The DOI matches its Crossref record; 494 of the 494 references it cites were found in a registry or an index.
The Urokinase Plasminogen Activator System: A Target for Anti-Cancer Therapy
Abstract
The urokinase plasminogen activator (uPA) system (uPAS) consists of the uPA, its cognate receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and 2 (PAI-2). The uPA converts the proenzyme plasminogen in the serine protease plasmin, involved in a number of physiopathological processes requiring basement membrane (BM) and/or extracellular matrix (ECM) remodelling, including tumor progression and metastasis. Data accumulated over the past years have made increasingly clear that the uPAS has a multifunctional task in the neoplastic evolution, affecting tumor angiogenesis, malignant cell proliferation, adhesion and migration, intravasation and growth at the metastatic site. In agreement with their role in cancer progression and metastasis, an increased expression of uPA, uPAR, and PAI-1 has been documented in several malignant tumors, and a positive correlation between the levels of one or more uPAS members and a poor prognosis has been frequently reported. This is particularly evident in breast cancer, for which uPA has been demonstrated to be the most potent independent prognostic factor described to date. The involvement of the uPAS in cancer progression identifies its components as suitable targets for anti-cancer therapy. Several therapeutical approaches aimed at inhibiting the uPA/uPAR functions have been shown to possess anti-tumor effects in xenograft models, including selective inhibitors of uPA activity, antagonist peptides, monoclonal antibodies able to prevent uPA binding to uPAR and gene therapy techniques silencing uPA/uPAR expression. All these strategies, however, although promising, need definitive confirmation in humans as, up to now, only few uPA inhibitors entered clinical trial.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, the plasminogen system has been linked to cancer with expression of PAI-1 linked to poor outcome in breast cancer (70).”
From Diabetes and Cancer (2010) · cites this paper as [70]
Citations
Cites
7 retracted
Items 201–400 of 494
Gondi, C. S., Lakka, S. S., Dinh, D. H., Olivero, W. C., Gujrati, M., & Rao, J. S. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3032 · Cited by 92
Katz, B. A., Mackman, R. L., Luong, C., Radika, K., Martelli, A., Sprengeler, P. A., Wang, J., Chan, H., & Wong, L. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00104-6 · Cited by 91
Kirchheimer, J. C., Wojta, J., Christ, G., & Binder, B. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5424 · Cited by 90
Transcriptional and posttranscriptional regulation of the plasminogen activator system
Medcalf, R. L., Muñoz‐Cánoves, P., & Nagamine, Y. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-12-0814 · Cited by 90
Stupack, D. G. (2007) · PubMed · Cited by 89
Metastasis Markers in Bladder Cancer: A Review of the Literature and Clinical Considerations
Gontero, P., Banisadr, S., Frea, B., & Brausi, M. A. (2004) · European Urology · doi:10.1016/j.eururo.2004.04.001 · Cited by 89
The role of vitronectin as multifunctional regulator in the hemostatic and immune systems
Preissner, K. T. (1989) · Annals of Hematology · doi:10.1007/bf00349063 · Cited by 87
Hiendlmeyer, E., Regus, S., Wassermann, S., Hlubek, F., Haynl, A., Dimmler, A. W., Koch, C., Knoll, C., van Beest, M., Reuning, U., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-3627-2 · Cited by 87
Inhibition of lung tumourigenesis by sulindac: comparison of two experimental protocols
Castonguay, A. (1997) · Carcinogenesis · doi:10.1093/carcin/18.3.491 · Cited by 86
Structure-function relationships in serpins: current concepts and controversies.
Gils, A., & Declerck, P. J. (1998) · PubMed · Cited by 85
Setyono-Han, B., Stürzebecher, J., Schmalix, W. A., Muehlenweg, B., Sieuwerts, A. M., Timmermans, M. A. M., Magdolen, V., Schmitt, M., Klijn, J. G. M., & Foekens, J. A. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-11-0712 · Cited by 85
Borgatti, M., Lampronti, I., Romanelli, A., Pedone, C., Saviano, M., Bianchi, N., Mischiati, C., & Gambari, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206780200 · Cited by 85
Meissauer, A., Kramer, M. D., Hofmann‐Apitius, M., Erkell, L. J., Jacob, E., Schirrmacher, V., & Brunner, G. (1991) · Experimental Cell Research · doi:10.1016/0014-4827(91)90064-2 · Cited by 84
Xing, R. H., Mazar, A. P., Henkin, J., & Rabbani, S. A. (1997) · PubMed · Cited by 84
Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice
Angelucci, A., Gravina, G. L., Rucci, N., Millimaggi, D., Festuccia, C., Muzi, P., Teti, A. M., Vicentini, C., & Bologna, M. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01100 · Cited by 83
Plasminogen Activator Inhibitor-1 Levels and Polymorphisms
Francis, C. W. (2002) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2002-126-1401-pailap · Cited by 82
Unexpected Role of Plasminogen Activator Inhibitor 1 in Cell Adhesion and Detachment
Czekay, R., & Loskutoff, D. J. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901102 · Cited by 82
Nozaki, S., Endo, Y., Kawashiri, S., Nakagawa, K., Yamamoto, E., Yonemura, Y., & Sasaki, T. (1998) · Oral Oncology · doi:10.1016/s1368-8375(97)00028-6 · Cited by 82
