A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

limma powers differential expression analyses for RNA-sequencing and microarray studies

Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979 · see citing works

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599 · see citing works

Mechanisms and Functions of Inflammasomes

Lamkanfi, M., & Dixit, V. M. (2014) · Cell · doi:10.1016/j.cell.2014.04.007 · Cited by 2,521 · see citing works

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works

Applications of the Morris water maze in the study of learning and memory

D’Hooge, R., & Deyn, P. P. D. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00067-4 · Cited by 2,035 · see citing works

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,841 · see citing works

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E. G., Wieghofer, P., Heinrich, A., Riemke, P., Hölscher, C., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3318 · Cited by 1,457 · see citing works

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409 · see citing works

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329 · see citing works

Origin, fate and dynamics of macrophages at central nervous system interfaces

Goldmann, T., Wieghofer, P., Jordão, M. J. C., Prutek, F., Hagemeyer, N., Frenzel, K., Amann, L., Staszewski, O., Kierdorf, K., Krueger, M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3423 · Cited by 1,209 · see citing works

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860 · see citing works

Innate immunity: the missing link in neuroprotection and neurodegeneration?

Nguyen, M. D., Julien, J., & Rivest, S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn752 · Cited by 698 · see citing works

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

Pascual, O., Ben Achour, S., Rostaing, P., Triller, A., & Bessis, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111098109 · Cited by 693 · see citing works

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

Goldmann, T., Wieghofer, P., Müller, P. F., Wolf, Y., Varol, D., Yona, S., Brendecke, S. M., Kierdorf, K., Staszewski, O., Datta, M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3531 · Cited by 688 · see citing works

Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis

Zrzavy, T., Hametner, S., Wimmer, I., Butovsky, O., Weiner, H. L., & Lassmann, H. (2017) · Brain · doi:10.1093/brain/awx113 · Cited by 684 · see citing works

The role of peripheral immune cells in the CNS in steady state and disease

Prinz, M., & Priller, J. (2017) · Nature Neuroscience · doi:10.1038/nn.4475 · Cited by 657 · see citing works

Microglia contact induces synapse formation in developing somatosensory cortex

Miyamoto, A., Wake, H., Ishikawa, A. W., Eto, K., Shibata, K., Murakoshi, H., Koizumi, S., Moorhouse, A. J., Yoshimura, Y., & Nabekura, J. (2016) · Nature Communications · doi:10.1038/ncomms12540 · Cited by 649 · see citing works

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

Zhou, Q., Wang, H., Schwartz, D. M., Stoffels, M., Park, Y. H., Zhang, Y., Yang, D., Demirkaya, E., Takeuchi, M., Tsai, W. L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3459 · Cited by 643 · see citing works

Inflammasomes in the CNS

Walsh, J. G., Muruve, D. A., & Power, C. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3638 · Cited by 637 · see citing works

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

Tay, T. L., Mai, D., Dautzenberg, J., Fernández-Klett, F., Lin, G., Sagar, Datta, M., Drougard, A., Stempfl, T., Ardura-Fabregat, A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4547 · Cited by 597 · see citing works

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

Bain, C. C., Hawley, C. A., Garner, H., Scott, C. L., Schridde, A., Steers, N. J., Mack, M., Joshi, A., Guilliams, M., Mowat, A. M. I., et al. (2016) · Nature Communications · doi:10.1038/ncomms11852 · Cited by 527 · see citing works

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Walle, L., Opdenbosch, N. V., Jacques, P., Fossoul, A., Verheugen, E., Vogel, P., Beyaert, R., Elewaut, D., Kanneganti, T., van Loo, G., et al. (2014) · Nature · doi:10.1038/nature13322 · Cited by 499 · see citing works

A20 in inflammation and autoimmunity

Catrysse, L., Vereecke, L., Beyaert, R., & Loo, G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.005 · Cited by 494 · see citing works

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

Gris, D., Ye, Z., Iocca, H. A., Wen, H., Craven, R. R., Gris, P., Huang, M., Schneider, M., Miller, S. D., & Ting, J. P.-Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904145 · Cited by 429 · see citing works

Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging

Füger, P., Hefendehl, J. K., Veeraraghavalu, K., Wendeln, A.-C., Schlosser, C., Obermüller, U., Wegenast-Braun, B. M., Neher, J. J., Martus, P., Kohsaka, S., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4631 · Cited by 401 · see citing works

