The A-Z of bacterial translation inhibitors

VMD: visual molecular dynamics

Humphrey, W., Dalke, A., & Schulten, K. (1996) · Journal of Molecular Graphics · doi:10.1016/0263-7855(96)00018-5 · Cited by 66,952 · see citing works

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

Guex, N., & Peitsch, M. (1997) · Electrophoresis · doi:10.1002/elps.1150181505 · Cited by 11,589 · see citing works

Escherichia coli and Salmonella :cellular and molecular biology

Neidhardt, F. C. (1996) · ASM Press eBooks · Cited by 8,230 · see citing works

Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance

Chopra, I., & Roberts, M. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.2.232-260.2001 · Cited by 4,517 · see citing works

A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics

Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.049 · Cited by 2,982 · see citing works

RASMOL: biomolecular graphics for all

Sayle, R. A. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89080-5 · Cited by 2,587 · see citing works

The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

Nissen, P., Hansen, J., Ban, N., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.920 · Cited by 2,269 · see citing works

Crystal structure of the ribosome at 5.5 Å resolution

Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H. D., & Noller, H. F. (2001) · Science · doi:10.1126/science.1060089 · Cited by 1,944 · see citing works

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

Carter, A. P., Clemons, W. M., Brodersen, D. E., Morgan-Warren, R. J., Wimberly, B. T., & Ramakrishnan, V. (2000) · Nature · doi:10.1038/35030019 · Cited by 1,615 · see citing works

Molecular mechanisms that confer antibacterial drug resistance

Walsh, C. T. (2000) · Nature · doi:10.1038/35021219 · Cited by 1,579 · see citing works

Structure of the 70S Ribosome Complexed with mRNA and tRNA

Selmer, M., Dunham, C., Murphy, F., Weixlbaumer, A., Petry, S., Kelley, A. C., Weir, J., & Ramakrishnan, V. (2006) · Science · doi:10.1126/science.1131127 · Cited by 1,352 · see citing works

The Molecular Basis of Antibiotic Action

Gale, E. F. (1981) · Medical Entomology and Zoology · Cited by 1,219 · see citing works

Recognition of Cognate Transfer RNA by the 30 <i>S</i> Ribosomal Subunit

Ogle, J. M., Brodersen, D. E., Clemons, W. M., Tarry, M. J., Carter, A. P., & Ramakrishnan, V. (2001) · Science · doi:10.1126/science.1060612 · Cited by 1,162 · see citing works

Interaction of antibiotics with functional sites in 16S ribosomal RNA

Moazed, D., & Noller, H. F. (1987) · Nature · doi:10.1038/327389a0 · Cited by 1,150 · see citing works

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

Schlünzen, F., Zarivach, R., Harms, J., Bashan, A., Tocilj, A., Albrecht, R., Yonath, A., & Franceschi, F. J. (2001) · Nature · doi:10.1038/35101544 · Cited by 1,057 · see citing works

The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit

Brodersen, D. E., Clemons, W. M., Carter, A. P., Morgan-Warren, R. J., Wimberly, B. T., & Ramakrishnan, V. (2000) · Cell · doi:10.1016/s0092-8674(00)00216-6 · Cited by 950 · cited 18× · see citing works

Crystal Structure of the Ternary Complex of Phe-tRNA Phe , EF-Tu, and a GTP Analog

Nissen, P., Kjeldgaard, M., Thirup, S., Polekhina, G., Reshetnikova, L. S., Clark, B. F. C., & Nyborg, J. (1995) · Science · doi:10.1126/science.270.5241.1464 · Cited by 851 · see citing works

Structure of the A Site of <i>Escherichia coli</i> 16 <i>S</i> Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

Fourmy, D., Recht, M. I., Blanchard, S. C., & Puglisi, J. D. (1996) · Science · doi:10.1126/science.274.5291.1367 · Cited by 829 · see citing works

Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form

Ogle, J. M., Murphy, F. V., Tarry, M. J., & Ramakrishnan, V. (2002) · Cell · doi:10.1016/s0092-8674(02)01086-3 · Cited by 663 · see citing works

Thiopeptide Antibiotics

Bagley, M. C., Dale, J. W., Merritt, E. A., & Xiong, X. (2005) · Chemical Reviews · doi:10.1021/cr0300441 · Cited by 612 · see citing works

