connective tissue and smooth muscle fibers of corpus cavernosum were measured on Masson trichromic—stained slices. Picrosirius red—stained slices were assessed under polarized light for different types of collagen. The Student's t test was applied for mean comparisons, with P < .05 considered significant. Testosterone serum concentrations decreased and adrenal mass index increased, confirming the effectiveness of the stress protocol. Smooth muscle fibers of corpus cavernosum decreased from 14.07% (CG) to 8.98% (SG) (P = .02), and connective tissue increased from 53.66% (CG) to 64.47% (SG) (P = .01). Also, there was a higher level of type I collagen in the SG animals compared with the CG. Stress stimuli induced structural changes in the corpus cavernosum of rats suggestive of penile fibrosis, which may play a role in erection dysfunction.
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“The corpus cavernosum tissues of male rats under long-term stress had morphological changes (10).”
From Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in patients with psychogenic erectile dysfunction (2023) · cites this paper as [10]
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“Recent experimental evidence suggests that chronic stress is also closely related to ED (9–12).”
From Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in patients with psychogenic erectile dysfunction (2023) · cites this paper as [10]
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Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation
Hatzimouratidis, K., Amar, E., Eardley, I., Giuliano, F., Hatzichristou, D., Montorsi, F., Vardi, Y., & Wespes, E. (2010) · European Urology · doi:10.1016/j.eururo.2010.02.020 · Cited by 1,223
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Cited by
Xu, J., Chen, Y., Gu, L., Liu, X., Yang, J., Li, M., Rao, K., Dong, X., Yang, S., Huang, B., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1103621 · Cited by 13
Metadata
- Authors
- De Souza, D. B., Silva, D., Cortez, C. M., Costa, W. S., & Sampaio, F. J. B.
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 2012-07-08
- Volume
- 33
- Issue
- 4
- Pages
- 735-739
- ISSN
- 0196-3635
- 1939-4640
- Cited by
- 34
- References
- 1
- Language
- en
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