The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease
Abstract
Alzheimer's disease (AD) is an irrevocable chronic brain disorder featured by neuronal loss, microglial accumulation, and progressive cognitive impairment. The proper pathophysiology of this life-threatening disorder is not completely understood and no exact remedies have been found yet. Over the last few decades, research on AD has mainly highlighted pathomechanisms linked to a couple of the major pathological hallmarks, including extracellular senile plaques made of amyloid-β (Aβ) peptides, and intracellular neurofibrillary tangles (NFTs) made of tau proteins. Aβ can induce apoptosis, trigger an inflammatory response, and inhibit the synaptic plasticity of the hippocampus, which ultimately contributes to reducing cognitive functions and memory impairment. Recently, a third disease hallmark, the neuroinflammatory reaction that is mediated by cerebral innate immune cells, has become a spotlight in the current research area, assured by pre-clinical, clinical, and genetic investigations. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a cytokine producer, is significantly associated with physiological inflammatory proceedings and thus shows a promising candidate for inflammation- based AD therapy. Recent data reveal that phytochemicals, mainly polyphenol compounds, exhibit potential neuroprotective functions and these may be considered as a vital resource for discovering several drug candidates against AD. Interestingly, phytochemicals can easily interfere with the signaling pathway of NF-κB. This review represents the anti-neuroinflammatory potential of polyphenols as inhibitors of NF-κB to combat AD pathogenesis.
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“the presence of anti-inflammatory and antioxidant properties is another crucial feature of natural compounds contributing to their therapeutic potential (Uddin et al., 2021)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Uddin et al., 2021
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Cited by
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Shi, M., Chu, F., Zhu, F., & Zhu, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.870517 · Cited by 275
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Metadata
- Authors
- Uddin, M. S., Hasana, S., Ahmad, J., Hossain, M. F., Rahman, M. M., Behl, T., Rauf, A., Ahmad, A., Hafeez, A., Perveen, A., & Ashraf, G. M.
- Affiliations
- Southeast University (BD)
- The University of Agriculture, Peshawar (PK)
- Pharmakon Neuroscience Research Network, Dhaka,Bangladesh
- Chitkara University (IN)
- University of Swabi (PK)
- Amity University (IN)
- Glocal University (IN)
- King Abdulaziz University (SA)
- Corresponding author
- Uddin, Md. Sahab
- Ashraf, Ghulam Md
- ORCID
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2021-01
- Volume
- 27
- Issue
- 3
- Pages
- 402-414
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W3101281606
- Cited by
- 49
- References
- 174
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 10
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, polyphenols, NF-κB inhibition, neuroinflammation, neuroprotection, amyloid-beta, neurofibrillary tangles, microglia, phytochemicals, anti-inflammatory drug candidates, innate immune response
- MeSH terms
- Alzheimer Disease, Humans, Amyloid beta-Peptides, NF-kappa B, Microglia, Polyphenols
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