Ontogeny and homeostasis of CNS myeloid cells

Prinz, M., Erny, D., & Hagemeyer, N. (2017) · Nature Immunology · doi:10.1038/ni.3703 · Cited by 391 · see citing works

Targeting mi<scp>R</scp>‐155 restores abnormal microglia and attenuates disease in <scp>SOD</scp>1 mice

Butovsky, O., Jedrychowski, M. P., Cialic, R., Krasemann, S., Murugaiyan, G., Fanek, Z., Greco, D. J., Wu, P. M., Doykan, C. E., Kiner, O., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24304 · Cited by 358 · see citing works

Astrocyte-Specific Inactivation of the Neurofibromatosis 1 Gene (NF1) Is Insufficient for Astrocytoma Formation

Bajenaru, M. L., Zhu, Y., Hedrick, N. M., Donahoe, J. S., Parada, L. F., & Gutmann, D. H. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5100-5113.2002 · Cited by 322 · see citing works

Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis

Meissner, F., Molawi, K., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002396107 · Cited by 319 · see citing works

Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IκB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell Proliferation

Podolin, P. L., Callahan, J. F., Bolognese, B. J., Li, Y. H., Carlson, K., Davis, T. G., Mellor, G. W., Evans, C., & Roshak, A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.074484 · Cited by 298 · see citing works

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Matmati, M., Jacques, P., Maelfait, J., Verheugen, E., Kool, M., Sze, M., Geboes, L., Louagie, E., Guire, C. M., Vereecke, L., et al. (2011) · Nature Genetics · doi:10.1038/ng.874 · Cited by 288 · see citing works

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

Inoue, M., Williams, K. L., Gunn, M. D., & Shinohara, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201836109 · Cited by 288 · see citing works

The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial

Singh, N., Hopkins, S. J., Hulme, S., Galea, J. P., Hoadley, M. E., Vail, A., Hutchinson, P. J., Grainger, S., Rothwell, N. J., King, A. T., et al. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-1 · Cited by 284 · see citing works

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

Vereecke, L., Sze, M., Guire, C. M., Rogiers, B., Chu, Y., Schmidt‐Supprian, M., Pasparakis, M., Beyaert, R., & Loo, G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092474 · Cited by 278 · see citing works

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

Wang, W., Nguyen, L. T. T., Burlak, C., Chegini, F., Guo, F., Chataway, T., Ju, S., Fisher, O. S., Miller, D. W., Datta, D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610099113 · Cited by 270 · see citing works

A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse

Liu, L., & Duff, K. (2008) · Journal of Visualized Experiments · doi:10.3791/960 · Cited by 268 · see citing works

The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis

Centonze, D., Muzio, L., Rossi, S., Furlan, R., Bernardi, G., & Martino, G. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.179 · Cited by 192 · see citing works

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Gorp, H. V., Saavedra, P. H. V., de Vasconcelos, N. M., Opdenbosch, N. V., Walle, L. V., Matusiak, M., Prencipe, G., Insalaco, A., Hauwermeiren, F. V., Demon, D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613156113 · Cited by 185 · see citing works

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

Waisman, A., Ginhoux, F., Greter, M., & Bruttger, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.005 · Cited by 183 · see citing works

Creating reference gene annotation for the mouse C57BL6/J genome assembly

Mudge, J. M., & Harrow, J. (2015) · Mammalian Genome · doi:10.1007/s00335-015-9583-x · Cited by 169 · see citing works

Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis

Hövelmeyer, N., Hao, Z., Kranidioti, K., Kassiotis, G., Buch, T., Frommer, F., von Hoch, L., Krämer, D., Minichiello, L., Kollias, G. A., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5875 · Cited by 169 · see citing works

Microglia plasticity during health and disease: An immunological perspective

Shemer, A., Erny, D., Jung, S., & Prinz, M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.003 · Cited by 168 · see citing works

Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis

Shaw, P. J., Lukens, J. R., Burns, S., Chi, H., McGargill, M. A., & Kanneganti, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000217 · Cited by 160 · see citing works

Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation

Hagemeyer, N., Kierdorf, K., Frenzel, K., Xue, J., Ringelhan, M., Abdullah, Z., Godin, I., Wieghofer, P., Jordão, M. J. C., Ulas, T., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201693801 · Cited by 144 · see citing works

