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Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design
Abstract
This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds. Keywords: lead compound, isosterism, antagonist, pharmacodynamic, pharmacokinetic, hplc, prostaglandin-h synthase-2 (pghs-
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Cited by
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Hernandes, M., Cavalcanti, S. M., Moreira, D. R., de Azevedo Junior, W., & Leite, A. C. (2010) · Current Drug Targets · doi:10.2174/138945010790711996 · Cited by 723
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds
Ramesh, R., & Reddy, D. S. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00718 · Cited by 624
HIV‐1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design
Zhan, P., Chen, X., Li, D., Fang, Z., De Clercq, E., & Liu, X. (2013) · Medicinal Research Reviews · doi:10.1002/med.20241 · Cited by 192
Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation
Jachak, G. R., Ramesh, R., Sant, D. G., Jorwekar, S. U., Jadhav, M. R., Tupe, S. G., Deshpande, M. V., & Reddy, D. S. (2015) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5b00245 · Cited by 52
Ring Closure To Form Metal Chelates in 3D Fragment-Based de Novo Design
Foscato, M., Houghton, B. J., Occhipinti, G., Deeth, R. J., & Jensen, V. R. (2015) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5b00424 · Cited by 21
Metadata
- Authors
- Lima, L., & Barreiro, E.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-01-01
- Volume
- 12
- Issue
- 1
- Pages
- 23-49
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2079991727
- Cited by
- 672
- References
- 0
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
