Cited by 372Pregnancy and Medication ImpactPharmacogenetics and Drug MetabolismPharmaceutical studies and practices

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Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy: A Database for Parameters Required in Physiologically Based Pharmacokinetic Modelling

Abduljalil, Khaled, Furness, Penny, Johnson, Trevor N., Rostami-Hodjegan, Amin, Soltani, Hora·2012·Clinical Pharmacokinetics

DOI 10.2165/11597440-000000000-00000

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Abstract

Background Pregnancy is associated with considerable changes in the physiological, anatomical and biochemical attributes in women. These may alter the exposure to xenobiotics between pregnant and non-pregnant women who receive similar doses, with implications for different susceptibility to environmental pollutants or therapeutic agents. Physiologically based pharmacokinetic (PBPK) models together with in vitro in vivo extrapolation (IVIVE) of absorption, distribution, metabolism and excretion (ADME) characteristics may capture the likely changes. However, such models require comprehensive information on the longitudinal variations of PBPK parameter values; a set of data that are as yet not available from a singular source. Aim The aim of this article was to collect, integrate and analyse the available time-variant parameters that are needed for the PBPK modelling of xenobiotic kinetics in a healthy pregnant population. Methods A structured literature search was carried out on anatomical, physiological and biochemical parameters likely to change in pregnancy and alter the kinetics of xenobiotics. Collated data were carefully assessed, integrated and analysed for trends with gestational age. Algorithms were generated to describe the changes in parameter values with gestational age. These included changes in maternal weight, the individual organ volumes and blood flows, glomerular filtration rates, and some drug-metabolising enzyme activities. Results Articles were identified u…

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Authors: Abduljalil, K., Furness, P., Johnson, T. N., Rostami-Hodjegan, A., & Soltani, H.
Affiliations: Simcyp (United Kingdom) (GB)
Sheffield Hallam University (GB)
Corresponding author: Abduljalil, Khaled
ORCID: Abduljalil, Khaled
Furness, Penny
Johnson, Trevor N.
Soltani, Hora
Venue: Clinical Pharmacokinetics
Publisher: Springer Science and Business Media LLC
Published: 2012-06
Volume: 51
Issue: 6
Pages: 365-396
ISSN: 0312-5963 (ISSN-L)
DOI: 10.2165/11597440-000000000-00000
OpenAlex: W2225273737
Cited by: 371
References: 382
Citations by year: 2026: 22 · 2025: 31 · 2024: 40 · 2023: 34 · 2022: 30 · 2021: 30 · 2020: 31 · 2019: 29 · 2018: 23 · 2017: 22 · 2016: 17 · 2015: 16 · 2014: 20 · 2013: 16 · 2012: 8
FWCI: 18.53
Type: journal article
Language: en
Open access: closed
Locations: Clinical Pharmacokinetics (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: pregnancy, gestational age, physiological changes in pregnancy, physiologically based pharmacokinetic modeling, time-varying parameters, organ volume, cardiac output, glomerular filtration rate, drug-metabolizing enzymes, protein binding, maternal weight
MeSH terms: Algorithms, Body Weight, Female, Gestational Age, Glomerular Filtration Rate, Humans, Inactivation, Metabolic, Models, Biological, Organ Size, Pregnancy, Reference Values, Regional Blood Flow, Xenobiotics, Databases, Factual

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Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy: A Database for Parameters Required in Physiologically Based Pharmacokinetic Modelling

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