Cited by 685Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record.

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

Agostinho, Paula, A. Cunha, Rodrigo, Oliveira, Catarina·2010·Current Pharmaceutical Design

DOI 10.2174/138161210793176572

Open this paper in CoChat — free account

Abstract

Alzheimers disease (AD) is the most common neurodegenerative disorder that affects the elderly. The increase of lifeexpectancy is transforming AD into a major health-care problem. AD is characterized by a progressive impairment of memory and other cognitive skills leading to dementia. The major pathogenic factor associated to AD seems to be amyloid-beta peptide (Aβ) oligomers that tend to accumulate extracellularly as amyloid deposits and are associated with reactive microglia and astrocytes as well as with degeneration of neuronal processes. The involvement of microglia and astrocytes in the onset and progress of neurodegenerative process in AD is becoming increasingly recognized, albeit it is commonly accepted that neuroinflammation and oxidative stress can have both detrimental and beneficial influences on the neural tissue. However, little is known about the interplay of microglia, astrocytes and neurons in response to Aβ, especially in the early phases of AD. This review discusses current knowledge about the involvement of neuroinflammation in AD pathogenesis, focusing on phenotypic and functional responses of microglia, astrocytes and neurons in this process. The abnormal production by glia cells of pro-inflammatory cytokines, chemokines and the complement system, as well as reactive oxygen and nitrogen species, can disrupt nerve terminals activity causing dysfunction and loss of synapses, which correlates with memory decline; these are phenomena preceding the neuronal death associated with late stages of AD. Thus, therapeutic strategies directed at controlling the activation of microglia and astrocytes and the excessive production of pro-inflammatory and pro-oxidant factors may be valuable to control neurodegeneration in dementia. Keywords: Amyloid-beta, microglia, astrocytes, neurons, pro-inflammatory factors, reactive oxygen species, neurodegeneration, Alzheimer's disease, Dementia, Neuroinflammation, Pro-oxidant factors, Memory, Mild cognitive impairment, CNS, cytokines, prostaglandins, IL-1, PPAR-g, Complement system, Amyloid pla, Trophic factors, Glia-derived neurotrophic factor, Glial scars, Ca2+ overload, Homeostasis, Antioxidants, Electron transport chain, Curcumin, Quercetin

Integrity signals

Registry

Crossref · 10.2174/138161210793176572

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 301–400 of 678

Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease?
Silva, J., Alves, C., Soledade, F., Martins, A., Pintéus, S., Gaspar, H., Alfonso, A., & Pedrosa, R. (2023) · Marine Drugs · doi:10.3390/md21080451 · Cited by 35
“Chronic neuroinflammation is one of the hallmarks of PD pathophysiology and, under inflammatory conditions, activated glial cells release pro-inflammatory factors, such as cytokines and prostaglandins, as well as neurotoxic factors, such as reactive oxygen species (ROS)/reactive nitrogen species (RNS) and complement p…”
Background
Innovative approaches to Alzheimer's therapy: Harnessing the power of heterocycles, oxidative stress management, and nanomaterial drug delivery system
Umar, M., Rehman, Y., Ambreen, S., Mumtaz, S. M., Shaququzzaman, M., Alam, M. M., & Ali, R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102298 · Cited by 33
Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model
Kim, J. H., Meng, H. W., He, M. T., Choi, J. M., Lee, D., & Cho, E. J. (2020) · Molecules · doi:10.3390/molecules25173942 · Cited by 31
“The neuronal oxidative stress by production of ROS and RNS leads to neuroinflammation, synaptic dysfunction, neuronal apoptosis, subsequently result in memory and cognitive impairment in AD patients [38,39].”
Background
Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats
Ali, A. A., El-Fattah, A. I. A., Abu‐Elfotuh, K., & Elariny, H. A. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107729 · Cited by 30
Insights into the Mechanism of the Therapeutic Potential of Herbal Monoamine Oxidase Inhibitors in Neurological Diseases
Mannan, A., Singh, T. G., Singh, V., Garg, N., Kaur, A., & Singh, M. (2021) · Current Drug Targets · doi:10.2174/1389450122666210707120256 · Cited by 30
α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease
Yamini, P., Ray, R. S., Yadav, S., Dhaliwal, J., Yadav, M., Kondepudi, K. K., & Chopra, K. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173402 · Cited by 32
Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo
Rao, S. P., Xie, W., Kwon, Y. I. C., Juckel, N., Xie, J., Dronamraju, V., Vince, R., Lee, M. K., & More, S. S. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102484 · Cited by 28
Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity
Sheu, S.-Y., Hong, Y.-W., Sun, J., Liu, M.-H., Chen, C., & Ke, C. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0842-x · Cited by 28
“Thus, therapeutic strategies directed at controlling the activation of microglia and astrocytes and the excessive production of pro-inflammatory and pro-oxidant factors may be valuable to control neurodegeneration in AD and dementia [13].”
