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Cited by 135Antioxidant Activity and Oxidative StressRedox biology and oxidative stressExercise and Physiological Responses

Biomarkers for Oxidative Stress: Clinical Application in Pediatric Medicine

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Tsukahara, Hirokazu·2007·Current Medicinal Chemistry
DOI 10.2174/092986707779941177
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Abstract

Loads of reactive oxygen species (ROS), including superoxide anion and nitric oxide, that overburden antioxidant systems induce oxidative stress in the body. Major cellular targets of ROS are membrane lipids, proteins, nucleic acids, and carbohydrates. Circumstantial evidence suggests that ROS play a crucial role in the initiation and progression of various diseases in children and adolescents. The involvement of ROS and oxidative stress in pediatric diseases is an important concern, but oxidative stress status in young subjects and appropriate methods for its measurement remain to be defined. Recently, specific biomarkers for oxidative damage and antioxidant defense have been introduced into the field of pediatric medicine. This review is intended to provide an overview of clinical applications of oxidative stress biomarkers in the field of pediatric medicine. First, this review presents the biochemistry and pathophysiology of ROS and antioxidant defense systems. Second, it presents a list of clinically applicable biomarkers, along with pediatric diseases in which enhanced oxidative stress might be involved. The discussion emphasizes that several reliable biomarkers are easily measurable using enzyme-linked immunosorbent assay. Third, this review presents age-related reference normal ranges of oxidative stress biomarkers, including urinary acrolein-lysine, 8-hydroxy-2'-deoxyguanosine, nitrite/nitrate, and pentosidine, and the changes of the parameters in several clinical conditions, including atopic dermatitis and diabetes mellitus. New and interesting data on oxidative stress and antioxidant defenses in neonatal biology are also presented. Fourth, this review discusses the ever-accumulating body of data linking oxidative stress to disturbances of the nitric oxide system and vascular endothelial activation/dysfunction. Finally, this review describes the reported clinical trials that have evaluated the efficacy of antioxidants for oxidative-stress related diseases. Suggestions are advanced for the direction of future trials using antioxidant therapies. Repeated measurement of appropriate parameters will enable us to discern the pathophysiological patterns of pediatric diseases and guide our therapies appropriately.

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Research works printed but not linked: 166

  1. Halliwell, B.; Zhao, K.; Whiteman, M. Free Radic. Res., 1999, 31, 651-669.
  2. Toyokuni, S. Pathol. Int., 1999, 49, 91-102.
  3. Gladwin, M.T.; Schechter, A.N.; Kim-Shapiro, D.B.; Patel, R.P.; Hogg, N.; Shiva, S.; Cannon, R.O. III.; Kelmm M.; Wink, D.A.; Espey, M.G.; Oldfield, E.H.; Pluta, R.M.; Freeman, B.A.; Lancaster, J.R. Jr.; Feelisch, M.; Lundberg, J.O. Nat. Chem. Biol., 2005, 1, 308-314.
  4. Bryan, N.S. Free Radic. Biol. Med., 2006, 41, 691-701.
  5. Uchida, K. Trends Cardiovasc. Med., 1999, 9, 109-113.
  6. Kharitonov, S.A.; Barnes, P.J. Biomarkers, 2002, 7, 1-32.
  7. Jakus, V.; Rietbrock, N. Physiol. Res., 2004, 53, 131-142.
  8. Noiri, E.; Tsukahara, H. J. Investig. Med., 2005, 53, 167-175.
  9. Nagano, T.; Yoshimura, T. Chem. Rev., 2002, 102, 1235-1270.
  10. Kapitulnik, J. Mol. Pharmacol., 2004, 66, 773-779.
  11. Maines, M.D. Antioxid. Redox Signal., 2005, 7, 1761-1766.
  12. Otani, K.; Shimizu, S.; Chijiiwa, K.; Yamaguchi, K.; Kuroki, S.; Tanaka, M. J. Surg. Res., 2001, 96, 44-49.
  13. Yamaguchi, T.; Shioji, I.; Sugimoto, A.; Yamaoka, M. Biochem. Biophys. Res. Commun., 2002, 293, 517-520.
  14. Hokamaki, J.; Kawano, H.; Yoshimura, M.; Soejima, H.; Miyamoto, S.; Kajiwara, I.; Kojima, S.; Sakamoto, T.; Sugiyama, S.; Hirai, N.; Shimomura, H.; Nagayoshi, Y.; Tsujita, K.; Shioji, I.; Sasaki, S.; Ogawa, H. J. Am. Coll. Cardiol., 2004, 43, 1880-1885.