RODENBURG, W. K., Kjøller, L., Petersen, H. H., & Andreasen, A. (1998) · Biochemical Journal · doi:10.1042/bj3290055 · Cited by 82
The regulatory region of the human plasminogen activator inhibitor type-1 (PAI-1) gene
Riccio, A., Lund, L. R., Sartorio, R., Lania, A., Anderasen, P. A., Danø, K., & Blasi, F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.7.2805 · Cited by 81
Lengyel, E. R., Wang, H., Stepp, E., Juarez, J., Wang, Y., Doe, W. F., Pfarr, C. M., & Boyd, D. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23176 · Cited by 81
Chekhun, V. F., Kulik, G. I., Yurchenko, O. V., Tryndyak, V., Todor, I. N., Luniv, L. S., Tregubova, N. A., Pryzimirska, T. V., Montgomery, B. A., Rusetska, N., et al. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.01.038 · Cited by 81
Nanbu, R., Menoud, P. A., & Nagamine, Y. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4920 · Cited by 78
Gavrilov, D. K., Kenzior, O., Evans, M., Calaluce, R., & Folk, W. R. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00077-6 · Cited by 78
Colombatti, M., Greenfield, L., & Youle, R. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35741-1 · Cited by 77
Béné, M. C., Castoldi, G., Knapp, W., Rigolin, G. M., Escribano, L., Lemež, P., Ludwig, W., Matutes, E., Orfao, A., Lanza, F., et al. (2003) · Leukemia · doi:10.1038/sj.leu.2403250 · Cited by 77
Cuevas, B. D., Winter-Vann, A. M., Johnson, N. L., & Johnson, G. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209507 · Cited by 76
Prognostic significance of proteolytic enzymes in human brain tumors
Bindal, A. K., Hammoud, M. A., Shi, W. M., Wu, S. Z., Sawaya, R. A., & Rao, J. S. (1994) · Journal of Neuro-Oncology · doi:10.1007/bf01052886 · Cited by 75
Nuclear Factor Kappa B is a Promising Therapeutic Target in Inflammatory Lung Disease
Park, G. Y., & Christman, J. W. (2006) · Current Drug Targets · doi:10.2174/138945006777435317 · Cited by 74
Heiss, M. M., Simon, E. H., Beyer, B. C. M., Gruetzner, K. U., Tarabichi, A., Babic, R., Schildberg, F. W., & Allgayer, H. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.08.003 · Cited by 74
Seetoo, D., Crowe, P. J., Russell, P. J., & Yang, J. (2003) · Journal of Surgical Oncology · doi:10.1002/jso.10210 · Cited by 73
Angelucci, A., Gravina, G. L., Biordi, L. A., Millimaggi, D., Muzi, P., Vicentini, C., Bologna, M., & Festuccia, C. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-09-0637 · Cited by 72
Slivova, V., Zaloga, G. P., DeMichele, S. J., Mukerji, P., Huang, Y. S., Siddiqui, R. A., Harvey, K. A., Valachovicova, T., & Slíva, D. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5201_9 · Cited by 72
Cohen, R., Xi, X., Crowley, C., Lucas, B., Levinson, A. D., & Shuman, M. (1991) · Blood · doi:10.1182/blood.v78.2.479.479 · Cited by 72
Varró, A., Noble, P., Pritchard, D. M., Kennedy, S., Hart, C. A., Dimaline, R., & Dockray, G. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2399 · Cited by 71
Harvey, S. R., Hurd, T. C., Markus, G., Martinick, M., Penetrante, R. M., Tan, D., Venkataraman, P., DeSouza, N., Sait, S. N. J., Driscoll, D. L., et al. (2003) · PubMed · Cited by 71
Lengyel, E. R., Wang, H., Gum, R. J., Simon, C., Wang, Y., & Boyd, D. D. (1997) · Oncogene · doi:10.1038/sj.onc.1201098 · Cited by 71
Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2
D'Orazio, D., Besser, D., Marksitzer, R., Kunz, C., Hume, D. A., Kiefer, B., & Nagamine, Y. (1997) · Gene · doi:10.1016/s0378-1119(97)00445-9 · Cited by 70
Miyake, H., Hara, I., Yamanaka, K., Arakawa, S., & Kamidono, S. (1999) · International Journal of Oncology · doi:10.3892/ijo.14.3.535 · Cited by 70
Leik, C. E., Su, E. J., Nambi, P., Crandall, D., & Lawrence, D. A. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02244.x · Cited by 70
Lung carcinoma in African Americans and whites
Schwartz, A. G., & Swanson, G. M. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970101)79:1 · Cited by 70
Kobayashi, H., Suzuki, M., Tanaka, Y., Hirashima, Y., & Terao, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007650200 · Cited by 70
Sperl, S., Jacob, U., de Prada, N. A., Stürzebecher, J., Wilhelm, O. G., Bode, W., Magdolen, V., Huber, R., & Moroder, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5113 · Cited by 70
Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer
Memarzadeh, S., Kozak, K. R., Chang, L., Natarajan, S., Shintaku, P. I., Reddy, S. T., & Farias‐Eisner, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152127499 · Cited by 70
Guo, Y., Mazar, A. P., Lebrun, J. J., & Rabbani, S. A. (2002) · PubMed · Cited by 70
Wang, C., Yang, Q., & Craik, C. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.12250 · Cited by 69
Lamy, S., Lafleur, R., Bédard, V., Moghrabi, A., Barrette, S., Gingras, D., & Béliveau, R. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21023 · Cited by 69
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin
Liu, S., Redeye, V., Kuremsky, J. G., Kuhnen, M., Molinolo, A., Bugge, T. H., & Leppla, S. H. (2005) · Nature Biotechnology · doi:10.1038/nbt1091 · Cited by 68
Berkenblit, A., Matulonis, U. A., Kroener, J. F., Dezube, B. J., Lam, G. N., Cuasay, L. C., Brünner, N., Jones, T. R., Silverman, M. H., & Gold, M. A. (2005) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.05.023 · Cited by 67
