Cited by 407Protein Hydrolysis and Bioactive PeptidesProteins in Food SystemsInfant Nutrition and Health

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Biofunctional peptides from milk proteins: mineral binding and cytomodulatory effects.

H., Meisel, J., FitzGerald·2003·Current Pharmaceutical Design

DOI 10.2174/1381612033454847

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Abstract

The protein fraction of milk contains many valuable components and biologically active substances. Moreover, milk proteins are precursors of many different biologically active peptides which are inactive within the sequence of the precursor protein but can be released by enzymatic proteolysis. Many milk protein-derived peptides, such as caseinophosphopeptides, reveal multi-functional bioactivities. Caseinophosphopeptides can form soluble organophosphate salts and may function as carriers for different minerals, especially calcium. Furthermore, they have been shown to exert cytomodulatory effects. Cytomodulatory peptides inhibit cancer cell growth or they stimulate the activity of immunocompetent cells and neonatal intestinal cells, respectively. Several bioactive peptides derived from milk proteins are potential modulators of various regulatory processes in the body and thus may exert beneficial physiological effects. Caseinophosphopeptides are already produced on an industrial-scale and as a consequence these peptides have been considered for application as ingredients in both 'functional foods' and pharmaceutical preparations. Although the physiological significance as exogenous regulatory substances is not yet fully understood, both mineral binding and cytomodulatory peptides derived from bovine milk proteins are claimed to be health enhancing components that can be used to reduce the risk of disease or to enhance a certain physiological function.

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Authors: H., M., & J., F.
Venue: Current Pharmaceutical Design
Publisher: Bentham Science Publishers Ltd.
Published: 2003-06-01
Volume: 9
Issue: 16
Pages: 1289-1295
ISSN: 1381-6128 (ISSN-L)
DOI: 10.2174/1381612033454847
OpenAlex: W1995475849
Cited by: 407
References: 0
Citations by year: 2026: 3 · 2025: 7 · 2024: 16 · 2023: 11 · 2022: 16 · 2021: 29 · 2020: 20 · 2019: 14 · 2018: 24 · 2017: 26 · 2016: 30 · 2015: 30 · 2014: 27 · 2013: 24 · 2012: 23
FWCI: 3.22
Type: journal article
Language: en
Open access: closed
Locations: Current Pharmaceutical Design (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: bioactive peptides, milk protein, caseinophosphopeptides, mineral binding, calcium, tumor cell growth inhibition, immune cells, intestinal cells, functional foods, bovine milk proteins, enzymatic proteolysis
MeSH terms: Adjuvants, Immunologic, Animals, Antineoplastic Agents, Biological Availability, Calcium, Carrier Proteins, Caseins, Cattle, Drug Carriers, Humans, Milk Proteins, Minerals, Peptides, Phosphopeptides, Protein Binding

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Biofunctional peptides from milk proteins: mineral binding and cytomodulatory effects.

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