Cited by 423Drug Solubulity and Delivery SystemsFlavonoids in Medical ResearchPhytochemicals and Antioxidant Activities

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Bioavailability of Quercetin: Problems and Promises

Cai, X., Fang, Z., Dou, J., Yu, A., Zhai, G.·2013·Current Medicinal Chemistry

DOI 10.2174/09298673113209990120

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Abstract

Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.

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Background
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Background
FORMULATION AND IN VITRO EVALUATION OF SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF QUERCETIN FOR ENHANCEMENT OF ORAL BIOAVAILABILITY
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Background
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“However, the application of quercetin in the pharmaceutical field is limited due to its poor solubility, low bioavailability, and poor permeability [62].”
Background
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“Despite the many medicinal properties of quercetin, due to its poor solubility in water and its rapid metabolism, the bioavailability of quercetin is low, and its use is limited [20, 21].”
Application of Quercetin and its Novel Formulations in the Treatment of Malignancies of Central Nervous System: An Updated Review of Current Evidence based on Molecular Mechanisms
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“Despite of its potential health benefits for human, application of quercetin has been limited due to its poor water solubility, chemical instability and low bioavailability [14].”
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Intermolecular Interaction Between BODIPY and TPE Enhances Phototherapy
Gong, Z., Kang, G., Shi, R., et al. (2024) · Advanced Optical Materials · doi:10.1002/adom.202303033 · Cited by 9
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Ferraz, C. R., Franciosi, A., Emídio, N. B., Rasquel-Oliveira, F. S., Manchope, M. F., de Carvalho, T. T., Artero, N. A., Fattori, V., Vicentini, F. T. M. C., Casagrande, R., et al. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822923-1.00023-6 · Cited by 11
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“…effects of quercetin against degenerative diseases as demonstrated in a vast of cell-based in vitro, animal in vivo and human clinical settings (Cai et al., 2013; Gupta et al., 2016; Massi et al., 2017; Rani et al., 2015; Wang et al., 2018) (See Table 1 for Journal of Food Bioactives |…”
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“Because of quercetin ’ s short biological half-life, biochemical unpredictability, difficult to dissolve in water, and low the absorption of nutrients it might not be as useful in the dietary supplement and medicine sectors [85].”
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“This is due to some inherited properties, such as high hydrophobicity, low bioavailability and poor stability in physiological solutions [10,11].”
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“Moreover, QCT has low chemical stability, water-solubility, short biological half-life, and less bioavailability affecting its efficacy in food processing and pharmaceutical industries [10].”
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“The therapeutic application of quercetin is limited by its low bioavailability and water solubility [88].”
ROS responsive quercetin nanoparticles with neuron-targeted peptide inhibits ferroptosis to repair spinal cord injury
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“29 It is a hydrophobic drug with poor bioavailability, 30 and it limits its application as a drug delivery vehicle.”
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Authors: Cai, X., Fang, Z., Dou, J., Yu, A., & Zhai, G.
Affiliations: Shandong University (CN)
Corresponding author: Fang, Z.
Zhai, G.
ORCID: Cai, X.
Zhai, G.
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2013-05-01
Volume: 20
Issue: 20
Pages: 2572-2582
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/09298673113209990120
OpenAlex: W2133019478
Cited by: 423
References: 0
Citations by year: 2026: 39 · 2025: 39 · 2024: 42 · 2023: 53 · 2022: 46 · 2021: 42 · 2020: 42 · 2019: 29 · 2018: 22 · 2017: 15 · 2016: 22 · 2015: 17 · 2014: 11 · 2013: 4
FWCI: 10.83
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: quercetin, bioavailability, flavonoids, drug delivery systems, inclusion complexes, liposomes, nanoparticles, micelles, solubility enhancement, permeability, antioxidant activity, anti-inflammatory activity, anticancer activity
MeSH terms: Biocompatible Materials, Biological Availability, Drug Carriers, Half-Life, Humans, Liposomes, Micelles, Prodrugs, Quercetin, Solubility, Nanoparticles

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Bioavailability of Quercetin: Problems and Promises

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