Cited by 1,509Chemotherapy-induced cardiotoxicity and mitigationBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanisms

The DOI matches its Crossref record.

Doxorubicin: The Good, the Bad and the Ugly Effect

Carvalho, Cristina, Santos, Renato, Cardoso, Susana, Correia, Sonia, Oliveira, Paulo, Santos, Maria, Moreira, Paula·2009·Current Medicinal Chemistry

DOI 10.2174/092986709788803312

Open this paper in CoChat — free account

Abstract

The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers. Despite extensive clinical utilization, the mechanisms of action of DOX remain under intense debate. A growing body of evidence supports the view that this drug can be a double-edge sword. Indeed, injury to nontargeted tissues often complicates cancer treatment by limiting therapeutic dosages of DOX and diminishing the quality of patients' life during and after DOX treatment. The literature shows that the heart is a preferential target of DOX toxicity. However, this anticancer drug also affects other organs like the brain, kidney and liver. This review is mainly devoted to discuss the mechanisms underlying not only DOX beneficial effects but also its toxic outcomes. Additionally, clinical studies focusing the therapeutic efficacy and side effects of DOX treatment will be discussed. Finally, some potential strategies to attenuate DOX-induced toxicity will be debated.

Integrity signals

Registry

Crossref · 10.2174/092986709788803312

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 401–500 of 1,000

In Vitro and In Vivo Cardioprotective Effects of Curcumin against Doxorubicin-Induced Cardiotoxicity: A Systematic Review
Zhang, Q., & Wu, L. (2022) · Journal of Oncology · doi:10.1155/2022/7277562 · Cited by 33
“Doxorubicin (adriamycin) is an effective chemotherapy drug which belongs to nonselective class I anthracycline family [14].”
Background
Using green biosynthesized kaempferol-coated sliver nanoparticles to inhibit cancer cells growth: an in vitro study using hepatocellular carcinoma (HepG2)
Alyami, N. M., Alyami, H. M., & Almeer, R. (2022) · Cancer Nanotechnology · doi:10.1186/s12645-022-00132-z · Cited by 33
Synthetic lethal approaches for assessing combinatorial efficacy of chemotherapeutic drugs
Jackson, R. A., & Chen, E. S. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.01.014 · Cited by 33
Advancing Raman microspectroscopy for cellular and subcellular analysis: towards in vitro high-content spectralomic analysis
Byrne, H. J., Bonnier, F., Casey, A., Maher, M. A., McIntyre, J., Efeoğlu, E., & Farhane, Z. (2018) · Applied Optics · doi:10.1364/ao.57.000e11 · Cited by 33
“[32] Doxorubicin (DOX), a non cell cycle specific chemotherapeutic agent, is one of the two first anthracycline antibiotics isolated from Streptomyces peucetius[33] and among the most widely used chemotherapeutic agents, despite its numerous side effects,[34, 35] and is highly effective in treating different types of…”
Background
Hydroxyethyl Starch-Based Nanoparticles Featured with Redox-Sensitivity and Chemo-Photothermal Therapy for Synergized Tumor Eradication
Yu, C., Liu, C., Wang, S., et al. (2019) · Cancers · doi:10.3390/cancers11020207 · Cited by 33
“Despite its wide use, DOX can cause severe side effects [32].”
Background
Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy
Zhou, J.-C., Jin, C., Wei, X.-L., Xu, R., Wang, R.-Y., Zhang, Z.-M., Tang, B., Yu, J.-M., Yu, J.-J., Shang, S., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1118017 · Cited by 38
“Doxorubicin (DOX), an anthracycline antibiotic, has an extensive antitumor effect against assorted solid and hematologic tumors (Carvalho et al., 2009).”