NLRP3 Inflammasome and MS/EAE

Inoue, M., & Shinohara, M. L. (2013) · Autoimmune Diseases · doi:10.1155/2013/859145 · Cited by 123 · see citing works

Central nervous system myeloid cells as drug targets: current status and translational challenges

Biber, K. P. H., Möller, T., Boddeke, E., & Prinz, M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.14 · Cited by 111 · see citing works

Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes

Wang, X., Deckert, M., Xuân, N. T., Nishanth, G., Just, S., Waisman, A., Naumann, M., & Schlüter, D. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1183-9 · Cited by 87 · see citing works

A20 deficiency causes spontaneous neuroinflammation in mice

Guedes, R. P., Csizmadia, E., Moll, H. P., Ma, A. I., Ferran, C. J., & da Silva, C. G. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-122 · Cited by 63 · see citing works

Neuronal FLT1 receptor and its selective ligand VEGF‐B protect against retrograde degeneration of sensory neurons

Dhondt, J., Peeraer, E., Verheyen, A., Nuydens, R., Buysschaert, I., Poesen, K., Geyte, K. V., Beerens, M., Shibuya, M., Haigh, J. J., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-170944 · Cited by 59 · see citing works

LPA 5 receptor plays a role in pain sensitivity, emotional exploration and reversal learning

Callaerts‐Vegh, Z., Leo, S., Vermaercke, B., Meert, T. F., & D’Hooge, R. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00840.x · Cited by 44 · see citing works

Reply to Verbeeck and Kearsley: Addressing the challenges of including lianas in global vegetation models

Schnitzer, S. A., van der Heijden, G. M. F., & Powers, J. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521823113 · Cited by 17 · see citing works

The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works

Microglia: Immune and non-immune functions

Borst, K., Dumas, A. A., & Prinz, M. (2021) · Immunity · doi:10.1016/j.immuni.2021.09.014 · Cited by 804 · see citing works

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Voet, S., Srinivasan, S., Lamkanfi, M., & van Loo, G. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201810248 · Cited by 761 · see citing works

NF-κB: At the Borders of Autoimmunity and Inflammation

Barnabei, L., Laplantine, E., Mbongo, W., Rieux‐Laucat, F., & Weil, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.716469 · Cited by 641 · see citing works

Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice

Shan, S., Zhang, Y., Zhao, H., Zeng, T., & Zhao, X. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134261 · Cited by 528 · see citing works

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Voet, S., Prinz, M., & van Loo, G. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.11.005 · Cited by 503 · see citing works

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

Wang, L., & Hauenstein, A. V. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100889 · Cited by 426 · see citing works

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease

Yang, J., Wise, L., & Fukuchi, K.-I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00724 · Cited by 387 · see citing works

Cellular Specificity of NF-κB Function in the Nervous System

Dresselhaus, E. C., & Meffert, M. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01043 · Cited by 345 · see citing works

Targeting the Microglial NLRP3 Inflammasome and Its Role in Parkinson's Disease

Haque, M. E., Akther, M., Jakaria, M., Kim, I., Azam, S., & Choi, D. (2019) · Movement Disorders · doi:10.1002/mds.27874 · Cited by 248 · see citing works

Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation

Han, B., Jiang, W., Cui, P., Zheng, K., Dang, C., Wang, J., Li, H., Chen, L., Zhang, R., Wang, Q. M., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00863-5 · Cited by 208 · see citing works

Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression

Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02231-x · Cited by 206 · see citing works

Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

Wang, A., Tian, Y., Zhang, W., Tian, T., Gong, S.-X., Huang, W., & Zhou, Q. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.286954 · Cited by 187 · see citing works

Targeting neuroinflammation in Alzheimer’s disease: from mechanisms to clinical applications

Si, Z.-Z., Zou, C.-J., Mei, X., Mei, X., Luo, H., Shen, Y., Hu, J., Li, X.-X., Wu, L., & Liu, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.353484 · Cited by 192 · see citing works

On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective

Nouri, Z., Fakhri, S., El‐Senduny, F. F., Sanadgol, N., Abdel‐Ghani, G. E., Farzaei, M. H., & Chen, J. (2019) · Biomolecules · doi:10.3390/biom9110690 · Cited by 168 · see citing works