Maurer, F. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.7.1664 · Cited by 67
Sintich, S. M., Steinberg, J., Kozlowski, J. M., Lee, C., Pruden, S. J., Sayeed, S., & Sensibar, J. A. (1999) · The Prostate · doi:10.1002/(sici)1097-0045(19990501)39:2 · Cited by 66
Development of Irreversible Diphenyl Phosphonate Inhibitors for Urokinase Plasminogen Activator
Joossens, J., der Veken, P. V., Lambeir, A., Augustyns, K., & Haemers, A. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm0499209 · Cited by 66
Ohba, K., Miyata, Y., Kanda, S., Koga, S., Hayashi, T., & Kanetake, H. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000165150.46006.92 · Cited by 66
Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
Sakakibara, T., Hibi, K., Koike, M., Fujiwara, M., Kodera, Y., Ito, K., & Nakao, A. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602743 · Cited by 65
Bürgle, M., Koppitz, M., Riemer, C., Kessler, H., König, B., Weidle, U. H., Kellermann, J., Lottspeich, F., Graeff, H., Schmitt, M., et al. (1997) · Biological Chemistry · doi:10.1515/bchm.1997.378.3-4.231 · Cited by 65
Shariat, S. F., Monoski, M. A., Andrews, B., Wheeler, T. M., Lerner, S. P., & Slawin, K. M. (2003) · Urology · doi:10.1016/s0090-4295(02)02522-0 · Cited by 65
Wendt, M. D., Rockway, T. W., Geyer, A. G., McClellan, W. J., Weitzberg, M., Zhao, X., Mantei, R. A., Nienaber, V. L., Stewart, K. D., Klinghofer, V., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm0300072 · Cited by 65
Evaluation of ovarian findings in asymptomatic postmenopausal women with color doppler ultrasound
Vuento, M., PIRHONEN, J. P., Mäkinen, J., Laippala, P. J., Grönroos, M. A., & Salmi, T. (1995) · Cancer · doi:10.1002/1097-0142(19951001)76:7 · Cited by 65
Subramanian, R., Gondi, C. S., Lakka, S. S., Jutla, A., & Rao, J. S. (2006) · International Journal of Oncology · doi:10.3892/ijo.28.4.831 · Cited by 65
Tierney, M. J., & Medcalf, R. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010627200 · Cited by 63
Altus, M. S., & Nagamine, Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54839-0 · Cited by 63
Duffy, M. J., Duggan, C. R., Mulcahy, H. E., McDermott, E. W. M., & O’Higgins, N. J. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.6.1177 · Cited by 62
Urokinase system expression in gastric carcinoma
Beyer, B. C. M., Heiss, M. M., Simon, E. H., Gruetzner, K. U., Babic, R., Jauch, K., Schildberg, F. W., & Allgayer, H. (2006) · Cancer · doi:10.1002/cncr.21682 · Cited by 62
Prognostic relevance of TGF‐β1 and PAI‐1 in cervical cancer
Hazelbag, S., Kenter, G. G., Gorter, A., & Fleuren, G. J. (2004) · International Journal of Cancer · doi:10.1002/ijc.20512 · Cited by 62
Zlobec, I., Minoo, P., Baumhoer, D., Baker, K., Terracciano, L., Jass, J. R., & Lugli, A. (2007) · Cancer · doi:10.1002/cncr.23208 · Cited by 61
Clinical significance of urokinase‐type plasminogen activator activity in hepatocellular carcinoma
Itoh, T., Hayashi, Y., Kanamaru, T., Morita, Y., Suzuki, S., Wang, W., Zhou, L., Rui, J., Yamamoto, M., Kuroda, Y., et al. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02150.x · Cited by 61
Ertongur, S., Lang, S., Mack, B., Wosikowski, K., Muehlenweg, B., & Gires, O. (2004) · International Journal of Cancer · doi:10.1002/ijc.20192 · Cited by 61
Expression and Characterization of Pro α2-Plasmin Inhibitor
Sumi, Y., Ichikawa, Y., Nakamura, Y., Miura, O., & Aoki, N. (1989) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122920 · Cited by 61
Kobayashi, H., Sugino, D., She, M. Y., Ohi, H., Hirashima, Y., Shinohara, H., Fujie, M., Shibata, K., & Terao, T. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2530817.x · Cited by 60
Urokinase-Type Plasminogen Activator Expression in Human Prostate Carcinomas
Veldhuizen, P. J. V., Sadasivan, R., Cherian, R., & Wyatt, A. (1996) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)41739-2 · Cited by 60
Sato, S., Kopitz, C., Schmalix, W. A., Muehlenweg, B., Kessler, H., Schmitt, M., Krüger, A., & Magdolen, V. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03311-2 · Cited by 60
Werle, B., Kotzsch, M., Lah, T. T., Kos, J., Gabrijelcic‐Geiger, D., Spieß, E., Schirren, J., Ébert, W., Fiehn, W., Luther, T., et al. (2004) · PubMed · Cited by 60
Fish, P. V., Barber, C., Brown, D. G., Butt, R. P., Collis, M. G., DICKINSON, R. P., Henry, B. T., Horne, V. A., Huggins, J. P., King, E., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm061066t · Cited by 60
Krüger, A., Soeltl, R., Lutz, V., Wilhelm, O. G., Magdolen, V., Rojo, E. E., Hantzopoulos, P. A., Graeff, H., Gänsbacher, B., & Schmitt, M. (2000) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700144 · Cited by 60
Henderson, B. R., Tansey, W. P., Phillips, S. M., Ramshaw, I. A., & Kefford, R. F. (1992) · PubMed · Cited by 59
Nienaber, V. L., Wang, J., Davidson, D. J., & Henkin, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7239 · Cited by 58
Nekarda, H., Schlegel, P. G., Schmitt, M., Stark, M., Mueller, J. D., Fink, U., & Siewert, J. R. (1998) · PubMed · Cited by 58
Mani, S., Rudin, C. M., Kunkel, K., Holmlund, J., Geary, R. S., Kindler, H. L., Dorr, F. A., & Ratain, M. J. (2002) · PubMed · Cited by 58