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

Kohanski, M. A., Dwyer, D. J., Wierzbowski, J., Cottarel, G., & Collins, J. J. (2008) · Cell · doi:10.1016/j.cell.2008.09.038 · Cited by 576 · see citing works

Macrolide Resistance Conferred by Base Substitutions in 23S rRNA

Vester, B., & Douthwaite, S. R. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.1-12.2001 · Cited by 562 · see citing works

The Oxazolidinone Linezolid Inhibits Initiation of Protein Synthesis in Bacteria

Swaney, S. M., Aoki, H., GANOZA, M. C., et al. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.12.3251 · Cited by 557 · see citing works

Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3

Pioletti, M., Schlünzen, F., Harms, J., Zarivach, R., Glühmann, M., Avila, H., Bashan, A., Bartels, H., Auerbach, T., Jacobi, C., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.8.1829 · Cited by 527 · see citing works

The structures of four macrolide antibiotics bound to the large ribosomal subunit.

Hansen, J., Ippolito, J., Ban, N., Nissen, P., Moore, P., & Steitz, T. (2002) · Molecules and Cells · doi:10.1016/s1097-2765(02)00570-1 · Cited by 523 · see citing works

Mechanism of bactericidal action of aminoglycosides

Davis, B. D. (1987) · Microbiological Reviews · doi:10.1128/mr.51.3.341-350.1987 · Cited by 511 · see citing works

Initiation of mRNA translation in prokaryotes

Gualerzi, C. O., & Pon, C. L. (1990) · Biochemistry · doi:10.1021/bi00477a001 · Cited by 502 · see citing works

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

Moazed, D., & Noller, H. F. (1989) · Cell · doi:10.1016/0092-8674(89)90128-1 · Cited by 500 · see citing works

Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA

Moazed, D., Robertson, J., & Noller, H. F. (1988) · Nature · doi:10.1038/334362a0 · Cited by 486 · see citing works

tRNA selection and kinetic proofreading in translation

Blanchard, S. C., Gonzalez, R. L., Kim, H. D., Chu, S., & Puglisi, J. D. (2004) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb831 · Cited by 466 · see citing works

The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome

Tenson, T., Lovmar, M., & Ehrenberg, M. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00662-4 · Cited by 461 · see citing works

A structural understanding of the dynamic ribosome machine

Steitz, T. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2352 · Cited by 449 · see citing works

Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance

Connell, S. R., Tracz, D. M., Nierhaus, K. H., & Taylor, D. E. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.12.3675-3681.2003 · Cited by 449 · see citing works

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.

Tu, D., Blaha, G., Moore, P., & Steitz, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.005 · Cited by 439 · see citing works

Initiation of Protein Synthesis from the A Site of the Ribosome

Wilson, J. E., Pestova, T. V., Hellen, C. U. T., & Sarnow, P. (2000) · Cell · doi:10.1016/s0092-8674(00)00055-6 · Cited by 430 · see citing works

Inhibitors of protein synthesis

Vázquez, D. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80689-7 · Cited by 413 · see citing works

Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit

Hansen, J. L., Moore, P. B., & Steitz, T. A. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00668-5 · Cited by 392 · see citing works

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

Spahn, C. M. T., Gómez-Lorenzo, M. G., Grassucci, R. A., Jørgensen, R., Andersen, G. R., Beckmann, R., Penczek, P. A., Ballesta, J. P. G., & Frank, J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600102 · Cited by 385 · see citing works

Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions

Shinabarger, D. L., Marotti, K. R., Murray, R. W., Lin, A. H., Melchior, E. P., Swaney, S. M., Dunyak, D. S., Demyan, W. F., & Buysse, J. M. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.10.2132 · Cited by 382 · see citing works

Fidelity at the Molecular Level: Lessons from Protein Synthesis

Zaher, H. S., & Green, R. (2009) · Cell · doi:10.1016/j.cell.2009.01.036 · Cited by 381 · see citing works

Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site

Vicens, Q., & Westhof, É. (2001) · Structure · doi:10.1016/s0969-2126(01)00629-3 · Cited by 375 · see citing works

Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis

Mukhtar, T. A., & Wright, G. D. (2005) · Chemical Reviews · doi:10.1021/cr030110z · Cited by 374 · see citing works

Insights into the decoding mechanism from recent ribosome structures

Ogle, J. M., Carter, A. P., & Ramakrishnan, V. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00066-5 · Cited by 372 · see citing works

Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

Borovinskaya, M. A., Pai, R., Zhang, W., Schuwirth, B., Holton, J., Hirokawa, G., Kaji, H., Kaji, A., & Cate, J. H. D. (2007) · Nature Structural &Molecular Biology · doi:10.1038/nsmb1271 · Cited by 366 · see citing works

An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA

Schmeing, T. M., Huang, K. S., Strobel, S. A., & Steitz, T. A. (2005) · Nature · doi:10.1038/nature04152 · Cited by 351 · see citing works

Ribosome-inactivating proteins: progress and problems

Stirpe, F., & Battelli, M. G. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6078-7 · Cited by 348 · see citing works

Visualization of elongation factor Tu on the Escherichia coli ribosome

Stark, H., Rodnina, M. V., Rinke-Appel, J., Brimacombe, R. L. C., Wintermeyer, W., & van Heel, M. (1997) · Nature · doi:10.1038/38770 · Cited by 347 · see citing works

Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA

Moazed, D., & Noller, H. F. (1987) · Biochimie · doi:10.1016/0300-9084(87)90215-x · Cited by 338 · see citing works

A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503

Kehrenberg, C., Schwarz, Š., Jacobsen, L., et al. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04754.x · Cited by 337 · see citing works

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy

Valle, M., Zavialov, A. V., Li, W., Stagg, S. M., Sengupta, J., Nielsen, R. C., Nissen, P., Harvey, S. C., Ehrenberg, M., & Frank, J. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb1003 · Cited by 333 · see citing works

Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates

Lu, J., & DEUTSCH, C. J. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.08.089 · Cited by 328 · see citing works

The Ribosome, Structure, Function, Antibiotics, and Cellular Interactions

Garrett, R. A. (2000) · Research at the University of Copenhagen (University of Copenhagen) · Cited by 325 · see citing works

Visualization of elongation factor G on the Escherichia coli 70S ribosome: The mechanism of translocation

Agrawal, R. K., Penczek, P. A., Grassucci, R. A., & Frank, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6134 · Cited by 325 · see citing works

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

Wilson, D. N., Schluenzen, F., Harms, J. M., Starosta, A. L., Connell, S. R., & Fucini, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804276105 · Cited by 317 · see citing works

Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit

Ippolito, J. A., Kanyo, Z. F., Wang, D., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800379d · Cited by 307 · see citing works

Resistance to Linezolid: Characterization of Mutations in rRNA and Comparison of Their Occurrences in Vancomycin-Resistant Enterococci

Prystowsky, J., Siddiqui, F., Chosay, J. G., Shinabarger, D. L., Millichap, J. G., Peterson, L. R., & Noskin, G. A. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.7.2154-2156.2001 · Cited by 301 · see citing works

EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome.

Agrawal, R. K., Heagle, A. B., Penczek, P. A., Grassucci, R. A., & Frank, J. (1999) · Nature Structural Biology · doi:10.1038/10695 · Cited by 298 · see citing works

Cryo‐EM reveals an active role for aminoacyl‐tRNA in the accommodation process

Valle, M., Sengupta, J., Swami, N. K., Grassucci, R. A., Burkhardt, N., Nierhaus, K. H., Agrawal, R. K., & Frank, J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf326 · Cited by 296 · see citing works

Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.

