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Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic

Bader, I., Groot, C., Tan, H. S., Milongo, J.-M. A., den Haan, J., Verberk, I. M. W., Yong, K. X. X., Orellina, J. A., Campbell, S. R., Wilson, D., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01545-1 · Cited by 12 · see citing works

Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma

Masson, E., Serrano, J., Léger-Charnay, E., & Acar, N. (2024) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1303649 · Cited by 11 · see citing works

The APOE E4 Allele Is Associated with Faster Rates of Neuroretinal Thinning in a Prospective Cohort Study of Suspect and Early Glaucoma

Mullany, S., Marshall, H. N., Díaz‐Torres, S., Berry, E. C., Schmidt, J. M., Thomson, D., Qassim, A., To, M., Dimasi, D. P., Kuot, A., et al. (2022) · Ophthalmology Science · doi:10.1016/j.xops.2022.100159 · Cited by 11 · see citing works

Genetic Factors Implicated in the Investigation of Possible Connections between Alzheimer’s Disease and Primary Open Angle Glaucoma

Kuang, G., Salowe, R., & O’Brien, J. M. (2023) · Genes · doi:10.3390/genes14020338 · Cited by 11 · see citing works

Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications

Zong, F., You, J., Wu, H., & Wang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1640110 · Cited by 10 · see citing works

Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic Avenues

Vasconcelos, C. F. M., Ribas, V. T., & Petrs‐Silva, H. (2023) · Cells · doi:10.3390/cells12172155 · Cited by 11 · see citing works

Background polygenic risk modulates the association between glaucoma and cardiopulmonary diseases and measures: an analysis from the UK Biobank

Kolli, A., Sekimitsu, S., Wang, J., Segrè, A. V., Friedman, D. S., Elze, T., Pasquale, L. R., Wiggs, J. L., & Zebardast, N. (2022) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2021-320305 · Cited by 10 · see citing works

Inverse Association of APOE ε4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging

Freeman, E. E., Bastasic, J., Grant, A., Leung, G., Li, G., Buhrmann, R., & Roy‐Gagnon, M. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.13.9 · Cited by 8 · see citing works

Evaluating the Optic Nerve Crush Model to Understand the Function of Microglia in Glaucoma Neuroprotection

Gu, X., Truong, T., Heaster, T. M., Kim, T., Kang, G. J., Yung, J., Baca, M., Chaney, S. Y., Hofmann, J. W., Eastham, J., et al. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.12.56 · Cited by 7 · see citing works

A common 19 bp APOE enhancer deletion is protective against Alzheimer’s disease in African Americans

Brutman, J. N., Busald, T., Nizamis, E., Kaufman, E. J., Lin, E., Hendricks, N. E., Chintamen, S., Sulovari, A., Smukowski, S. N., Ye, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68808-3 · Cited by 7 · see citing works

No Strong Association between the Apolipoprotein E E4 Allele and Glaucoma

Mullany, S., Díaz‐Torres, S., Schmidt, J. M., Thomson, D., Qassim, A., Marshall, H. N., Knight, L. S. W., Berry, E. C., Kolovos, A., Dimasi, D. P., et al. (2023) · Ophthalmology Science · doi:10.1016/j.xops.2023.100287 · Cited by 7 · see citing works

Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies

Ward, E., Benowitz, L. I., Brunner, T. M., Bu, G., Cayouette, M., Canto-Soler, V., Mesquita, S. D., Polo, A. D., DiAntonio, A., Duan, X., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00858-5 · Cited by 7 · see citing works

Role of APOE in glaucoma.

Yi, W.-H., Lv, D., Sun, Y., Mu, J.-Y., & Lu, X. (2023) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2023.149414 · Cited by 7 · see citing works

A Component or Multiple Components of Bleeding Gums May Ameliorate Both Glaucoma and Alzheimer’s Disease

Lehrer, S. P., Rheinstein, P. H., & Schmeidler, J. (2022) · Cureus · doi:10.7759/cureus.21004 · Cited by 4 · see citing works

Female-Specific Association between the Apolipoprotein E E4 Allele and Age at Diagnosis of Glaucoma in UK Biobank

Shi, Y., Hu, J., Liu, W. J., Qiu, W. Q., He, X., Zhang, M., Gao, Y., Zhang, X., & Fan, Z. (2024) · Ophthalmology Glaucoma · doi:10.1016/j.ogla.2024.07.009 · Cited by 3 · see citing works

Transcriptome Profiling of Trabecular Meshwork Progenitor Cells

Fan, X., Kennedy, S., Bilir, E. K., Lane, B. S., Kingston, O. A., Xu, C., Kearns, V., Willoughby, C. E., & Sheridan, C. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10900-0 · Cited by 3 · see citing works

Lipid metabolism disorder promoting retinal structural and functional damage in ApoE−/− mice with age superposition

Yang, R., Chen, S.-L., Ng, T. K., Liang, J., Huang, S., Deng, M., Wu, Z., Sun, Y., Fu, C., Pang, C. P., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02043-7 · Cited by 3 · see citing works

The Role of Menopause and Its Association with the Apolipoprotein E4 Allele for Age at Diagnosis of Glaucoma in Women

Shi, Y., Liu, W. J., Hu, J., Qiu, W. Q., He, X., Gao, Y., Zhang, X., & Fan, Z. (2025) · Ophthalmology Science · doi:10.1016/j.xops.2025.100726 · Cited by 2 · see citing works

Leveraging Alzheimer’s Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma

Tolosa‐Tort, P., & DeWan, A. T. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05074-2 · Cited by 2 · see citing works

Associations of diabetes mellitus with primary open angle glaucoma and Alzheimer’s disease: a large cohort study in UK biobank

Shi, Y., He, X., Liu, W. J., Hu, J., Qiu, W. Q., Zhang, X., & Fan, Z. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1506560 · Cited by 3 · see citing works

Common Variants rs429358 and rs7412 in APOE Gene Are Not Associated with POAG in a Saudi Cohort

Kondkar, A. A., Sultan, T., Azad, T. A., Khatlani, T., Alshehri, A., Osman, E. A., Lobo, G. P., Almobarak, F. A., & Al‐Obeidan, S. A. (2024) · Biology · doi:10.3390/biology13010062 · Cited by 2 · see citing works

Exploring the role of apolipoprotein E gene promoter polymorphisms in susceptibility to normal-tension glaucoma in a Korean population

Park, Y. J., Shin, H., & Kim, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-58442-8 · Cited by 2 · see citing works

Association of High-Density Lipoprotein Cholesterol with Macular Structure in Nonglaucomatous Individuals

Inooka, T., Tomita, R., Suzumura, A., Fujikawa, S., Kimura, Y., Kominami, T., Kojima, T., Ueno, S., Ito, Y., Nishiguchi, K. M., et al. (2026) · Ophthalmology Science · doi:10.1016/j.xops.2026.101073 · Cited by 1 · see citing works

The utility of aqueous and serum apolipoprotein E and galectin-3 as biomarkers of neuroinflammation in glaucoma

Helwe, H. E., Falah, H. K., Xue, Y., Baldwin, G., Vasan, R. A., Song, C., Lo, K., Meeker, A., Wang, S. L., Valle, D. S.-D., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-45007-0 · Cited by 1 · see citing works

Neuroinflammation and mononuclear phagocytes in glaucoma: From ocular pathogenesis to central visual pathway involvement — A comprehensive review

Bastelica, P., Reboussin, É., Przegralek, L., Darche, M., Buffault, J., Goazigo, A. R.-L., Labbé, A., Parsadaniantz, S. M., & Baudouin, C. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119648 · Cited by 1 · see citing works

Neuroinflammation in glaucoma: a myriad of cellular pathways and players

MacLean, M., Lydon, S. D., Gomes, C., Pizzi, E. M., Diemler, C. A., Yablonski, S. E. R., Howell, G. R., Meyer, J. S., & Libby, R. T. (2026) · Mammalian Genome · doi:10.1007/s00335-026-10253-0 · Cited by 1 · see citing works

APOE ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin

Kondkar, A. A., Azad, T. A., Sultan, T., Khatlani, T., Alshehri, A., Radhakrishnan, R., Lobo, G. P., Alsirhy, E. Y., Almobarak, F. A., Osman, E. A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084571 · Cited by 1 · see citing works

Artificial Intelligence and Glaucoma

Liu, S., You, Y., & Graham, S. L. (2021) · Current practices in ophthalmology · doi:10.1007/978-981-16-0634-2_6

Distribution of rare LOXL1 missense alleles, haplotypes, and diplotypes suggests association with reduced risk of glaucoma-related exfoliation syndromePreprint

Aboobakar, I. F., Igo, R. P., Kinzy, T. G., Bailey, J. N. C., Khor, C. C., Aung, T., Ritch, R., Sit, A. J., Lee, R. K., Pericak‐Vance, M. A., et al. (2021) · medRxiv · doi:10.1101/2021.08.05.21261676

Ophthalmology Perspective on The Theory of Amyloid Beta Toxicity: Implications on Future Studies

AlRyalat, S. A., Alshrouf, M. A., AlMomani, A., & Ryalat, A. T. (2024) · High Yield Medical Reviews · doi:10.59707/hymrligd8327

“Optic nerve of steel”: A case of very high intraocular pressures with markedly little visual field progression over years

Xue, Y., & Margeta, M. A. (2025) · American Journal of Ophthalmology Case Reports · doi:10.1016/j.ajoc.2025.102325

Implication de CYP27A1 dans le métabolisme du cholestérol rétinien, les interactions glie-neurones et l’intégrité rétinienne : une approche multi-modèles

Urban, J. (2024) · doi:10.70675/f982bab0z1b03z4cc0zbdafzac11ae1deb5c

Biomarkers in Glaucoma: From Diagnosis to Future Therapeutic Strategies

Merugu, S., Vyas, J., Soni, G., & Yadav, K. S. (2026) · MedComm – Future Medicine · doi:10.1002/mef2.70073

Should ApoE4 gene editing therapy be approached with caution when AD is accompanied by retinal neurodegenerative diseases?

Wenhua, Y., Wenjing, M., Yan, D., Fei, L., Chen, J., Xia, T., Guan, Y., Xin, L., Huang, Y., Guo, Y., et al. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1934307

Apolipoprotein E Polymorphisms in Patients With Primary Open-Angle Glaucoma

Zetterberg, M., Tasa, G., Palmér, M. S., Juronen, E., Teesalu, P., Blennow, K., & Zetterberg, H. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.01.031 · Cited by 38 · see citing works

Neurodegenerative Genes Polymorphisms of the -491A/T APOE , the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population

Nowak, A., Przybyłowska-Sygut, K., Gacek, M., Kamińska, A., Szaflik, J. P., Szaflik, J., & Majsterek, I. (2013) · Ophthalmic Genetics · doi:10.3109/13816810.2013.838277 · Cited by 5 · see citing works

An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma.

Liao, R., Ye, M.-J., & Xu, X. (2014) · PubMed · Cited by 16 · see citing works

The Role of Apolipoprotein E Gene Polymorphisms in Primary Open-angleGlaucoma

Ressiniotis, T. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.2.258 · Cited by 48 · see citing works

“Association of APOE gene polymorphisms with primary open angle glaucoma in Brazilian patients”

Occhiutto, M. L., de Melo, M. B., de Vasconcellos, J. P. C., Rodrigues, T. A. R., Bajano, F. F., Costa, F. F., & Costa, V. P. (2020) · Ophthalmic Genetics · doi:10.1080/13816810.2020.1849314 · Cited by 6 · see citing works