  15. Renke, J.; Popadiuk, S.; Korzon, M.; Bugajczyk, B.; Wozniak, M. Free Radic. Biol. Med., 2000, 29, 101-104.
  16. Manary, M.J.; Leeuwenburgh, C.; Heinecke, J.W. J. Pediatr., 2000, 137, 421-424.
  17. Tsukahara, H.; Haruta, T.; Ono, N.; Kobata, R.; Fukumoto, Y.; Hiraoka, M.; Mayumi, M. Redox Rep., 2000, 5, 295-298
  18. Nemeth, I.; Boda, D. Intensive Care Med., 2001, 27, 216-221.
  19. Cardin, R.; Saccoccio, G.; Masutti, F.; Bellentani, S.; Farinati, F.; Tiribelli, C. J. Hepatol., 2001, 34, 587-592.
  20. Fulia, F.; Gitto, E.; Cuzzocrea, S.; Reiter, R.J.; Dugo, L.; Gitto, P.; Barberi, S.; Cordaro, S.; Barberi, I. J. Pineal. Res., 2001, 31, 343-349.
  21. Omata N.; Tsukahara, H.; Ito, S.; Ohshima, Y.; Yasutomi, M.; Yamada, A.; Jiang, M.; Hiraoka, M.; Nambu, M.; Deguchi, Y.; Mayumi, M. Life Sci., 2001, 69, 223-228.
  22. Sebekova, K.; Podracka, L.; Blazicek, P.; Syrova, D.; Heidland, A.; Schinzel, R. Pediatr. Nephrol., 2001, 16, 1105-1112.
  23. Reichenbach, J.; Schubert, R.; Schindler, D.; Muller, K.; Bohles, H.; Zielen, S. Antioxid. Redox Signal., 2002, 4, 465-469.
  24. Hayashi, M.; Araki, S.; Arai, N.; Kumada, S.; Itoh, M.; Tamagawa, K.; Oda, M.; Morimatsu, Y. Brain Dev., 2002, 24, 770-775.
  25. Kamireddy, R.; Kavuri, S.; Devi, S.; Vemula, H.; Chandana, D.; Harinarayanan, S.; James, R.; Rao, A. Clin. Chim. Acta, 2002, 325, 147-150.
  26. Giray, B.; Hincal, F. Free Radic. Res., 2002, 36, 55-62.
  27. Matsubasa, T.; Uchino, T.; Karashima, S.; Kondo, Y.; Maruyama, K.; Tanimura, M.; Endo, F. Free Radic. Res., 2002, 36, 189-193.
  28. Jareno, E.J.; Roma, J.; Romero, B.; Marin, N.; Muriach, M.; Johnsen, S.; Bosch-Morell, F.; Marselou, L.; Romero, F.J. Free Radic. Res., 2002, 36, 341-344.
  29. Shimizu, T.; Satoh, Y.; Syoji, H.; Tadokoro, R.; Sinohara, K.; Oguchi, S.; Shiga, S.; Yamashiro, Y. Free Radic. Res., 2002, 36, 1067-1070.
  30. Patel, M.N. Free Radic. Res., 2002, 36, 1139-1146.
  31. Hayashi, M.; Arai, N.; Satoh, J.; Suzuki, H.; Katayama, K.; Tamagawa, K.; Morimatsu, Y. J. Child Neurol., 2002, 17, 725-730.
  32. Yamamoto, T.; Shibata, N.; Kobayashi, M.; Saito, K.; Osawa, M. J. Child Neurol., 2002, 17, 793-799.
  33. Ristoff, E.; Hebert, C.; Njalsson, R.; Norgren, S.; Rooyackers, O.; Larsson, A. J. Inherit. Metab. Dis., 2002, 25, 577-584.
  34. Tsukahara, H.; Haruta, T.; Todoroki, Y.; Hiraoka, M.; Noiri, E.; Maeda, M.; Mayumi, M. Life Sci., 2002, 71, 2797-2806.
  35. Kolker, S.; Mayatepek, E.; Hoffmann, G.F. Neuropediatrics, 2002, 33, 225-231.
  36. Bayir, H.; Kagan, V.E.; Tyurina, Y.Y.; Tyurin, V.; Ruppel, R.A.; Adelson, P.D.; Graham, S.H.; Janesko, K.; Clark, R.S.; Kochanek, P.M. Pediatr. Res., 2002, 51, 571-578.
  37. Erdogan, O.; Oner, A.; Aydin, A.; Isimer, A.; Demircin, G.; Bulbul, M. Acta Paediatr., 2003, 92, 546-550.
  38. Medina, J.; Garcia-Buey, L.; Moreno-Otero, R. Aliment. Pharmacol. Ther., 2003, 17, 1-16.
  39. Hoeldtke, R.D.; Bryner, K.D.; McNeill, D.R.; Hobbs, G.R.; Baylis, C. Am. J. Hypertens., 2003, 16, 761-766.
  40. Corradi, M.; Folesani, G.; Andreoli, R.; Manini, P.; Bodini, A.; Piacentini, G.; Carraro, S.; Zanconato, S.; Baraldi, E. Am. J. Respir. Crit. Care Med., 2003, 167, 395-399.
