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Cited by 5Acute Myocardial Infarction ResearchAntiplatelet Therapy and Cardiovascular DiseasesCardiac Health and Mental Health

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

The Effects of Long-acting Nitrates on 5-year Cardiac Events of Patients with Coronary Thrombolytic Therapy for Acute Myocardial Infarction.

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NAGAO, Ken, KANMATSUSE, Katsuo, OOIWA, Kouji, SATOU, Kazuyosi, WATANABE, Ikuyoshi, YAMASITA, Makoto, KIKUSHIMA, Kimio·2000·Internal Medicine
DOI 10.2169/internalmedicine.39.877
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Abstract

OBJECTIVE: A retrospective study was performed to evaluate the effects of using long-term long acting nitrates without a dose-free interval in treating patients undergoing thrombolytic therapy for acute myocardial infarction (MI). PATIENTS AND METHODS: A total of 297 patients taking prescribed medication for secondary prevention of the MI were selected for the study. They were divided into a nitrate group consisting of 222 patients who had continuously received long-acting nitrates without a dose-free interval, and a control group consisting of 75 patients who were not able to use the long-acting nitrates because of adverse effects. The primary endpoint was cardiac events, either cardiac death or a nonfatal MI, in five years. RESULTS: The incidence of primary endpoint in five years was 13.4 percent in the nitrate group and 6.2 percent in the control group, a 2.2-fold increase in risk. However, the difference was not significant. After adjustment for age, there was no statistically significant difference between the incidence of primary endpoint in the nitrate group (9.8%) and that in the control group (5.7%). A Cox proportional-hazards regression analysis revealed that the long-acting nitrates were not related to the incidence of primary endpoint (p=0.23). CONCLUSION: The administration of long-term long-acting nitrates without a dose-free interval had no benefit of reducing the incidence of cardiac events of patients undergoing thrombolytic therapy for acute MI.

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Crossref · 10.2169/internalmedicine.39.877

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Metadata

Authors
NAGAO, K., KANMATSUSE, K., OOIWA, K., SATOU, K., WATANABE, I., YAMASITA, M., & KIKUSHIMA, K.
Affiliations
  • Nihon University (JP)
  • Surugadai Nihon University Hospital (JP)
ORCID
NAGAO, Ken
Venue
Internal Medicine
Publisher
Japanese Society of Internal Medicine
Published
2000
Volume
39
Issue
11
Pages
877-884
ISSN
  • 0918-2918 (ISSN-L)
  • 1349-7235
DOI
10.2169/internalmedicine.39.877
OpenAlex
W2074181253
Cited by
5
References
23
Citations by year
2026: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
  • Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
long-acting nitrates, acute myocardial infarction, thrombolysis, secondary prevention, cardiac events, cardiovascular mortality, nonfatal myocardial infarction, adverse drug reactions
MeSH terms
Coronary Vessels, Female, Humans, Male, Middle Aged, Myocardial Infarction, Nitrates, Retrospective Studies, Time Factors, Thrombolytic Therapy, Incidence

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