Microsphere based improved sunscreen formulation of ethylhexyl methoxycinnamate
Abstract
Polymethylmethacrylate (PMMA) microspheres of ethylhexyl methoxycinnamate (EHM) were prepared by emulsion solvent evaporation method to improve its photostability and effectiveness as sunscreening agent. Process parameters like stirring speed and aqueous polyvinyl alcohol (PVA) concentration were analyzed in order to optimize the formulations. Shape and surface morphology of the microspheres were examined using scanning electron microscopy. Particle size of the microspheres was determined using laser diffraction particle size analyzer. The PMMA microspheres of EHM were incorporated in water-removable cream base. The in vitro drug release of EHM in pH 7.4 was performed using dialysis membrane. Thin layer chromatography was performed to determine photostability of EHM inside the microspheres. The formulations were evaluated for sun protection factor (SPF) and minimum erythema dose (MED) in albino rats. Cream base formulation containing microspheres prepared using EHM:PMMA in ratio of 1:3 (C(3)) showed slowest drug (EHM) release and those prepared with EHM: PMMA in ratio of 1:1 showed fastest release. The cream base formulations containing EHM loaded microspheres had shown better SPF (more than 16.0) as compared to formulation C(d) that contained 3% free EHM as sunscreen agent and showed SPF 4.66. These studies revealed that the incorporation of EHM loaded PMMA microspheres into cream base had greatly increased the efficacy of sunscreen formulation approximately four times. Furt…
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The efficacy of octinoxate (OMC) can be increased when it is encapsulated in polymethylmethacrylate microspheres.
“The efficacy of OMC can be further increased when encapsulated in polymethylmethacrylate microsphere (76).”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [76]
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Photoprotection: a Review of the Current and Future Technologies
Wang, S. Q., Balagula, Y., & Osterwalder, U. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2009.01289.x · Cited by 294 · see citing works
- Authors
- Gogna, D., Jain, S., Yadav, A., & Agrawal, G.
- Affiliations
- Dr. Hari Singh Gour University (IN)
- Shree Dhanvantary Pharmacy College (IN)
- Corresponding author
- Agrawal, G.
- Venue
- Current Drug Delivery
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2007-04-01
- Volume
- 4
- Issue
- 2
- Pages
- 153-159
- ISSN
- 1567-2018 (ISSN-L)
- OpenAlex
- W2157803996
- Cited by
- 30
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- ethylhexyl methoxycinnamate, poly(methyl methacrylate) microspheres, sunscreen formulation, photostability, emulsion solvent evaporation, controlled drug release, sun protection factor, minimal erythema dose, polyvinyl alcohol
- MeSH terms
- Animals, Chemistry, Pharmaceutical, Chromatography, Thin Layer, Cinnamates, Dose-Response Relationship, Radiation, Drug Carriers, Drug Compounding, Drug Stability, Erythema, Hydrogen-Ion Concentration, Lasers, Microscopy, Electron, Scanning, Microspheres, Ointment Bases, Particle Size, Photolysis, Polyvinyl Alcohol, Radiation Injuries, Experimental, Scattering, Radiation, Solubility, Sunscreening Agents, Surface Properties, Technology, Pharmaceutical, Ultraviolet Rays, Polymethyl Methacrylate, Rats
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