Adipokines as regulators of muscle metabolism and insulin sensitivityThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,239 · see citing works

cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081 · see citing works

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,074 · see citing works

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053 · see citing works

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works

Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works

Skeletal muscle triglyceride levels are inversely related to insulin action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity

Pajvani, U. B., Hawkins, M., Combs, T. P., Rajala, M. W., Doebber, T., Berger, J. P., Wagner, J. A., Wu, M., Knopps, A., Xiang, A. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311113200 · Cited by 1,163 · see citing works

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096 · see citing works

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Hundal, R. S., Krssak, M., Dufour, S., Laurent, D., Lebon, V, Chandramouli, V, Inzucchi, S. E., Schumann, W. C., Petersen, K. F., Landau, B. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2063 · Cited by 1,052 · cited 1× · see citing works

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

Tomas, E., Tsao, T.-S., Saha, A. K., Murrey, H. E., Zhang, C. C., Itani, S. I., Lodish, H. F., & Ruderman, N. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222657499 · Cited by 973 · see citing works

Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma

Nakano, Y., Tobe, T., Choi-Miura, N.-H., Mazda, T., & Tomita, M. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021483 · Cited by 915 · see citing works

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209033200 · Cited by 911 · see citing works

Defective STAT signaling by the leptin receptor in diabetic mice.

Ghilardi, N., Ziegler, S., Wiestner, A. C., Stoffel, R., Heim, M. H., & Skoda, R. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6231 · Cited by 793 · see citing works

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

van Heek, M., Compton, D. S., France, C. F., Tedesco, R. P., Fawzi, A. B., Graziano, M. P., Sybertz, E. J., Strader, C. D., & Davis, H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119171 · Cited by 752 · see citing works

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

Lönnqvist, F., Arner, P., Nordfors, L., & Schalling, M. (1995) · Nature Medicine · doi:10.1038/nm0995-950 · Cited by 708 · see citing works

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 670 · see citing works

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

Mao, X., Kikani, C. K., Riojas, R. A., Langlais, P. R., Wang, L., Ramos, F. J., Fang, Q., Christ-Roberts, C. Y., Hong, J., Kim, R. Y., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1404 · Cited by 661 · see citing works

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

Shimabukuro, M., Koyama, K., Chen, G., Wang, M.-Y., Trieu, F., Lee, Y., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4637 · Cited by 646 · see citing works

Lipid oxidation is reduced in obese human skeletal muscle

Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

Petersen (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215001 · Cited by 622 · cited 1× · see citing works

Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity

Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402367200 · Cited by 550 · see citing works

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

Yoon, M. J., Lee, G. Y., Chung, J.-J., Ahn, Y. H., Hong, S. H., & Kim, J. B. (2006) · Diabetes · doi:10.2337/db05-1322 · Cited by 546 · see citing works

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

Turner, N., Bruce, C. R., Beale, S. M., Hoehn, K. L., So, T., Rolph, M. S., & Cooney, G. J. (2007) · Diabetes · doi:10.2337/db07-0093 · Cited by 520 · see citing works

Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss.

Simoneau, J., Veerkamp, J. H., Turcotte, L. P., & Kelley, D. E. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.2051 · Cited by 491 · see citing works

Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

Summers, S. A., Garza, L. A., Zhou, H., & Birnbaum, M. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5457 · Cited by 475 · see citing works

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

Muoio, D. M., Dohm, G. L., Fiedorek, F. T., Tapscott, E. B., Coleman, R., & Dohn, G. L. (1997) · Diabetes · doi:10.2337/diab.46.8.1360 · Cited by 458 · see citing works

Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36

Bonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410 · see citing works

Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity

Goodpaster, B. H., Katsiaras, A., & Kelley, D. E. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2191 · Cited by 390 · see citing works

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

Zhou, Y.-T., Shimabukuro, M., Koyama, K., Lee, Y., Wang, M.-Y., Trieu, F., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6386 · Cited by 373 · see citing works

Overfeeding Rapidly Induces Leptin and Insulin Resistance

Wang, J., Obici, S., Morgan, K., Barzilai, N., Feng, Z., & Rossetti, L. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2786 · Cited by 355 · see citing works

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

Ceddia, R. B., Somwar, R., Maida, A., Fang, X., Bikopoulos, G. J., & Sweeney, G. (2004) · Diabetologia · doi:10.1007/s00125-004-1609-y · Cited by 340 · see citing works

Skeletal muscle lipid metabolism with obesity

Hulver, M. W., Berggren, J. R., Cortright, R. N., Dudek, R. W., Thompson, R. P., Pories, W. J., MacDonald, K. G., Cline, G. W., Shulman, G. I., Dohm, G. L., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2002 · Cited by 339 · see citing works

