Currently Used Antimycotics: Spectrum, Mode of Action and Resistance Occurrence
Abstract
The increasing incidence of fungal infections combined with the emerging problem of antifungal drug resistance have prompted investigations of the mode of action of the currently used antifungal therapeutics (antimycotics). The routinely used antimycotics can be grouped into six different classes based on their mode of action. In this review, the mode of action and antifungal spectrum of these classes are discussed, together with possible resistance development against them.
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Griseofulvin acts by disrupting spindle and cytoplasmic microtubule production, thereby inhibiting fungal mitosis.
“Griseofulvin (a tricyclic spirodiketone, first isolated from Penicillium griseofulvum) acts by disrupting spindle and cytoplasmic microtubule production, thereby inhibiting fungal mitosis (Figure 1, [34]).”
From <i>Candida</i>Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [34]
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- Authors
- Francois, I., Aerts, A., Cammue, B., & Thevissen, K.
- Venue
- Current Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-12-01
- Volume
- 6
- Issue
- 8
- Pages
- 895-907
- ISSN
- 1389-4501 (ISSN-L)
- OpenAlex
- W2132807381
- Cited by
- 49
- References
- 0
- Citations by year
- 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- antifungal agents, antifungal resistance, mechanism of action, antifungal spectrum, fungal infection
- MeSH terms
- Allylamine, Animals, Antifungal Agents, Azoles, Humans, Mycoses, Polyenes, Thiocarbamates, Drug Resistance, Fungal
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