Emerging β-Amyloid Therapies for the Treatment of Alzheimers Disease

Solution NMR Studies of the Aβ(1−40) and Aβ(1−42) Peptides Establish that the Met35 Oxidation State Affects the Mechanism of Amyloid Formation

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The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

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Targeting soluble Aβ peptide with Tramiprosate for the treatment of brain amyloidosis

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Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

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Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease

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N-Methylated Peptide Inhibitors of β-Amyloid Aggregation and Toxicity. Optimization of the Inhibitor Structure

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Design strategies for anti-amyloid agents

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The potential application of iron chelators for the treatment of neurodegenerative diseases

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Structure-Based Design, Synthesis, and Memapsin 2 (BACE) Inhibitory Activity of Carbocyclic and Heterocyclic Peptidomimetics

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Investigations of the Molecular Mechanism of Metal-Induced Aβ (1−40) Amyloidogenesis

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Thioflavins released from nanoparticles target fibrillar amyloid β in the hippocampus of APP/PS1 transgenic mice

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Clusterin in Alzheimer’s disease: a player in the biological behavior of amyloid-beta

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Effect of conjugated linoleic acid, μ-calpain inhibitor, on pathogenesis of Alzheimer's disease

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An updated patent review of calpain inhibitors (2012 – 2014)

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Structure‐Based Organic Synthesis of Drug Prototypes: A Personal Odyssey

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A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

Aillaud, I., Kaniyappan, S., Chandupatla, R., Ramirez, L. M., Alkhashrom, S., Eichler, J., Horn, A. H. C., Zweckstetter, M., Mandelkow�, E., Sticht, H., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-00959-z · Cited by 32 · see citing works

Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes

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IMM-H004, a novel coumarin derivative compound, protects against amyloid beta-induced neurotoxicity through a mitochondrial-dependent pathway

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The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment

Zieneldien, T., Kim, J., & Cao, C. (2022) · Geriatrics · doi:10.3390/geriatrics7020024 · Cited by 29 · see citing works

Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain

Lee, E., Eom, J.-E., Kim, H.-L., Kang, D.-H., Jun, K.-Y., Jung, D. S., & Kwon, Y. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.01.015 · Cited by 28 · see citing works

Substrate-Controlled and Organocatalytic Asymmetric Synthesis of Carbocyclic Amino Acid Dipeptide Mimetics

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BACE Inhibitors for the Treatment of Alzheimer's Disease

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Effects of lipids and aging on the neurotoxicity and neuronal loss caused by intracerebral injections of the amyloid-β peptide in the rat

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Fibrillar and Oligomeric β‐Amyloid as Distinct Local Biomarkers for Alzheimer's Disease

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Amyloid beta peptide-induced cholinergic fibres loss in the cerebral cortex of the rat is modified by diet high in lipids and by age

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The Amyloid Hypothesis and the clearance and degradation of Alzheimer's β-peptide

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Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson’s disease

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What Is the Rationale for New Treatment Strategies in Alzheimer's Disease?

Rogawski, M. A. (2004) · CNS Spectrums · doi:10.1017/s1092852900024743 · Cited by 19 · see citing works

In silico and in vitro studies to elucidate the role of Cu 2+ and galanthamine as the limiting step in the amyloid beta (1–42) fibrillation process

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Stereoselective Synthesis of Constrained Oxacyclic Hydroxyethylene Isosteres of Aspartic Protease Inhibitors: Aldol and Mukaiyama Aldol Methodologies for Branched Tetrahydrofuran 2-Carboxylic Acids

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Synthesis and In Vitro Evaluation of Imidazo[1,2-b]pyridazines as Ligands for β-Amyloid Plaques

Zeng, F., Alagille, D., Tamagnan, G. D., et al. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml100005j · Cited by 15 · see citing works

Reversibility of β-Amyloid Self-Assembly: Effects of pH and Added Salts Assessed by Fluorescence Photobleaching Recovery

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La Lunga Attesa : Towards a Molecular Approach to Neuroimaging and Therapeutics in Alzheimer's Disease

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Detection of interactions of the β‐amyloid peptide with small molecules employing transferred NOEs

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Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation

Zhou, C., Zhang, J., Luo, X., Lian, F., Zeng, Y., Zhang, Z., Zhang, H., & Zhang, N. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.3c00280 · Cited by 6 · see citing works

Demenze degenerative primarie

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The Aβcentric Pathway of Alzheimer’s Disease

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Antibody-based therapeutics

Tachibana, T., & Kuwabara, T. (2019) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2019.01.006 · Cited by 1 · see citing works

Generation of Stable Cell Lines of APP695 (K595N, M596L) Gene Over-Expression via Lentiviral Over-Expression System

Zhang, H., Hao, R., Yu, Z., et al. (2024) · Biology Bulletin · doi:10.1134/s1062359023602586

Additional file 1 of A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

Aillaud, I., Kaniyappan, S., Chandupatla, R. R., Ramirez, L. M., Alkhashrom, S., Eichler, J., Horn, A. H. C., Zweckstetter, M., Mandelkow, E., Sticht, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18865021

Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins

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Processing of Amyloid Precursor Protein and Amyloid Peptide Neurotoxicity

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The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

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Secreted Forms of β‐Amyloid Precursor Protein Protect Against Ischemic Brain Injury

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