Membrane transport of long-chain fatty acids: evidence for a facilitated process

Abumrad, N. A., Harmon, C. M., & Ibrahimi, A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33310-1 · Cited by 326 · see citing works

Functional and pathological roles of the 12- and 15-lipoxygenases

Dobrian, A. D., Lieb, D. C., Cole, B. K., Taylor, D., Chakrabarti, S. K., & Nadler, J. L. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.10.005 · Cited by 324 · see citing works

Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1

Waki, H., Yamauchi, T., Kamon, J., Kita, S., Ito, Y., Hada, Y., Uchida, S., Tsuchida, A., Takekawa, S., & Kadowaki, T. (2005) · Endocrinology · doi:10.1210/en.2004-1096 · Cited by 319 · see citing works

Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting

Åhrén, B., Månsson, S., Gingerich, R. L., & Havel, P. J. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.1.r113 · Cited by 298 · see citing works

Leptin in human physiology and therapeutics

Dardeno, T. A., Chou, S. H.-H., Moon, H., Chamberland, J. P., Fiorenza, C. G., & Mantzoros, C. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.06.002 · Cited by 288 · see citing works

Increased Rates of Fatty Acid Uptake and Plasmalemmal Fatty Acid Transporters in Obese Zucker Rats

Luiken, J. J. F. P., Arumugam, Y., Dyck, D. J., Bell, R. C., Pelsers, M. M. L., Turcotte, L. P., Tandon, N. N., Glatz, J. F. C., & Bonen, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100052200 · Cited by 282 · see citing works

Leptin signalling

Sweeney, G. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(02)00006-2 · Cited by 271 · see citing works

Reduced central leptin sensitivity in rats with diet-induced obesity

Levin, B. E., & Dunn-Meynell, A. A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00245.2002 · Cited by 264 · see citing works

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes

Civitarese, A. E., Jenkinson, C. P., Richardson, D. K., Bajaj, M., Cusi, K. J., Kashyap, S. R., Berria, R., Belfort, R., DeFronzo, R. A., Mandarino, L. J., et al. (2004) · Diabetologia · doi:10.1007/s00125-004-1359-x · Cited by 258 · see citing works

Relationship Between Insulin Sensitivity and Sphingomyelin Signaling Pathway in Human Skeletal Muscle

Strączkowski, M., Kowalska, I., Nikołajuk, A., Dzienis-Straczkowska, S., Kinalska, I., Baranowski, M., Żendzian‐Piotrowska, M., Brzezinska, Z., & Górski, J. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1215 · Cited by 258 · see citing works

Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible

Banks, W. A., & Farrell, C. L. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00468.2002 · Cited by 241 · see citing works

Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes

van Loon, L. J. C., Koopman, R., Manders, R., van der Weegen, W., van Kranenburg, G. P., & Keizer, H. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00464.2003 · Cited by 239 · see citing works

Role of adiponectin in human skeletal muscle bioenergetics

Civitarese, A. E., Ukropcova, B., Carling, S., Hulver, M., DeFronzo, R. A., Mandarino, L., Ravussin, E., & Smith, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.002 · Cited by 234 · see citing works

Adiponectinemia in Visceral Obesity: Impact on Glucose Tolerance and Plasma Lipoprotein and Lipid Levels in Men

Côté, M., Mauriège, P., Bergeron, J., Alméras, N., Tremblay, A., Lemieux, I., & Després, J.-P. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1711 · Cited by 230 · see citing works

Palmitate transport and fatty acid transporters in red and white muscles

Bonen, A., Luiken, J. J. F. P., Liu, S., Dyck, D. J., Kiens, B., Kristiansen, S., Turcotte, L. P., Vusse, G. J., & Glatz, J. F. C. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.3.e471 · Cited by 228 · see citing works

Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance

Steinberg, G. R., Parolin, M. L., Heigenhauser, G. J. F., & Dyck, D. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00542.2001 · Cited by 207 · see citing works

Impaired Activation of AMP-Kinase and Fatty Acid Oxidation by Globular Adiponectin in Cultured Human Skeletal Muscle of Obese Type 2 Diabetics

Chen, M. B., McAinch, A. J., Macaulay, S. L., Castelli, L. A., O’Brien, P. E., Dixon, J. B., Cameron‐Smith, D., Kemp, B. E., & Steinberg, G. R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1980 · Cited by 199 · see citing works

Heterogeneity of pig intestinal<scp>d</scp>-glucose transport systems

Halaihel, N., Gerbaud, D., Vasseur, M., & Alvarado, F. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.6.c1130 · Cited by 199 · see citing works

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

Kellerer, M., Koch, M., Metzinger, E., Mushack, J., Capp, E., & Häring, H. (1997) · Diabetologia · doi:10.1007/s001250050832 · Cited by 198 · see citing works