Background
Fe3O4‐Incorporated Metal‐Organic Framework for Chemo/Ferroptosis Synergistic Anti‐Tumor via the Enhanced Chemodynamic Therapy
Xu, Y., Wang, S., Xiong, J., Zheng, P., Zhang, H., Chen, S., Ma, Q., Shen, J., Velkov, T., Dai, C., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303839 · Cited by 33
Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents
Lu, C., Wei, J., Gao, C., Sun, M., Dong, D., & Mu, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113373 · Cited by 37
Structural analysis of doxorubicin-polymer conjugates
Sanyakamdhorn, S., Bekale, L. A., Agudelo, D., & Tajmir‐Riahi, H. A. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.07.070 · Cited by 32
Therapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue
Kozhukharova, I. V., Zemelko, V. I., Kovaleva, Z. V., Lp, A., Lyublinskaya, O. G., & Nikolsky, N. N. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2346-6 · Cited by 32
Protective mechanisms of protocatechuic acid against doxorubicin-induced nephrotoxicity in rat model
Molehin, O. R., Adeyanju, A. A., Adefegha, S. A., Oyeyemi, A. O., & Idowu, K. A. (2019) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2018-0191 · Cited by 32
Demethylzeylasteral inhibits proliferation, migration, and invasion through FBXW7/c‐Myc axis in gastric cancer
Li, Y., Su, Y., Zhao, Y., Hu, X., Zhao, G., He, J., Wan, S., Lü, M., & Cui, H. (2021) · MedComm · doi:10.1002/mco2.73 · Cited by 32
Polysaccharide from Spirulina platensis Evokes Antitumor Activity in Gastric Cancer Cells via Modulation of Galectin-3 and Exhibited Cyto/DNA Protection: Structure–Function Study
Uppin, V., Dharmesh, S. M., & Ravi, S. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00176 · Cited by 34
Gold nanorods/tetrahedral DNA composites for chemo-photothermal therapy
He, Z., Wang, Q., Zhang, N., Yan, J., Li, L., Cao, J., & He, B. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac032 · Cited by 32
“However, the short half-life, severe drug tolerance and serious cardiotoxicity of DOX are the disadvantages [25].”
Background
PRMT1 suppresses doxorubicin-induced cardiotoxicity by inhibiting endoplasmic reticulum stress
Kim, S. W., Ahn, B.-Y., Tran, T. T. V., Pyun, J., Kang, J., & Leem, Y.-E. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110412 · Cited by 33
Fucoidan Protects against Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Preventing Mitochondrial Function Injury
Ji, Y., Jin, D., Qi, J., Wang, X., Zhang, C., An, P., Luo, Y., & Luo, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810685 · Cited by 33
“Doxorubicin (DOXO) is a broad-spectrum anthracycline antibiotic drug, and DOXO-based chemotherapy remains the cornerstone in cancer treatment, which is used for a variety of cancers, such as breast cancer, solid tumors, leukemia and soft-tissue sarcomas [4,5].”
Background
Breast cancer targeted chemotherapy based on doxorubicin-loaded bombesin peptide modified nanocarriers
Wang, C., Sun, X., Wang, K., et al. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1049721 · Cited by 32
“Therefore, new research efforts are necessary to overcome its poor tumor selectivity and severe side effects in healthy tissues, and to reduce the drug resistance associated with DOX (Carvalho et al., 2009; Toldo et al., 2013).”
Background
Novel 1,2,4-triazole derivatives as antitumor agents against hepatocellular carcinoma
Radwan, R. R., Zaher, N. H., & El-Gazzar, M. G. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.07.008 · Cited by 32
“10 for curing a wide range of neoplasms including acut e leukemia, malignant lymphoma, and breast cancer [23, 24].”
Fluorescence correlation spectroscopy for multiple-site equilibrium binding: a case of doxorubicin–DNA interaction
Zhang, X., Poniewierski, A., Sozański, K., et al. (2019) · Physical Chemistry Chemical Physics · doi:10.1039/c8cp06752j · Cited by 32
Electrochemical Sensor Based on Poly(Azure B)-DNA Composite for Doxorubicin Determination
Porfireva, A. V., Vorobev, V., Babkina, S. S., et al. (2019) · Sensors · doi:10.3390/s19092085 · Cited by 32
In situ biosensing technologies for an organ-on-a-chip
Kim, J., Kim, J., Jin, Y., & Cho, S. (2023) · Biofabrication · doi:10.1088/1758-5090/aceaae · Cited by 34
“The type of organ response to the administered drug closely correlates with the res-ults of previous clinical studies [97–102].”
Focused ultrasound mediated drug delivery from temperature-sensitive liposomes: in-vitro characterization and validation
Escoffre, J., Novell, A., de Smet, M., & Bouakaz, A. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/22/8135 · Cited by 34
“In agreement with data available in the literature, these results demonstrated that the released DOX freely crosses the plasma membrane of glioblastoma cells (Carvalho et al 2009).”
