IL-3 Control Tau Modifications and Protects Cortical Neurons from Neurodegeneration
Open accessAbstract
Interleukin-3 (IL-3) regulates the proliferation, survival and differentiation of haematopoietic cells via interaction with specific cell-surface receptors. IL-3 is expressed in several non-hematopoietic cell types. Studies have demonstrated the presence of IL-3 in the central nervous system, however, its physiological role in these cells is poorly understood. Previously we have been demonstrated that IL-3 prevents neuronal death induced by fibrillary β amyloid in these cells, by PI 3-kinase and Jak/STAT pathway activation. In this study, we demonstrated that IL-3 significantly reduced Aβ-promoted neurite degeneration and toxicity. Thus, this cytokine provides cellular protection against Aβ neurotoxicity in primary cortical neuronal cells, by modulating microtubular dynamics and prevention of tau cleavage and hyperphosphorylation. We also demonstrates that IL-3 is expressed in the "in vivo" mouse model of AD, Tg2576, which also expresses human AβPP with the Swedish mutation. In summary, these results suggest that IL-3 could play a neuroprotective role in AD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other inflammatory factors such as IL-3, IL-6, IL-18, TNFα, and MIF are involved in tau phosphorylation and/or truncation.
“Other inflammatory factors such as IL-3, IL-6, IL-18, tumor necrosis factor-α (TNFα), and macrophage migration inhibitory factor (MIF) are also found to be involved in tau phosphorylation and/or truncation [166–170].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [169]
Cited by
Sorted by citations
Inflammatory Response in the CNS: Friend or Foe?
Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573 · see citing works
Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
Chen, Y., & Yu, Y. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02853-3 · Cited by 516 · see citing works
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., et al. (2021) · Nature · doi:10.1038/s41586-021-03734-6 · Cited by 322 · see citing works
Parviainen, L., Dihanich, S., Anderson, G. W., Wong, A. M. S., Brooks, H., Abeti, R., Rezaie, P., Lalli, G., Pope, S. A. S., Heales, S., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0476-y · Cited by 72 · see citing works
Elomaa, A.-P., NISKANEN, L. K., Herzig, K., Viinamäki, H. T., Hintikka, J. J., Koivumaa-Honkanen, H. T., Honkalampi, K. M., Valkonen‐Korhonen, M., Harvima, I. T., & Lehto, S. M. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-2 · Cited by 62 · see citing works
Panek, M., Pietras, T., Szemraj, J., & Kuna, P. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1734 · Cited by 27 · see citing works
Increased IL-3 Serum Levels in Chronic Patients with Schizophrenia: Associated with Psychopathology
Xiu, M. H., Lin, C. G., Tian, L., Tan, Y. L., Chen, J., Chen, S., Tan, S. P., Wang, Z. R., Yang, F. D., Chen, D. C., et al. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.029 · Cited by 27 · see citing works
Wang, Z., Ma, Y., Sun, Y., Tan, L., Wang, H.-F., Yu, J., & Initiative, A. D. N. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02679-5 · Cited by 28 · see citing works
IL-5 blocks apoptosis and tau hyperphosphorylation induced by Aβ25–35 peptide in PC12 cells
Zhou, Y., Li, C., Li, D., Zheng, Y., & Wang, J. (2017) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0550-8 · Cited by 20 · see citing works
A Novel Panel of Plasma Proteins Predicts Progression in Prodromal Alzheimer’s Disease
Araújo, D. C., Initiative, A. D. N., Veloso, A., Gomes, K. B., de Souza, L. C., Ziviani, N., & Caramelli, P. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220256 · Cited by 19 · see citing works
Brain interleukins and Alzheimer’s disease
Abdelhamed, H. G., Hassan, A. A., Sakraan, A., Al-Deeb, R. T., Mousa, D. M., Ezz, H. S. A., Noor, N. A., Khadrawy, Y. A., & Radwan, N. M. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01538-5 · Cited by 20 · see citing works
