Clinical Characteristics of 852 Patients with Subacute Thyroiditis before Treatment
Open accessAbstract
OBJECTIVE: Subacute thyroiditis (SAT) is a transient inflammatory disease of the thyroid. We evaluated the clinical characteristics based on laboratory and imaging studies in patients with SAT before treatment. PATIENTS: We reviewed the medical records of 852 patients (107 men and 745 women) with SAT who visited our thyroid clinic at Kuma Hospital from 1996 through 2004. RESULTS: SAT developed most often in female patients aged 40 to 50 years, with significant seasonal clusters during summer to early autumn. While the rates of any virus infections and diseases did not differ from those in the general population, recurrent episodes of SAT at intervals of 13.6+/-5.6 years accounted for 1.6% of all cases. At the onset of SAT, 28.2% of patients had temperatures greater than 38 degrees C and typical symptoms associated with thyrotoxicosis developed in more than 60% of patients. Before treatment, most of the abnormal laboratory findings associated with thyrotoxicosis, inflammation, and liver dysfunction reached peak levels within 1 week after onset. Ultrasound examination showed that half of the patients with unilateral thyroid pain presented with bilateral hypoechogenic area in the thyroid and the rate of bilateral hypoechogenic area tended to increase 2 months after onset. CONCLUSION: Laboratory studies of thyroid dysfunction and inflammation related to SAT presented peak levels within 1 week after onset.
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Recurrence rates of 1%-4% have been reported for subacute thyroiditis.
“In addition, recurrence rates of 1%-4% have been reported (24,620,623).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [623]
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Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938 · see citing works
- Authors
- Nishihara, E., Ohye, H., Amino, N., Takata, K., Arishima, T., Kudo, T., Ito, M., Kubota, S., Fukata, S., & Miyauchi, A.
- Affiliations
- Kuma Hospital (JP)
- Kuma Hospital, Center for Excellence in Thyroid Care
- Venue
- Internal Medicine
- Published
- 2008
- Volume
- 47
- Issue
- 8
- Pages
- 725-729
- ISSN
- 0918-2918 (ISSN-L)
- 1349-7235
- OpenAlex
- W2077858993
- Cited by
- 223
- References
- 19
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 16 · 2023: 13 · 2022: 41 · 2021: 25 · 2020: 17 · 2019: 13 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 13 · 2014: 6 · 2013: 6 · 2012: 13
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- subacute thyroiditis, thyrotoxicosis, clinical features, thyroid ultrasound, thyroid inflammation, liver dysfunction, seasonal occurrence, thyroid pain
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alanine Transaminase, Aspartate Aminotransferases, C-Reactive Protein, Female, Humans, Liver, Male, Middle Aged, Pain, Recurrence, Retrospective Studies, Seasons, Thyroid Gland, Thyroid Hormones, Thyroiditis, Subacute, Ultrasonography, Incidence
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