Result
Comparison of pharmacokinetics, tissue distribution and pharmacodynamics of liposomal and free doxorubicin in tumour-bearing mice following intratumoral injection
Ren, S., Li, C., Dai, Y., et al. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12257 · Cited by 31
“Since the 1970s, doxorubicin (DOX) has been considered as one of the most potent chemotherapeutic drugs in HCC treatment.([3,4]) However, the clinical application of DOX is restricted for severe dose-related toxicity on nontumourous tissues, among which cardiotoxicity is the most prominent adverse reaction.”
Background
Antibody-Conjugated, DNA-Based Nanocarriers Intercalated with Doxorubicin Eliminate Myofibroblasts in Explants of Human Lens Tissue
Gerhart, J. V., Greenbaum, M., Casta, L., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.239079 · Cited by 31
“…and pharmacodynamic properties, and history of use as a chemotherapeutic agent for human cancers (Trouet, 1972; Um et al., 2006; Carvalho et al., 2009; Roh et al., 2010; Nishikawa et al., 2011; Roh et al., 2011; Jiang et al., 2012; Zhao et al., 2012; Kim et al., 2013).”
Background
Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress
Quryshi, N., Toro, L. N., Ait‐Aissa, K., Kong, A. L., & Beyer, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030797 · Cited by 31
“Other mechanisms of doxorubicin damage include nucleic acid and protein amalgamation, discharge of vasoactive amines, adjustments in adrenergic capacity and adenylate cyclase activity, changes in calcium transport and modifications in subcellular iron metabolism [146].”
Background
Reductive responsive micelle overcoming multidrug resistance of breast cancer by co-delivery of DOX and specific antibiotic
Cui, Y., Yang, Y., Ma, M., Xu, Y., Sui, J., Li, H., Liang, J., Sun, Y., Fan, Y., & Zhang, X. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01093a · Cited by 32
Alamandine significantly reduces doxorubicin-induced cardiotoxicity in rats
Hekmat, A. S., Navabi, Z., Alipanah, H., & Javanmardi, K. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211010896 · Cited by 32
Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses
Ou, H., Chu, P., Huang, Y., Cheng, H., Chou, W.-C., Yang, H.-L., Chen, H., & Tsai, K. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00719-w · Cited by 31
“Doxorubicin (Dox), an anthracycline antibiotic, has been widely used in the treatment of hematological malignancies and solid tumors for five decades [1].”
Background
Promising cardioprotective effect of baicalin in doxorubicin-induced cardiotoxicity through targeting toll-like receptor 4/nuclear factor-κB and Wnt/β-catenin pathways
El-Ela, S. R. A., Zaghloul, R. A., & Eissa, L. A. (2022) · Nutrition · doi:10.1016/j.nut.2022.111732 · Cited by 31
Aptamer-based Upconversion Fluorescence Sensor for Doxorubicin Detection
Mo, J., Wang, S., Zeng, J., & Ding, X. (2023) · Journal of Fluorescence · doi:10.1007/s10895-023-03184-5 · Cited by 29
“Particularly, the risk of heart failure increases remarkably when the DOX concentration in the blood is beyond a certain level [3].”
Background
Pretreatment Hepatoprotective Effect of Regular Aerobic Training Against Hepatic Toxicity Induced by Doxorubicin In Rats
Zolfagharzadeh, F., & Roshan, V. D. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.5.2931 · Cited by 31
“Indeed, almost 40% of patients suffered liver injury after DOX treatment (Carvalho et al., 2009).”
Background
Adsorption of Doxorubicin on Poly(methyl methacrylate)–Chitosan–Heparin-Coated Activated Carbon Beads
Miao, J., Zhang, F., Takieddin, M., et al. (2012) · Langmuir · doi:10.1021/la3000137 · Cited by 31
An Arthropod Hormone, Ecdysterone, Inhibits the Growth of Breast Cancer Cells via Different Mechanisms
Shuvalov, O., Fedorova, O., Tananykina, E., Gnennaya, Y., Daks, A., Petukhov, A., & Barlev, N. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.561537 · Cited by 30
Applications of Chitosan Nanoparticles in Drug Delivery
Tajmir‐Riahi, H. A., Nafisi, S., Sanyakamdhorn, S., Agudelo, D., & Chanphai, P. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0363-4_11 · Cited by 31
Simultaneous determination of doxorubicin and its dipeptide prodrug in mice plasma by HPLC with fluorescence detection
Han, J., Zhang, J., Zhao, H., et al. (2015) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2015.12.005 · Cited by 30
Systemic and cardiac susceptibility of immune compromised mice to doxorubicin
Favreau-Lessard, A. J., Blaszyk, H., Jones, M. A., Sawyer, D. B., & Pinz, I. M. (2019) · Cardio-Oncology · doi:10.1186/s40959-019-0037-6 · Cited by 30
“Anthracyclines are commonly administered as a therapeutic in adult and pediatric oncology due to its efficacy in treating a variety of solid and liquid based cancers such as leukemia, lymphoma, breast cancer, and lung cancer [3] regardless of the known side effects on the heart [4, 5].”