  41. Buonocore, G.; Perrone, S.; Longini, M.; Paffetti, P.; Vezzosi, P.; Gatti, M.G.; Bracci, R. Brain, 2003, 126, 1224-1230.
  42. Engler, M.M.; Engler, M.B.; Malloy, M.J.; Chiu, E.Y.; Schloetter, M.C.; Paul, S.M.; Stuehlinger, M.; Lin, K.Y.; Cooke, J.P.; Morrow, J.D.; Ridker, P.M.; Rifai, N.; Miller, E.; Witztum, J.L.; Mietus-Snyder, M. Circulation, 2003, 108, 1059-1063.
  43. Sogut, S.; Zoroglu, S.S.; Ozyurt, H.; Yilmaz, H.R.; Ozugurlu, F.; Sivasli, E.; Yetkin, O.; Yanik, M.; Tutkun, H.; Savas, H.A.; Tarakcioglu, M.; Akyol, O. Clin. Chim. Acta, 2003, 331, 111-117.
  44. Surdacki, A.; Tsikas, D.; Mayatepek, E.; Frolich, J.C. Clin. Chim. Acta, 2003, 334, 111-115.
  45. Kassab-Chekir, A.; Laradi, S.; Ferchichi, S.; Haj Khelil, A.; Feki, M.; Amri, F.; Selmi, H.; Bejaoui, M.; Miled, A. Clin. Chim. Acta, 2003, 338, 79-86.
  46. Bayir, H.; Kochanek, P.M.; Clark, R.S. Crit. Care Clin., 2003, 19, 529-549.
  47. Cabre, E.; Gassull, M.A. Curr. Opin. Clin. Nutr. Metab. Care, 2003, 6, 569-576.
  48. Yachie, A.; Toma, T.; Mizuno, K.; Okamoto, H.; Shimura, S.; Ohta, K.; Kasahara, Y.; Koizumi, S. Exp. Biol. Med. (Maywood), 2003, 228, 550-556.
  49. Tuo, J.; Jaruga, P.; Rodriguez, H.; Bohr, V.A.; Dizdaroglu, M. FASEB J., 2003, 17, 668-674.
  50. Rodriguez, M.C.; Tarnopolsky, M.A. Free Radic. Biol. Med., 2003, 34, 1217-1220.
  51. Andreadis, A.A.; Hazen, S.L.; Comhair, S.A.; Erzurum, S.C. Free Radic. Biol. Med., 2003, 35, 213-225.
  52. Misaki, K.; Takitani, K.; Ogihara, T.; Inoue, A.; Kawakami, C.; Kuno, T.; Kawamura, N.; Miyake, M.; Nakagawa, T.; Tamai, H. Free Radic. Res., 2003, 37, 1037-1042.
  53. Kato, M.; Minakami, H.; Kuroiwa, M.; Kobayashi, Y.; Oshima, S.; Kozawa, K.; Morikawa, A.; Kimura, H. Hematol. Oncol., 2003, 21, 11-16.
  54. Gualandri, W.; Gualandri, L.; Demartini, G.; Esposti, R.; Marthyn, P.; Volonte, S.; Stangoni, L.; Borgonovo, M.; Fraschini, F. Int. J. Clin. Pharmacol. Res., 2003, 23, 23-30.
  55. Turi, S.; Friedman, A.; Bereczki, C.; Papp, F.; Kovacs, J.; Karg, E.; Nemeth, I. J. Hypertens., 2003, 21, 145-152.
  56. Takeuchi, M.; Takahashi, T.; Taga, N.; Iwasaki, T.; Ohe, K.; Shimizu, H.; Suzuki, T.; Nakatsuka, H.; Yokoyama, M.; Sano, S.; Akagi, R.; Morita, K. J. Int. Med. Res., 2003, 31, 413-417.
  57. Pastore, A.; Tozzi, G.; Gaeta, L.M.; Giannotti, A.; Bertini, E.; Federici, G.; Digilio, M.C.; Piemonte, F. J. Pediatr., 2003, 142, 583-585.
  58. Tsukahara, H.; Shibata, R.; Ohshima, Y.; Todoroki, Y.; Sato, S.; Ohta, N.; Hiraoka, M.; Yoshida, A.; Nishima, S.; Mayumi, M. Life Sci., 2003, 72, 2509-2516.
