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Keratinocytes in Inflammatory Skin Diseases
Abstract
Although in the past, keratinocytes were considered simply as passive targets of immunological attack from infiltrating T lymphocytes, a number of studies have definitively demonstrated that keratinocytes actively participate in the cutaneous immune responses. Upon activation, keratinocytes express a plethora of cytokines, chemokines and accessory molecules, which can transmit both positive and negative signals to cells of innate and adaptive immunity. Dysregulation and abnormal expression of inflammatory mediators or their receptors in keratinocytes are relevant to the pathogenesis of chronic inflammatory skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis.
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Cited by
Tuckermann, J. P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B. E., Stride, B., Förster, I., Habenicht, A. J. R., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28034 · Cited by 252
Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202
The pathogenic role of tissue-resident immune cells in psoriasis
Boyman, O., Conrad, C., Tonel, G., Gilliet, M., & Nestle, F. O. (2007) · Trends in Immunology · doi:10.1016/j.it.2006.12.005 · Cited by 151
Organization of the skin immune system and compartmentalized immune responses in infectious diseases
Quaresma, J. A. S. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-18 · Cited by 149
What is a role of haeme oxygenase‐1 in psoriasis? Current concepts of pathogenesis
Wojas‐Pelc, A., & Marcinkiewicz, J. (2007) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2006.00505.x · Cited by 36
Metadata
- Authors
- Albanesi, C., Scarponi, C., Giustizieri, M., & Girolomoni, G.
- Venue
- Current Drug Target -Inflammation & Allergy
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-06-01
- Volume
- 4
- Issue
- 3
- Pages
- 329-334
- ISSN
- 1568-010X (ISSN-L)
- OpenAlex
- W1996188800
- Cited by
- 234
- References
- 0
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Albanesi, C., Scarponi, C., Giustizieri, M., & Girolomoni, G. (2005). Keratinocytes in Inflammatory Skin Diseases. Current Drug Target -Inflammation & Allergy. https://doi.org/10.2174/1568010054022033
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
