Antimicrobial peptides present in mammalian skin and gut are multifunctional defence molecules
Abstract
Antimicrobial peptides are major components of the innate immune defence. They are well conserved along evolution, non-toxic and they ensure potent defences against a large number of pathogens. They act by direct killing of microorganisms and they possess additional roles in the regulation of adaptive immune responses, by recruting or stimulating immune cells. Skin and gut are positioned at the interface of internal milieu and external environment. They represent a physical and chemical barrier against pathogens invasion and the antimicrobial peptides limit pathogen growth in normal conditions. During infection or injury, some of these peptides are overexpressed and disrupt microbial membranes and/or stimulate immune cell recruitment, allowing to return to homeostasis or to increase inflammation. Antimicrobial peptides expression is altered in several diseases: alpha-defensins deficiency is related with Crohn's disease and in skin, cathelicidin LL-37 and beta-defensin-2 are overexpressed in psoriasis, while in atopic dermatitis, their expression is decreased. The present review provides an up-to-date summary of the expression and the biological roles of the antimicrobial peptides found in the skin and gastrointestinal mucosa of the host, in normal and pathological conditions. The involvement of these natural antimicrobial peptides in inflammation, is also discussed.
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Tissues contain a variety of antimicrobial peptides, including defensins or cathelicidins, enzymes such as lysozyme that kill many Gram-positive bacteria, and iron-binding proteins such as hepcidin or haptoglobin that prevent bacterial growth by depriving bacteria of vital iron.
“These include antimicrobial peptides, such as defensins or cathelicidins, enzymes such as lysozyme that kill many Gram-positive bacteria, and iron-binding proteins such as hepcidin or haptoglobin that prevent the growth of bacteria by depriving them of vital iron [70].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [70]
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- Authors
- Metz-Boutigue, M.-H., Shooshtarizadeh, P., Prevost, G., Haikel, Y., & Chich, J.-F.
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-03-01
- Volume
- 16
- Issue
- 9
- Pages
- 1024-1039
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W2105775132
- Cited by
- 42
- References
- 0
- Citations by year
- 2022: 4 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 8 · 2014: 5 · 2013: 8 · 2012: 8
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- antimicrobial peptides, skin, intestine, innate immunity, mucosal barrier, alpha-defensins, human beta-defensin 2, cathelicidin LL-37, Crohn's disease, psoriasis, atopic dermatitis, inflammation, immune cell recruitment, adaptive immune regulation
- MeSH terms
- Animals, Anti-Infective Agents, Humans, Immunity, Innate, Mammals, Models, Biological, Models, Molecular, Peptide Biosynthesis, Peptides, Skin, Skin Diseases, Inflammatory Bowel Diseases, Gastrointestinal Tract, Adaptive Immunity
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