  59. Chariot, P.; Bignani, O. Muscle Nerve, 2003, 27, 662-668.
  60. Monici, M.C.; Aguennouz, M.; Mazzeo, A.; Messina, C.; Vita, G. Neurology, 2003, 60, 993-997.
  61. Ross, B.M.; McKenzie, I.; Glen, I.; Bennett, C.P. Nutr. Neurosci., 2003, 6, 277-281.
  62. Kaygusuz, I.; Ilhan, N.; Karlidag, T.; Keles, E.; Yalcin, S.; Cetiner, H. Otolaryngol. Head Neck Surg., 2003, 129, 265-268.
  63. Tsukahara, H.; Sekine, K.; Uchiyama, M.; Kawakami, H.; Hata, I.; Todoroki, Y.; Hiraoka, M.; Kaji, M.; Yorifuji, T.; Momoi, T.; Yoshihara, K.; Beppu, M.; Mayumi, M. Pediatr. Res., 2003, 54, 419-424.
  64. Lim, D.S.; Mooradian, S.J.; Goldberg, C.S.; Gomez, C.; Crowley, D.C.; Rocchini, A.P.; Charpie, J.R. Am. J. Cardiol., 2004, 94, 828-831.
  65. Back, E.I.; Frindt, C.; Nohr, D.; Frank, J.; Ziebach, R.; Stern, M.; Ranke, M.; Biesalski, H.K. Am. J. Clin. Nutr., 2004, 80, 374-384.
  66. James, S.J.; Cutler, P.; Melnyk, S.; Jernigan, S.; Janak, L.; Gaylor, D.W.; Neubrander, J.A. Am. J. Clin. Nutr., 2004, 80, 1611-1617.
  67. Kettle, A.J.; Chan, T.; Osberg, I.; Senthilmohan, R.; Chapman, A.L.; Mocatta, T.J.; Wagener, J.S. Am. J. Respir. Crit. Care Med., 2004, 170, 1317-1323.
  68. Posadas-Romero, C.; Torres-Tamayo, M.; Zamora-Gonzalez, J.; Aguilar-Herrera, B.E.; Posadas-Sanchez, R.; Cardoso-Saldana, G.; Ladron de Guevara, G.; Solis-Vallejo, E.; El Hafidi, M. Arthritis Rheum., 2004, 50, 160-165.
  69. Vargas, C.R.; Wajner, M.; Sirtori, L.R.; Goulart, L.; Chiochetta, M.; Coelho, D.; Latini, A.; Llesuy, S.; Bello-Klein, A.; Giugliani, R.; Deon, M.; Mello, C.F. Biochim. Biophys. Acta, 2004, 1688, 26-32.
  70. Gurkan, F.; Atamer, Y.; Ece, A.; Kocyigit, Y.; Tuzun, H.; Mete, M. Biol. Trace Elem. Res., 2004, 100, 97-104.
  71. Facorro, G.; Sarrasague, M.M.; Torti, H.; Hager, A.; Avalos, J.S.; Foncuberta, M.; Kusminsky, G. Bone Marrow Transplant., 2004, 33, 793-798.
  72. Pagano, G.; Degan, P.; d'Ischia, M.; Kelly, F.J.; Pallardo, F.V.; Zatterale, A.; Anak, S.S.; Akisik, E.E.; Beneduce, G.; Calzone, R.; De Nicola, E.; Dunster, C.; Lloret, A.; Manini, P.; Nobili, B.; Saviano, A.; Vuttariello, E.; Warnau, M. Carcinogenesis, 2004, 25, 1899-1909.
  73. Djordjevic, V.B.; Stankovic, T.; Cosic, V.; Zvezdanovic, L.; Kamenov, B.; Tasic-Dimov, D.; Stojanovic, I. Clin. Chem. Lab. Med., 2004, 42, 1117-1121.
  74. Sienra-Monge, J.J.; Ramirez-Aguilar, M.; Moreno-Macias, H.; Reyes-Ruiz, N.I.; Del Rio-Navarro, B.E.; Ruiz-Navarro, M.X.; Hatch, G.; Crissman, K.; Slade, R.; Devlin, R.B.; Romieu, I. Clin. Exp. Immunol., 2004, 138, 317-322.
  75. Lavine, J.E.; Schwimmer, J.B. Clin. Liver Dis., 2004, 8, 549-558.
  76. Gupta, M.; Gupta, Y.K.; Agarwal, S.; Aneja, S.; Kalaivani, M.; Kohli, K. Epilepsia, 2004, 45, 1636-1639.
  77. Tsukahara, H.; Ohta, N.; Sato, S.; Hiraoka, M.; Shukunami, K.; Uchiyama, M.; Kawakami, H.; Sekine, K.; Mayumi, M. Free Radic. Res., 2004, 38, 691-695.
