Han, Xianlin

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 2,075

Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics

Han, X., & Gross, R. W. (2003) · Journal of Lipid Research

Metabolomics and Mass Spectrometry StudiesMass Spectrometry Techniques and Applications

Cited by 914

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

MahmoudianDehkordi, S., Arnold, M., Nho, K., Ahmad, S., Jia, W., Xie, G., Louie, G., Kueider‐Paisley, A., Moseley, M. A., Thompson, J. W., et al. (2019) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchGut microbiota and health

Cited by 706

Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

Han, X., M. Holtzman, D., W. McKeel, D., Kelley, J., & Morris, J. C. (2002) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsSphingolipid Metabolism and Signaling

Cited by 626

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Kumashiro, N., Erion, D. M., Zhang, D., Kahn, M., Beddow, S. A., Chu, X., Still, C. D., Gerhard, G. S., Han, X., Dziura, J., et al. (2011) · Proceedings of the National Academy of Sciences

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 585

A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content

Finck, B. N., Han, X., Courtois, M., Aimond, F., Nerbonne, J. M., Kovacs, A., Gross, R. W., & Kelly, D. P. (2003) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsCardiovascular Function and Risk Factors

Cited by 501

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE

Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismAlzheimer's disease research and treatments

Cited by 474

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

Han, X., Rozen, S., Boyle, S. H., Hellegers, C., Cheng, H., Burke, J. R., Welsh-Bohmer, K. A., Doraiswamy, P. M., & Kaddurah-Daouk, R. (2011) · PLoS ONE

Sphingolipid Metabolism and SignalingDementia and Cognitive Impairment Research

Cited by 429

Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism

Circadian rhythm and melatoninDietary Effects on Health

Cited by 410

Quantitative Analysis and Molecular Species Fingerprinting of Triacylglyceride Molecular Species Directly from Lipid Extracts of Biological Samples by Electrospray Ionization Tandem Mass Spectrometry

Han, X., & Gross, R. W. (2001) · Analytical Biochemistry

Mass Spectrometry Techniques and ApplicationsMetabolomics and Mass Spectrometry Studies

Cited by 358

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

Nho, K., Kueider‐Paisley, A., MahmoudianDehkordi, S., Arnold, M., Risacher, S. L., Louie, G., Blach, C., Baillie, R., Han, X., Kastenmüller, G., et al. (2019) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 343

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology

Alzheimer's disease research and treatmentsSphingolipid Metabolism and Signaling

Cited by 280

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration

Liu, Q., Trotter, J., Zhang, J., Peters, M. M., Cheng, H., Bao, J., Han, X., Weeber, E. J., & Bu, G. (2010) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 268

CD36 Deficiency Rescues Lipotoxic Cardiomyopathy

Yang, J., Sambandam, N., Han, X., Gross, R. W., Courtois, M., Kovacs, A., Febbraio, M., Finck, B. N., & Kelly, D. P. (2007) · Circulation Research

Peroxisome Proliferator-Activated ReceptorsCardiovascular Function and Risk Factors

Cited by 246

Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers

Nho, K., Kueider-Paisley, A., Ahmad, S., MahmoudianDehkordi, S., Arnold, M., Risacher, S. L., Louie, G., Blach, C., Baillie, R., Han, X., et al. (2019) · JAMA Network Open

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 227

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease

Baloni, P., Funk, C. C., Yan, J., Yurkovich, J. T., Kueider-Paisley, A., Nho, K., Heinken, A., Jia, W., Mahmoudiandehkordi, S., Louie, G., et al. (2020) · Cell Reports Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 211

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Arnold, M., Nho, K., Kueider-Paisley, A., Massaro, T., Huynh, K., Brauner, B., MahmoudianDehkordi, S., Louie, G., Moseley, M. A., Thompson, J. W., et al. (2020) · Nature Communications

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 202

Microfluidics‐based electrospray ionization enhances the intrasource separation of lipid classes and extends identification of individual molecular species through multi‐dimensional mass spectrometry: development of an automated high‐throughput platform for shotgun lipidomics

Han, X., Yang, K., & Gross, R. W. (2008) · Rapid Communications in Mass Spectrometry

Mass Spectrometry Techniques and ApplicationsMetabolomics and Mass Spectrometry Studies

Cited by 190

Lipid Alterations in the Earliest Clinically Recognizable Stage of Alzheimers Disease: Implication of the Role of Lipids in the Pathogenesis of Alzheimers Disease

Han, X. (2005) · Current Alzheimer Research

Alzheimer's disease research and treatmentsSphingolipid Metabolism and Signaling

Cited by 183

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J., Sullivan, P. M., Fagan, A. M., Han, X., & Holtzman, D. M. (2001) · Neurochemistry International

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 180

Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

Horgusluoglu, E., Neff, R., Song, W., Wang, M., Wang, Q., Arnold, M., Krumsiek, J., Galindo‐Prieto, B., Ming, C., Nho, K., et al. (2022) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 175

The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis

Lehman, J. J., Boudina, S., Banke, N. H., Sambandam, N., Han, X., Young, D. M., Leone, T. C., Gross, R. W., Lewandowski, E. D., Abel, E. D., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 158

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease

Huynh, K., Lim, W. L. F., Giles, C., Jayawardana, K. S., Salim, A., Mellett, N. A., Smith, A. A. T., Olshansky, G., Drew, B. G., Chatterjee, P., et al. (2020) · Nature Communications

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 154

Hepatocyte-Macrophage Acetoacetate Shuttle Protects Against Tissue Fibrosis

Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J., & Crawford, P. A. (2019) · Cell Metabolism

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 138