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

Tezel, G. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100998 · Cited by 172 · see citing works

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Polykratis, A., Martens, A., Eren, R. O., Shirasaki, Y., Yamagishi, M., Yamaguchi, Y., Uemura, S., Miura, M., Holzmann, B., Kollias, G. A., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0324-3 · Cited by 161 · see citing works

Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis

Zhou, Y., Cui, C., Ma, X., Luo, W., Zheng, S. G., & Qiu, W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00391 · Cited by 150 · see citing works

Control of the inflammasome by the ubiquitin system

López‐Castejón, G. (2019) · FEBS Journal · doi:10.1111/febs.15118 · Cited by 144 · see citing works

Mechanisms of NLRP3 priming in inflammaging and age related diseases

Gritsenko, A., Green, J., Brough, D., & López‐Castejón, G. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.08.003 · Cited by 143 · see citing works

A20 at the Crossroads of Cell Death, Inflammation, and AutoimmunityPreprint

Martens, A., & Loo, G. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036418 · Cited by 138 · see citing works

A20 and cell death-driven inflammation

Priem, D., van Loo, G., & Bertrand, M. J. M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.001 · Cited by 139 · see citing works

Mitochondria at the interface between neurodegeneration and neuroinflammation

Bader, V., & Winklhofer, K. F. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.028 · Cited by 132 · see citing works

The IL-1 family cytokines and receptors in autoimmune diseases

Migliorini, P., Italiani, P., Pratesi, F., Puxeddu, I., & Boraschi, D. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102617 · Cited by 134 · see citing works

The Gut-Microglia Connection: Implications for Central Nervous System Diseases

Wang, Y., Wang, Z., Wang, Y., Li, F., Jia, J., Song, X., Qin, S., Wang, R., Jin, F., Kitazato, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02325 · Cited by 128 · see citing works

Microglia in neurodegenerative diseases

Xu, Y., Jin, M.-Z., Yang, Z., & Jin, M.-Z. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.290881 · Cited by 118 · see citing works

The role of innate immunity in Alzheimer's disease

Ennerfelt, H. E., & Lukens, J. R. (2020) · Immunological Reviews · doi:10.1111/imr.12896 · Cited by 121 · see citing works

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

Laffer, B., Bauer, D., Wasmuth, S., Busch, M., Jalilvand, T. V., Thanos, S., Meyer zu Hörste, G., Loser, K., Langmann, T., Heiligenhaus, A., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00430 · Cited by 120 · see citing works

VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1 β in macrophages

Huang, X., Feng, Z., Jiang, Y., Li, J., Xiang, Q., Guo, S. J., Yang, C., Fei, L., Guo, G., Zheng, L., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau7426 · Cited by 115 · see citing works

Roles and regulation of microglia activity in multiple sclerosis: insights from animal models

Distéfano‐Gagné, F., Bitarafan, S., Lacroix, S., & Gosselin, D. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00709-6 · Cited by 112 · see citing works

Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination

Rao, Z., Chen, X., Wu, J., Xiao, M., Zhang, J., Wang, B., Fang, L., Zhang, H., Wang, X., Yang, S., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02783 · Cited by 114 · see citing works

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia

Zhang, Y., Hou, B., Liang, P., Lu, X., Wu, Y., Zhang, X., Fan, Y., Liu, Y., Chen, T.-X., Liu, W., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04450-9 · Cited by 107 · see citing works

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

Van San, E., Debruyne, A. C., Veeckmans, G., Tyurina, Y. Y., Tyurin, V. A., Zheng, H., Choi, S. M., Augustyns, K., van Loo, G., Michalke, B., et al. (2023) · Cell Death &amp; Differentiation · doi:10.1038/s41418-023-01195-0 · Cited by 103 · see citing works

MiR-21-5p in macrophage-derived extracellular vesicles affects podocyte pyroptosis in diabetic nephropathy by regulating A20

Ding, X., Jing, N., Shen, A., Guo, F., Song, Y., Pan, M., Ma, X., Zhao, L., Zhang, H., Wu, L., et al. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01401-7 · Cited by 101 · see citing works

GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy

Zuo, Y., Chen, L., Gu, H., He, X., Ye, Z., Wang, Z., Shao, Q., & Xue, C. (2021) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.27 · Cited by 100 · see citing works

Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation

de Oliveira, L. G., Angelo, Y. D. S., Iglesias, A. H., & Peron, J. P. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624919 · Cited by 99 · see citing works

NF-κB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders?