  78. Muller, T.; Langner, C.; Fuchsbichler, A.; Heinz-Erian, P.; Ellemunter, H.; Schlenck, B.; Bavdekar, A.R.; Pradhan, A.M.; Pandit, A.; Muller-Hocker, J.; Melter, M.; Kobayashi, K.; Nagasaka, H.; Kikuta, H.; Muller, W.; Tanner, M.S.; Sternlieb, I.; Zatloukal, K.; Denk, H. Hepatology, 2004, 39, 963-969.
  79. Menke, T.; Niklowitz, P.; Reinehr, T.; de Sousa, G.J.; Andler, W. Horm. Res., 2004, 61, 153-158.
  80. Gangemi, S.; Saija, A.; Minciullo, P.L.; Tomaino, A.; Cimino, F.; Bisignano, G.; Briuglia, S.; Merlino, M.V.; Dallapiccola, B.; Salpietro, D.C. Inflamm. Res., 2004, 53, 601-603.
  81. Molnar, D.; Decsi, T.; Koletzko, B. Int. J. Obes. Relat. Metab. Disord., 2004, 28, 1197-1202.
  82. Yilmaz, T.; Kocan, E.G.; Besler, H.T. Int. J. Pediatr. Otorhinolaryngol., 2004, 68, 1053-1058.
  83. Atabek, M.E.; Vatansev, H.; Erkul, I. J. Pediatr. Endocrinol. Metab., 2004, 17, 1063-1068.
  84. Hamed, S.A.; Abdellah, M.M.; El-Melegy, N. J. Pharmacol. Sci., 2004, 96, 465-473.
  85. Lotito, A.P.; Muscara, M.N.; Kiss, M.H.; Teixeira, S.A.; Novaes, G.S.; Laurindo, I.M.; Silva, C.A.; Mello, S.B. J. Rheumatol., 2004, 31, 992-997.
  86. Tsukahara, H.; Jiang, M.Z.; Ohta, N.; Sato, S.; Tamura, S.; Hiraoka, M.; Maeda, M.; Mayumi, M. Life Sci., 2004, 75, 933-938.
  87. Yilmaz, T.; Kocan, E.G.; Besler, H.T.; Yilmaz, G.; Gursel, B. Otolaryngol. Head Neck Surg., 2004, 131, 797-803.
  88. Ghosh, S.; Bandyopadhyay, S.; Bhattacharya, D.K.; Mandal, C. Ann. Hematol., 2005, 84, 76-84.
  89. Tondel, M.; Arynchyn, A.; Jonsson, P.; Persson, B.; Tagesson, C. Arch. Environ., Contam. Toxicol., 2005, 48, 515-519.
  90. Hart, P.E.; Lodi, R.; Rajagopalan, B.; Bradley, J.L.; Crilley, J.G.; Turner, C.; Blamire, A.M.; Manners, D.; Styles, P.; Schapira, A.H.; Cooper, J.M. Arch. Neurol., 2005, 62, 621-626.
  91. Sirtori, L.R.; Dutra-Filho, C.S.; Fitarelli, D.; Sitta, A.; Haeser, A.; Barschak, A.G.; Wajner, M.; Coelho, D.M.; Llesuy, S.; Bello-Klein, A.; Giugliani, R.; Deon, M.; Vargas, C.R. Biochim. Biophys. Acta, 2005, 1740, 68-73.
  92. Saugstad, O.D. Biol. Neonate, 2005, 88, 228-236.
  93. Somjee, S.S.; Warrier, R.P.; Thomson, J.L.; Ory-Ascani, J.; Hempe, J.M. Br. J. Haematol., 2005, 128, 112-118.
  94. Serarslan, G.; Yilmaz, H.R.; Sogut, S. Clin. Exp. Dermatol., 2005, 30, 267-271.
  95. Chiarelli, F.; Di Marzio, D.; Santilli, F.; Mohn, A.; Blasetti, A.; Cipollone, F.; Mezzetti, A.; Verrotti, A. Diabetes Care, 2005, 28, 1690-1697.
  96. Tsukahara, H.; Sugaya, T.; Hayakawa, K.; Mori, Y.; Hiraoka, M.; Hata, A.; Mayumi, M. Early Hum. Dev., 2005, 81, 643-646.
  97. Wong, R.H.; Kuo, C.Y.; Hsu, M.L.; Wang, T.Y.; Chang, P.I.; Wu, T.H.; Huang, S. Environ. Health Perspect., 2005, 113, 1386-1390.
  98. Christen, S.; Finckh, B.; Lykkesfeldt, J.; Gessler, P.; Frese-Schaper, M.; Nielsen, P.; Schmid, E.R.; Schmitt, B. Free Radic. Biol. Med., 2005, 38, 1323-1332.
  99. Stephensen, C.B.; Marquis, G.S.; Douglas, S.D.; Wilson, C.M. Free Radic. Res., 2005, 39, 859-864.
  100. Martin-Gallan, P.; Carrascosa, A.; Gussinye, M.; Dominguez, C. Free Radic. Res., 2005, 39, 933-942.
  101. Kosecik, M.; Erel, O.; Sevinc, E.; Selek, S. Int. J. Cardiol., 2005, 100, 61-64.
  102. Cemek, M.; Dede, S.; Bayiroglu, F.; Caksen, H.; Cemek, F.; Yuca, K. Int. J. Pediatr. Otorhinolaryngol., 2005, 69, 823-827.
  103. Mohn, A.; Catino, M.; Capanna, R.; Giannini, C.; Marcovecchio, M.; Chiarelli, F. J. Clin. Endocrinol. Metab., 2005, 90, 2653-2658.
  104. Hargreaves, I.P.; Sheena, Y.; Land, J.M.; Heales, S.J. J. Inherit. Metab. Dis., 2005, 28, 81-88.
  105. Mandato, C.; Lucariello, S.; Licenziati, M.R.; Franzese, A.; Spagnuolo, M.I.; Ficarella, R.; Pacilio, M.; Amitrano, M.; Capuano, G.; Meli, R.; Vajro, P. J. Pediatr., 2005, 147, 62-66.
  106. Kulak, W.; Sobaniec, W.; Solowej, E.; Sobaniec, H. Life Sci., 2005, 77, 3031-3036.
  107. Tsukahara, H.; Toyo-Oka, M.; Kanaya, Y.; Ogura, K.; Kawatani, M.; Hata, A.; Hiraoka, M.; Mayumi, M. Pediatr. Int., 2005, 47, 528-531.
  108. Pavlova, E.L.; Lilova, M.I.; Savov, V.M. Pediatr. Nephrol., 2005, 20, 1599-1604.
  109. Ming, X.; Stein, T.P.; Brimacombe, M.; Johnson, W.G.; Lambert, G.H.; Wagner, G.C. Prostaglandins Leukot. Essent. Fatty Acids, 2005, 73, 379-384.
  110. Becker, K.; Pons-Kuhnemann, J.; Fechner, A.; Funk, M.; Gromer, S.; Gross, H.J.; Grunert, A.; Schirmer, R.H. Redox Rep., 2005, 10, 215-226.
  111. Zhou, J.F.; Lou, J.G.; Zhou, S.L.; Wang, J.Y. World J. Gastroenterol., 2005, 11, 368-371.
  112. Zwolinska, D.; Grzeszczak, W.; Szczepanska, M.; Kilis-Pstrusinska, K.; Szprynger, K. Nephron Clin. Pract., 2006, 103, c12-c18.
  113. Hata, I.; Kaji, M.; Hirano, S.; Shigematsu, Y.; Tsukahara, H.; Mayumi, M. Pediatr. Int., 2006, 48, 58-61.
  114. Starosta, V.; Griese, M. Pediatr. Pulmonol., 2006, 41, 67-73.
  115. Parra Cid, T.; T Conejo Garcia, J.R.; Carballo Alvarez, F.; de Arriba, G. Toxicology, 2003, 189, 99-111.
  116. Conklin, K.A. Integr. Cancer Ther., 2005, 4, 110-130.
  117. Kennedy, D.D.; Ladas, E.J.; Rheingold, S.R.; Blumberg, J.; Kelly, K.M. Pediatr. Blood Cancer, 2005, 44, 378-385.
  118. Simbre, V.C.; Duffy, S.A.; Dadlani, G.H.; Miller, T.L.; Lipshultz, S.E. Paediatr. Drugs, 2005, 7, 187-202.
  119. Denicola, A.; Radi, R. Toxicology, 2005, 208, 273-288.
  120. Stolarska, M.; Mlynarski, W.; Zalewska-Szewczyk, B.; Bodalski, J. Pharmacol. Rep., 2006, 58, 30-34.
  121. Schock, B.C.; Young, I.S.; Brown, V.; Fitch, P.S.; Taylor, R.; Shields, M.D.; Ennis, M. Pediatr. Res., 2001, 49, 155-161.
  122. Erden-Inal, M.; Sunal, E.; Kanbak, G. Cell Biochem. Funct., 2002, 20, 61-66.
  123. Kauffman, L.D.; Sokol, R.J.; Jones, R.H.; Awad, J.A.; Rewers, M.J.; Norris, J.M. Free Radic. Biol. Med., 2003, 35, 551-557.
  124. Miles, M.V.; Horn, P.S.; Tang, P.H.; Morrison, J.A.; Miles, L.; DeGrauw, T.; Pesce, A.J. Clin. Chim. Acta, 2004, 347, 139-144.