Harms, J., Wilson, D., Schluenzen, F., Connell, S., Stachelhaus, T., Zaborowska, Z., Spahn, C., & Fucini, P. (2008) · Molecules and Cells · doi:10.1016/j.molcel.2008.01.009 · Cited by 296 · see citing works

The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA

Hansen, L. H., Mauvais, P., & Douthwaite, S. R. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01202.x · Cited by 292 · see citing works

Structural Basis of the Ribosomal Machinery for Peptide Bond Formation, Translocation, and Nascent Chain Progression

Bashan, A., Agmon, I., Zarivach, R., Schluenzen, F., Harms, J. M., Berisio, R., Bartels, H., Franceschi, F. J., Auerbach, T., Hansen, H. A. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00009-1 · Cited by 286 · see citing works

The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli

Allen, G. S., Zavialov, A. V., Gursky, R. P., Ehrenberg, M., & Frank, J. (2005) · Cell · doi:10.1016/j.cell.2005.03.023 · Cited by 283 · see citing works

Simulating movement of tRNA into the ribosome during decoding

Sanbonmatsu, K. Y., Joseph, S., & Tung, C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503456102 · Cited by 282 · see citing works

Structural insights into peptide bond formation

Hansen, J., Schmeing, T., Moore, P., & Steitz, T. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.172404099 · Cited by 278 · see citing works

The Site of Action of Oxazolidinone Antibiotics in Living Bacteria and in Human Mitochondria

Leach, K. L., Swaney, S. M., Colca, J. R., McDonald, W. G., Blinn, J. R., Thomasco, L. M., Gadwood, R. C., Shinabarger, D. L., Xiong, L., & Mankin, A. S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.04.005 · Cited by 278 · see citing works

Mechanism of bactericidal action of aminoglycosides.

Davis, B. D. (1987) · Microbiological Reviews · doi:10.1128/mmbr.51.3.341-350.1987 · Cited by 278 · see citing works

Molecular Analysis of Cross-Resistance to Capreomycin, Kanamycin, Amikacin, and Viomycin in Mycobacterium tuberculosis

Maus, C. E., Plikaytis, B. B., & Shinnick, T. M. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.8.3192-3197.2005 · Cited by 276 · see citing works

Altered Methylation of Ribosomal RNA in an Erythromycin-Resistant Strain of Staphylococcus aureus

Lai, C. J., & Weisblum, B. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.856 · Cited by 275 · see citing works

Paromomycin binding induces a local conformational change in the A-site of 16 s rRNA

Fourmy, D., Yoshizawa, S., & Puglisi, J. D. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1551 · Cited by 273 · see citing works

From Amino Acids to Heteroaromatics—Thiopeptide Antibiotics, Nature's Heterocyclic Peptides

Hughes, R. A., & Moody, C. J. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200700728 · Cited by 269 · see citing works

Insights into erythromycin action from studies of its activity as inducer of resistance

Weisblum, B. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.4.797 · Cited by 267 · see citing works

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

Skinner, R. H., Cundliffe, E., & Schmidt, F. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44232-3 · Cited by 266 · see citing works

Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction.

Schmeing, T., Huang, K. S., Kitchen, D., Strobel, S., & Steitz, T. (2005) · Molecules and Cells · doi:10.1016/j.molcel.2005.09.006 · Cited by 261 · see citing works

The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin

Lin, A. H., Murray, R. W., Vidmar, T. J., & Marotti, K. R. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.10.2127 · Cited by 261 · see citing works

Folding zones inside the ribosomal exit tunnel

Lu, J., & DEUTSCH, C. J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1021 · Cited by 255 · see citing works

Capreomycin Binds across the Ribosomal Subunit Interface Using tlyA-Encoded 2′-O-Methylations in 16S and 23S rRNAs

Johansen, S. K., Maus, C. E., Plikaytis, B. B., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.044 · Cited by 251 · see citing works

Regulatory Nascent Peptides in the Ribosomal Tunnel

Tenson, T., & Ehrenberg, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00669-4 · Cited by 240 · see citing works

Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

Schlünzen, F., Pyetan, E., Fucini, P., Yonath, A., & Harms, J. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04346.x · Cited by 240 · see citing works

Inhibitors of Protein Biosynthesis

Vázquez, D. (1979) · Molecular biology, biochemistry, and biophysics · doi:10.1007/978-3-642-81309-2 · Cited by 238 · see citing works

Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance

Gaynor, M., & Mankin, A. S. (2003) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026033452159 · Cited by 237 · see citing works

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

Villa, E., Sengupta, J., Trabuco, L. G., LeBarron, J., Baxter, W. T., Shaikh, T. R., Grassucci, R. A., Nissen, P., Ehrenberg, M., Schulten, K. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811370106 · Cited by 232 · see citing works

