p53 is an important regulator of CCL2 gene expression
Open accessAbstract
The p53 protein is a sequence-specific DNA-binding factor that regulates inflammatory genes such as CCL2/MCP-1 that may play a role in various diseases. A recent study has indicated that the knockdown of human p53 leads to a strong negative regulation of CCL2 induction. We are therefore interested in how p53 regulates CCL2 gene expression. In the following study, our findings indicate that UV-induced p53 accumulation in mouse macrophages significantly decreases LPS-induced CCL2 production, and that p53 binds to CCL2 5'UTR in the region (16-35). We also found that a p53 domain (p53pep170) mimics full length p53 to down-regulate CCL2 promoter activity. Treatment of p53-deficient mouse primary macrophages with synthetic p53pep170 was found to decrease LPS-induced production of CCL2 without association with cellular endogenous p53. CCL2 production induced by lentiCLG in human monocytes or mouse primary macrophages was blocked in the presence of p53pep170. Overall, these results demonstrate that p53 or its derived peptide (p53pep170) is an important regulator of CCL2 gene expression via its binding activity, and acts as a novel model for future studies linking p53 and its short peptide to pave the way to possible pharmaceutical intervention of CCL2-mediated inflammatory and cancer diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Published chromatin immunoprecipitation experiments show a direct association of p53 with the Ccl2 gene regulatory sequences.
“Published chromatin immunoprecipitation experiments show a direct association of p53 with the Ccl2 gene regulatory sequences (Hacke et al., 2010; Tang et al., 2012)”
From p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells (2013) · cites this paper as Tang et al., 2012
The Ccl2 gene may be directly transactivated by p53.
“The Ccl2 gene, which may be directly transactivated by p53 (Hacke et al., 2010; Tang et al., 2012)”
From p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells (2013) · cites this paper as Tang et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559 · see citing works
p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,338 · see citing works
Combadière, C., Potteaux, S., Rodero, M., Simon, T., Pézard, A., Esposito, B., Merval, R., Proudfoot, A., Tedgui, A., & Mallat, Z. (2008) · Circulation · doi:10.1161/circulationaha.107.745091 · Cited by 714 · see citing works
NF- kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.
Ueda, A., Okuda, K., Ohno, S., Shirai, A., IGARASHI, T., Matsunaga, K., Fukushima, J., Kawamoto, S., Ishigatsubo, Y., & Okubo, T. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.5.2052 · Cited by 523 · see citing works
Eugenin, E. A., Osiecki, K., Lopez, L., Goldstein, H., Calderon, T. M., & Berman, J. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3863-05.2006 · Cited by 392 · see citing works
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
Zheng, H., You, H., Zhou, X. Z., Murray, S. A., Uchida, T., Wulf, G. M., Gu, L., Tang, X., Lu, K. P., & Xiao, Z. J. (2002) · Nature · doi:10.1038/nature01116 · Cited by 384 · see citing works
Self-citationLoetscher, P., Seitz, M., Lewis, I. C., Baggiolini, M., & Moser, B. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.13.7926371 · Cited by 323 · see citing works
Gonzalez, E., Rovin, B. H., Sen, L., Cooke, G. E., Dhanda, R., Mummidi, S., Kulkarni, H. R., Bamshad, M. J., Telles, V., Anderson, S. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202357499 · Cited by 302 · see citing works
The role of tetramerization in p53 function
Chêne, P. (2001) · Oncogene · doi:10.1038/sj.onc.1204373 · Cited by 273 · see citing works
Lü, X., & Kang, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.035899 · Cited by 260 · see citing works