Background
Inhibition of TFF3 Enhances Sensitivity—and Overcomes Acquired Resistance—to Doxorubicin in Estrogen Receptor-Positive Mammary Carcinoma
Poh, H.-M., Chiou, Y., Chong, Q. Y., et al. (2019) · Cancers · doi:10.3390/cancers11101528 · Cited by 30
Structure and biological properties of exopolysaccharide isolated from Citrobacter freundii
Choudhuri, I., Khanra, K., Maity, P., Patra, A., Maity, G. N., Pati, B. R., Nag, A., Mondal, S., & Bhattacharyya, N. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.063 · Cited by 30
Exercise Inhibits Doxorubicin-Induced Damage to Cardiac Vessels and Activation of Hippo/YAP-Mediated Apoptosis
Tao, R.-H., Kobayashi, M., Yang, Y., et al. (2021) · Cancers · doi:10.3390/cancers13112740 · Cited by 30
“Doxorubicin (Dox) is one of the most effective chemotherapy agents for treating children, adolescents, and young adults with bone and soft-tissue sarcomas [1].”
Background
Diffusion of small molecule drugs is affected by surface interactions and crowder proteins
Dey, D., Nunes‐Alves, A., Wade, R. C., & Schreiber, G. (2022) · iScience · doi:10.1016/j.isci.2022.105088 · Cited by 30
“Doxorubicin (DOX) is widely used as an anti-cancer agent (Carvalho et al., 2009); quinacrine dihydrochloride has been used for antimalarial and antiprotozoal therapy (Ehsanian et al.”
Aptamers in cancer therapy: problems and new breakthroughs
Jin, B., Guo, Z., Chen, Z., Chen, H., Li, S., Deng, Y., Jin, L. J., Liu, Y., Zhang, Y., & He, N. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02579e · Cited by 33
Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice
Gu, L., Zhang, H., Liu, T., Draganov, A. B., Yi, S., Wang, B., & Zhou, M. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0566 · Cited by 29
The potential beneficial role of Ginkgetin in doxorubicin-induced hepatotoxicity: Elucidating the underlying claim
Alherz, F. A., Negm, W. A., El-Masry, T. A., Elmorshedy, K. E., & El-Kadem, A. H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115010 · Cited by 31
Empagliflozin treatment of cardiotoxicity: A comprehensive review of clinical, immunobiological, neuroimmune, and therapeutic implications
Vaziri, Z., Saleki, K., Aram, C., Alijanizadeh, P., Pourahmad, R., Azadmehr, A., & Ziaei, N. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115686 · Cited by 31
Folic acid-functionalized PEGylated niosomes co-encapsulated cisplatin and doxoribicin exhibit enhanced anticancer efficacy
Sharafshadeh, M. S., Tafvizi, F., Khodarahmi, P., & Ehtesham, S. (2024) · Cancer Nanotechnology · doi:10.1186/s12645-024-00252-8 · Cited by 34
Mechanisms of doxorubicin-induced cardiac inflammation and fibrosis; therapeutic targets and approaches
Song, L., Qiu, Q., Ju, F., & Zheng, C. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.110140 · Cited by 35
Inorganic Phosphate Prevents Erk1/2 and Stat3 Activation and Improves Sensitivity to Doxorubicin of MDA-MB-231 Breast Cancer Cells
Sapio, L., Sorvillo, L., Illiano, M., Chiosi, E., Spina, A., & Naviglio, S. (2015) · Molecules · doi:10.3390/molecules200915910 · Cited by 28
“Although doxorubicin exerts robust antitumor activity, the appearance of important dose-dependent side effects, such as cardiotoxicity, and the acquisition of drug-resistance severely limited its clinical effectiveness [9,11].”