Structural Basis for the Antibiotic Activity of Ketolides and Azalides

Schlünzen, F., Harms, J., Franceschi, F. J., Hansen, H. A. S., Bartels, H., Zarivach, R., & Yonath, A. (2003) · Structure · doi:10.1016/s0969-2126(03)00022-4 · Cited by 231 · see citing works

Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA

Woodcock, J., Moazed, D., Cannon, M., Davies, J., & Noller, H. F. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07863.x · Cited by 229 · see citing works

Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics

Nicolaou, K. C., Chen, J. S., Edmonds, D. J., & Estrada, A. A. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200801695 · Cited by 225 · see citing works

Quality control by the ribosome following peptide bond formation

Zaher, H. S., & Green, R. (2008) · Nature · doi:10.1038/nature07582 · Cited by 224 · see citing works

Fusidic Acid: a New Antibiotic

Godtfredsen, W. O., JAHNSEN, S., Lorck, H., et al. (1962) · Nature · doi:10.1038/193987a0 · Cited by 220 · see citing works

Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center 1 1Edited by D. E. Draper

Kloss, P., Xiong, L., Shinabarger, D. L., et al. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3247 · Cited by 214 · see citing works

The Weird and Wonderful World of Bacterial Ribosome Regulation

Wilson, D. N., & Nierhaus, K. H. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701360843 · Cited by 208 · see citing works

The Ribosomal Peptidyl Transferase Center: Structure, Function, Evolution, Inhibition

Polacek, N., & Mankin, A. S. (2005) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230500326334 · Cited by 205 · see citing works

The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome

Qin, Y., Polacek, N., Vesper, O., Staub, E., Einfeldt, E., Wilson, D. N., & Nierhaus, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.09.037 · Cited by 205 · see citing works

Conformational switch in the decoding region of 16S rRNA during aminoacyl-tRNA selection on the ribosome.

Rodnina, M. V., Pape, T., & Wintermeyer, W. (2000) · Nature Structural Biology · doi:10.1038/72364 · Cited by 204 · see citing works

A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits

Schmeing, T. M., Seila, A. C., Hansen, J. L., Freeborn, B., Strauss-Soukup, J. K., Scaringe, S. A., Strobel, S. A., Moore, P. B., & Steitz, T. A. (2002) · Nature Structural Biology · doi:10.1038/nsb758 · Cited by 195 · see citing works

16S rRNA Mutation Associated with Tetracycline Resistance in a Gram-Positive Bacterium

Ross, J. I., Eady, E. A., Cove, J. H., & Cunliffe, W. J. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.7.1702 · Cited by 194 · see citing works

Ribotoxin recognition of ribosomal RNA and a proposal for the mechanism of translocation

Wool, I. G., Glück, A., & Endo, Y. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90407-z · Cited by 194 · see citing works

Elongation Factor 2 as a Novel Target for Selective Inhibition of Fungal Protein Synthesis

Justice, M. C., Hsu, M., Tse, B., Ku, T., Balkovec, J. M., Schmatz, D. M., & NIELSEN, J. B. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3148 · Cited by 189 · see citing works

Kinetically Competent Intermediates in the Translocation Step of Protein Synthesis

Pan, D., KIRILLOV, S. V., & Cooperman, B. S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.014 · Cited by 189 · see citing works

Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA

Douthwaite, S. R., Hansen, L. H., & Mauvais, P. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01841.x · Cited by 187 · see citing works

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

Brown, L. C. W., Acker, M. G., Clardy, J., Walsh, C. T., & Fischbach, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900008106 · Cited by 187 · see citing works

Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity

Davidovich, C., Bashan, A., Auerbach-Nevo, T., Yaggie, R. D., Gontarek, R. R., & Yonath, A. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0700041104 · Cited by 186 · see citing works

Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome

Rodnina, M. V., Savelsbergh, A., Matassova, N., Katunin, V. I., Semenkov, Y. P., & Wintermeyer, W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9586 · Cited by 186 · see citing works

Conformational Changes of the Small Ribosomal Subunit During Elongation Factor G-dependent tRNA–mRNA Translocation

Peske, F., Savelsbergh, A., Katunin, V. I., Rodnina, M. V., & Wintermeyer, W. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.08.097 · Cited by 185 · see citing works