Schmitt, M., Goretzki, L., Jänicke, F., Calvete, J. J., Eulitz, M., Kobayashi, H., Chucholowski, N., & Graeff, H. (1991) · PubMed · Cited by 58
Lanza, Castoldi, Castagnar, Todd, Moretti, Spisani, Latorraca, Focarile, Roberti, & Traniello (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00932.x · Cited by 57
Regulation of Plasminogen Gene Expression by Interleukin-6
Jenkins, G. R., Seiffert, D., Parmer, R. J., & Miles, L. A. (1997) · Blood · doi:10.1182/blood.v89.7.2394 · Cited by 56
Binding site of α2-plasmin inhibitor to plasminogen
Sugiyama, N., Sasaki, T., Iwamoto, M., & Abiko, Y. (1988) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(88)90094-5 · Cited by 55
Cousin, E., Medcalf, R. L., Bergonzelli, G. E., & Kruithof, E. K. O. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.14.3881 · Cited by 55
Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma
Dass, C. R., Nadesapillai, A. P. W., Robin, D., Howard, M. L., Fisher, J., Zhou, H., & Choong, P. (2005) · Clinical & Experimental Metastasis · doi:10.1007/s10585-006-9004-3 · Cited by 55
Skelly, M. M., Troy, A., Duffy, M. J., Mulcahy, H. E., Duggan, C., Connell, T. G., O’Donoghue, D. P., & Sheahan, K. D. (1997) · PubMed · Cited by 55
Offersen, B. V., Pfeiffer, P., Andreasen, P. A., & Overgaard, J. (2007) · Lung Cancer · doi:10.1016/j.lungcan.2006.11.018 · Cited by 55
Kawamura, I., Morishita, R., Tsujimoto, S., Manda, T., Tomoi, M., Tomita, N., Goto, T., Ogihara, T., & Kaneda, Y. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301478 · Cited by 54
Takeuchi, Y., Nakao, A., Harada, A., Nonami, T., Fukatsu, T., & Takagi, H. (1993) · PubMed · Cited by 53
España, F., Estellés, A., Fernández, P. J., Gilabert, J., Sánchez-Cuenca, J. M., & Griffin, J. H. (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649712 · Cited by 53
Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice
Mutoh, M., Niho, N., Komiya, M., Takahashi, M., Ohtsubo, R., Nakatogawa, K., Ueda, K., Sügimura, T., & Wakabayashi, K. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn028 · Cited by 53
The urokinase-type plasminogen activator system in resected non-small-cell lung cancer
Salden, M., Splinter, T. A. W., Peters, H. A., Look, M. P., Timmermans, M. A. M., van Meerbeeck, J. P. A. M., & Foekens, J. A. (2000) · Annals of Oncology · doi:10.1023/a:1008312801800 · Cited by 52
Hansen, M. A., Wind, T., Blouse, G. E., Christensen, A., Petersen, H. H., Kjelgaard, S., Mathiasen, L., Holtet, T. L., & Andreasen, P. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505933200 · Cited by 52
Shiratsuchi, T., Ishibashi, H., & Shirasuna, K. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10181 · Cited by 52
Dissecting the Circuitry of Protein Kinase A and cAMP Signaling in Cancer Genesis
Cho‐Chung, Y. S., Nesterova, M., Becker, K. G., Srivastava, R. K., Park, Y. G., Lee, Y. N., Cho, Y. S., Kim, M., Neary, C. L., & Cheadle, C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04324.x · Cited by 52
Abi‐Habib, R. J., Singh, R., Liu, S., Bugge, T. H., Leppla, S. H., & Frankel, A. E. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0315 · Cited by 50
Identification of a novel inhibitor of urokinase-type plasminogen activator
Zhu, M. J., Gokhale, V. M., Szabó, L., Muñoz, R. M., Baek, H., Sridevi, B., Hurley, L. H., Hoff, D. D. V., & Han, H. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0520 · Cited by 50
Selleri, C., Montuori, N., Ricci, P., Visconte, V., Baiano, A., Carriero, M. V., Rotoli, B., Rossi, G., & Ragno, P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1311 · Cited by 50
Different Roles for Plasminogen Activators and Metalloproteinases in Melanoma Metastasis
Mueller, B. M. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-61107-0_5 · Cited by 49
Frederickson, M., Callaghan, O., Chessari, G., Congreve, M., Cowan, S., Matthews, J. E., McMenamin, R. L., Smith, D.-M., Vinković, M., & Wallis, N. G. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm701359z · Cited by 49
Chemosensitivity and p53-dependent apoptosis in epithelial ovarian carcinoma
Sato, S., Kigawa, J., Minagawa, Y., Okada, M., Shimada, M., Takahashi, M., Kamazawa, S., & Terakawa, N. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19991001)86:7 · Cited by 49
Maurer, G. D., Leupold, J. H., Schewe, D. M., Biller, T., Kates, R. E., Hornung, H.-M., Lau‐Werner, U., Post, S., & Allgayer, H. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1668 · Cited by 49
Hapke, S., Gawaz, M., Dehne, K., Köhler, J., Marshall, J. F., Graeff, H., Schmitt, M., Reuning, U., & Lengyel, E. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2118-2132.2001 · Cited by 49
Alonso, D. F., Tejera, Á. M., Ef, F., Joffé, E. B. D. K., & Gomez, D. E. (1998) · PubMed · Cited by 49
Alitalo, R., Stephens, R., Vaheri, A., & Mustjoki, S. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614558 · Cited by 49
Alonso, D. F., Farias, E., Ladeda, V., Davel, L., Puricelli, L., & Joffé, E. B. D. K. (1996) · Breast Cancer Research and Treatment · doi:10.1007/bf01806809 · Cited by 48
Sawai, H., Okada, Y., Funahashi, H., Matsuo, Y., Takahashi, H., Takeyama, H., & Manabe, T. (2006) · BMC Cell Biology · doi:10.1186/1471-2121-7-8 · Cited by 48
Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder.