A glance through the effects of CD4 + T cells, CD8 + T cells, and cytokines on Alzheimer's disease
Afsar, A., Chen, M., Xuan, Z., & Li, Z. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.10.058 · Cited by 19 · see citing works
Increased inflammation in BA21 brain tissue from African Americans with Alzheimer’s disease
Ferguson, S. A., Varma, V., Sloper, D. T., Panos, J., & Sarkar, S. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00512-2 · Cited by 18 · see citing works
Chen, P., Yan, Q., Wang, S., Wang, C., & Zhao, P. (2016) · Gene · doi:10.1016/j.gene.2016.04.032 · Cited by 14 · see citing works
Interleukin‐3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells
Lopez, C. L., Zamorano, P., Teuber, S., Salas, M., Carola Otth, L., Hidalgo, M. A., Concha, I. I., & Zambrano, Á. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25790 · Cited by 10 · see citing works
Self-citationNeural stem cells isolated from amyloid precursor protein-mutated mice for drug discovery
Baldassarro, V. A. (2013) · World Journal of Stem Cells · doi:10.4252/wjsc.v5.i4.229 · Cited by 10 · see citing works
Jia, X.-X., Chen, C., Hu, C., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03511-8 · Cited by 6 · see citing works
Haag, N., & Zempel, H. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00806-x · Cited by 4 · see citing works
da Silva, S. J. R., Matthews, Q., Cazaux, S., Vigar, J. R. J., Santos, B. N. R., Carvalho, D. C. M., Cranmer, L. A., Duplat, D., Singh, S., Simchi, M., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeb7039 · Cited by 3 · see citing works
Interleukin 3 Inhibits Glutamate-Cytotoxicity in Neuroblastoma Cell Line
Matus, V., Castro‐Guarda, M., Cárcamo-Fierro, J., Morera, F. J., & Zambrano, Á. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04123-x · Cited by 2 · see citing works
Self-citationKokhan, V. S., Андреевич, А. Р., Anokhin, P. K., & Shamakina, I. Y. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297924604453 · Cited by 3 · see citing works
Kokhan, V. S., Levashova, A. I., Nesterov, M. S., Pikalov, V. A., & Chicheva, M. M. (2025) · Biology · doi:10.3390/biology14060682 · Cited by 2 · see citing works
Chan, D. C. Y., Kim, C., Kang, R. Y., Kuhn, M. K., Cramer, S., Ünsal, H., Beidler, L. M., Turner, K. L., Neuberger, T., Zhang, N., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.17.585383 · Cited by 1 · see citing works
Reevaluation of EPO and its Derivatives Centering on β Common ReceptorPreprint
Luo, Y., Wang, R., & Yang, Z. (2024) · doi:10.22541/au.170667577.79095000/v1
The effect of C-reactive protein and interleukin-3 on mild cognitive impairment with APOE ɛ4
Yang, X., Chi, L., Qiao, M., Huang, A. C., Wu, H., Chen, S., Fan, J., Lin, X., Chen, J., & Initiative, A. D. N. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251333149
Wang, Z.-B., Ma, Y.-H., Sun, Y., Tan, L., Wang, H.-F., & Yu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26558030
- Authors
- Zambrano, A., Otth, C., B. Maccioni, R., & I. Concha, I.
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-11-01
- Volume
- 7
- Issue
- 7
- Pages
- 615-624
- ISSN
- 1567-2050 (ISSN-L)
- OpenAlex
- W1967250452
- Cited by
- 29
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- other-oa
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- interleukin-3, tau hyperphosphorylation, tau cleavage, amyloid-beta toxicity, cortical neurons, neuroprotection, Alzheimer's disease, neurite degeneration, microtubule dynamics, PI3K signaling, JAK/STAT signaling, Tg2576 mice, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Cells, Cultured, Humans, Interleukin-3, Mice, Inbred C57BL, Mice, Transgenic, Nerve Degeneration, Amyloid beta-Peptides, tau Proteins, Cytoprotection, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
