The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A Practical Guide for Calculating Indirect Costs of Disease
Abstract
There may be some discussion about whether indirect costs should be taken into account at all in an economic appraisal, but there is certainly considerable debate about the proper way of estimating these costs. This reviews offers a practical guide for quantifying and valuing these indirect costs of disease, both at an aggregated level of general cost of illness studies, and in an economic appraisal of specific healthcare programmes. Two methods of calculating these costs are considered: the traditional human capital approach, and the more recently developed friction cost method. The former method estimates the potential value of lost production as a result of disease, whereas the latter method intends to derive more realistic estimates of indirect costs, taking into account the degree of scarcity of labour in the economy. All necessary steps in the estimation procedure and the data required at various points will be described and discussed in detail.
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“Data for the assessment of the economic evaluation reporting standards were extracted using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 statement.”
From Productivity outcomes from chronic pain management interventions in the working age population; a systematic review (2024) · cites this paper as [20]
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Cites
The friction cost method for measuring indirect costs of disease
Koopmanschap, M. A., Rutten, F., van Ineveld, B. M., & Roijen, L. H. (1995) · Journal of Health Economics · doi:10.1016/0167-6296(94)00044-5 · Cited by 1,141
Self-citationEconomics of coronary artery bypass grafting.
Williams, A. (1985) · BMJ · doi:10.1136/bmj.291.6491.326 · Cited by 718
Drummond, M. (1992) · PharmacoEconomics · doi:10.2165/00019053-199202010-00001 · Cited by 489
Labor and Health Status in Economic Evaluation of Health Care: The Health and Labor Questionnaire
Roijen, L. H., Essink‐Bot, M., Koopmanschap, M., Bonsel, G. J., & Rutten, F. (1996) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462300009764 · Cited by 308
Self-citationIndirect Costs in Economic Studies
Koopmanschap, M. A., & Rutten, F. (1993) · PharmacoEconomics · doi:10.2165/00019053-199304060-00006 · Cited by 170
Self-citationGerard, K., Donaldson, C., & Maynard, A. (1989) · Diabetic Medicine · doi:10.1111/j.1464-5491.1989.tb02107.x · Cited by 145
The impact of indirect costs on outcomes of health care programs
Koopmanschap, M. A., & Rutten, F. (1994) · Health Economics · doi:10.1002/hec.4730030606 · Cited by 90
Self-citationCyclical variation in vacancy durations and vacancy flows
OURS, J. C. V., & Ridder, G. (1991) · European Economic Review · doi:10.1016/0014-2921(91)90010-g · Cited by 41
Costs of illness in Sweden, 1964-1975
Lindgren, B. (1981) · Medical Entomology and Zoology · Cited by 27
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“We estimated the costs of lost productivity using a human capital approach.([30]) Full- and part-time workers were analysed separately.”
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Lowenberg, M., van Barreveld, M., Volkers, A., van Gennep, S., Duijvestein, M., van Bodegraven, A. V., Hulshoff, M., Jansen, J. M., van Asseldonk, D. V., West, R., et al. (2024) · United European Gastroenterology journal · doi:10.1002/ueg2.12661
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Lofland, J. H., & Frick, K. D. (2002) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/14737167.2.5.485 · Cited by 1
Horn, E. K., Verheul, R., Thunnissen, M. M., Delimon, J., Goorden, M., Roijen, L. H., Soons, M. B. J., Meerman, A. M. M. A., Ziegler, U. M., Rossum, B. V., et al. (2015) · Journal of Personality Disorders · doi:10.1521/pedi_2015_29_210 · Cited by 2
“7 applied the friction-cost method, which takes into account the fact that a formerly unemployed person may replace a person who becomes disabled [38].”
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“Using a human capital approach, the patients’ income were analyzed for potential lost production.(9) The income categories were then averaged and put into new categories: $20,000, $47,500, $112,500, $200,000, $250,000, and no answer.”
MethodWrynne, C. L. (2018) · Research Portal (King's College London)
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Vervaart, M., Burger, E. A., & Aas, E. (2018) · Nordic Journal of Health Economics · doi:10.5617/njhe.4881
“We applied the friction cost method to calculate productivity costs (Koopmanschap & Rutten, 1996).”
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Neri, S., & Ornaghi, A. (2021) · Springer eBooks · doi:10.1007/978-3-319-69909-7_1260-2
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IJff, M. A., Huijbregts, K. M., van Marwijk, H., Beekman, A. T. F., Hakkaart-van Roijen, L., Rutten, F., Unützer, J., & Feltz-Cornelis, C. M. V. D. (2021) · Figshare · doi:10.6084/m9.figshare.15079730
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Metadata
- Authors
- Koopmanschap, M. A., & Rutten, F. F. H.
- Affiliations
- Erasmus University Rotterdam (NL)
- Corresponding author
- Koopmanschap, Marc A.
- Venue
- PharmacoEconomics
- Published
- 1996-11
- Volume
- 10
- Issue
- 5
- Pages
- 460-466
- ISSN
- 1170-7690 (ISSN-L)
- OpenAlex
- W1980604588
- Cited by
- 358
- References
- 9
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 8 · 2023: 2 · 2022: 17 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 19 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 12 · 2012: 8
- FWCI
- 22.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PharmacoEconomics (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Environmental Valuation
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Global Health Care Issues
- Keywords
- economic burden, human capital approach, friction cost method, productivity loss, economic evaluation, labor shortage, cost estimation
- MeSH terms
- Cost-Benefit Analysis, Delivery of Health Care, Humans, Disease Management
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