Roberti, A., Chaffey, L., & Greaves, D. R. (2022) · Biology · doi:10.3390/biology11030372 · Cited by 103 · see citing works

The Ubiquitin System and A20: Implications in Health and Disease

Mooney, E. C., & Sahingur, S. E. (2020) · Journal of Dental Research · doi:10.1177/0022034520949486 · Cited by 95 · see citing works

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Terzioglu, G., & Young-Pearse, T. L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00674-9 · Cited by 95 · see citing works

Emerging role of mesenchymal stromal cells (MSCs)-derived exosome in neurodegeneration-associated conditions: a groundbreaking cell-free approach

Yari, H., Mikhailova, M. V., Mardasi, M., Jafarzadehgharehziaaddin, M., Shahrokh, S., Thangavelu, L. P., Ahmadi, H., Shomali, N., Yaghoubi, Y., Zamani, M., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03122-5 · Cited by 98 · see citing works

Metabolons in plant primary and secondary metabolism

Obata, T. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09619-x · Cited by 91 · see citing works

Inflammasome assembly in neurodegenerative diseases

Singh, J., Habean, M. L., & Panicker, N. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.07.009 · Cited by 83 · see citing works

Microglial NLRP3 inflammasome activation in multiple sclerosis

(2020) · Advances in Protein Chemistry and Structural Biology · doi:10.1016/bs.apcsb.2019.08.007 · Cited by 83 · see citing works

A20: A multifunctional tool for regulating immunity and preventing disease

Malynn, B. A., & Ma, A. I. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.04.002 · Cited by 80 · see citing works

Microglial glutaminase 1 deficiency mitigates neuroinflammation associated depression

Ji, C., Tang, Y., Zhang, Y., Li, C., Liang, H., Ding, L., Xia, X., Xiong, L., Qi, X., & Zheng, J. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.10.009 · Cited by 79 · see citing works

Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics

Cui, Y., Yu, H., Bu, Z., Wen, L., Yan, L.-L., & Feng, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.894298 · Cited by 79 · see citing works

Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson’s Disease

Yan, S., Wei, X., Jian, W., Qin, Y., Liu, J., Zhu, S., Jiang, F., Lou, H., & Zhang, B. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00078 · Cited by 75 · see citing works

Functional analysis of deubiquitylating enzymes in tumorigenesis and development

Cheng, J., Guo, J., North, B. J., Wang, B., Cui, C., Li, H., Tao, K., Zhang, L., & Wei, W. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.188312 · Cited by 74 · see citing works

Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology

Mohebiany, A. N., Ramphal, N. S., Karram, K., Liberto, G. D., Novkovic, T., Klein, M., Marini, F., Kreutzfeldt, M., Härtner, F., Lacher, S. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.097 · Cited by 69 · see citing works

Brain Parenchymal and Extraparenchymal Macrophages in Development, Homeostasis, and Disease

Brioschi, S., Zhou, Y., & Colonna, M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900821 · Cited by 65 · see citing works

The Role of Osteopontin in Microglia Biology: Current Concepts and Future Perspectives

Rosmus, D.-D., Lange, C., Ludwig, F., Ajami, B., & Wieghofer, P. (2022) · Biomedicines · doi:10.3390/biomedicines10040840 · Cited by 68 · see citing works

Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation

Sun, W., Wang, Q., Zhang, R., & Zhang, N. (2023) · Food & Function · doi:10.1039/d3fo00122a · Cited by 67 · see citing works

Central nervous system demyelinating diseases: glial cells at the hub of pathology

Coutinho-Costa, V. G., Araújo, S., Alves-Leon, S., & Gomes, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1135540 · Cited by 67 · see citing works

NLRP3 Inflammasome’s Activation in Acute and Chronic Brain Diseases—An Update on Pathogenetic Mechanisms and Therapeutic Perspectives with Respect to Other Inflammasomes

Chiarini, A., Gui, L., Viviani, C., Armato, U., & Prà, I. D. (2023) · Biomedicines · doi:10.3390/biomedicines11040999 · Cited by 61 · see citing works