Background
Anesthetic modulation of neuroinflammation in Alzheimer's disease
Tang, J. X., Eckenhoff, M. F., & Eckenhoff, R. G. (2011) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32834871c5 · Cited by 30
Posttreatment with propofol attenuates lipopolysaccharide-induced up-regulation of inflammatory molecules in primary microglia
Peng, M., Ye, J., Wang, Y., Chen, C., & Wang, C. (2014) · Inflammation Research · doi:10.1007/s00011-014-0713-9 · Cited by 29
“Therefore, strategies to inhibit microglial activation may reduce production of neurotoxic factors and be valuable to control neuroinflammatory diseases [29, 30].”
Suppressed Retinal Degeneration in Aged Wild Type and APPswe/PS1ΔE9 Mice by Bone Marrow Transplantation
Yang, Y. J., Shiao, C., Hemingway, J. F., Jorstad, N. L., Shalloway, B. R., Chang, R. C., & Keene, C. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064246 · Cited by 29
“Microglia can be both beneficial and harmful, depending on the balance between neuroprotective and cytotoxic functions [27,28,29], but innate immune activation is altered in chronic neurodegenerative conditions to promote exaggerated microglial responses and a predominance of neurotoxic proinflammatory and oxidative m…”
Background
Edaravone attenuates intracerebroventricular streptozotocin‐induced cognitive impairment in rats
Reeta, K. H., Singh, D., & Gupta, Y. K. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13543 · Cited by 28
“Proinflammatory cytokines (TNF-ɑ, IL-1ß, IFN-c, IL-18) released from activated microglia and other non-neuronal cells like endothelial cells have received a considerable attention for their role in AD (Rojo et al., 2008; Agostinho et al., 2010; Wang et al., 2015).”
Background
Malignant Brain Aging: The Formidable Link Between Dysregulated Signaling Through Mechanistic Target of Rapamycin Pathways and Alzheimer’s Disease (Type 3 Diabetes)
de la Monte, S. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230555 · Cited by 28
Triglyceride-glucose index as a valuable predictor for aged 65-years and above in critical delirium patients: evidence from a multi-center study
Huang, X., Cheng, H., Yuan, S., Ling, Y., Tan, S., Tang, Y., Niu, C., & Lyu, J. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04420-0 · Cited by 28
“With the onset of IR in the brain, degradation and clearance of Aβ are impeded, and abnormal Aβ deposition stimulates glial cells to release a variety of inflammatory factors and generate oxygen free radicals that induce oxidative stress and activate apoptosis [44].”
Background
Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer’s disease
Guan, J.-Z., Guan, W. P., Maeda, T., & Makino, N. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0006-0 · Cited by 28
“However, the level of cognitive dementia, including that due to Alzheimer’s disease or vascular dementia is not always associated with the telomere length of leukocytes [24].”
Background
Aquilariae Lignum extract attenuates glutamate-induced neuroexcitotoxicity in HT22 hippocampal cells
Lee, J., Kim, W., Jeon, Y.-J., Lee, S.-K., & Son, C. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.032 · Cited by 28
Proteomic Approaches to Study Cysteine Oxidation: Applications in Neurodegenerative Diseases
Pham, T. K., Buczek, W. A., Mead, R. J., Shaw, P. J., & Collins, M. O. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.678837 · Cited by 31
Sinensetin Attenuates Amyloid Beta25-35-Induced Oxidative Stress, Inflammation, and Apoptosis in SH-SY5Y Cells Through the TLR4/NF-κB Signaling Pathway
Zhi, Z., Tang, X., Wang, Y., Chen, R., & Ji, H. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03406-x · Cited by 29
Overflow Microfluidic Networks: Application to the Biochemical Analysis of Brain Cell Interactions in Complex Neuroinflammatory Scenarios
Bianco, F., Tonna, N., Lovchik, R. D., Mastrangelo, R., Morini, R., Ruiz, A., Delamarche, E., & Matteoli, M. (2012) · Analytical Chemistry · doi:10.1021/ac302094z · Cited by 28
Maternal high fructose-induced hippocampal neuroinflammation in the adult female offspring via PPARγ-NF-κB signaling
Liu, W., Wu, C., Fu, M., Tain, Y., Liang, C., Hung, C., Chen, I.-C., Lee, Y., Wu, C.-Y., & Wu, K. L. H. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108378 · Cited by 27
Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity
Hung, C., Lee, Y., Kuo, Y.-M., Hsu, P.-C., Tsay, H.-J., Hsu, Y.-T., Lee, C.-C., Liang, J.-J., & Shie, F. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1508-2 · Cited by 28
Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract of Chrysanthellum americanum in a Rat Model of Irritable Bowel Syndrome
Cojocariu, R. O., Ciobica, A. S., Balmuș, I.-M., Guenné, S., Trifan, A. V., Stanciu, C., Hrițcu, L. D., & Lefter, R. M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3492767 · Cited by 28
RETRACTED: Long non-coding RNA Mirt2 prevents TNF-α-triggered inflammation via the repression of microRNA-101
Han, Y., Kang, C., Kang, M., Quan, W., Gao, H., & Zhong, Z. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105878 · Cited by 27
Retracted
Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease
Fülöp, T., Tripathi, S., Rodrigues, S., Desroches, M., Bunt, T., Eiser, A. R., Bernier, F., Beauregard, P. B., Barron, A. E., Khalil, A., et al. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s264910 · Cited by 27
An insight into prodrug strategy for the treatment of Alzheimer’s disease
Bhilare, N. V., Marulkar, V. S., Kumar, D., Chatap, V. K., Patil, K. S., & Shirote, P. J. (2022) · Medicinal Chemistry Research · doi:10.1007/s00044-022-02859-1 · Cited by 27
A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia
Lutz, J. A., Kulshrestha, M., Rogers, D. T., & Littleton, J. M. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.06.012 · Cited by 27
A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy
Prat, A., Behrendt, M., Marcinkiewicz, E., Boridy, S., Sairam, R., Seidah, N. G., & Maysinger, D. (2011) · Journal of Aging Research · doi:10.4061/2011/251517 · Cited by 26
“Given that metabolic dysfunction and oxidative stress are early events in AD [33, 47, 48] and that many of the neuroprotective effects of estrogens have been attributed to rescue of mitochondrial function [49] we also decided to investigate mitochondrial status following estrogen deprivation.”
Background
Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND
Vartak-Sharma, N., Nooka, S., & Ghorpade, A. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.006 · Cited by 27
Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25–35 in rats
Zhuo, Y., Guo, H., Cheng, Y., Wang, C., Wang, C., Wu, J., Zou, Z., Gan, D., Li, Y., & Xu, J. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9814-1 · Cited by 25
Roles of Microglial Ion Channel in Neurodegenerative Diseases
Cojocaru, A., Burada, E., Bălșeanu, A.-T., Deftu, A., Cătălin, B., Popa‐Wagner, A., & Osiac, E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061239 · Cited by 28
New Insights into the Gut Microbiota in Neurodegenerative Diseases from the Perspective of Redox Homeostasis
Wang, Y., Zhang, Z., Li, B., He, B., Li, L., Nice, E. C., Zhang, W., & Xu, J. F. (2022) · Antioxidants · doi:10.3390/antiox11112287 · Cited by 30
Neuroprotection of round scad (Decapterus maruadsi) hydrolysate in glutamate-damaged PC12 cells: Possible involved signaling pathways and potential bioactive peptides
Zhang, Q., Su, G., Zhao, T., Sun, B., Zheng, L. P., & Zhao, M. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103690 · Cited by 26
Concordant and Discordant Cerebrospinal Fluid and Plasma Cytokine and Chemokine Responses in Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease
de la Monte, S. M., Tong, M., & Hapel, A. J. (2023) · Biomedicines · doi:10.3390/biomedicines11092394 · Cited by 28
“In the CNS, pro-inflammatory cytokines and chemokines can be generated locally by activated microglia and astrocytes [14,26,35,54,125], or they could be transported across the blood–brain barrier from the peripheral circulation [52,153].”
A Comprehensive Review of the Antioxidant, Antimicrobial, and Therapeutic Efficacies of Black Cumin ( Nigella sativa L.) Seed Oil and Its Thymoquinone
Chatterjee, G., Saha, A. K., Khurshid, S., & Saha, A. (2025) · Journal of Medicinal Food · doi:10.1089/jmf.2024.k.0149 · Cited by 26
Regulation of Pancreatic Fibrosis by Acinar Cell-Derived Exosomal miR-130a-3p via Targeting of Stellate Cell PPAR-γ
Wang, Q., Wang, H., Jing, Q., et al. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s299298 · Cited by 25
3‐(2,4‐Dimethoxybenzylidene)‐anabaseine: A promising candidate drug for Alzheimer's disease?
