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Thermosensitive Polymeric Hydrogels As Drug Delivery Systems
Abstract
Thermosensitive hydrogels are very important biomaterials used in drug delivery systems (DDSs), which gained increasing attention of researchers. Thermosensitive hydrogels have great potential in various applications, such as drug delivery, cell encapsulation, tissue engineering, and etc. Especially, injectable thermosensitive hydrogels with lower sol-gel transition temperature around physiological temperature have been extensively studied. By in vivo injection, the hydrogels formed non-flowing gel at body temperature. Upon incorporation of pharmaceutical agents, the hydrogel systems could act as sustained drug release depot in situ. Injectable thermosensitive hydrogel systems have a number of advantages, including simplicity of drug formulation, protective environment for drugs, prolonged and localized drug delivery, and ease of application. The objective of this review is to summarize fundamentals, applications, and recent advances of injectable thermosensitive hydrogel as DDSs, including chitosan and related derivatives, poly(N-isopropylacrylamide)-based (PNIPAAM) copolymers, poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) copolymers and its derivatives, and poly(ethylene glycol)/ biodegradable polyester copolymers. Keywords: Injectable, thermosensitive, hydrogel, phase transition, drug delivery, controlled release, chitosan, N-Isopropylacrylamide, pluronic, PEG, PLA, PLGA, PCL, PCLA, PHB
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“Thermo-responsive polymers show sol-gel transitions with a change in temperature of the external environment and hydrogels made of thermoresponsive polymers find tremendous drug delivery applications through simple chemical modifications [29,30,31,32]”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [32]
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Classification, processing and application of hydrogels: A review
Ullah, F., Othman, M. B. H., Javed, F. T., Ahmad, Z., & Akil, H. M. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.07.053 · Cited by 1,566
Poly(N-isopropylacrylamide)-based smart hydrogels: Design, properties and applications
Tang, L., Wang, L., Yang, X. J., Feng, Y., Yu, L., & Feng, W. (2020) · Progress in Materials Science · doi:10.1016/j.pmatsci.2020.100702 · Cited by 875
Formulation of Poloxamers for Drug Delivery
Bodratti, A. M., & Alexandridis, P. (2018) · Journal of Functional Biomaterials · doi:10.3390/jfb9010011 · Cited by 590
Bustamante-Torres, M., Romero-Fierro, D., Arcentales-Vera, B., Palomino, K., Magaña, H., & Bucio, E. (2021) · Gels · doi:10.3390/gels7040182 · Cited by 454
Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications
Larrañeta, E., Stewart, S. A., Ervine, M., Al-Kasasbeh, R., & Donnelly, R. F. (2018) · Journal of Functional Biomaterials · doi:10.3390/jfb9010013 · Cited by 305
Metadata
- Authors
- Gong, C., Qi, T., Wei, X., Qu, Y., Wu, Q., Luo, F., & Qian, Z.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Qi, T.
- Wu, Q.
- Qian, Z.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-12-01
- Volume
- 20
- Issue
- 1
- Pages
- 79-94
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W4241712141
- Cited by
- 228
- References
- 0
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 15 · 2023: 18 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 23 · 2018: 23 · 2017: 16 · 2016: 20 · 2015: 13 · 2014: 11 · 2013: 7
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Polymer-Based Agricultural Enhancements
- Keywords
- thermosensitive hydrogel, injectable hydrogel, drug delivery systems, sol-gel transition, controlled drug release, chitosan, poly(N-isopropylacrylamide), poloxamer, polyethylene glycol, PLGA, PCL, polyhydroxybutyrate, cell encapsulation, tissue engineering
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