Inflammasome Signaling in the Aging Brain and Age-Related Neurodegenerative Diseases

Brahadeeswaran, S., Sivagurunathan, N., & Latchoumycandane, C. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02683-5 · Cited by 61 · see citing works

ALKBH5-Mediated m6A Modification of A20 Regulates Microglia Polarization in Diabetic Retinopathy

Chen, T., Zhu, W., Wang, C., Dong, X., Yu, F., Su, Y., Huang, J., Huo, L., & Wan, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.813979 · Cited by 58 · see citing works

The Astrocytic cAMP Pathway in Health and Disease

Zhou, Z., Ikegaya, Y., & Koyama, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030779 · Cited by 59 · see citing works

P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress

Verma, A., Azhar, G., Zhang, X., Patyal, P., Grishma, K. C., Sharma, S., Che, Y., & Wei, J. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020950 · Cited by 55 · see citing works

Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond

McCarty, M. F., Assanga, S. B. I., Luján, L. M. L., O’Keefe, J. H., & DiNicolantonio, J. J. (2020) · Nutrients · doi:10.3390/nu13010047 · Cited by 54 · see citing works

Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage

Lü, J., Sun, Z., Fang, Y., Zheng, J., Xu, S., Xu, W., Shi, L., Mei, S., Wu, H., Liang, F., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01360 · Cited by 52 · see citing works

Activation of NLRP3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice

Li, X., Zhang, Y., Li, B., Yang, H., Cui, J., Li, X., Zhang, X., Sun, H., Meng, Q., Wu, S., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.105487 · Cited by 53 · see citing works

Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review)

Zheng, Y., Zhang, X., Zhang, R., Wang, Z., Gan, J., Gao, Q., Yang, L., Xu, P., & Jiang, X. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5314 · Cited by 52 · see citing works

The NLRP3 inflammasome: a new player in neurological diseases

Eren, E., & Özören, N. (2019) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1909-31 · Cited by 51 · see citing works

The roles of ubiquitination in extrinsic cell death pathways and its implications for therapeutics

Seo, J., Kim, M. W., Bae, K., Lee, S. C., Song, J., & Lee, E. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.11.012 · Cited by 47 · see citing works

Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis

Plastini, M. J., Desu, H. L., & Brambilla, R. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00269 · Cited by 48 · see citing works

A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage

Deng, H., Deji, Q.-Z., Zhaba, W.-D., Liu, J., Gao, S.-Q., Han, Y., Zhou, M., & Wang, C.-X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623256 · Cited by 47 · see citing works

Regulation of leukocyte function by citric acid cycle intermediates

Patil, N. K., Bohannon, J. K., Hernandez, A., Patil, T. K., & Sherwood, E. R. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mir1118-415r · Cited by 49 · see citing works

Neuroprotective Effect of Taohong Siwu Decoction on Cerebral Ischemia/Reperfusion Injury via Mitophagy-NLRP3 Inflammasome Pathway

Ji, Z.-J., Shi, Y., Li, X., Hou, R., Yang, Y., Liu, Z., Duan, X., Liu, Q., Chen, W., & Peng, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.910217 · Cited by 47 · see citing works

Naringenin: its chemistry and roles in neuroprotection

Atoki, A. V., Aja, P. M., Shinkafi, T. S., Ondari, E. N., & Awuchi, C. G. (2023) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2243089 · Cited by 46 · see citing works

No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death

Weir, A. L., & Vince, J. E. (2022) · Biochemical Journal · doi:10.1042/bcj20210711 · Cited by 45 · see citing works

Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome

Wei, C., Guo, S., Liu, W., Jin, F., Wei, B., Fan, H., Su, H., Liu, J., Zhang, N., Fang, D., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.610734 · Cited by 42 · see citing works

p38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia

Lin, H., Dixon, S. G., Hu, W., Hamlett, E. D., Jin, J., Ergul, A., & Wang, G. Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02909-0 · Cited by 41 · see citing works

Role of NLRP3 inflammasome in central nervous system diseases

Zhang, L., Tang, Y., Huang, P., Luo, S., She, Z., Peng, H., Chen, Y., Luo, J., Duan, W., Xiong, J., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01256-y · Cited by 43 · see citing works

Fucoxanthinol from the Diatom Nitzschia Laevis Ameliorates Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV-2 Microglia