Background
Fragmentation of Injectable Bioadhesive Hydrogels Affords Chemotherapeutic Macromolecules
Yamada, Y., & Schneider, J. P. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00701 · Cited by 29
Nanomaterials as nanocarriers: a critical assessment why these are multi-chore vanquisher in breast cancer treatment
Naz, S., Shahzad, H., Ali, A., & Zia, M. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1375937 · Cited by 29
“Adriamycin halts the growth of tumour cells and has been used since 1970s to cure a wide variety of tumours [154].”
Background
Reduction Responsive Nanovesicles Derived from Novel α-Tocopheryl–Lipoic Acid Conjugates for Efficacious Drug Delivery to Sensitive and Drug Resistant Cancer Cells
Maiti, B., Kumar, K., Moitra, P., Kondaiah, P., & Bhattacharya, S. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00497 · Cited by 30
Intermediate filament protein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin
Khalil, S. R., Mohammed, A. T., El‐fattah, A. H. A., & Zaglool, A. W. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.02.024 · Cited by 29
Fabrication of doxorubicin and chlorotoxin-linked Eu-Gd2O3 nanorods with dual-model imaging and targeted therapy of brain tumor
Zhang, W., Huang, Z., Pu, X., et al. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.04.018 · Cited by 29
Enhanced mitophagy mediated by the YAP/Parkin pathway protects against DOX-induced cardiotoxicity
Xiao, D., Chang, W., Ding, W., Wang, Y., Fa, H., & Wang, J. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.05.015 · Cited by 30
Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer
Yuan, Y., Zhang, X., Du, K., Zhu, X., Chang, S., Chen, Y., Xu, Y., Sun, J., Luo, X., Deng, S., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05254-1 · Cited by 30
Doxorubicin covalently conjugated heparin displays anti-cancer activity as a self-assembled nanoparticle with a low-anticoagulant effect
Lee, J.-H., Yang, S.-B., Lee, J. H., Lim, H., Lee, S., Kang, T., Lim, J.-H., Kim, Y. J., & Park, J. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120930 · Cited by 29
Dual-Targeting Exosomes for Improved Drug Delivery in Breast Cancer
Tran, N. H., Nguyen, D. D. N., Nguyen, N. M., Tran, C., Thi, N. T. N., Ho, D. T. K., Nguyen, H., & Tu, L. N. (2023) · Nanomedicine · doi:10.2217/nnm-2022-0328 · Cited by 31
Effect of fermented Cordyceps�sinensis on doxorubicin‑induced cardiotoxicity in rats
Wu, R., Yao, P., Wang, H., Gao, Y. L., Yu, H., Wang, L., Cui, X., Xu, X., & Gao, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9310 · Cited by 29
“However, DOX has limited clinical use as it induces severe cardiotoxicity, that leads to irreversible cardiac injuries such as heart failure and left ventricular dysfunction (2).”
Huangkui capsule alleviates doxorubicin-induced proteinuria via protecting against podocyte damage and inhibiting JAK/STAT signaling
Zhao, L., Han, S., & Chai, C. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116150 · Cited by 28
The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage
Castaño, B. A., Schorer, S., Guo, Y., Calzetta, N. L., Gottifredi, V., Wiesmüller, L., & Biber, S. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae061 · Cited by 29
“When treating with the chemotherapeutic agent doxorubicin, which interferes with topoisomerase action generating DNA double-strand breaks ( 65 ,66 ), the opposite phenotype was observed.”