Zawieja, P. P., Kornprobst, J., & Métais, P. (2012) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2011.00827.x · Cited by 25
Shotgun proteomics reveals possible mechanisms for cognitive impairment in Mucopolysaccharidosis I mice
Baldo, G., Lorenzini, D. M., Santos, D. S., Mayer, F. Q., Vitry, S., Bigou, S., Heard, J. M., Matte, Ú. D. S., & Giugliani, R. (2014) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2014.12.301 · Cited by 25
Protective Effects of the Caffeine Against Neurodegenerative Diseases
Tellone, E., Galtieri, A., Russo, A., & Ficarra, S. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666171009104040 · Cited by 25
Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug
Mhillaj, E., Papi, M., Paciello, F., Silvestrini, A., Rolesi, R., Palmieri, V., Perini, G., Fetoni, A. R., Trabace, L., & Mancuso, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.561179 · Cited by 25
“…with the abnormal formation of reactive oxygen species and reactive nitrogen species (ROS and RNS, respectively), has been reported to be responsible for the increasing neuronal death, mainly in brain cognitive areas (e.g., hippocampus and frontal cortex) (reviewed in Agostinho et al., 2010).”
Background
Reduction in TNF alpha and oxidative stress by liraglutide: Impact on ketamine-induced cognitive dysfunction and hyperlocomotion in rats
Sedky, A. A., & Magdy, Y. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119523 · Cited by 26
Inhibition of Adult Hippocampal Neurogenesis Plays a Role in Sevoflurane-Induced Cognitive Impairment in Aged Mice Through Brain-Derived Neurotrophic Factor/Tyrosine Receptor Kinase B and Neurotrophin-3/Tropomyosin Receptor Kinase C Pathways
Xu, L., Guo, Y., Wang, G.-M., Sun, G.-Q., Sun, W., Li, J., Li, X.-L., Wu, J., & Zhang, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.782932 · Cited by 16
Elevated CSF and plasma microparticles in a rat model of streptozotocin-induced cognitive impairment
Hosseinzadeh, S., Zahmatkesh, M., Zarrindast, M., Hassanzadeh, G., Karimian, M., & Sarrafnejad, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.019 · Cited by 26
LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice
Latour, A., Gu, Y., Kassis, N., Daubigney, F., Colin, C., Gausserès, B., Middendorp, S., Paul, J., Hindie, V., Rain, J., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1113-x · Cited by 26
Lipids and lipoproteins may play a role in the neuropathology of Alzheimer’s disease
Akyol, Ö., Akyol, S., Chou, M., Chen, S., Liu, C., Selek, S., Soares, J. C., & Chen, C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1275932 · Cited by 27
“Inflammatory cytokines, oxidative stress, and ox-LDL can induce its expression (Mehta et al., 2006), and these stimuli may be regarded as a hallmark of AD (Agostinho et al., 2010).”
Background
Alkaloids as drug leads in Alzheimer's treatment: Mechanistic and therapeutic insights
Islam, M. R., Akash, S., Islam, M. M., Sarkar, N., Kumer, A., Chakraborty, S., Dhama, K., Al‐Shaeri, M., Anwar, Y., Wilairatana, P., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148886 · Cited by 27
VGF expression by T lymphocytes in patients with Alzheimer's disease
Busse, S., Steiner, J., Glorius, S., Dobrowolny, H., Greiner-Bohl, S., Mawrin, C., Bommhardt, U., Hartig, R., Bogerts, B., & Busse, M. (2015) · Oncotarget · doi:10.18632/oncotarget.3569 · Cited by 23
Acid-base fractions separated from Streblus asper leaf ethanolic extract exhibited antibacterial, antioxidant, anti-acetylcholinesterase, and neuroprotective activities
Prasansuklab, A., Theerasri, A., Payne, M. S., Ung, A. T., & Tencomnao, T. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2288-4 · Cited by 23
12-oxo-phytodienoic acid, a plant-derived oxylipin, attenuates lipopolysaccharide-induced inflammation in microglia
Taki-Nakano, N., Kotera, J., & Ohta, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.04.060 · Cited by 24
Association Between the Gut Microbiota and Alzheimer’s Disease: An Update on Signaling Pathways and Translational Therapeutics
Kulkarni, R., Kumari, S., Dhapola, R., Sharma, P., Singh, S. K., Medhi, B., & HariKrishnaReddy, D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04545-2 · Cited by 26
“These pathologies ultimately progress to neurodegeneration [5].”
Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation
Jantas, D., Gręda, A., Leśkiewicz, M., Grygier, B., Pilc, A., & Lasoń, W. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2014.12.011 · Cited by 22
“proteins, neuroinflammation, excitotoxicity and apoptotic-like programmed cell death (PCD) are the most common (Agostinho et al., 2010; Agostini et al., 2011; Navarro and Boveris, 2009; Swerdlow, 2009; Yong-Kee et al., 2012).”
Background
Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease
Salazar, A., Osse, A. M. L., Ortiz, A. A., Murtishaw, A. S., & Kinney, J. W. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.10.013 · Cited by 26
Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues
Mishchenko, M., Shtrygol’, S., Lozynskyi, A., Khomyak, S., Novikov, V. P., Karpenko, O., Holota, S. M., & Lesyk, R. (2021) · Scientia Pharmaceutica · doi:10.3390/scipharm89020022 · Cited by 23
“regulation [11], free radical formation [12], and cyclooxygenases-1 and 2 (COX-1/2) upregulation, etc.”
Background
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades
Herrera‐Arozamena, C., Estrada, M., López‐Caballero, P., Pérez, C., Morales-Garcia, J. A., Pérez‐Castillo, A., del Sastre, E., Fernández‐Mendívil, C., Duarte, P., Michalska, P., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01883 · Cited by 24
The neuroprotective effects of the combined extract of mulberry fruit and mulberry leaf against hydrogen peroxide-induced cytotoxicity in SH-SY5Y Cells
Mairuae, N., Palachai, N., & Noisa, P. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-03930-z · Cited by 23
Exploring the mechanism of metformin action in Alzheimer’s disease and type 2 diabetes based on network pharmacology, molecular docking, and molecular dynamic simulation
Shi, X., Li, L., Liu, Z., Wang, F., & Huang, H. (2023) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188231187493 · Cited by 24
Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin’s neuroprotective action against diabetes-induced cognitive impairment
Zheng, Y., Wang, C., Liu, W., Chen, J., Sun, Y., Chang, D., Wang, H., Xu, W., Lu, J., Zhou, X., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116579 · Cited by 22
β-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer’s Disease
Yang, C., Li, X., Mo, Y., Liu, S., Zhao, L., Ma, X., Fang, Z., Chen, J., Chen, Y., Yu, X., et al. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0226-2 · Cited by 23
“(Kurz and Perneczky 2011; Agostinho et al. 2010; Casadesus et al. 2004; Arendt 2009); however, removal of neurotoxic Ab may attenuate symptoms or delay disease”
Background
Neuroinflammation and Cognitive Dysfunction in Chronic Disease and Aging
Hein, A. M., & O’Banion, M. K. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9340-1 · Cited by 22
“…are found clustered around amyloid plaques, and elevated levels of cytokines and other inflammatory mediators found in patients with AD have been proposed to contribute to ongoing pathology, neural dysfunction, and synaptic loss (Mrak and Griffin, 2005; Agostinho et al., 2010; Heneka et al., 2010).”
Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?
Nunes, A. R., Alves, M., Moreira, P., Oliveira, P., & Silva, B. (2014) · Current Neuropharmacology · doi:10.2174/1570159x13666141204220539 · Cited by 20
Changes in Plasma β-NGF and Its Receptors Expression on Peripheral Blood Monocytes During Alzheimer’s Disease Progression
Crispoltoni, L., Stabile, A. M., Pistilli, A., Venturelli, M., Cerulli, G. G., Fonte, C., Smania, N., Schena, F. F., & Rende, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160625 · Cited by 24
A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
Lax, E., Warhaftig, G., Ohana, D., Maayan, R., Delayahu, Y., Roska, P., Ponizovsky, A. M., Weizman, A., Yadid, G., & Moshe Szyf, A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00322 · Cited by 23
“Significance was assessed by the Fisher hyper-geometric test. functions were associated with other neuropsychiatric disorders such as Alzheimer’s disease (Agostinho et al., 2010).”
Method
Calycopterin Promotes Survival and Outgrowth of Neuron-Like PC12 Cells by Attenuation of Oxidative- and ER-Stress-Induced Apoptosis along with Inflammatory Response
Farimani, M. M., Sarvestani, N. N., Ansari, N., & Khodagholi, F. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200420a · Cited by 22
Multifaceted neuroprotective approach of Trolox in Alzheimer's disease mouse model: targeting Aβ pathology, neuroinflammation, oxidative stress, and synaptic dysfunction
Tahir, M., Kang, M. H., Park, T. J., Ali, J., Choe, K., Park, J. S., & Kim, M. O. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1453038 · Cited by 23
Adverse events in older adults and the risk of dementia and cognitive decline
Nilaweera, D., Gurvich, C., Freak-Poli, R., Woods, R., Owen, A., Murray, A., Orchard, S. G., Britt, C., Wu, Z., McNeil, J., et al. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100592 · Cited by 21
“Other theories relating stress with dementia pathology focus on oxidative stress and neuroinflammation, both of which are increased with the chronically stressed (Agostinho et al., 2010), including bereaved individuals (Fagundes et al.”