Haringman, J. J., Gerlag, D. M., Smeets, T. J. M., Baeten, D., den Bosch, F. E. V., Bresnihan, B., Breedveld, F. C., Dinant, H. J., Legay, F., Gram, H., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21975 · Cited by 258 · see citing works
p53 is a suppressor of inflammatory response in mice
Komarova, E. A., Krivokrysenko, V. I., Wang, K., Neznanov, N. S., Chernov, M. V., Komarov, P. G., Brennan, M., Golovkina, T. V., Rokhlin, O. W., Kuprash, D. V., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3213fje · Cited by 243 · see citing works
p53 domains: identification and characterization of two autonomous DNA-binding regions.Preprint
Wang, Y., Reed, M. J., Wang, P., Stenger, J. E., Mayr, G. A., Anderson, M. E., Schwedes, J. F., & Tegtmeyer, P. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2575 · Cited by 239 · see citing works
Regulation of Human p53 Activity and Cell Localization by Alternative Splicing
Ghosh, A., Stewart, D., & Matlashewski, G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.7987-7997.2004 · Cited by 221 · see citing works
Multiple Roles of Chemokine (C-C Motif) Ligand 2 in Promoting Prostate Cancer Growth
Zhang, J., Lu, Y., & Pienta, K. J. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq044 · Cited by 216 · see citing works
Chen, L. I., Nishinaka, T., Kwan, K. W., Kitabayashi, I., Yokoyama, K., Fu, Y. F., Gruenwald, S., & Chiu, R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4380-4389.1994 · Cited by 186 · see citing works
Göser, S., Öttl, R., Brodner, A., Dengler, T. J., Torzewski, J., Egashira, K., Rose, N. R., Katus, H. A., & Kaya, Z. (2005) · Circulation · doi:10.1161/circulationaha.105.572396 · Cited by 152 · see citing works
Tang, X., Marciano, D. L., Leeman, S. E., & Amar, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501159102 · Cited by 151 · see citing works
Self-citationA Novel Human p53 Isoform Is an Essential Element of the ATR-Intra-S Phase Checkpoint
Rohaly, G., Chemnitz, J., Dehde, S., Nunez, A. M., Heukeshoven, J., Deppert, W., & Dornreiter, I. (2005) · Cell · doi:10.1016/j.cell.2005.04.032 · Cited by 148 · see citing works
Schilling, M., Strecker, J., Schäbitz, W.-R., Ringelstein, E. B., & Kiefer, R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.025 · Cited by 144 · see citing works
Regulation of Joint Destruction and Inflammation by p53 in Collagen-Induced Arthritis
Yamanishi, Y., Boyle, D. L., Pinkoski, M. J., Mahboubi, A., Lin, T., Han, Z., Zvaifler, N. J., Green, D. R., & Firestein, G. S. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64356-8 · Cited by 142 · see citing works
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
Joerger, A. C., Rajagopalan, S., Natan, E., Veprintsev, D. B., Robinson, C. V., & Fersht, A. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905867106 · Cited by 142 · see citing works
Δ160p53 is a novel N‐terminal p53 isoform encoded by Δ133p53 transcript
Marcel, V., Perrier, S., Aoubala, M., Ageorges, S., Groves, M. J., Diot, A., Fernandes, K., Tauro, S., & Bourdon, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.005 · Cited by 132 · see citing works
Oligomerization Is Required for p53 to be Efficiently Ubiquitinated by MDM2
Maki, C. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16531 · Cited by 125 · see citing works
Ip, W., Wong, C. K., & Lam, C. W. K. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03085.x · Cited by 125 · see citing works
Unger, T., Mietz, J. A., Scheffner, M., Yee, C., & Howley, P. M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5186 · Cited by 123 · see citing works
Avery‐Kiejda, K. A., Zhang, X. D., Adams, L. J., Scott, R. J., Vojtěšek, B., Lane, D. P., & Hersey, P. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1422 · Cited by 122 · see citing works
Ho, A. M. ‐., Wong, C. K., & Lam, C. W. K. (2008) · Immunobiology · doi:10.1016/j.imbio.2008.01.003 · Cited by 121 · see citing works
Pulmonary Chemokine Expression Is Coordinately Regulated by STAT1, STAT6, and IFN-γ
