Bridging neurocognitive aging and disease modification: targeting functional mechanisms of memory impairment
Open accessAbstract
Risk for Alzheimers disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a persons age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimers disease. Keywords: Memory, mild cognitive impairment, hippocampus, dentate gyrus/CA3, pattern separation, pattern completion, animal models, neuroimaging
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Hippocampal function declines with age and is often measured by fear conditioning, which measures short-term memory.
“Hippocampal function, critical for spatial and memory consolidation, declines with age (Gallagher et al., 2010; Miller and O’Callaghan, 2005; Park and Reuter-Lorenz, 2009) and is often measured by fear-conditioning, which measures short-term memory.”
From Loss of epigenetic information as a cause of mammalian aging (2023) · cites this paper as Gallagher et al., 2010
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Cites
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Loss of epigenetic information as a cause of mammalian aging
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- Authors
- Gallagher, M., Bakker, A., Yassa, M. A., & Stark, C. E. L.
- Affiliations
- Johns Hopkins University (US)
- University of California, Irvine (US)
- Corresponding author
- Gallagher, M.
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-05-01
- Volume
- 7
- Issue
- 3
- Pages
- 197-199
- ISSN
- 1567-2050 (ISSN-L)
- PMC
- PMC3008592
- OpenAlex
- W2091802932
- Cited by
- 32
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 6
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- National Institute on Aging (RC2AG036419, P01AG009973, T32AG027668)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, amnestic mild cognitive impairment, age-related memory impairment, hippocampus, dentate gyrus, CA3, pattern separation, pattern completion, preclinical Alzheimer's disease, disease modification, memory recovery, animal models, neuroimaging
- MeSH terms
- Aged, Aging, Alzheimer Disease, Animals, Cognition Disorders, Disease Models, Animal, Hippocampus, Humans, Memory, Memory Disorders, Neural Pathways, Drug Design, Nootropic Agents
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