Li, Y., Liu, L., Sun, P., Zhang, Y., Wu, T., Sun, H., Cheng, K., & Chen, F. (2020) · Marine Drugs · doi:10.3390/md18020116 · Cited by 41 · see citing works

Glial Cells and Brain Diseases: Inflammasomes as Relevant Pathological Entities

Martínez, E. M., Díaz‐Muñoz, M., & Vázquez‐Cuevas, F. G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.929529 · Cited by 42 · see citing works

A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization

Hou, L., Ye, Y., Gou, H., Tang, H., Zhou, Y., Xu, X., & Xu, Y. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113264 · Cited by 40 · see citing works

To re-examine the intersection of microglial activation and neuroinflammation in neurodegenerative diseases from the perspective of pyroptosis

Li, Y., Li, Y., & Zhu, Z. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1284214 · Cited by 41 · see citing works

The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders

Rimessi, A., Patergnani, S., Morciano, G., Carinci, M., Leo, S., & Pinton, P. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.339473 · Cited by 39 · see citing works

Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity

Ruan, J., Schlüter, D., & Wang, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01783-8 · Cited by 36 · see citing works

NF-κB Activation Accounts for the Cytoprotective Effects of PERK Activation on Oligodendrocytes during EAE

Lei, Z., Yue, Y., Stone, S., Wu, S., & Lin, W. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1156-20.2020 · Cited by 35 · see citing works

Microglial activation in the dorsal striatum participates in anxiety-like behavior in Cyld knockout mice

Han, Y.-Y., Jin, K., Pan, Q.-S., Li, B., Wu, Z.-Q., Gan, L., Yang, L., & Long, C. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.011 · Cited by 35 · see citing works

Caffeine Inhibits Activation of the NLRP3 Inflammasome via Autophagy to Attenuate Microglia-Mediated Neuroinflammation in Experimental Autoimmune Encephalomyelitis

Wang, H., Song, K.-Y., Feng, J., Huang, S., Guo, X., Zhang, L., Zhang, G., Huo, Y., Zhang, R., Ma, Y., et al. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01894-8 · Cited by 34 · see citing works

A De Novo Frameshift Mutation in TNFAIP3 Impairs A20 Deubiquitination Function to Cause Neuropsychiatric Systemic Lupus Erythematosus

Duan, R., Liu, Q., Li, J., Bian, X., Yuan, Q., Li, Y., Long, F., Gao, S., Wei, S., Li, P., et al. (2019) · Journal of Clinical Immunology · doi:10.1007/s10875-019-00695-4 · Cited by 33 · see citing works

Cause or consequence? The role of IL-1 family cytokines and receptors in neuroinflammatory and neurodegenerative diseases

Boraschi, D., Italiani, P., Migliorini, P., & Bossù, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1128190 · Cited by 33 · see citing works

Repetitive transcranial magnetic stimulation ameliorates cognitive deficits in mice with radiation-induced brain injury by attenuating microglial pyroptosis and promoting neurogenesis via BDNF pathway

Qin, T., Guo, L. T., Wang, X., Zhou, G., Liu, L., Zhang, Z.-W., & Ding, G. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01591-0 · Cited by 32 · see citing works

Neuroinflammation Associated With Inborn Errors of Immunity

Lindahl, H., & Bryceson, Y. T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.827815 · Cited by 34 · see citing works

Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase

Tan, W., Su, P. P., Leff, J., Gao, X., Chen, J., Guan, A. K., Kalyanasundaram, G., Ma, A. I., & Guan, Z. (2022) · Cell Discovery · doi:10.1038/s41421-022-00377-3 · Cited by 33 · see citing works

MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation

Yue, D., Zhao, J., Chen, H., Guo, M., Chen, C., Zhou, Y., & Xu, L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1710-2 · Cited by 31 · see citing works

MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3)

Li, L., Qi, C., Liu, Y., Shen, Y., Zhao, X., Qin, H., Zhang, Y., & Yu, T. (2021) · Bioengineered · doi:10.1080/21655979.2021.1969195 · Cited by 29 · see citing works

Inflammasome Molecular Insights in Autoimmune Diseases

Neamţu, M., Bild, V., Vasincu, A., Arcan, O. D., Bulea, D., Ababei, D. C., Rusu, R.-N., Macadan, I., Sciucă, A. M., & Neamțu, A. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46040220 · Cited by 33 · see citing works

