The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance
Abstract
Macrolides are among the most clinically important antibiotics. However, many aspects of macrolide action and resistance remain obscure. In this review we summarize the current knowledge, as well as unsolved questions, regarding the principles of macrolide binding to the large ribosomal subunit and the mechanism of drug action. Two mechanisms of macrolide resistance, inducible expression of Erm methyltransferase and peptide-mediated resistance, appear to depend on specific interactions between the ribosome-bound macrolide molecule and the nascent peptide. The similarity between these mechanisms and their relation to the general mode of macrolide action is discussed and the discrepancies between currently available data are highlighted.
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Cites
Crystal structure of the ribosome at 5.5 Å resolution
Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H. D., & Noller, H. F. (2001) · Science · doi:10.1126/science.1060089 · Cited by 1,944
Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells
Chittum, H. S., & Champney, W. S. (1995) · Current Microbiology · doi:10.1007/bf00295501 · Cited by 88
Cited by
Natural products to drugs: natural product-derived compounds in clinical trials
Butler, M. S. (2008) · Natural Product Reports · doi:10.1039/b514294f · Cited by 1,075
Helicobacter pylori infection and antibiotic resistance — from biology to clinical implications
Tshibangu-Kabamba, E., & Yamaoka, Y. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00449-x · Cited by 517
Antibiotic Resistance and the MRSA Problem
Vestergaard, M., Frees, D., & Ingmer, H. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0057-2018 · Cited by 490
The A-Z of bacterial translation inhibitors
Wilson, D. N. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409230903307311 · Cited by 322
Bioaccumulation and analytics of pharmaceutical residues in the environment: A review
Puckowski, A., Mioduszewska, K., Łukaszewicz, P., Borecka, M., Caban, M., Maszkowska, J., & Stepnowski, P. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.02.049 · Cited by 304
Metadata
- Authors
- Gaynor, M., & Mankin, A.
- Venue
- Current Topics in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2003-05-01
- Volume
- 3
- Issue
- 9
- Pages
- 949-960
- ISSN
- 1568-0266 (ISSN-L)
- OpenAlex
- W2127826649
- Cited by
- 235
- References
- 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