Background
Role of Astrocytes in Neurodegenerative Diseases
George, E., González, J., Capani, F., & Morales, L. (2011) · InTech eBooks · doi:10.5772/31166 · Cited by 21
“Similarly, this peptide decreases glutamate uptake in cultured astrocytes, thus increasing oxidative stress and and activation of mitogen-activated protein kinase cascades (Agostinho et al., 2010; Matos et al., 2008).”
Background
Organophosphates Induced Alzheimer's Disease: An Epigenetic Aspect
Yadav, S. S., Singh, M. K., & Yadav, R. S. (2016) · Journal of Clinical Epigenetics · Cited by 21
Streptozotocin alters glucose transport, connexin expression and endoplasmic reticulum functions in neurons and astrocytes
Biswas, J., Gupta, S., Verma, D., & Singh, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.018 · Cited by 21
“Studies in last few years have showed the massive role of non-neuronal cells in AD pathology (Agostinho et al., 2010, Verkhratsky et al., 2010).”
Pine needle extract prevents hippocampal memory impairment in acute restraint stress mouse model
Lee, J., Kim, H.-G., Lee, H.-W., Kim, W., Ahn, Y., & Son, C. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.06.024 · Cited by 23
“In a state of excitotoxicity, reactive glial cells are deeply associated with neuroinflammatory response and oxidative stress (Agostinho et al., 2010) via”
Background
Effects of Supplementation with Folic Acid and Its Combinations with Other Nutrients on Cognitive Impairment and Alzheimer’s Disease: A Narrative Review
Puga, A. M., Ruperto, M., Samaniego-Vaesken, M. D. L., Montero-Bravo, A., Partearroyo, T., & Varela‐Moreiras, G. (2021) · Nutrients · doi:10.3390/nu13092966 · Cited by 23
“Neuroinflammation and oxidative stress play a critical role in the pathogenesis of dementia [81].”
Background
Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms
Kakkar, A., Singh, H., Singh, B. K., Kumar, A., Mishra, A. K., & Chopra, H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251374353 · Cited by 26
Polyphenols Suppress and Modulate Inflammation
Kim, J., Lee, K. W., & Lee, H. J. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00029-3 · Cited by 22
Ang (1–7)/Mas receptor-axis activation promotes amyloid beta-induced altered mitochondrial bioenergetics in discrete brain regions of Alzheimer's disease-like rats
Varshney, V., & Garabadu, D. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102122 · Cited by 20
Tannic acid inhibits lipopolysaccharide-induced cognitive impairment in adult mice by targeting multiple pathological features
Ullah, R., Ali, G., Baseer, A., Khan, S. I., Akram, M., Khan, S., Ahmad, N., Farooq, U., Nawaz, N. K., Shaheen, S., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108970 · Cited by 20
Analysis of Cerebral Small Vessel Changes in AD Model Mice
Shibly, A. Z., Sheikh, A. M., Michikawa, M., Tabassum, S., Azad, A. K., Zhou, X., Zhang, Y., Yano, S., & Nagai, A. (2022) · Biomedicines · doi:10.3390/biomedicines11010050 · Cited by 21
“Therefore, restoration of the blood–brain barrier functions along with increased clearance of A β could provide a better outcome of AD therapy.”
Background
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
Bosco, L. D., Weber, G., Parfitt, G. M., Paese, K., Gonçalves, C. O. F., Serodre, T., Furtado, C. A., Santos, A. P., Monserrat, J. M., & Barros, D. M. (2015) · BioMed Research International · doi:10.1155/2015/104135 · Cited by 20
Protective Effects of (E)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeine Against Hydrogen Peroxide-Induced Injury in PC12 Cells
Chen, B., Yue, R., Yang, Y., Zeng, H., Chang, W.-L., Gao, N., Yuan, X., Zhang, W., & Shan, L. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1498-5 · Cited by 20
“However, all clinical studies conducted to date have not proven a clear beneficial effect of antioxidant treatment in AD [38], the most common neurodegenerative disorder [39].”
Background
Effects and mechanism of amyloid β1-42 on mitochondria in astrocytes
Yao, Y., Huang, J., Chen, Y., Hu, H., Tang, X., & Li, X. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8761 · Cited by 20
“In addition, they may also promote secondary damage or degeneration following CNS injury (28).”