Hasui, Y., Suzumiya, J., Marutsuka, K., Sumiyoshi, A., Hashida, S., & Ishikawa, E. (1989) · PubMed · Cited by 48
Gum, R. J., Juárez, J., Allgayer, H., Mazar, A. P., Wang, Y., & Boyd, D. D. (1998) · Oncogene · doi:10.1038/sj.onc.1201917 · Cited by 48
Dondi, D., Festuccia, C., Piccolella, M., Bologna, M., & Motta, M. (2006) · Oncology Reports · doi:10.3892/or.15.2.393 · Cited by 47
Sawai, H., Liu, J., Reber, H. A., Hines, O. J., & Eibl, G. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0257 · Cited by 47
Tissue Factor Regulates Plasminogen Binding and Activation
Fan, Z., Larson, P. J., Bognacki, J. J., Raghunath, P. N., Tomaszewski, J. E., Kuo, A., Canziani, G., CHAIKEN, I. M., Cines, D. B., & Higazi, A. A. (1998) · Blood · doi:10.1182/blood.v91.6.1987 · Cited by 47
Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme
Hall, W. A., & Vallera, D. A. (2006) · Neurosurgical FOCUS · doi:10.3171/foc.2006.20.4.15 · Cited by 46
McCabe, N. P., Angwafo, F., Zaher, A., Selman, S. H., Kouinche, A., & Jankun, J. (2000) · Oncology Reports · doi:10.3892/or.7.4.879 · Cited by 46
Prognostic value of urokinase-type plasminogen activator in patients with superficial bladder cancer
Hasui, Y., Marutsuka, K., Asada, Y., & Osada, Y. (1996) · Urology · doi:10.1016/s0090-4295(99)80378-1 · Cited by 46
Strojan, P., Budihna, M., Šmid, L. M., Vrhovec, I., & Skrk, J. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(98)00029-x · Cited by 46
Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro
Brooks, T., Slomp, J., Quax, P. H. A., de Bart, A. C. W., Spencer, M. T., Verheijen, J. H., & Charlton, P. (2000) · Clinical & Experimental Metastasis · doi:10.1023/a:1011882421528 · Cited by 45
Li, H., Griscelli, F., Lindenmeyer, F., Opolon, P., Sun, L.-Q., Connault, E., Soria, J., Soria, C., Perricaudet, M., & Yeh, P. (1999) · Human Gene Therapy · doi:10.1089/10430349950016438 · Cited by 45
Wang, H., Yang, L., Jamaluddin, M. S., & Boyd, D. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401257200 · Cited by 45
Pakneshan, P., Szyf, M., & Rabbani, S. A. (2005) · Current Cancer Drug Targets · doi:10.2174/156800905774574011 · Cited by 45
Sieńczyk, M., & Oleksyszyn, J. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.03.002 · Cited by 45
Kobayashi, H., Suzuki, M., Kanayama, N., Nishida, T., Takigawa, M., & Terao, T. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03068.x · Cited by 44
Nordengren, J., Fredstorp-Lidebring, M., Bendahl, P., Brünner, N., Fernö, M., Högberg, T., Stephens, R. W., Wïllén, R., & Casslén, B. G. (2001) · International Journal of Cancer · doi:10.1002/ijc.1611 · Cited by 44
Steiner, E., Pollow, K., Hasenclever, D., Schormann, W., Hermes, M., Schmidt, M., Puhl, A. G., Brulport, M., Bauer, A., Petry, I. B., et al. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2007.11.025 · Cited by 44
Rigolin, G. M., Tieghi, A., Ciccone, M., Bragotti, L. Z., Cavazzini, F., Porta, M. G. D., Castagnari, B., Carroccia, R., Guerra, G., Cuneo, A., et al. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04176.x · Cited by 44
Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice
Rustamzadeh, E., Hall, W. A., Todhunter, D. A., Vallera, V. D., Low, W. C., Liu, H., Panoskaltsis‐Mortari, A., & Vallera, D. A. (2006) · International Journal of Cancer · doi:10.1002/ijc.22278 · Cited by 44
Chorostowska‐Wynimko, J., Swiercz, R., Skrzypczak‐Jankun, E., Wojtowicz, A., Selman, S. H., & Jankun, J. (2003) · PubMed · Cited by 44
Witte, J., Foekens, J. A., Brünner, N., Heuvel, J. J. T. M., van Tienoven, T., Look, M. P., Klijn, J. G. M., Geurts-Moespot, A. J., Grebenchtchikov, N. I., Benraad, T. J., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1867 · Cited by 43
Kobayashi, H., Shinohara, H., Fujie, M., Gotoh, J., Itoh, M., Takeuchi, K., & Terao, T. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910630326 · Cited by 43
Smith, R. C., Xue, A., Gill, A. J., Scarlett, C. J., Saxby, A. J., Clarkson, A., & Hugh, T. J. (2007) · World Journal of Surgery · doi:10.1007/s00268-006-0289-9 · Cited by 43
Oh, S., Lee, O.-H., Schroeder, C. P., Oh, Y. W., Shi, K., Cha, H., Park, R., Onn, A., Herbst, R. S., Li, C., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0142 · Cited by 43
Small interfering RNA induced transcriptional gene silencing in human cells
Morris, K. V. (2007) · The biomedical & life sciences collection. · doi:10.69645/vhcz2546 · Cited by 43
Behrendt, N., Rønne, E., & Danø, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53416-5 · Cited by 42
Kobayashi, H., Gotoh, J., Kanayama, N., Hirashima, Y., Terao, T., & Sugino, D. (1995) · PubMed · Cited by 42
Schmiedeberg, N., Schmitt, M., Rölz, C., Truffault, V., Sukopp, M., Bürgle, M., Wilhelm, O. G., Schmalix, W. A., Magdolen, V., & Kessler, H. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020254q · Cited by 42
Yang, H., Henkin, J., Kim, K. H., & Greer, J. (1990) · Journal of Medicinal Chemistry · doi:10.1021/jm00173a008 · Cited by 42
On receptor inhibitors and chemotherapy.
