The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The Effects of Long-acting Nitrates on 5-year Cardiac Events of Patients with Coronary Thrombolytic Therapy for Acute Myocardial Infarction.
Open accessAbstract
OBJECTIVE: A retrospective study was performed to evaluate the effects of using long-term long acting nitrates without a dose-free interval in treating patients undergoing thrombolytic therapy for acute myocardial infarction (MI). PATIENTS AND METHODS: A total of 297 patients taking prescribed medication for secondary prevention of the MI were selected for the study. They were divided into a nitrate group consisting of 222 patients who had continuously received long-acting nitrates without a dose-free interval, and a control group consisting of 75 patients who were not able to use the long-acting nitrates because of adverse effects. The primary endpoint was cardiac events, either cardiac death or a nonfatal MI, in five years. RESULTS: The incidence of primary endpoint in five years was 13.4 percent in the nitrate group and 6.2 percent in the control group, a 2.2-fold increase in risk. However, the difference was not significant. After adjustment for age, there was no statistically significant difference between the incidence of primary endpoint in the nitrate group (9.8%) and that in the control group (5.7%). A Cox proportional-hazards regression analysis revealed that the long-acting nitrates were not related to the incidence of primary endpoint (p=0.23). CONCLUSION: The administration of long-term long-acting nitrates without a dose-free interval had no benefit of reducing the incidence of cardiac events of patients undergoing thrombolytic therapy for acute MI.
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“there is limited evidence from long-term trials assessing hard cardiovascular endpoints (e.g., myocardial infarction or stroke)”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [164]
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Cites
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ACC/AHA guidelines for the management of patients with acute myocardial infarction
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MECHANISM OF TOLERANCE DEVELOPMENT TO ORGANIC NITRATES
Needleman, P., & Johnson, E. M. (1973) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29462-9 · Cited by 496
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Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure
Packer, M., Lee, W. H., Kessler, P., Gottlieb, S. S., Medina, N., & Yushak, M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198709243171304 · Cited by 360
Norris, R. M., Whitlock, R. M. L., Barratt-Boyes, C., & Small, C. W. (1975) · Circulation · doi:10.1161/01.cir.51.4.614 · Cited by 238
Reduction of CK and CK-MB indexes of infarct size by intravenous nitroglycerin.
Bussmann, W. D., Passek, D., Seidel, W., & Kaltenbach, M. (1981) · Circulation · doi:10.1161/01.cir.63.3.615 · Cited by 175
Cited by
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Effect of Long-Term Nitrate Treatment on Cardiac Events in Patients With Vasospastic Angina
Kosugi, M., Nakagomi, A., Shibui, T., Kato, K., Kusama, Y., Atarashi, H., & Mizuno, K. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-0056 · Cited by 49
Long-Term Nitrate Therapy After Acute Myocardial Infarction Does not Improve or Aggravate Prognosis
Kojima, S., Matsui, K., Sakamoto, T., Ishihara, M., Kimura, K., Miyazaki, S., Yamagishi, M., Tei, C., Hiraoka, H., Sonoda, M., et al. (2007) · Circulation Journal · doi:10.1253/circj.71.301 · Cited by 34
Broad regulation of matrix and adhesion molecules in THP-1 human macrophages by nitroglycerin
Krishnatry, A. S., Brazeau, D. A., & Fung, H. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.10.004 · Cited by 14
Krishnatry, A. S., Fung, S. M., Brazeau, D. A., Soda, D. M., & Fung, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.12.002 · Cited by 8
Kurhaluk, N., Kołodziejska, R., Buyun, L., Kamiński, P., & Tkaczenko, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083461 · Cited by 3
“Despite these promising findings, there is limited evidence from long-term trials assessing hard cardiovascular endpoints (e.g., myocardial infarction or stroke), which highlights the need for large, well-designed prospective studies, particularly in ageing populations [164,165].”
Metadata
- Authors
- NAGAO, K., KANMATSUSE, K., OOIWA, K., SATOU, K., WATANABE, I., YAMASITA, M., & KIKUSHIMA, K.
- Affiliations
- Nihon University (JP)
- Surugadai Nihon University Hospital (JP)
- ORCID
- NAGAO, Ken
- Venue
- Internal Medicine
- Published
- 2000
- Volume
- 39
- Issue
- 11
- Pages
- 877-884
- ISSN
- 0918-2918 (ISSN-L)
- 1349-7235
- OpenAlex
- W2074181253
- Cited by
- 5
- References
- 23
- Citations by year
- 2026: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- long-acting nitrates, acute myocardial infarction, thrombolysis, secondary prevention, cardiac events, cardiovascular mortality, nonfatal myocardial infarction, adverse drug reactions
- MeSH terms
- Coronary Vessels, Female, Humans, Male, Middle Aged, Myocardial Infarction, Nitrates, Retrospective Studies, Time Factors, Thrombolytic Therapy, Incidence
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