Background
Adzuki bean (Vigna angularis) extract reduces amyloid-β aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease
Miyazaki, H., Okamoto, Y., Motoi, A., et al. (2019) · Nutrition Research and Practice · doi:10.4162/nrp.2019.13.1.64 · Cited by 20
“Alternatively, oxidative stress is reported to have an important role in the onset and progression of Alzheimer’s disease [29], and it has been reported that the polyphenols of adzuki beans have the ability to suppress oxidative stress [30].”
Background
Exploring the role of mitochondrial proteins as molecular target in Alzheimer’s disease
Chadha, S., Behl, T., Sehgal, A., Kumar, A., & BUNGAU, S. G. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.11.008 · Cited by 20
Unearthing of Key Genes Driving the Pathogenesis of Alzheimer’s Disease via Bioinformatics
Zhao, X., Yao, H., & Li, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.641100 · Cited by 20
Ang(1–7) exerts Nrf2-mediated neuroprotection against amyloid beta-induced cognitive deficits in rodents
Varshney, V., & Garabadu, D. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06447-1 · Cited by 20
ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease
Zhou, Y., Liu, X., Ma, S., Zhang, N., Yang, D., Wang, L., Ye, S., Zhang, Q., Ruan, J., Ma, J., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101625r · Cited by 18
Neuronutraceuticals Combating Neuroinflammaging: Molecular Insights and Translational Challenges—A Systematic Review
Satyam, S. M., & Bairy, L. K. (2022) · Nutrients · doi:10.3390/nu14153029 · Cited by 21
“Studies have revealed that neuroinflammatory reactions could be viewed as the result of ongoing oxidative stress [71,72].”
Background
The Therapeutic Potential of Novel Carnosine Formulations: Perspectives for Drug Development
Bonaccorso, A., Privitera, A., Grasso, M., Salamone, S., Carbone, C., Pignatello, R., Musumeci, T., Caraci, F., & Caruso, G. (2023) · Pharmaceuticals · doi:10.3390/ph16060778 · Cited by 19
Is interaction of amyloid β-peptides with metals involved in cognitive activity?
Tamano, H., & Takeda, A. (2015) · Metallomics · doi:10.1039/c5mt00076a · Cited by 19
Similarities and differences of copper and zinc cations binding to biologically relevant peptides studied by vibrational spectroscopies
Schirer, A., Khoury, Y. E., Faller, P., & Hellwig, P. (2017) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-017-1449-0 · Cited by 20
Prophylactic neuroprotective efficiency of co-administration of Ginkgo biloba and Trifolium pretense against sodium arsenite-induced neurotoxicity and dementia in different regions of brain and spinal cord of rats
Abdou, H. M., Yousef, M. I., El-Mekkawy, D. A., & Al‐Shami, A. S. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.05.015 · Cited by 19
“…and production of pro-inflammatory cytokines, prostaglandin E2, chemokines, nitric oxide (NO•) and ROS, so that induces neuronal apoptosis by damaging the mitochondrial electron transfer chain (ETC) function in neurons and resulting in disruption of neuronal ATP synthesis (Agostinho et al., 2010).”