Characterization of focused ultrasound blood-brain barrier disruption effect on inflammation as a function of treatment parameters

Angolano, C., Hansen, E., Ajjawi, H., Nowlin, P., Zhang, Y., Fomin-Thunemann, N., Ferran, C. J., & Todd, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117762 · Cited by 29 · see citing works

Caspase-1: A Promising Target for Preserving Blood–Brain Barrier Integrity in Acute Stroke

Ye, X., Song, G., Huang, S., Liang, Q., Fang, Y., Lian, L., & Zhu, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.856372 · Cited by 29 · see citing works

Investigating the NLRP3 inflammasome and its regulator miR ‐223‐3p in multiple sclerosis and experimental demyelination

Galloway, D. A., Carew, S. J., Blandford, S. N., Benoit, R. Y., Fudge, N. J., Berry, T., Moore, G. R. W., Barron, J., & Moore, C. S. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15650 · Cited by 30 · see citing works

An Ultrasound‐Activated Supramolecular Modulator Enhancing Autophagy to Prevent Ventricular Arrhythmias Post‐Myocardial Infarction

Pang, Y., Li, Q., Wang, J., Wang, S., Sharma, A. K., Xu, Y., Hu, H., Li, J., Liu, S., & Sun, Y. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202415802 · Cited by 28 · see citing works

17β-Estradiol Reduces Demyelination in Cuprizone-fed Mice by Promoting M2 Microglia Polarity and Regulating NLRP3 Inflammasome

Aryanpour, R., Zibara, K., Pasbakhsh, P., Jame'ei, S. B., Namjoo, Z., Ghanbari, A., Mahmoudi, R., Amani, S., & Kashani, I. R. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.03.025 · Cited by 28 · see citing works

Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response

Uyar, O., Dominguez, J. M., Bordeleau, M., Lapeyre, L., Ibáñez, F. G., Vallières, L., Tremblay, M., Corbeil, J., & Boivin, G. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02437-7 · Cited by 28 · see citing works

Bidirectional association between inflammatory bowel disease and depression among patients and their unaffected siblings

Zhang, B., Wang, H. E., Bai, Y., Tsai, S., Su, T., Chen, T., Wang, Y., & Chen, M. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15855 · Cited by 27 · see citing works

Immunopathogenesis of multiple sclerosis: molecular and cellular mechanisms and new immunotherapeutic approaches

Aliyu, M., Zohora, F. T., Ceylan, A., Hossain, F., Yazdani, R., & Azizi, G. (2024) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2024.2330642 · Cited by 28 · see citing works

Resolvin D1 : A key endogenous inhibitor of neuroinflammation

Roohbakhsh, A., Etemad, L., & Karimi, G. (2022) · BioFactors · doi:10.1002/biof.1891 · Cited by 27 · see citing works

One immune system plays many parts: The dynamic role of the immune system in chronic pain and opioid pharmacology

Mustafa, S., Bajic, J. E., Barry, B., Evans, S. G., Siemens, K. R., Hutchinson, M. R., & Grace, P. M. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109459 · Cited by 28 · see citing works

A20-deficient microglia and CD8 T cells in the brain

Mohebiany, A. N., & Waisman, A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.49.6

A20 deficiency causes spontaneous neuroinflammation in mice

Guedes, R. P., Csizmadia, E., Moll, H. P., Ma, A. I., Ferran, C. J., & da Silva, C. G. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-122 · Cited by 63 · see citing works

Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology

Mohebiany, A. N., Ramphal, N. S., Karram, K., Liberto, G. D., Novkovic, T., Klein, M., Marini, F., Kreutzfeldt, M., Härtner, F., Lacher, S. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.097 · Cited by 69 · see citing works

Overexpression of the ubiquitin‐editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation

Perga, S., Montarolo, F., Martire, S., Bonaldo, B., Bono, G., Bertolo, J., Magliozzi, R., & Bertolotto, A. (2020) · Brain Pathology · doi:10.1111/bpa.12906 · Cited by 18 · see citing works

JOURNAL OF

Guedes, R. P., Csizmadia, E., Moll, H. P., Ma, A. I., & Ferran, C. J. (2015)