Background
Activation of microbubbles by low-level therapeutic ultrasound enhances the antitumor effects of doxorubicin
Yang, S., Wang, P., Wang, X., Su, X., & Liu, Q. (2014) · European Radiology · doi:10.1007/s00330-014-3334-3 · Cited by 27
Fe/Mg-Modified Carbonate Apatite with Uniform Particle Size and Unique Transport Protein-Related Protein Corona Efficiently Delivers Doxorubicin into Breast Cancer Cells
Haque, S. T., Karim, M. E., Abidin, S. A. Z., Othman, I., Holl, M. M. B., & Chowdhury, E. H. (2020) · Nanomaterials · doi:10.3390/nano10050834 · Cited by 28
Study on the Molecular Mechanisms Against Human Breast Cancer from Insight of Elemental Distribution in Tissue Based on Laser-Induced Breakdown Spectroscopy (LIBS)
Wei, H., Zhao, Z., Lin, Q., et al. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02292-8 · Cited by 28
Synergistic effect of photodynamic treatment and doxorubicin on triple negative breast cancer cells
Sadeghloo, A. Y., Khorsandi, K., & Kianmehr, Z. (2020) · Photochemical & Photobiological Sciences · doi:10.1039/d0pp00132e · Cited by 28
Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer
Kugeratski, F. G., McAndrews, K. M., & Kalluri, R. (2021) · Endocrinology · doi:10.1210/endocr/bqaa250 · Cited by 27
Protective effect of nanocurcumin against neurotoxicity induced by doxorubicin in rat’s brain
Khadrawy, Y. A., Hosny, E. N., & Mohammed, H. S. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.04.003 · Cited by 29
Anti-Proliferative Effect of Doxorubicin-Loaded AS1411 Aptamer on Colorectal Cancer Cell
Lohlamoh, W., Soontornworajit, B., & Rotkrua, P. (2021) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2021.22.7.2209 · Cited by 28
“Dox, a chemotherapeutic drug for cancer treatment, is also toxic to normal cells resulting in a number of side effects to the patients (Carvalho et al., 2009).”
Background
Engineered Polymer-Supported Biorthogonal Nanocatalysts Using Flash Nanoprecipitation
Huang, R., Hirschbiegel, C., Zhang, X., Gupta, A., Fedeli, S., Xu, Y., & Rotello, V. M. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c04496 · Cited by 28
Diselenide-triggered hydroxyethyl starch conjugate nanoparticles with cascade drug release properties for potentiating chemo-photodynamic therapy
Tan, R., Ge, J., Wang, C., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120748 · Cited by 28
Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells – Involvement of carbonyl reductase 1
Koczurkiewicz, P., Piska, K., Gunia‐Krzyżak, A., Bucki, A., Jamrozik, M., Lorenc, E., Ryszawy, D., Wójcik‐Pszczoła, K., Michalik, M., Marona, H., et al. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105511 · Cited by 27
AMP-activated Protein Kinase α2 and E2F1 Transcription Factor Mediate Doxorubicin-induced Cytotoxicity by Forming a Positive Signal Loop in Mouse Embryonic Fibroblasts and Non-carcinoma Cells
Yang, W., Park, I.-J., Yun, H., Im, D.-U., Ock, S., Kim, J., Seo, S.-M., Shin, H., Viollet, B., Kang, I., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.496315 · Cited by 28
Developing targeted drug delivery carriers for breast cancer using glutathione-sensitive doxorubicin-coupled glycated bovine serum albumin nanoparticles
Hsu, W., Ku, C.-L., Lai, Y.-R., Wang, S. S. ‐., Chou, S.-H., & Lin, T. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126114 · Cited by 28
Carbon nanomaterials as carriers for the anti-cancer drug doxorubicin: a review on theoretical and experimental studies
Gayathri, K., & Vidya, R. (2024) · Nanoscale Advances · doi:10.1039/d4na00278d · Cited by 21
Interaction of silver atomic quantum clusters with living organisms: bactericidal effect of Ag 3 clusters mediated by disruption of topoisomerase–DNA complexes
Neissa, J., Pérez-Arnáiz, C., Porto, V., Busto, N., Borrajo, E., Leal, J. M., López-Quintela, M. A., Garcı́a, B., & Domı́nguez, F. (2015) · Chemical Science · doi:10.1039/c5sc02022k · Cited by 27
Liquid formulation containing doxorubicin-loaded lipid-core nanocapsules: Cytotoxicity in human breast cancer cell line and in vitro uptake mechanism
Antonow, M. B., Asbahr, A. C. C., Raddatz, P. S., Beckenkamp, A., Buffon, A., Guterres, S. S., & Pohlmann, A. R. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.099 · Cited by 27
Effective drug delivery system based on hydrophobin and halloysite clay nanotubes for sustained release of doxorubicin
Wang, B., Han, Z., Song, B., Long, Y., Ma, Z., Xu, H., & Qiao, M. (2021) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2021.127351 · Cited by 27
Loading of DOX into a tetrahedral DNA nanostructure: the corner does matter
Xu, Y., Huang, S.-W., Ma, Y., & Ding, H. (2021) · Nanoscale Advances · doi:10.1039/d1na00753j · Cited by 27
A novel stimuli-responsive magnetic hydrogel based on nature-inspired tragacanth gum for chemo/hyperthermia treatment of cancerous cells
Khani, A., Eskandani, M., Derakhshankhah, H., Soleimani, K., Nakhjavani, S. A., Massoumi, B., Jahanban‐Esfahlan, R., Moloudi, K., & Jaymand, M. (2022) · Journal of Polymer Research · doi:10.1007/s10965-022-03004-7 · Cited by 28
“doxorubicin (DOX) as an anthracycline anticancer drug is widely used in chemotherapy owing to its efficacy and applicability for numerous cancers such as sarcomas, carcinomas, and hematological cancers [8, 9].”