Fulkerson, P. C., Zimmermann, N., Hassman, L. M., Finkelman, F. D., & Rothenberg, M. E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7565 · Cited by 116 · see citing works
Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats
Ikeda, Y., Yonemitsu, Y., Kataoka, C., Kitamoto, S., Yamaoka, T., Nishida, K.-I., Takeshita, A., Egashira, K., & Sueishi, K. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00919.2001 · Cited by 114 · see citing works
Demers, A., Mcnicoll, N., Febbraio, M., Servant, M., Marleau, S., Silverstein, R., & Ong, H. (2004) · Biochemical Journal · doi:10.1042/bj20040036 · Cited by 110 · see citing works
Slingerland, J., Jenkins, J. R., & Benchimol, S. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05744.x · Cited by 105 · see citing works
Staib, F., Robles, A. I., Varticovski, L., Wang, X. W., Zeebèrg, B. R., Sirotin, M., Zhurkin, V. B., Hofseth, L. J., Hussain, S. P., Weinstein, J. N., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1714 · Cited by 103 · see citing works
Hembruff, S. L., Jokar, I., Yang, H. H., & Cheng, N. (2010) · Neoplasia · doi:10.1593/neo.10200 · Cited by 92 · see citing works
Ånensen, N., Oyan, A. M., Bourdon, J., Kalland, K. H., Bruserud, Ø., & Gjertsen, B. T. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1970 · Cited by 92 · see citing works
Chemotherapeutic drugs and human tumor cells cytokine network
Levina, V. V., Su, Y., Nolen, B. M., Liu, X., Gordin, Y., Lee, M., Lokshin, A. E., & Gorelik, E. (2008) · International Journal of Cancer · doi:10.1002/ijc.23732 · Cited by 89 · see citing works
Hu, H., Sun, L., Guo, C., Liu, Q., Zhou, Z., Peng, L., Pan, J., Yu, L., Lou, J.-N., Yang, Z., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2491 · Cited by 84 · see citing works
Hofstetter, G., Berger, A., Fiegl, H., Slade, N., Zorić, A., Holzer, B., Schuster, E., Möbus, V. J., Reimer, D., Daxenbichler, G., et al. (2010) · Oncogene · doi:10.1038/onc.2009.482 · Cited by 82 · see citing works
Chen, X., Grey, J. Y., Thomas, S., Qiu, F.-H., Medford, R. M., Wasserman, M. A., & KUNSCH, C. A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01101.2003 · Cited by 78 · see citing works
Cell‐targeting and cell‐penetrating peptides for delivery of therapeutic and imaging agents
Juliano, R. L., Alam, R., Dixit, V., & Kang, H. M. (2009) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.4 · Cited by 76 · see citing works
Involvement of TRPC Channels in CCL2-Mediated Neuroprotection against Tat Toxicity
Yao, H., Peng, F., Dhillon, N. K., Callen, S. E., Bokhari, S. M., Stehno‐Bittel, L., Ahmad, S. O., Wang, J. Q., & Buch, S. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2781-08.2009 · Cited by 72 · see citing works
Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform
Slatter, T. L., Hung, N. A., Campbell, H. G., Rubio, C., Mehta, R., Renshaw, P., Williams, G., Wilson, M., Engelmann, A., Jeffs, A. R., et al. (2011) · Blood · doi:10.1182/blood-2010-11-321851 · Cited by 72 · see citing works
Regulatory role of p53 in experimental autoimmune encephalomyelitis
Okuda, Y., Okuda, M., & Bernard, C. C. A. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00428-9 · Cited by 69 · see citing works
Shaulian, E., Zauberman, A., Milner, J., Davies, E. A., & Oren, M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05940.x · Cited by 68 · see citing works
Scanu, A., Oliviero, F., Gruaz, L., Sfriso, P., Pozzuoli, A., Frezzato, F., Agostini, C., Burger, D., & Punzi, L. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2930 · Cited by 66 · see citing works
Dwarakanath, R. S., Sahar, S., Reddy, M. A., Castanotto, D., Rossi, J. J., & Natarajan, R. D. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.02.007 · Cited by 64 · see citing works
Chen, Y., Chiang, W., Lin, S., Wu, K., Tsai, T., & Hsieh, B. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.062620 · Cited by 63 · see citing works
Regulation of MCP-1 chemokine transcription by p53
