Targeted thromboelastographic (TEG) blood component and pharmacologic hemostatic therapy in traumatic and acquired coagulopathy
Open accessAbstract
Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivity and specificity of these CCTs have led trauma coagulation researchers and clinicians to use Viscoelastic Tests (VET) such as Thromboelastography (TEG) to provide Targeted Thromboelastographic Hemostatic and Adjunctive Therapy (TTHAT) in a goal directed fashion to those trauma patients in need of hemostatic resuscitation. This review describes the utility of VETs, in particular, TEG, to provide TTHAT in trauma and acquired non-trauma-induced coagulopathy. Keywords: Thromboelastography, point-of-care, acquired coagulopathy, blood component therapy, systemic hemostatic agents, trauma-induced coagulopathy, hemostatic resuscitation, tranexamic acid, targeted pharmacologic therapy.
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Point-of-care viscoelastic tests may direct resuscitative efforts to avoid over treatment.
“Additionally, these point-of-care tests may direct resuscitative efforts to avoid over treatment (89–91).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [89]
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Flagged first, then by citations
Research works printed but not linked: 2
- [62]Walsh M. Jbara M. Miller A. Lawson J. Thromboelastographic guided blood component therapy for severe hemorrhage. 2014 Blood Bulletin
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- Authors
- Walsh, M., Fritz, S., Hake, D., Son, M., Greve, S., Jbara, M., Chitta, S., Fritz, B., Miller, A., K Bader, M., McCollester, J., Binz, S., Liew-Spilger, A., Thomas, S., Crepinsek, A., Shariff, F., Ploplis, V., & J. Castellino, F.
- Affiliations
- Memorial Hospital of South Bend (US)
- Indiana University South Bend (US)
- Self Regional Healthcare (US)
- Mayo Clinic (US)
- University of Notre Dame (US)
- Corresponding author
- Walsh, Mark
- Venue
- Current Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2016-05-04
- Volume
- 17
- Issue
- 8
- Pages
- 954-970
- ISSN
- 1389-4501 (ISSN-L)
- PMC
- PMC5374842
- OpenAlex
- W2295828145
- Cited by
- 58
- References
- 227
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 9 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 4 · 2017: 1 · 2016: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Drug Targets (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
- Funders
- CSL Behring
- Haemonetics Corporation
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Keywords
- trauma-induced coagulopathy, thromboelastography, viscoelastic coagulation tests, blood component therapy, hemostatic resuscitation, acquired coagulopathy, tranexamic acid, point-of-care coagulation testing, coagulation tests
- MeSH terms
- Blood Coagulation Disorders, Hemostatic Techniques, Humans, Partial Thromboplastin Time, Platelet Count, Prothrombin Time, Sensitivity and Specificity, Thrombelastography, Wounds and Injuries
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