Ryan, P. D., & Chabner, B. A. (2000) · PubMed · Cited by 42
Ulisse, S., Baldini, E., Toller, M., Marchioni, E., Giacomelli, L., Antoni, E. D., Ferretti, E., Marzullo, A., Graziano, F. M., Trimboli, P., et al. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.04.017 · Cited by 41
Inherent Instability of Plasminogen Activator Inhibitor Type 2 mRNA Is Regulated by Tristetraprolin
Yu, H., Stasinopoulos, S. J., Leedman, P. J., & Medcalf, R. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213027200 · Cited by 41
Activation of CD95L fusion protein prodrugs by tumor-associated proteases
Watermann, I., Gerspach, J., Lehne, M., Seufert, J., Schneider, B., Pfizenmaier, K., & Wajant, H. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402051 · Cited by 40
Arts, J., Grimbergen, J. M., Bosma, P. J., Rahmsdorf, H. J., & Kooistra, T. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00393.x · Cited by 40
Nanbu, R., Montero, L., D'Orazio, D., & Nagamine, Y. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00169.x · Cited by 40
Kondraganti, S., Gondi, C. S., McCutcheon, I. E., Dinh, D., Gujrati, M., Rao, J., & Olivero, W. C. (2006) · International Journal of Oncology · doi:10.3892/ijo.28.6.1353 · Cited by 40
Muehlenweg, B., Assfalg‐Machleidt, I., Gil-Parrado, S., Bürgle, M., Creutzburg, S., Schmitt, M., Auerswald, E. A., Machleidt, W., & Magdolen, V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000383200 · Cited by 39
A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells
Croucher, D. R., Saunders, D. N., Stillfried, G. E., & Ranson, M. (2007) · Biochemical Journal · doi:10.1042/bj20070767 · Cited by 39
Shiomi, H., Eguchi, Y., Tani, T., Kodama, M., & Hattori, T. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64761-x · Cited by 39
Zhang, L. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i25.3970 · Cited by 38
Plasminogen activator inhibitor-1 gene polymorphism and colorectal cancer risk and prognosis
Loktionov, A. S. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00556-6 · Cited by 38
Champelovier, P., Boucard, N., Levacher, G., Simon, A., Seigneurin, D., & Praloran, V. (2002) · Urological Research · doi:10.1007/s00240-002-0270-5 · Cited by 38
Mohanam, S., Chandrasekar, N., Yanamandra, N., Siddique, K., Mirza, F., Dinh, D. H., Olivero, W. C., & Rao, J. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205893 · Cited by 38
Luther, T., Kotzsch, M., Meye, A., Langerholc, T., Füssel, S., Olbricht, N., Albrecht, S., Ockert, D., Muehlenweg, B., Friedrich, K., et al. (2003) · PubMed · doi:10.1267/thro03040705 · Cited by 38
Tan, X., Egami, H., Nozawa, F., Abe, M., & Baba, H. (2006) · International Journal of Oncology · doi:10.3892/ijo.28.2.369 · Cited by 37
Simeone, A., Nieves-Alicea, R., McMurtry, V., Colella, S., Krahe, R., & Tari, A. M. (2007) · International Journal of Oncology · doi:10.3892/ijo.30.4.785 · Cited by 37
Harbeck, N., Schmitt, M., Paepke, S., Allgayer, H., & Kates, R. E. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360601040970 · Cited by 37
Regulation of Urokinase Receptor Expression by p53: Novel Role in Stabilization of uPAR mRNA
Shetty, S., Velusamy, T., Idell, S., Shetty, P. K., Mazar, A. P., Bhandary, Y. P., & Shetty, R. R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00080-07 · Cited by 37
Antitumor efficacy of a urokinase activation–dependent anthrax toxin
Rønø, B., Rømer, J., Liu, S., Bugge, T. H., Leppla, S. H., & Kristjansen, P. E. G. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0163 · Cited by 37
Kobayashi, H., Yagyu, T., Inagaki, K., Kondo, T., Suzuki, M., Kanayama, N., & Terao, T. (2004) · Cancer · doi:10.1002/cncr.20034 · Cited by 36
Suramin in adrenocortical cancer: limited efficacy and serious toxicity
Arlt, W., Reincke, M., Siekmann, L., WInkelmann, W., & Allolio, B. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02549.x · Cited by 36
Graf, M., Reif, S., Hecht, K., Pelka‐Fleischer, R., Pfister, K., & Schmetzer, H. M. (2005) · American Journal of Hematology · doi:10.1002/ajh.20337 · Cited by 36
Maurer, F., & Medcalf, R. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26074 · Cited by 36
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines
Barber, C., DICKINSON, R. P., & Fish, P. V. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.03.094 · Cited by 36
Alpha 2-plasmin inhibitor and its deficiency states.
