Modeling Oxidative Stress in the Central Nervous System
Abstract
Oxidative stress is associated with the onset and pathogenesis of several prominent central nervous system disorders. Consequently, there is a pressing need for experimental methods for studying neuronal responses to oxidative stress. A number of techniques for modeling oxidative stress have been developed, including the use of inhibitors of the mitochondrial respiratory chain, depletion of endogenous antioxidants, application of products of lipid peroxidation, use of heavy metals, and models of ischemic brain injury. These experimental approaches can be applied from cell culture to in vivo animal models. Their use has provided insight into the molecular underpinnings of oxidative stress responses in the nervous system, including cell recovery and cell death. Reactive oxygen species contribute to conformational change-induced activation of signaling pathways, inactivation of enzymes through modification of catalytic cysteine residues, and subcellular redistribution of signaling molecules. In this review, we will discuss several methods for inducing oxidative stress in the nervous system and explore newly emerging concepts in oxidative stress signaling.
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The correlation between oxidative stress status and affective disorders development could arise from the vulnerability of the central nervous system to oxidative damage.
“In fact, the correlation between the oxidative stress status and affective disorders development could arise from the vulnerability of central nervous system (CNS) to oxidative damage.”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [29]
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- Authors
- Lehtinen, M., & Bonni, A.
- Affiliations
- Harvard University (US)
- Venue
- Current Molecular Medicine
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2006-12-01
- Volume
- 6
- Issue
- 8
- Pages
- 871-881
- ISSN
- 1566-5240 (ISSN-L)
- OpenAlex
- W2009700583
- Cited by
- 50
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2018: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS41021, R01NS041021)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- oxidative stress, central nervous system, antioxidant depletion, lipid peroxidation, heavy metals, ischemic brain injury, reactive oxygen species, oxidative stress signaling, neuronal cell death, cysteine modification, signaling pathway activation
- MeSH terms
- Central Nervous System, Humans, Models, Biological, Signal Transduction, Oxidative Stress, Neurodegenerative Diseases
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