Background
The anti-tumor and renoprotection study of E-[c(RGDfK)2]/folic acid co-modified nanostructured lipid carrier loaded with doxorubicin hydrochloride/salvianolic acid A
Zhang, B., Zhang, Y., Dang, W., Xing, B., Yu, C., Guo, P., Pi, J., Deng, X., Qi, D., & Liu, Z. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01628-x · Cited by 26
“For example, free DOX damages normal kidney cells through mitochondrial oxidative damage caused by production of reactive oxygen species (ROS) [42].”
Background
Prospects and challenges of synergistic effect of fluorescent carbon dots, liposomes and nanoliposomes for theragnostic applications
Faghihi, H., Mozafari, M. R., Bumrungpert, A., Parsaei, H., Taheri, S. V., Mardani, P., Dehkharghani, F. M., Pudza, M. Y., & Alavi, M. (2023) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2023.103614 · Cited by 27
Comparative study of superparamagnetic iron oxide/doxorubicin co-loaded poly (lactic-co-glycolic acid) nanospheres prepared by different emulsion solvent evaporation methods
Mosafer, J., & Teymouri, M. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1362415 · Cited by 27
“Dox is derived by chemical semisynthesis from a bacterial species (wild type strains of Streptomyces) and widely used as chemotherapeutic agent [31].”
Background
Protective effects of zinc on rat sperm chromatin integrity involvement: DNA methylation, DNA fragmentation, ubiquitination and protamination after bleomycin etoposide and cis-platin treatment
Khadivi, F., Razavi, S., & Hashemi, F. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.09.039 · Cited by 28
Synergistic Mechanisms of Selected Polyphenols in Overcoming Chemoresistance and Enhancing Chemosensitivity in Colorectal Cancer
Hon, K. W., & Naidu, R. (2024) · Antioxidants · doi:10.3390/antiox13070815 · Cited by 29
“The long-term effectiveness of doxorubin in CRC treatment also encounters drug resistance [91].”
Background
Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR‐RES Ovarian Cancer Cells via Inhibition of P‐glycoprotein Expression
Choi, H. S., Cho, S., Kim, M. K., et al. (2016) · Phytotherapy Research · doi:10.1002/ptr.5708 · Cited by 26
“Doxorubicin is a commonly used chemotherapeutic drug (Carvalho et al., 2009; Tacar et al., 2013).”
Background
Inertial Microfluidic Purification of Floating Cancer Cells for Drug Screening and Three-Dimensional Tumor Models
Zhang, J., Chintalaramulu, N., Vadivelu, R. K., An, H., Yuan, D., Jin, J., Ooi, C. H., Cock, I. E., Li, W., & Nguyen, N. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00273 · Cited by 27
An Electrochemical Strategy for the Simultaneous Detection of Doxorubicin and Simvastatin for Their Potential Use in the Treatment of Cancer
Rus, I., Tertiş, M., Barbălată, C. I., et al. (2021) · Biosensors · doi:10.3390/bios11010015 · Cited by 26
Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques
Gayraud, F., Klußmann, M., & Neundorf, I. (2021) · Molecules · doi:10.3390/molecules26061591 · Cited by 26
“However, their usage is restricted owing to their poor water solubility and undesired side effects leading to high toxicity [47].”
Background
Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling – A case study of doxorubicin with dose metrics considerations
Li, H., Yuan, H., Middleton, A., Li, J., Nicol, B., Carmichael, P. L., Guo, J., Peng, S., & Zhang, Q. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105171 · Cited by 27
Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity
Li, W., Cao, J., Wang, X., Zhang, Y., Sun, Q., Jiang, Y., Yao, J., Li, C., Wang, Y., & Wang, W. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.773834 · Cited by 28
Expression and Functional Contribution of Different Organic Cation Transporters to the Cellular Uptake of Doxorubicin into Human Breast Cancer and Cardiac Tissue
Otter, M., Csader, S., Keiser, M., & Oswald, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010255 · Cited by 27
“The clinical use of doxorubicin is limited by its high variability in terms of efficacy and safety [3,4,28].”