Bone and muscle loss after spinal cord injury: organ interactions

Qin, W., Bauman, W. A., & Cardozo, C. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05806.x · Cited by 189 · see citing works

Peripheral metabolic actions of leptin

Muoio, D. M., & Lynis Dohm, G. (2002) · Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism · doi:10.1053/beem.2002.0223 · Cited by 183 · see citing works

The Stimulatory Effect of Globular Adiponectin on Insulin-Stimulated Glucose Uptake and Fatty Acid Oxidation Is Impaired in Skeletal Muscle From Obese Subjects

Bruce, C. R., Mertz, V. A., Heigenhauser, G. J. F., & Dyck, D. J. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3154 · Cited by 164 · see citing works

Impaired leptin responsiveness in aged rats.

Scarpace, P. J., Matheny, M. E., Moore, R. L., & Tümer, N. (2000) · Diabetes · doi:10.2337/diabetes.49.3.431 · Cited by 154 · see citing works

Leptin Resistance During Aging Is Independent of Fat Mass

Gabriely, I., Xiao, H., Yang, X. M., Rossetti, L., & Barzilai, N. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1016 · Cited by 153 · see citing works

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

Colombo, C., Cutson, J. J., Yamauchi, T., Vinson, C., Kadowaki, T., Gavrilova, O., & Reitman, M. L. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2727 · Cited by 147 · see citing works

Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women.

Holloway, G. P., Thrush, A. B., Heigenhauser, G. J. F., Tandon, N. N., Dyck, D. J., Bonen, A., & Spriet, L. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00639.2006 · Cited by 147 · see citing works

Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients

Debard, C., Laville, M., Berbe, V., Loizon, E., Guillet, C., Morio, B., Boirie‌, Y., & Vidal, H. (2004) · Diabetologia · doi:10.1007/s00125-004-1394-7 · Cited by 145 · see citing works

Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression

Chandrasekar, B., Boylston, W. H., Venkatachalam, K., Webster, N. J. G., Prabhu, S. D., & Valente, A. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804236200 · Cited by 143 · see citing works

AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment

Steinberg, G. R., Rush, J. W. E., & Dyck, D. J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00318.2002 · Cited by 133 · see citing works

Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats

Mullen, K. L., Pritchard, J. M., Ritchie, I. R. W., Snook, L. A., Chabowski, A., Bonen, A., Wright, D. C., & Dyck, D. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90774.2008 · Cited by 133 · see citing works

Metabolic actions of insulin in men and women

Magkos, F., Wang, X., & Mittendorfer, B. (2010) · Nutrition · doi:10.1016/j.nut.2009.10.013 · Cited by 129 · see citing works

Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia

Smith, A. C., Mullen, K. L., Junkin, K. A., Nickerson, J., Chabowski, A., Bonen, A., & Dyck, D. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00677.2006 · Cited by 127 · see citing works

The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans

Steinberg, G. R., McAinch, A. J., Chen, M. B., O’Brien, P. E., Dixon, J. B., Cameron‐Smith, D., & Kemp, B. E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0638 · Cited by 114 · see citing works

Development of leptin resistance in rat soleus muscle in response to high-fat diets

Steinberg, G. R., & Dyck, D. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.6.e1374 · Cited by 112 · see citing works

Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats

Steinberg, G. R., Bonen, A., & Dyck, D. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00303.2001 · Cited by 102 · see citing works

Leptin directly alters lipid partitioning in skeletal muscle

Muoio, D. M., Dohm, G. L., Fiedorek, F. T., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.8.1360 · Cited by 101 · see citing works

Increased Fatty Acid Uptake and Altered Fatty Acid Metabolism in Insulin-Resistant Muscle of Obese Zucker Rats

Turcotte, L. P., Swenberger, J. R., Zavitz Tucker, M., & Yee, A. J. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1389 · Cited by 100 · see citing works

Protein kinase C modulates insulin action in human skeletal muscle

Cortright, R. N., Azevedo, J. L., Zhou, Q., Sinha, M. K., Pories, W. J., Itani, S. I., & Dohm, G. L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.3.e553 · Cited by 100 · see citing works

Chronic Leptin Administration Decreases Fatty Acid Uptake and Fatty Acid Transporters in Rat Skeletal Muscle

Steinberg, G. R., Dyck, D. J., Calles-Escandon, J., Tandon, N. N., Luiken, J. J. F. P., Glatz, J. F. C., & Bonen, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107683200 · Cited by 91 · see citing works

Stearoyl-CoA desaturase and insulin signaling — What is the molecular switch?

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Adiponectin protects rat hippocampal neurons against excitotoxicity

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