Cited by 58Trauma, Hemostasis, Coagulopathy, ResuscitationBlood transfusion and managementHemostasis and retained surgical items

Targeted thromboelastographic (TEG) blood component and pharmacologic hemostatic therapy in traumatic and acquired coagulopathy

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Walsh, Mark, Fritz, Stephanie, Hake, Daniel, Son, Michael, Greve, Sarah, Jbara, Manar, Chitta, Swetha, Fritz, Braxton +10 more·2016·Current Drug Targets

Abstract

Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivity and specificity of these CCTs have led trauma coagulation researchers and clinicians to use Viscoelastic Tests (VET) such as Thromboelastography (TEG) to provide Targeted Thromboelastographic Hemostatic and Adjunctive Therapy (TTHAT) in a goal directed fashion to those trauma patients in need of hemostatic resuscitation. This review describes the utility of VETs, in particular, TEG, to provide TTHAT in trauma and acquired non-trauma-induced coagulopathy. Keywords: Thromboelastography, point-of-care, acquired coagulopathy, blood component therapy, systemic hemostatic agents, trauma-induced coagulopathy, hemostatic resuscitation, tranexamic acid, targeted pharmacologic therapy.

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Research works printed but not linked: 2

  1. [62]Walsh M. Jbara M. Miller A. Lawson J. Thromboelastographic guided blood component therapy for severe hemorrhage. 2014 Blood Bulletin
  2. [77]Schochl H. Maegele M. Solomon C. Gorlinger K. Voelckel W. Early and individualized goal-directed therapy for trauma-induced coagulopathy. Scand. J. Trauma Resusc. Emerg. Med. 2012 20 15 1 11 22364525 PMC3306198

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Authors
Walsh, M., Fritz, S., Hake, D., Son, M., Greve, S., Jbara, M., Chitta, S., Fritz, B., Miller, A., K Bader, M., McCollester, J., Binz, S., Liew-Spilger, A., Thomas, S., Crepinsek, A., Shariff, F., Ploplis, V., & J. Castellino, F.
Affiliations
  • Memorial Hospital of South Bend (US)
  • Indiana University South Bend (US)
  • Self Regional Healthcare (US)
  • Mayo Clinic (US)
  • University of Notre Dame (US)
Corresponding author
Walsh, Mark
Venue
Current Drug Targets
Published
2016-05-04
Volume
17
Issue
8
Pages
954-970
ISSN
1389-4501 (ISSN-L)
OpenAlex
W2295828145
Cited by
58
References
227
Citations by year
2026: 5 · 2025: 4 · 2024: 2 · 2023: 9 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 4 · 2017: 1 · 2016: 1
FWCI
0.73
Type
journal article
Language
en
Open access
Locations
  • Current Drug Targets (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
Funders
  • CSL Behring
  • Haemonetics Corporation
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
Keywords
trauma-induced coagulopathy, thromboelastography, viscoelastic coagulation tests, blood component therapy, hemostatic resuscitation, acquired coagulopathy, tranexamic acid, point-of-care coagulation testing, coagulation tests
MeSH terms
Blood Coagulation Disorders, Hemostatic Techniques, Humans, Partial Thromboplastin Time, Platelet Count, Prothrombin Time, Sensitivity and Specificity, Thrombelastography, Wounds and Injuries

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