TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects
Abstract
We recently revealed that p.H157Y (rs2234255), a rare coding variant of triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer's disease (AD) susceptibility in Han Chinese. Contrastingly, although p.H157Y was previously identified in both AD cases and controls by several sequencing studies, no association of this variant with disease susceptibility was reported. To gain a credible conclusion on the association between p.H157Y and AD risk, a meta-analysis involving 7,102 cases and 7,408 controls was conducted. Our results indicated that p.H157Y was associated with an increased risk of AD (OR=3.65, 95% CI: 1.61-8.28; P=0.002), further establishing TREM2 as an important susceptibility gene for this disease.
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Homozygous Q33X, Y38C and T66M variants have been identified in patients with Nasu-Hakola disease.
“Homozygous Q33X, Y38C and T66M variants have been identified in patients with Nasu-Hakola disease [44, 47, 95].”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [47]
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TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation
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Obst, J., Hall-Roberts, H. L., Smith, T. B., Kreuzer, M., Magno, L., Di Daniel, E., Davis, J. B., & Mead, E. (2021) · Scientific Reports · doi:10.1038/s41598-021-96144-7 · Cited by 36 · see citing works
- Authors
- Jiang, T., Hou, J.-K., Gao, Q., Yu, J.-T., Zhou, J.-S., Zhao, H.-D., & Zhang, Y.-D.
- Affiliations
- Nanjing First Hospital (CN)
- Venue
- Current Neurovascular Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2016-09-28
- Volume
- 13
- Issue
- 4
- Pages
- 318-320
- ISSN
- 1567-2026 (ISSN-L)
- OpenAlex
- W2513053838
- Cited by
- 36
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 4
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Neurovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- TREM2, Alzheimer's disease, genetic susceptibility, Han Chinese, myeloid cells, disease risk
- MeSH terms
- Alzheimer Disease, Humans, Membrane Glycoproteins, Mutation, Receptors, Immunologic, Risk Factors, Genetic Predisposition to Disease, Asian People
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