Background
Chronic Cardiotoxicity Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)
Narkar, A., Willard, J. M., & Blinova, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063199 · Cited by 27
Anthracycline-induced cardiotoxicity: targeting high-density lipoproteins to limit the damage?
Abrahams, C., Woudberg, N. J., & Lecour, S. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01694-y · Cited by 25
“The latter, oxidize proteins, lipids and nucleic acids leading to mitochondrial dysfunction and opening of the mitochondrial permeability transition pore (mPTP), thus resulting in apoptosis (see review [30]).”
BackgroundInfluential
Overcoming Non‐Specific Interactions for Efficient Encapsulation of Doxorubicin in Ferritin Nanocages for Targeted Drug Delivery
Budiarta, M., Roy, S., Katenkamp, T., Feliu, N., & Beck, T. (2023) · Small · doi:10.1002/smll.202205606 · Cited by 26
RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin
Reyes, M. E., Ma, J., Grove, M. L., Ater, J. L., Morrison, A. C., & Hildebrandt, M. A. T. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.07.020 · Cited by 24
Overview of DNA Self-Assembling: Progresses in Biomedical Applications
Jorge, A. F., & Eritja, R. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040268 · Cited by 27
Recent advances in biomimetic strategies for the immunotherapy of glioblastoma
You, H., Geng, S., Li, S., Imani, M., Brambilla, D., Sun, T., & Jiang, C. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122694 · Cited by 27
Doxorubicin Delivery into Tumor Cells by Stable Cavitation without Contrast Agents
Chettab, K., Mestas, J., Lafond, M., et al. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00880 · Cited by 25
Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin
Wen, K., Zhou, M., Lu, H., Bi, Y., Ruan, L., Chen, J., & Hu, Y. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01051 · Cited by 25
Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice
Hu, X., Li, B., Li, L., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5347204 · Cited by 25
“Introduction Anthracyclines are the primary choice particularly in patients with severe leukemias, lymphomas, and solid tumors [1].”
Background
Doxorubicin treatment modulates chemoresistance and affects the cell cycle in two canine mammary tumour cell lines
Levi, M., Salaroli, R., Parenti, F., et al. (2021) · BMC Veterinary Research · doi:10.1186/s12917-020-02709-5 · Cited by 25
“Despite extensive clinical utilization, the mechanisms of action of DOX remain under intense debate and further understanding of DOX influence on cell biological events could lead to an improvement in the drug’s efficacy [12, 13, 16].”
Background
Hyperthermia Enhances Doxorubicin Therapeutic Efficacy against A375 and MNT-1 Melanoma Cells
Salvador, D., Bastos, V., & Oliveira, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010035 · Cited by 25
“Then, this complex translocates into the nucleus, where DOX dissociates and binds to DNA, obstructing the cleaving activity of topoisomerase II and disrupting nucleic acid synthesis [14,15].”
Background

Authors: Carvalho, C., Santos, R., Cardoso, S., Correia, S., Oliveira, P., Santos, M., & Moreira, P.
Affiliations: Centro de Neurociências e Biologia Celular (PT)
Corresponding author: Moreira, Paula
ORCID: Carvalho, Cristina
Santos, Renato
Cardoso, Susana
Oliveira, Paulo
Santos, Maria
Moreira, Paula
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2009-09-01
Volume: 16
Issue: 25
Pages: 3267-3285
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/092986709788803312
OpenAlex: W2102897174
Cited by: 1,509
References: 0
Citations by year: 2026: 102 · 2025: 147 · 2024: 174 · 2023: 169 · 2022: 153 · 2021: 150 · 2020: 120 · 2019: 85 · 2018: 84 · 2017: 53 · 2016: 63 · 2015: 62 · 2014: 43 · 2013: 35 · 2012: 29
FWCI: 14.12
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
Keywords: doxorubicin, anthracyclines, cardiotoxicity, drug toxicity mechanisms, anticancer mechanism, neurotoxicity, nephrotoxicity, hepatotoxicity, chemotherapy side effects
MeSH terms: Antibiotics, Antineoplastic, Doxorubicin, Humans, Molecular Conformation, Neoplasms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Doxorubicin: The Good, the Bad and the Ugly Effect

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks