The DOI matches its Crossref record; 145 of the 146 references it cites were found in a registry or an index.
Lipid Alterations in the Earliest Clinically Recognizable Stage of Alzheimers Disease: Implication of the Role of Lipids in the Pathogenesis of Alzheimers Disease
Abstract
Lipids have many important yet distinct functions in cellular homeostasis such as forming an impermeable barrier separating intracellular and extracellular compartments, providing a matrix for the appropriate interactions of membrane-associated proteins, and serving as storage reservoirs for biologically active second messengers. Alterations in cellular lipids may therefore result in abnormal cellular functions. This review summarizes the results from the examination of lipid alterations in Alzheimer's disease (AD). In addition to the effects of cholesterol on AD, substantial depletions of plasmalogen and sulfatide as well as dramatic increases in ceramide are specifically manifested at the earliest clinically recognizable stage of AD. The potential mechanism(s) underlying these changes and the potential consequences of these changes in neuronal function and in AD development are also discussed. Collectively, this review will provide an overview of the lipid alterations in Alzheimer's disease and the relationship of these lipid alterations with the development of AD pathogenesis.
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“Notably, previous studies have shown that the lipids that were or tended to be decreased in PLCG2 KO mice (cerebrosides, sulfatides and plasmalogens) have been also reported to be decreased early in AD (39–41).”
From Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain (2023) · cites this paper as [40]
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1 retracted
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RetractedThe Clinical Dementia Rating (CDR): Current version and scoring rules
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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
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Triglyceride accumulation protects against fatty acid-induced lipotoxicity
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Self-citationApolipoprotein E: Far More Than a Lipid Transport Protein
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Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain
Hopp, S. C., Rogers, J. G., Smith, S., Campos, G., Miller, H., Barannikov, S., Kuri, E. G., Wang, H., Han, X., Bieniek, K. F., et al. (2023) · doi:10.1101/2023.12.06.570499 · Cited by 4
Self-citation
Metadata
- Authors
- Han, X.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Han, Xianlin
- ORCID
- Han, Xianlin
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-01-01
- Volume
- 2
- Issue
- 1
- Pages
- 65-77
- ISSN
- 1567-2050 (ISSN-L)
- OpenAlex
- W1986724957
- Cited by
- 183
- References
- 146
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01 AG0 3991, P01AG003991)
- National Heart, Lung, and Blood Institute (P01HL57278, P01HL057278)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, lipid changes, cholesterol, plasmalogens, sulfatide, ceramide, Alzheimer's disease pathogenesis, neuronal function, membrane lipids
- MeSH terms
- Alzheimer Disease, Apolipoproteins E, Ceramides, Cholesterol, Humans, Plasmalogens, Sulfoglycosphingolipids
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