Saito, H. (1988) · PubMed · Cited by 36
Rustamzadeh, E., Li, C., Doumbia, S., Hall, W. A., & Vallera, D. A. (2003) · Journal of Neuro-Oncology · doi:10.1023/a:1026238331739 · Cited by 35
Daneri‐Navarro, A., Macías-López, G. G., Oceguera‐Villanueva, A., del Toro‐Arreola, S., Bravo‐Cuéllar, A., Pérez‐Montfort, R., & Orbach-Arbouys, S. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(97)10038-7 · Cited by 35
Beppu, M., Ikebe, T., & Shirasuna, K. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00080-1 · Cited by 35
Iwamoto, J., Mizokami, Y., Takahashi, K., Nakajima, K., Ohtsubo, T., Miura, S., Narasaka, T., Takeyama, H., Omata, T., Shimokobe, K., et al. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510015665 · Cited by 35
Expression of UPA and UPAR is associated with the clinical course of urinary bladder neoplasms
Seddighzadeh, M., Steineck, G., Larsson, P., Wijkström, H., Norming, U., Onelöv, E., & Linder, S. T. (2002) · International Journal of Cancer · doi:10.1002/ijc.10426 · Cited by 35
PEGylated DX-1000: Pharmacokinetics and Antineoplastic Activity of a Specific Plasmin Inhibitor
Devy, L., Rabbani, S. A., Stochl, M., Ruskowski, M., Mackie, I. J., Naa, L., Toews, M., van Gool, R., Chen, J., Ley, A., et al. (2007) · Neoplasia · doi:10.1593/neo.07544 · Cited by 35
Plasminogen activator inhibitor‐1 as a potential marker for the malignancy of gastric cancer
Sakakibara, T., Hibi, K., Koike, M., Fujiwara, M., Kodera, Y., Ito, K., & Nakao, A. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00185.x · Cited by 35
Hofmann, H., Bartling, B., Simm, A., Murray, R., Aziz, N. A., Hansen, G., Silber, R., & Burdach, S. E. G. (2006) · Oncology Reports · doi:10.3892/or.16.3.587 · Cited by 35
Expression of E-Cadherin and uPA and their Association with the Prognosis of Pancreatic Cancer
Shin, S. J., Kim, K. O., Kim, M. K., Lee, K. H., Hyun, M. S., Kim, K., Choi, J. H., & SONG, H. S. (2005) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyi094 · Cited by 35
Giannopoulou, I., Mylona, E., Kapranou, A., Mavrommatis, J., Markaki, S., Zoumbouli, C., Keramopoulos, A., & Nakopoulou, L. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.03.003 · Cited by 35
Antalis, T., Costelloe, E. O., Muddiman, J. D., Ogbourne, S. M., & Donnan, K. (1996) · Blood · doi:10.1182/blood.v88.10.3686.bloodjournal88103686 · Cited by 35
Tecimer, C., Doering, D. L., Goldsmith, L. J., Meyer, J. S., Abdulhay, G., & Wittliff, J. L. (2000) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.2000.010005372.x · Cited by 34
Suramin in Non-small Cell Lung Cancer and Advanced Breast Cancer: Two Parallel Phase II Studies
Mirza, M. R., Jakobsen, E. H., Pfeiffer, P., Lindebjerg-Clasen, B., Bergh, J. C. S., & Rose, C. (1997) · Acta Oncologica · doi:10.3109/02841869709109226 · Cited by 34
Swiercz, R., Wolfe, J. D., Zaher, A., & Jankun, J. (1998) · PubMed · Cited by 34
Meroni, G., Buraggi, G., Mantovani, R., & Taramelli, R. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00373.x · Cited by 33
Increased levels of plasminogen activator inhibitor-1 (PAI-1) in human brain tumors
Rao, J. S., Rayford, A., Morantz, R. A., Festoff, B. W., & Sawaya, R. A. (1993) · Journal of Neuro-Oncology · doi:10.1007/bf01049977 · Cited by 33
Naka, T., Kuester, D., Boltze, C., Schulz, T., Samii, A., Herold, C., Ostertag, H., & Roessner, A. (2007) · Human Pathology · doi:10.1016/j.humpath.2007.06.005 · Cited by 33
Żesławska, E., Jacob, U., Schweinitz, A., Coombs, G. S., Bode, W., & Madison, E. L. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00267-5 · Cited by 33
Skeldal, S., Krogdahl, A., Sørensen, J. A., Andreasen, P. A., & Gao, S. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-02-0114 · Cited by 33
Nielsen, A., Scarlett, C. J., Samra, J. S., Gill, A. J., Li, Y., Allen, B., & Smith, R. C. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03531.x · Cited by 33
Pappot, H., Pedersen, A. N., Brünner, N., & Christensen, I. J. (2005) · Lung Cancer · doi:10.1016/j.lungcan.2005.10.002 · Cited by 33
Zannetti, A., Vecchio, S. D., Romanelli, A., Scala, S., Saviano, M., Calı̀, G., Stoppelli, M. P., Pedone, C., & Salvatore, M. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.07.024 · Cited by 32
Almasi, C. E., Høyer‐Hansen, G., Christensen, I. J., Danø, K., & Pappot, H. (2005) · Lung Cancer · doi:10.1016/j.lungcan.2004.11.020 · Cited by 32
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines
Barber, C., DICKINSON, R. P., & Horne, V. A. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00701-6 · Cited by 32
