In Vitro Models for the Study of Non-Alcoholic Fatty Liver Disease
Abstract
Non-alcoholic fatty liver disease is regarded as the hepatic manifestation of metabolic syndrome and is an important and common cause of chronic liver disease with a potential to develop end-stage liver disease. While important advances in the pathophysiology have been achieved using genetically modified and diet-induced animal models, in-vitro models have been only recently proposed. These models include primary culture and immortalized cell lines. Here we critically review the characteristics of the in vitro models described, the advantages and limitations of the in vitro approach, and the results derived.
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Given earlier clinical and in vitro activities of P. kurroa and picroside II, the results in HepG2 cells gain relevance.
“But in view of the earlier clinical and in vitro activities shown by P. kurroa and picroside II, these results in HepG2 cells gain relevance [48].”
From Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells (2021) · cites this paper as [48]
Cites
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
Shimabukuro, M., Zhou, Y.-T., Levi, M., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2498 · Cited by 1,142 · see citing works
Dyck, D. J. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-037 · Cited by 136 · see citing works
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Teng, Y., Zhao, Z., Tasnim, F., Huang, X., & Yu, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120904 · Cited by 62 · see citing works
Hernández, A., Reyes, D., Geng, Y., Arab, J. P., Cabrera, D., Sepulveda, R., Solis, N., Buist-Homan, M., Arrese, M., & Moshage, H. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165857 · Cited by 42 · see citing works
Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells
Dhami-Shah, H., Vaidya, R., Talwadekar, M., Shaw, E., Udipi, S., Kolthur-Seetharam, U., & Vaidya, A. D. B. (2021) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2021.04.007 · Cited by 15 · see citing works
“kurroa and picroside II, these results in HepG2 cells gain relevance [48].”
Background
- Authors
- C. Chavez-Tapia, N., Rosso, N., & Tiribelli, C.
- Affiliations
- AREA Science Park (IT)
- Corresponding author
- Tiribelli, C.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-03-01
- Volume
- 18
- Issue
- 7
- Pages
- 1079-1084
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2150942966
- Cited by
- 86
- References
- 2
- Citations by year
- 2025: 27 · 2024: 2 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 11 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 1 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Theoretical Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- non-alcoholic fatty liver disease, in vitro model, primary hepatocyte culture, metabolic syndrome, end-stage liver disease, fatty acids, chronic liver disease
- MeSH terms
- Animals, Cell Line, Dietary Fats, Fatty Liver
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