Cited by 312Natural Compounds in Disease TreatmentBioactive Natural Diterpenoids ResearchPhytochemistry and Biological Activities

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Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.

Qiu, Daoming, Kao, Peter N.·2003·Drugs in R & D

DOI 10.2165/00126839-200304010-00001

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Abstract

Extracts of Tripterygium wilfordii hook. f. (leigong teng, Thundergod vine) are effective in traditional Chinese medicine for treatment of immune inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus, nephritis and asthma. Characterisation of the terpenoids present in extracts of Tripterygium identified triptolide, a diterpenoid triepoxide, as responsible for most of the immunosuppressive, anti-inflammatory and antiproliferative effects observed in vitro. Triptolide inhibits lymphocyte activation and T-cell expression of interleukin-2 at the level of transcription. In all cell types examined, triptolide inhibits nuclear factor-kappaB transcriptional activation at a unique step in the nucleus after binding to DNA. Further characterisation of the molecular mechanisms of triptolide action will serve to elucidate pathways of immune system regulation.

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Authors: Qiu, D., & Kao, P. N.
Affiliations: Stanford Medicine (US)
Corresponding author: Kao, Peter N.
ORCID: Kao, Peter N.
Venue: Drugs in R & D
Publisher: Springer Science and Business Media LLC
Published: 2003
Volume: 4
Issue: 1
Pages: 1-18
ISSN: 1174-5886 (ISSN-L)
DOI: 10.2165/00126839-200304010-00001
OpenAlex: W1994342907
Cited by: 311
References: 103
Citations by year: 2026: 7 · 2025: 12 · 2024: 10 · 2023: 9 · 2022: 19 · 2021: 9 · 2020: 13 · 2019: 12 · 2018: 10 · 2017: 23 · 2016: 8 · 2015: 15 · 2014: 20 · 2013: 24 · 2012: 14
FWCI: 2.09
Type: journal article
Language: en
Open access: closed
Locations: Drugs in R&D (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-62588, R01HL062588)
National Institute of Allergy and Infectious Diseases (R01AI039624, AI-39624)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Physical Sciences › Chemistry › Organic Chemistry › Bioactive Natural Diterpenoids Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords: triptolide, Tripterygium wilfordii, diterpenoids, immunosuppression, anti-inflammatory mechanism, interleukin-2, T cell activation, lymphocyte activation, rheumatoid arthritis, systemic lupus erythematosus, nephritis, asthma, antiproliferative activity, traditional Chinese medicine
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Diterpenes, Drugs, Chinese Herbal, Epoxy Compounds, Humans, Immunosuppressive Agents, Phenanthrenes, Tripterygium

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Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.

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