Hacke, K., Rincon-Orozco, B., Buchwalter, G., Siehler, S. Y., Wasylyk, B., Wiesmüller, L., & Rösl, F. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-82 · Cited by 63 · see citing works
Tanaka, K., Kurebayashi, J., Sohda, M., Nomura, T., Prabhakar, U., Li, Y., & Sonoo, H. (2008) · Thyroid · doi:10.1089/thy.2008.0237 · Cited by 57 · see citing works
Lehmann, M. H., Masanetz, S., Kramer-Hämmerle, S., & Erfle, V. (2006) · Journal of Cell Science · doi:10.1242/jcs.03231 · Cited by 57 · see citing works
Yang, S. J., IglayReger, H. B., Kadouh, H. C., & Bodary, P. F. (2009) · Diabetologia · doi:10.1007/s00125-009-1309-8 · Cited by 57 · see citing works
Kaustov, L., Lukin, J. A., Lemak, A. S., Duan, S., Ho, M., Doherty, R., Penn, L. Z., & Arrowsmith, C. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611297200 · Cited by 54 · see citing works
Lawrence, D. M. P., Seth, P., Durham, L. C., Diaz, F., Boursiquot, R., Ransohoff, R. M., & Major, E. O. (2005) · Glia · doi:10.1002/glia.20261 · Cited by 53 · see citing works
Chemokines as novel therapeutic targets in inflammatory diseases
Ajuebor, M. N., Swain, M. G., & Perretti, M. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)00854-7 · Cited by 51 · see citing works
Bleomycin Sensitivity of Mice Expressing Dominant-Negative p53 in the Lung Epithelium
Ghosh, S., Mendoza, T. M., Ortiz, L. A., Hoyle, G. W., Fermin, C. D., Brody, A. R., Friedman, M. B., & Morris, G. F. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2109094 · Cited by 43 · see citing works
Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells
Marra, F., Delogu, W., Petrai, I., Pastacaldi, S., Bonacchi, A., Efsen, E., Aleffi, S., Bertolani, C., Pinzani, M., & Geñtilini, P. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00336.2003 · Cited by 43 · see citing works
Bernatoniene, J., Zhang, Q., Doğan, S., Mitchell, T. J., Paton, J. C., & Finn, A. H. R. (2008) · The Journal of Infectious Diseases · doi:10.1086/593177 · Cited by 41 · see citing works
Baum, N., Schiene‐Fischer, C., Frost, M., Schümann, M., Sabapathy, K., Ohlenschläger, O., Große, F., & Schlott, B. (2009) · Oncogene · doi:10.1038/onc.2009.248 · Cited by 38 · see citing works
Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE−/− mice
Tam, S. P., Ancsin, J. B., Tan, R., & Kisilevsky, R. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500191-jlr200 · Cited by 38 · see citing works
MCP1 Directs Trafficking of Hematopoietic Stem Cell-Derived Fibroblast Precursors in Solid Tumor
Abangan, R. S., WILLIAMS, C. R., Mehrotra, M., Duncan, J. D., & LaRue, A. C. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.080839 · Cited by 33 · see citing works
Secretion of Monocyte Chemoattractant Protein-1 (MCP-1) by Human Mononuclear Phagocytes
Leonard, E. J., Skeel, A., Yoshimura, T., & Rankin, J. A. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2952-1_7 · Cited by 25 · see citing works
Tang, X., Molina, M., & Amar, S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1600 · Cited by 23 · see citing works
Self-citationShimomura, H., Matsuura, M., Saito, S., Hirai, Y., Isshiki, Y., & Kawahara, K. (2001) · Infection and Immunity · doi:10.1128/iai.69.6.3663-3669.2001 · Cited by 22 · see citing works
Khiati, A., Chaloin, O., Muller, S., Tardieu, M., & Horellou, P. (2010) · Journal of NeuroVirology · doi:10.3109/13550281003735691 · Cited by 19 · see citing works
McIntosh, L. M., Barnes, J. L., Barnes, V. L., & McDonald, J. R. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03819.x · Cited by 18 · see citing works
Sabath, D. E., Koehler, K. M., Yang, W., Phan, V. N., & Wilson, J. (1998) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.1998.0185 · Cited by 16 · see citing works
Kondo, M., Maegawa, H., Obata, T., Ugi, S., Ikeda, K., Morino, K., Nakai, Y., Nishio, Y., Maeda, S., & Kashiwagi, A. (2008) · Endocrinology · doi:10.1210/en.2008-1361 · Cited by 12 · see citing works
