Cited by 109Pain Mechanisms and TreatmentsPain Management and Opioid UseTreatment of Major Depression

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Antidepressants as Analgesics

McCleane, Gary·2008·CNS Drugs

DOI 10.2165/00023210-200822020-00005

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Abstract

Depression is a common accompaniment of pain, particularly when pain is unremitting. The use of a variety of antidepressant medications is associated with pain reduction, an effect that is independent of the mood-enhancing qualities of these drugs. This pain relief is a consequence of a wide variety of actions of antidepressants on the neuroregulatory mechanisms associated with pain perception and transmission. The older tricyclic antidepressants (TCAs) and the newer 'balanced' reuptake inhibitors (such as duloxetine) seem to be more efficacious in terms of providing pain relief than the selective serotonin reuptake inhibitors (SSRIs). Unfortunately, adverse effects are not uncommon during antidepressant use, particularly with TCAs. It is now becoming apparent that TCAs can have an analgesic effect when applied topically and that this effect is produced by peripheral mechanisms rather than systemic uptake. Antidepressants remain a major therapeutic tool in the management of chronic pain.

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Authors: McCleane, G.
Corresponding author: McCleane, Gary
Venue: CNS Drugs
Publisher: Springer Science and Business Media LLC
Published: 2008
Volume: 22
Issue: 2
Pages: 139-156
ISSN: 1172-7047 (ISSN-L)
DOI: 10.2165/00023210-200822020-00005
OpenAlex: W1989133401
Cited by: 109
References: 158
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 7 · 2012: 7
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Locations: CNS Drugs (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: antidepressants, analgesia, chronic pain, tricyclic antidepressants, duloxetine, selective serotonin reuptake inhibitors, pain perception, pain transmission, adverse effects
MeSH terms: Analgesics, Animals, Antidepressive Agents, Clinical Trials as Topic, Disease Models, Animal, Humans, Pain

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