Magdolen, V., Bürgle, M., de Prada, N. A., Schmiedeberg, N., Riemer, C., Schroeck, F. R., Kellermann, J., Degitz, K., Wilhelm, O. G., Schmitt, M., et al. (2001) · Biological Chemistry · doi:10.1515/bc.2001.150 · Cited by 32
Nozaki, S., Endo, Y., Nakahara, H., Yoshizawa, K., Hashiba, Y., Kawashiri, S., Tanaka, A., Nakagawa, K., Matsuoka, Y., Kogo, M., et al. (2005) · Oral Oncology · doi:10.1016/j.oraloncology.2005.05.013 · Cited by 32
Structure of Human α2-Plasmin Inhibitor Deduced from the cDNA Sequence1
Tone, M., Kikuno, R. F., Kume-Iwaki, A., & Hashimoto-Gotoh, T. (1987) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122141 · Cited by 31
Lutz, V., Reuning, U., Krüger, A., Luther, T., von Steinburg, S. P., Graeff, H., Schmitt, M., Wilhelm, O. G., & Magdolen, V. (2001) · Biological Chemistry · doi:10.1515/bc.2001.095 · Cited by 31
Aref, S., El-Sherbiny, M., Mabed, M., Menessy, A., & El‐Refaei, M. F. (2003) · Hematology · doi:10.1080/10245330310001621323 · Cited by 31
Kim, M. H., Yoo, H., Jang, H., Baek, M. J., Kim, H., Kim, K. K., Shin, B. A., Ahn, B. W., & Jung, Y. D. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.19.4.689 · Cited by 31
Riisbro, R., Christensen, I. J., Nielsen, H. J., Brünner, N., Nilbert, M. C., & Fernebro, E. (2005) · The International Journal of Biological Markers · doi:10.1177/172460080502000203 · Cited by 31
Koutsilieris, M., Reyes‐Moreno, C., Sourla, A., Dimitriadou, V., & Choki, I. (1997) · PubMed · Cited by 30
Rustamzadeh, E., Vallera, D. A., Todhunter, D. A., Low, W. C., Panoskaltsis‐Mortari, A., & Hall, W. A. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9051-7 · Cited by 30
Prognostic value of plasminogen activator inhibitor‐1 in head and neck squamous cell carcinoma
Speleman, L., Kerrebijn, J. D. F., Look, M. P., Meeuwis, C. A., Foekens, J. A., & Berns, E. M. J. J. (2006) · Head & Neck · doi:10.1002/hed.20527 · Cited by 30
Thomas, S., Muralidharan, A., & Shah, G. V. (2007) · International Journal of Oncology · doi:10.3892/ijo.31.6.1425 · Cited by 29
de Bock, C. E., Lin, Z., Itoh, T., Morris, D. L., Murrell, G. A. C., & Wang, Y. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04778.x · Cited by 29
Sakakibara, T., Hibi, K., Kodera, Y., Ito, K., Akiyama, S., & Nakao, A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0196 · Cited by 29
Hénic, E., Sixt, M., Hansson, S. R., Høyer‐Hansen, G., & Casslén, B. G. (2005) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.09.038 · Cited by 29
Cobos, E., Jumper, C., & Lox, C. D. (2003) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/107602960300900309 · Cited by 29
Cited by
Sorted by citations
Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366
Diabetes and Cancer: A Consensus Report
Giovannucci, E. L., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20078 · Cited by 1,082
Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry
Mucha, A., Kafarski, P. K., & Berlicki, Ł. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200587f · Cited by 679
Exploring the next generation of antibody–drug conjugates
Tsuchikama, K., Anami, Y., Ha, S. Y. Y., & Yamazaki, C. M. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00850-2 · Cited by 659
Wood, S. L., Pernemalm, M., Crosbie, P. A. J., & Whetton, A. D. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.10.001 · Cited by 494
Metadata
- Authors
- Ulisse, S., Baldini, E., Sorrenti, S., & D'Armiento, M.
- Affiliations
- Sapienza University of Rome (IT)
- Venue
- Current Cancer Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-02-01
- Volume
- 9
- Issue
- 1
- Pages
- 32-71
- ISSN
- 1568-0096 (ISSN-L)
- OpenAlex
- W2135351121
- Cited by
- 312
- References
- 493
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 16 · 2021: 18 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 17 · 2016: 17 · 2015: 23 · 2014: 33 · 2013: 31 · 2012: 25
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Cancer Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- urokinase, urokinase receptor, plasminogen activator inhibitor-1, plasminogen activator inhibitor-2, plasmin, extracellular matrix remodeling, metastasis, tumor progression, tumor angiogenesis, breast cancer, prognostic factors, cancer therapy, uPA inhibitors, monoclonal antibodies, gene therapy, xenograft models
- MeSH terms
- Antineoplastic Agents, Humans, Neoplasms, Urokinase-Type Plasminogen Activator
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review