MH2 domain of Smad3 reduces HIV-1 Tat-induction of cytokine secretion
Eldeen, M. B., Deshmane, S. L., Simbiri, K. O., Khalili, K., Amini, S., & Sawaya, B. E. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.04.004 · Cited by 12 · see citing works
p53 Peptide Prevents LITAF-Induced TNF-Alpha-Mediated Mouse Lung Lesions and Endotoxic Shock
Tang, X., O'Reilly, A., Asano, M., Merrill, J. C., Yokoyama, K. K., & Amar, S. (2011) · Current Molecular Medicine · doi:10.2174/156652411796268731 · Cited by 11 · see citing works
Self-citationNeidhart (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200012)43:12 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [28]Kondo M Maeqawa H Obata T Transcription factor activating protein-2beta: a positive regulator of monocyte chemoattractant protein-1 gene expression Endocrinology 2009 150 1654 61 19022887
- [60]Hacke K Rincon-Orozco B Buchwalter G Regulation of MCP-1 chemokine transcription by p53 Mol Cancer 2010 9 82 93 20406462 PMC2864217
Cited by
Sorted by citations
Iannello, A., Thompson, T. W., Ardolino, M., Lowe, S. W., & Raulet, D. H. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130783 · Cited by 414 · see citing works
Whitmore, S. E., & Lamont, R. J. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003933 · Cited by 319 · see citing works
Walton, J. B., Blagih, J., Ennis, D. P., Leung, E. Y. L., Dowson, S., Farquharson, M., Tookman, L. A., Orange, C., Athineos, D., Mason, S. M., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1272 · Cited by 232 · see citing works
TP53 gain-of-function mutation promotes inflammation in glioblastoma
Ham, S. W., Jeon, H.-Y., Jin, X., Kim, E.-J., Kim, J.-K., Shin, Y. J., Lee, Y., Kim, S. H., Lee, S. Y., Seo, S., et al. (2019) · Cell Death & Differentiation · doi:10.1038/s41418-018-0126-3 · Cited by 213 · see citing works
The role of p53 in anti-tumor immunity and response to immunotherapy
Carlsen, L., Zhang, S., Tian, X., Cruz, A. D. L., George, A., Arnoff, T. E., & El‐Deiry, W. S. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1148389 · Cited by 92 · see citing works
Nahta, R., Al‐Mulla, F., Al-Temaimi, R. A., Amedei, A., Andrade-Vieira, R., Bay, S., Brown, D. G., Calaf, G. M., Castellino, R. C., Cohen-Solal, K., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv028 · Cited by 61 · see citing works
Immune Surveillance of Unhealthy Cells by Natural Killer CellsPreprint
Iannello, A., & Raulet, D. H. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.020255 · Cited by 54 · see citing works
Hu, Z., Brooks, S. A., Dormoy, V., Hsu, C.-W., Hsu, H.-Y., Lin, L., Massfelder, T., Rathmell, W. K., Xia, M., Al‐Mulla, F., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv036 · Cited by 51 · see citing works
Liu, X., Fang, S., Liu, H., Wang, X., Dai, X., Yin, Q., Yun, T., Wang, W., Zhang, Y., Liao, H., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.07.002 · Cited by 48 · see citing works
Wang, W., Liu, H., Dai, X., Fang, S., Wang, X., Zhang, Y., Yao, H., Zhang, X., & Chao, J. (2015) · Scientific Reports · doi:10.1038/srep16900 · Cited by 42 · see citing works
Lü, Z., Zou, J., Hu, Y., Li, S., Zhou, T. Y., Gong, J., Li, J., Zhang, X., Zhou, J., Lu, M. S., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.7621 · Cited by 37 · see citing works
Uddin, M. A., & Barabutis, N. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102952 · Cited by 35 · see citing works
The Link between Regional Tidal Stretch and Lung Injury during Mechanical Ventilation
Yen, S., Preissner, M., Bennett, E., Dubsky, S., Carnibella, R. P., O’Toole, R., Roddam, L. F., Jones, H. D., Dargaville, P. A., Fouras, A., et al. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0143oc · Cited by 35 · see citing works
Modulation of immune responses by the tumor suppressor p53
Lowe, J. M., Shatz, M., Resnick, M. A., & Menéndez, D. (2013) · Biodiscovery · doi:10.7750/biodiscovery.2013.8.2 · Cited by 29 · see citing works
