The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Erectile Dysfunction
Abstract
Erectile dysfunction is defined as the inability to achieve and maintain an erection sufficient to permit satisfactory sexual intercourse.1 It has been estimated to affect 20 million to 30 million men in the United States.2,3 It may result from psychological, neurologic, hormonal, arterial, or cavernosal impairment or from a combination of these factors. In this article we provide a brief overview of the physiology of erection and the pathophysiology of erectile dysfunction, followed by a discussion of drug treatment for the disorder.Physiology of Penile ErectionPenile erection is a neurovascular event modulated by psychological factors and hormonal status. . . .
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“The mechanism of action of the phosphodiesterase type 5 (PDE5) inhibitors (i.e., sildenafil, tadalafil, and vardenafil) involves inhibition of the PDE5 isoenzyme located in penile vascular smooth muscle cells.”
From Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles (2004) · cites this paper as [5]
In the citing paper
“The PDE5 inhibitors have no effect on the penis in the absence of sexual stimulation.”
From Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles (2004) · cites this paper as [5]
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Citations
Cites
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
Oral Sildenafil in the Treatment of Erectile Dysfunction
Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120
Self-citation(1999) · doi:10.1016/s0090-4295(99)00099-0 · Cited by 1,051
Treatment of Men with Erectile Dysfunction with Transurethral Alprostadil
Padma-Nathan, H., Hellstrom, W. J. G., Kaiser, F. E., Labasky, R. F., Lue, T. F., Nolten, W. E., Norwood, P. C., Peterson, C. A., Shabsigh, R., Tam, P. Y., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701023360101 · Cited by 574
Self-citationIncreased incidence of depressive symptoms in men with erectile dysfunction
Shabsigh, R., Klein, L. T., Seidman, S., Kaplan, S. A., Lehrhoff, B. J., & Ritter, J. S. (1998) · Urology · doi:10.1016/s0090-4295(98)00292-1 · Cited by 296
Cited by
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
Shamloul, R., & Ghanem, H. (2013) · The Lancet · doi:10.1016/s0140-6736(12)60520-0 · Cited by 1,091
A side effect resource to capture phenotypic effects of drugs
Kuhn, M., Campillos, M., Letunic, I., Jensen, L. J., & Bork, P. (2010) · Molecular Systems Biology · doi:10.1038/msb.2009.98 · Cited by 899
Authors/Task Force Members: Joep Perk (Chairperson) (Sweden)*, G. D. B. (. (2012) · European Journal of Preventive Cardiology · doi:10.1177/2047487312450228 · Cited by 863
Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.3 · Cited by 853
Metadata
- Authors
- Lue, T. F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-06-15
- Volume
- 342
- Issue
- 24
- Pages
- 1802-1813
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4249523014
- Cited by
- 1,252
- References
- 5
- FWCI
- 30.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Erectile Dysfunction. https://app.cochat.ai/papers/10.1056/nejm200006153422407
- The paper
- Lue, T. F. (2000). Erectile Dysfunction. New England Journal of Medicine. https://doi.org/10.1056/nejm200006153422407
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
