Disentangling the Role of the Tau Gene Locus in Sporadic Tauopathies
Abstract
Fibrillar aggregates of abnormally hyperphosphorylated tau protein are the major component of the pathological entities, including intraneuronal neurofibrillary tangles that define the broad class of late-onset neurodegenerative disorders called the tauopathies. Mutations in the tau gene (MAPT) causing familial frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) confirm that tau protein dysfunction could be a primary cause of neuronal loss. However, in the sporadic tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) where MAPT mutation is absent, common variation in MAPT that defines the H1 and H2 haplotype clades strongly influences disease risk. Surprisingly, this influence on risk extends to sporadic Parkinson's disease (PD), traditionally not defined as a tauopathy. This review will focus on recent work aimed at elucidating the mechanistic basis of this haplotype-specific effect on disease risk, implicating elevated levels of MAPT expression, particularly via increased transcription and/or alterations in splicing. This conforms to an emerging picture of a shared mechanism that underlies the fundamental process(es) leading to neuronal death. Increased availability of the fibrillogenic protein substrates of the pathological aggregates that define several neurodegenerative proteopathies, eg α-synuclein in PD, β-amyloid in AD and tau in the tauopathies, contributes to causation and risk in the familial and spora…
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SNPs within the H1 haplotype of the MAPT locus are associated with increased risk for CBD, PSP, and FTD.
“Recent genome-wide association studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) within the H1 haplotype of the MAPT locus are associated with increased risk for CBD, PSP, and FTD [20, 24, 32].”
From Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia (2017) · cites this paper as [32]
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- Authors
- Vandrovcova, J., Anaya, F., Kay, V., Lees, A., Hardy, J., & de Silva, R.
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-12-01
- Volume
- 7
- Issue
- 8
- Pages
- 726-734
- ISSN
- 1567-2050 (ISSN-L)
- OpenAlex
- W2150550276
- Cited by
- 43
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Parkinson's UK (G-0907)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- tau gene, MAPT, progressive supranuclear palsy, corticobasal degeneration, Parkinson's disease, neurofibrillary tangles, tau hyperphosphorylation, alternative splicing, neurodegeneration, proteinopathies, alpha-synuclein, amyloid-beta
- MeSH terms
- Animals, Genetic Markers, Humans, Nerve Degeneration, tau Proteins, Genetic Predisposition to Disease, Tauopathies
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