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Cited by 63Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychological Treatments and Disorders

The DOI matches its Crossref record, with a small difference in title or year; 85 of the 85 references it cites were found in a registry or an index.

Third-Generation Antidepressants: Do They Offer Advantages Over the SSRIs?

Olver, James S., Burrows, Graham D., Norman, Trevor R.·2001·CNS Drugs
DOI 10.2165/00023210-200115120-00004
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Abstract

Third-generation antidepressants are a group of antidepressant agents of variable action, not confined to serotonin reuptake inhibition. These agents include venlafaxine, reboxetine, nefazodone and mirtazapine. Claims have been made for these agents in terms of improved efficacy, faster speed of onset of effect and greater safety in the treatment of depression compared with previous medications, such as the selective serotonin reuptake inhibitors (SSRIs). This article reviews the evidence for these improvements. Thirty active comparator studies were reviewed involving the third-generation antidepressant agents. While there were isolated reports of improvements over comparator agents for venlafaxine, reboxetine and mirtazepine, there were no convincing differences between third-generation agents and comparators in terms of overall efficacy, relapse prevention and speed of onset. The third-generation antidepressants were, however, of equivalent safety to SSRIs and maintained improvements in safety over first-generation agents.

Overview

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Crossref · 10.2165/00023210-200115120-00004

Cites

85 of 85 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 16

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Metadata

Authors
Olver, J. S., Burrows, G. D., & Norman, T. R.
Affiliations
The University of Melbourne (AU)
Corresponding author
Norman, Trevor R.
ORCID
Norman, Trevor R.
Venue
CNS Drugs
Publisher
Springer Science and Business Media LLC
Published
2001
Volume
15
Issue
12
Pages
941-954
ISSN
1172-7047 (ISSN-L)
DOI
10.2165/00023210-200115120-00004
OpenAlex
W2087328751
Cited by
63
References
85
Citations by year
2025: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2018: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Locations
  • CNS Drugs (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bristol-Myers Squibb
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
Keywords
venlafaxine, reboxetine, nefazodone, mirtazapine, depression, selective serotonin reuptake inhibitors, antidepressant efficacy, relapse prevention, onset of action, drug safety
MeSH terms
Antidepressive Agents, Clinical Trials as Topic, Depressive Disorder, Humans, Selective Serotonin Reuptake Inhibitors, Secondary Prevention

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