Kim, S., Sy, V., Araki, T., Babushkin, N., Huang, D., Tan, D., Liao, E. P., Liu, C., Wan, S., Poretsky, L., et al. (2013) · Journal of Diabetes · doi:10.1111/1753-0407.12114 · Cited by 22 · see citing works
Song, J., Lee, B., Kang, S., Oh, Y., Kim, E., Kim, C. H., Song, H., & Lee, J. E. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.1.24 · Cited by 22 · see citing works
Leibovich-Rivkin, T., Liubomirski, Y., Meshel, T., Abashidze, A., Brisker, D., Solomon, H., Rotter, V., Weil, M., & Ben‐Baruch, A. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-158 · Cited by 20 · see citing works
Guo, S., Liu, R., Wen, Y., Liu, L., Li, Y., Li, Y.-X., Li, Y., Hao, W., Peng, J., Chen, D., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.10.008 · Cited by 14 · see citing works
RetractedThe Photomodulation Activity of Metformin Against Oral Microbiome
Afrasiabi, S., Pourhajibagher, M., & Bahador, A. (2019) · Journal of lasers in medical sciences · doi:10.15171/jlms.2019.39 · Cited by 11 · see citing works
Bala, S., Calenda, C. D., Catalano, D. E., Babuta, M., Kodys, K., Nasser, I. A., Vidal, B., & Szabó, G. (2020) · Hepatology Communications · doi:10.1002/hep4.1540 · Cited by 9 · see citing works
p53 suppresses CCL2-induced subcutaneous tumor xenograft
Tang, X., & Amar, S. (2014) · Tumor Biology · doi:10.1007/s13277-014-2906-9 · Cited by 7 · see citing works
Self-citationThe Key Network of mRNAs and miRNAs Regulated by HIF1A in Hypoxic Hepatocellular Carcinoma Cells
Liu, T., Tang, J. Y., Li, X., Lin, Y., Yang, Y., Ma, K., Hui, Z., Ma, H., Qin, Y., Lei, H., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.857507 · Cited by 6 · see citing works
Self-citationFrom Genome Guardian to Immune Modulator: The Expanding Roles of Tumor Suppressor p53
Wang, W., Liu, J., Feng, Z., & Hu, W. (2025) · Molecular and Cellular Biology · doi:10.1080/10985549.2025.2571187 · Cited by 4 · see citing works
AT2R Activation Improves Wound Healing in a Preclinical Mouse Model
Harrison, J. M., Leong, E. K., Osborne, N. D., Marshall, J. S., & Bezuhly, M. (2024) · Biomedicines · doi:10.3390/biomedicines12061238 · Cited by 3 · see citing works
Lenka, S., Bhuyan, S. K., & Bhuyan, R. (2022) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-022-00306-z · Cited by 2 · see citing works
CellsSurveillance of Unhealthy Cells by Natural Killer
Iannello, A., & Raulet, D. H. (2013)
Keinan, G., Sayal, K., Gonen, A., Zhu, J., Granovsky, L., & England, J. L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.20.533433
Zhang, Y., He, Y., Ding, Y., & Liu, C. (2022) · PubMed Central · doi:10.7518/hxkq.2022.01.014
Chan, Q., Liang, W., Flisikowska, T., Ebner, F., & Flisikowski, K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1837646
- Authors
- Tang, X., Asano, M., O’Reilly, A., Farquhar, A., Yang, Y., & Amar, S.
- Affiliations
- Boston University (US)
- Venue
- Current Molecular Medicine
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-08-01
- Volume
- 12
- Issue
- 8
- Pages
- 929-943
- ISSN
- 1566-5240 (ISSN-L)
- PMC
- PMC3786129
- OpenAlex
- W2078374333
- Cited by
- 30
- References
- 70
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 6
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (R01DE014079)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- p53, MCP-1, gene expression regulation, 5' untranslated region, macrophages, lipopolysaccharide, promoter activity, inflammation, chemokine induction
- MeSH terms
- Animals, Base Sequence, Binding Sites, Gene Expression Regulation, Humans, Lipopolysaccharides, Luciferases, Macrophages, Molecular Sequence Data, Peptide Fragments, Promoter Regions, Genetic, Transcriptional Activation, Tumor Suppressor Protein p53, Genes, Reporter, Mice, Knockout, Inflammation Mediators, Chemokine CCL2, 5' Untranslated Regions, Cell Line, Tumor, Mice, Interleukin-1beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