Background
Recent Understanding of the Molecular Mechanisms of Alzheimer?s Disease
Grimm, M. O. W., & Hartmann, T. (2011) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s5-004 · Cited by 20
Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer’s Disease
Amorim, J. A., Canas, P. M., Tomé, Â. R., Rolo, A. P., Agostinho, P. M., Palmeira, C. M., & Cunha, R. A. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170356 · Cited by 19
Self-citation
l ‐α‐aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory
Pereira, M. F., Amaral, I. M., Lopes, C. R., Leitão, C., Madeira, D., Lopes, J. P., Gonçalves, F. Q., Canas, P. M., Cunha, R. A., & Agostinho, P. M. (2021) · The FASEB Journal · doi:10.1096/fj.202100336r · Cited by 18
Self-citation
The influence of vinpocetine alone or in combination with Epigallocatechin-3-gallate, Coenzyme COQ10, Vitamin E and Selenium as a potential neuroprotective combination against aluminium-induced Alzheimer's disease in Wistar Albino Rats
Ali, A. A., Khalil, M. G., El‐latif, D. M. A., Okda, T. M., Abdelaziz, A. I., Abu‐Elfotuh, K., Kamal, M. M., & Wahid, A. M. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104557 · Cited by 18
Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress
Şener, G., Karakadıoglu, G., Özbeyli, D., Pazarbaşı, S. E., Yanardağ, R., Saçan, Ö., & Aykaç, A. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.04.009 · Cited by 22
Antihypertensive Medication Class and the Risk of Dementia and Cognitive Decline in Older Adults: A Secondary Analysis of the Prospective HELIAD Cohort
Liampas, I., Hatzimanolis, A., Siokas, V., Yannakoulia, M., Kosmidis, M. H., Sakka, P., Hadjigeorgiou, G. M., Scarmeas, N., & Dardiotis, E. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220439 · Cited by 18
Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer’s disease
Gunawan, C., Fleming, C. L., Irga, P. J., Wong, R. J., Amal, R., Torpy, F. R., Golzan, M., & McGrath, K. C. Y. (2024) · Environment International · doi:10.1016/j.envint.2024.108512 · Cited by 23
Gene Expression of Quaking in Sporadic Alzheimer’s Disease Patients is Both Upregulated and Related to Expression Levels of Genes Involved in Amyloid Plaque and Neurofibrillary Tangle Formation
Farnsworth, B., Peuckert, C., Zimmermann, B., JAZIN, E. E., Kettunen, P., & Emilsson, L. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160160 · Cited by 18
Physical enrichment enhances memory function by regulating stress hormone and brain acetylcholinesterase activity in rats exposed to restraint stress
Nawaz, A., Batool, Z., Shazad, S., Rafiq, S., Afzal, A., & Haider, S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.05.049 · Cited by 20
An Exploration of the Oryza sativa L. Cyanidin-3-glucoside on the Cognitive Function in Older Adults with Subjective Memory Impairment
Joo, S. H., Hahn, C., Lim, H. K., Yoon, K. D., Yoon, S. H., & Lee, C. U. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.06.17 · Cited by 19
Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme
Yui, D., Nishida, Y., Nishina, T., Mogushi, K., Tajiri, M., Ishibashi, S., Ajioka, I., Ishikawa, K., Mizusawa, H., Murayama, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143518 · Cited by 17
Altered temporal lobe white matter lipid ion profiles in an experimental model of sporadic Alzheimer's disease
Tong, M., Leão, R. A. C., Vimbela, G. V., Yalcin, E. B., Kay, J., Krotow, A., & de la Monte, S. M. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.04.010 · Cited by 17
“In addition, elevated sulfatides in brain have been associated with increased neuro-inflammation (Jeon et al., 2008), and neuroinflammation is a feature of both AD (Agostinho et al., 2010; Mehlhorn et al., 2000; Mrak, 2009) and the i.c. STZ model (de la Monte et al., 2017).”
APOE and AβPP Gene Variation in Cortical and Cerebrovascular Amyloid-β Pathology and Alzheimer's Disease: A Population-Based Analysis
Peuralinna, T., Tanskanen, M., Mäkelä, M., Polvikoski, T. M., Paetau, A. E., Kalimo, H., Sulkava, R. O., Hardy, J., Lai, S.-L., Arepalli, S., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-102049 · Cited by 18

Authors: Agostinho, P., A. Cunha, R., & Oliveira, C.
Affiliations: University of Coimbra (PT)
Corresponding author: Oliveira, Catarina
ORCID: Agostinho, Paula
Oliveira, Catarina
Venue: Current Pharmaceutical Design
Publisher: Bentham Science Publishers Ltd.
Published: 2010-08-01
Volume: 16
Issue: 25
Pages: 2766-2778
ISSN: 1381-6128 (ISSN-L)
DOI: 10.2174/138161210793176572
OpenAlex: W2114324710
Cited by: 685
References: 0
Citations by year: 2026: 35 · 2025: 44 · 2024: 46 · 2023: 43 · 2022: 52 · 2021: 61 · 2020: 58 · 2019: 42 · 2018: 44 · 2017: 51 · 2016: 32 · 2015: 36 · 2014: 34 · 2013: 37 · 2012: 41
FWCI: 20.75
Type: journal article
Language: en
Open access: closed
Locations: Current Pharmaceutical Design (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, neuroinflammation, oxidative stress, amyloid-beta oligomers, amyloid plaques, microglia, astrocytes, neurodegeneration, inflammatory cytokines, chemokines, complement system, reactive oxygen species, reactive nitrogen species, synaptic loss, memory impairment, mild cognitive impairment, glial activation, antioxidants, curcumin, quercetin, glial scar, calcium overload, PPARγ
MeSH terms: Alzheimer Disease, Animals, Antioxidants, Brain, Humans, Models, Neurological, Nerve Degeneration, Neuroglia, Drug Delivery Systems, Oxidative Stress, Inflammation Mediators

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks