Cited by 228Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsPolymer-Based Agricultural Enhancements

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Thermosensitive Polymeric Hydrogels As Drug Delivery Systems

Gong, C., Qi, T., Wei, X., Qu, Y., Wu, Q., Luo, F., Qian, Z.·2012·Current Medicinal Chemistry

DOI 10.2174/0929867311302010009

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Abstract

Thermosensitive hydrogels are very important biomaterials used in drug delivery systems (DDSs), which gained increasing attention of researchers. Thermosensitive hydrogels have great potential in various applications, such as drug delivery, cell encapsulation, tissue engineering, and etc. Especially, injectable thermosensitive hydrogels with lower sol-gel transition temperature around physiological temperature have been extensively studied. By in vivo injection, the hydrogels formed non-flowing gel at body temperature. Upon incorporation of pharmaceutical agents, the hydrogel systems could act as sustained drug release depot in situ. Injectable thermosensitive hydrogel systems have a number of advantages, including simplicity of drug formulation, protective environment for drugs, prolonged and localized drug delivery, and ease of application. The objective of this review is to summarize fundamentals, applications, and recent advances of injectable thermosensitive hydrogel as DDSs, including chitosan and related derivatives, poly(N-isopropylacrylamide)-based (PNIPAAM) copolymers, poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) copolymers and its derivatives, and poly(ethylene glycol)/ biodegradable polyester copolymers. Keywords: Injectable, thermosensitive, hydrogel, phase transition, drug delivery, controlled release, chitosan, N-Isopropylacrylamide, pluronic, PEG, PLA, PLGA, PCL, PCLA, PHB

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Authors: Gong, C., Qi, T., Wei, X., Qu, Y., Wu, Q., Luo, F., & Qian, Z.
Affiliations: Sichuan University (CN)
Corresponding author: Qi, T.
Wu, Q.
Qian, Z.
ORCID: Gong, C.
Qu, Y.
Wu, Q.
Qian, Z.
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2012-12-01
Volume: 20
Issue: 1
Pages: 79-94
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/0929867311302010009
OpenAlex: W4241712141
Cited by: 228
References: 0
Citations by year: 2026: 12 · 2025: 9 · 2024: 15 · 2023: 18 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 23 · 2018: 23 · 2017: 16 · 2016: 20 · 2015: 13 · 2014: 11 · 2013: 7
FWCI: 4.56
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Polymer-Based Agricultural Enhancements
Keywords: thermosensitive hydrogel, injectable hydrogel, drug delivery systems, sol-gel transition, controlled drug release, chitosan, poly(N-isopropylacrylamide), poloxamer, polyethylene glycol, PLGA, PCL, polyhydroxybutyrate, cell encapsulation, tissue engineering

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Thermosensitive Polymeric Hydrogels As Drug Delivery Systems

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