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Biofunctional peptides from milk proteins: mineral binding and cytomodulatory effects.
Abstract
The protein fraction of milk contains many valuable components and biologically active substances. Moreover, milk proteins are precursors of many different biologically active peptides which are inactive within the sequence of the precursor protein but can be released by enzymatic proteolysis. Many milk protein-derived peptides, such as caseinophosphopeptides, reveal multi-functional bioactivities. Caseinophosphopeptides can form soluble organophosphate salts and may function as carriers for different minerals, especially calcium. Furthermore, they have been shown to exert cytomodulatory effects. Cytomodulatory peptides inhibit cancer cell growth or they stimulate the activity of immunocompetent cells and neonatal intestinal cells, respectively. Several bioactive peptides derived from milk proteins are potential modulators of various regulatory processes in the body and thus may exert beneficial physiological effects. Caseinophosphopeptides are already produced on an industrial-scale and as a consequence these peptides have been considered for application as ingredients in both 'functional foods' and pharmaceutical preparations. Although the physiological significance as exogenous regulatory substances is not yet fully understood, both mineral binding and cytomodulatory peptides derived from bovine milk proteins are claimed to be health enhancing components that can be used to reduce the risk of disease or to enhance a certain physiological function.
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“Meisel and FitzGerald (2003) also demonstrated that normal cells are less sensitive to the apoptotic induction than malignant cells.”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Meisel and FitzGerald, 2003
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Metadata
- Authors
- H., M., & J., F.
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2003-06-01
- Volume
- 9
- Issue
- 16
- Pages
- 1289-1295
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W1995475849
- Cited by
- 407
- References
- 0
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 16 · 2023: 11 · 2022: 16 · 2021: 29 · 2020: 20 · 2019: 14 · 2018: 24 · 2017: 26 · 2016: 30 · 2015: 30 · 2014: 27 · 2013: 24 · 2012: 23
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- bioactive peptides, milk protein, caseinophosphopeptides, mineral binding, calcium, tumor cell growth inhibition, immune cells, intestinal cells, functional foods, bovine milk proteins, enzymatic proteolysis
- MeSH terms
- Adjuvants, Immunologic, Animals, Antineoplastic Agents, Biological Availability, Calcium, Carrier Proteins, Caseins, Cattle, Drug Carriers, Humans, Milk Proteins, Minerals, Peptides, Phosphopeptides, Protein Binding
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