  125. Andreazza, A.C.; Bordin, D.L.; Salvador, M. Clin. Chim. Acta, 2005, 362, 192-194.
  126. Aso, Y.; Takanashi, K.; Sekine, K.; Yoshida, N.; Takebayashi, K.; Yoshihara, K.; Inukai, T. J. Lab. Clin. Med., 2004, 144, 92-99.
  127. Foksinski, M.; Rozalski, R.; Guz, J.; Ruszkowska, B.; Sztukowska, P.; Piwowarski, M.; Klungland, A.; Olinski, R. Free Radic. Biol. Med., 2004, 37, 1449-1454.
  128. Leung, D.Y. J. Allergy Clin. Immunol., 2000, 105, 860-876.
  129. Forstermann, U.; Munzel, T. Circulation, 2006, 113, 1708-1714.
  130. Pacher, P.; Obrosova, I.G.; Mabley, J.G.; Szabo, C. Curr. Med. Cheml., 2005, 12, 267-275.
  131. Soro-Paavonen, A.; Forbes, J.M. Curr. Med. Chem., 2006, 13, 1777-1788.
  132. Jay, D.; Hitomi, H.; Griendling, K.K. Free Radic. Biol. Med., 2006, 40, 183-192.
  133. Dennery, P.A. Antioxid. Redox Signal., 2004, 6, 147-153.
  134. Das, K.C. Antioxid. Redox Signal., 2004, 6, 177-184.
  135. Roberts, J.M.; Lain, K.Y. Placenta, 2002, 23, 359-372.
  136. Wijnberger, L.D.E.; Krediet, T.G.; Visser, G.H.A.; van Bel, F.; Egberts, J. Early Hum. Dev., 2003, 71, 111-116.
  137. Zimmerman, A.W.; Veerkamp, J.H. Cell. Mol. Life Sci., 2002, 59, 1096-1116.
  138. Kamijo, A.; Sugaya, T.; Hikawa, A.; Okada, M.; Okumura, F.; Yamanouchi, M.; Honda, A.; Okabe, M.; Fujino, T.; Hirata, Y.; Omata, M.; Kaneko, R.; Fujii, H.; Fukamizu, A.; Kimura, K. Am. J. Pathol., 2004, 165, 1243-1255.
  139. Kamijo, A.; Kimura, K.; Sugaya, T.; Yamanouchi, M.; Hikawa, A.; Hirano, N.; Hirata, Y.; Goto, A.; Omata, M. J. Lab. Clin. Med., 2004, 143, 23-30.
  140. Nakamura, T.; Sugaya, T.; Kawagoe, Y.; Suzuki, T.; Inoue, T.; Node, K. Am. J. Nephrol., 2006, 26, 82-86.
  141. Kamijo, A.; Sugaya, T.; Hikawa, A.; Yamanouchi, M.; Hirata, Y.; Ishimitsu, T.; Numabe, A.; Takagi, M.; Hayakawa, H.; Tabei, F.; Sugimoto, T.; Mise, N.; Omata, M.; Kimura, K. Mol. Cell. Biochem., 2006, 284, 175-182.
  142. Sundberg, A.G.; Nilsson, R.; Appelkvist, E.L.; Dallner, G. Kidney Int., 1995, 48, 570-575.
  143. Branten, A.J.; Mulder, T.P.; Peters, W.H.; H Assmann, K.J.; Wetzels, J.F. Nephron, 2000, 85, 120-126.
  144. Lindmark-Mansson, H.; Akesson, B. Br. J. Nutr., 2000, 84, S103-S110.
  145. Shoji, H.; Oguchi, S.; Shimizu, T.; Yamashiro, Y. Pediatr. Res., 2003, 53, 850-852.
  146. Ohta, N.; Tsukahara, H.; Ohshima, Y.; Nishii, M.; Ogawa, Y.; Sekine, K.; Kasuga, K.; Mayumi, M. Early Hum. Dev., 2004, 78, 61-65.
  147. Todoroki, Y.; Tsukahara, H.; Ohshima, Y.; Shukunami, K.; Nishijima, K.; Kotsuji, F.; Hata, A.; Kasuga, K.; Sekine, K.; Nakamura, H.; Yodoi, J.; Mayumi, M. Free Radic. Res., 2005, 39, 291-297.
  148. Nishinaka, Y.; Nakamura, H.; Yodoi, J. Methods Enzymol., 2002, 347, 332-338.
  149. Hirai, N.; Kawano, H.; Yasue, H.; Shimomura, H.; Miyamoto, S.; Soejima, H.; Kajiwara, I.; Sakamoto, T.; Yoshimura, M.; Nakamura, H.; Yodoi, J.; Ogawa, H. Circulation, 2003, 108, 1446-1450.
  150. Cines, D.B.; Pollak, E.S.; Buck, C.A.; Loscalzo, J.; Zimmerman, G.A.; McEver, R.P.; Pober, J.S.; Wick, T.M.; Konkle, B.A.; Schwartz, B.S.; Barnathan, E.S.; McCrae, K.R.; Hug, B.A.; Schmidt, A.M.; Stern, D.M. Blood, 1998, 91, 3527-3561.
  151. Grisham, M.B.; Granger, D.N.; Lefer, D.J. Free Radic. Biol. Med., 1998, 25, 404-433.
  152. Sato, S.; Tsukahara, H.; Ohta, N.; Todoroki, Y.; Nishida, K.; Mayumi, M. Pediatr. Int., 2004, 46, 114.
  153. O'Riordan, E.; Chen, J.; Brodsky, S.V.; Smirnova, I.; Li, H.; Goligorsky, M.S. Kidney Int., 2005, 67, 1654-1658.
  154. Jiang, M.Z.; Tsukahara, H.; Ohshima, Y.; Todoroki, Y.; Hiraoka, M.; Maeda, M.; Mayumi, M. Life Sci., 2004, 75, 1159-1170.
  155. Jiang, M.Z.; Tsukahara, H.; Ohshima, Y.; Sato, S.; Todoroki, Y.; Hiraoka, M.; Mayumi, M. Free Radic. Res., 2004, 38, 473-480.
  156. Jiang, M.Z.; Tsukahara, H., Hayakawa, K.; Todoroki, Y.; Tamura, S.; Ohshima, Y.; Hiraoka, M.; Mayumi, M. Respir. Med., 2005, 99, 580-591.
  157. Mori, Y.; Tsukahara, H.; Jiang, M.Z.; Mayumi, M. Respir. Med., 2005, 99, 1068-1069.
  158. Tsukahara, H.; Imura, T.; Tsuchida, S.; Nunose, M.; Hori, C.; Hiraoka, M.; Gejyo, F.; Sudo, M. Acta Paediatr. Jpn., 1996, 38, 614-618.
  159. Tsukahara, H.; Hiraoka, M.; Kobata, R.; Hata, I.; Ohshima, Y.; Jiang, M.Z.; Noiri, E.; Mayumi, M. Redox Rep., 2000, 5, 23-28.
  160. Zatz, R.; Baylis, C. Hypertension, 1998, 32, 958-964.
  161. Heitzer, T.; Brockhoff, C.; Mayer, B.; Warnholtz, A.; Mollnau, H.; Henne, S.; Meinertz, T.; Munzel, T. Circ. Res., 2000, 86, E36-E41.
  162. Heitzer, T.; Krohn, K.; Albers, S.; Meinertz, T. Diabetologia, 2000, 43, 1435-1438.
  163. Higashi, Y.; Sasaki, S.; Nakagawa, K.; Fukuda, Y.; Matsuura, H.; Oshima, T.; Chayama, K. Am. J. Hypertens., 2002, 15, 326-332.
  164. Ceriello, A. Diabetes Care, 2003, 26, 1589-1596.
  165. Nickenig, G.; Harrison, D.G. Circulation, 2002, 105, 393-396.
  166. Pizzi, C.; Manfrini, O.; Fontana, F.; Bugiardini, R. Circulation, 2004, 109, 53-58. Table 2

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Authors
Tsukahara, H.
Affiliations
University of Fukui (JP)
Corresponding author
Tsukahara, Hirokazu
ORCID
Tsukahara, Hirokazu
Venue
Current Medicinal Chemistry
Publisher
Bentham Science Publishers Ltd.
Published
2007-02-01
Volume
14
Issue
3
Pages
339-351
ISSN
0929-8673 (ISSN-L)
DOI
10.2174/092986707779941177
OpenAlex
W1977636201
Cited by
135
References
0
Citations by year
2026: 2 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 13 · 2013: 9 · 2012: 11
FWCI
8.25
Type
journal article
Language
en
Open access
Locations
  • Current Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
  • University of Fukui Library (University of Fukui) (submittedVersion, cc-by-nc-nd)
  • Fukui University Repository (University of Fukui) (submittedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • University of Fukui
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
oxidative stress, oxidative stress biomarkers, reactive oxygen species, antioxidant defense, childhood diseases, 8-hydroxy-2'-deoxyguanosine, nitrite/nitrate, pentosidine, atopic dermatitis, diabetes mellitus, nitric oxide system, endothelial dysfunction, antioxidant therapy, children and adolescents
MeSH terms
Adolescent, Adult, Animals, Antioxidants, Child, Child, Preschool, Dermatitis, Atopic, Diabetes Mellitus, Endothelium, Vascular, Free Radicals, Humans, Infant, Infant, Newborn, Infant, Newborn, Diseases, Milk, Human, Nitric Oxide, Reference Values, Signal Transduction, Biomarkers, Reactive Oxygen Species, Oxidative Stress

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