GTPase activation of elongation factor EF‐Tu by the ribosome during decoding

Schuette, J.-C., Murphy, F. V., Kelley, A. C., Weir, J. R., Giesebrecht, J., Connell, S. R., Loerke, J., Mielke, T., Zhang, W., Penczek, P. A., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.26 · Cited by 185 · see citing works

U2504 Determines the Species Specificity of the A-site Cleft Antibiotics. The Structures of Tiamulin, Homoharringtonine and Bruceantin Bound to the Ribosome

Gürel, G., Blaha, G., Moore, P., & Steitz, T. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.04.005 · Cited by 184 · see citing works

Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

Liao, R., Duan, L., Lei, C., Pan, H., Ding, Y., Zhang, Q., Chen, D., Shen, B., Yu, Y., & Liu, W. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.01.007 · Cited by 181 · see citing works

Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors

Hausner, T. P., Atmadja, J., & Nierhaus, K. H. (1987) · Biochimie · doi:10.1016/0300-9084(87)90225-2 · Cited by 180 · see citing works

Cloning of yeast gene for trichodermin resistance and ribosomal protein L3.

Fried, H. M., & Warner, J. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.1.238 · Cited by 179 · see citing works

Structural insight into the role of the ribosomal tunnel in cellular regulation

Berisio, R., Schluenzen, F., Harms, J. M., Bashan, A., Auerbach, T., Baram, D., & Yonath, A. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb915 · Cited by 178 · see citing works

Inhibition of protein synthesis by streptogramins and related antibiotics

COCITO, C. G., Giambattista, M. D., Nyssen, E., et al. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/39.suppl_1.7 · Cited by 177 · see citing works

Translation and Protein Synthesis:  Macrolides

Katz, L., & Ashley, G. W. (2005) · Chemical Reviews · doi:10.1021/cr030107f · Cited by 177 · see citing works

Throwing a spanner in the works: antibiotics and the translation apparatus

Spahn, C. M. T., & Prescott, C. D. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00217518 · Cited by 175 · see citing works

Structural Basis for Interaction of the Ribosome with the Switch Regions of GTP-Bound Elongation Factors

Connell, S. R., Takemoto, C., Wilson, D. N., Wang, H., Murayama, K., Terada, T., Shirouzu, M., Rost, M., Schüler, M., Giesebrecht, J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.027 · Cited by 174 · see citing works

Mutations in the 16S rRNA Genes of<i>Helicobacter pylori</i>Mediate Resistance to Tetracycline

Trieber, C. A., & Taylor, D. E. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.8.2131-2140.2002 · Cited by 174 · see citing works

Translation initiation with 70S ribosomes: an alternative pathway for leaderless mRNAs

Moll, I. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh663 · Cited by 174 · see citing works

Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA

Connolly, K., Rife, J. P., & Culver, G. M. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06485.x · Cited by 173 · see citing works

The Ribosomal Peptidyl Transferase

Beringer, M., & Rodnina, M. V. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.015 · Cited by 172 · see citing works

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

Harms, J., Schlünzen, F., Fucini, P., Bartels, H., & Yonath, A. (2004) · BMC Biology · doi:10.1186/1741-7007-2-4 · Cited by 170 · see citing works

Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins

Wittmann, H. G., Stöffler, G., Apirion, D., Rosen, L., Tanaka, K., Tamaki, M., Takata, R., Dekio, S., Otaka, E., & Osawa, S. (1973) · Molecular and General Genetics MGG · doi:10.1007/bf00333665 · Cited by 169 · see citing works

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

Xiong, L., Shah, S., Mauvais, P., et al. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01203.x · Cited by 169 · see citing works

Studies on the formation of transfer ribonucleic acid-ribosome complexes

Pestka, S. (1970) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(70)90329-2 · Cited by 165 · see citing works

Programmed drug‐dependent ribosome stalling

Ramu, H., Mankin, A. S., & Vázquez‐Laslop, N. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06576.x · Cited by 165 · see citing works

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

Berisio, R., Harms, J. M., Schluenzen, F., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.14.4276-4279.2003 · Cited by 165 · see citing works

Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase

Jørgensen, R., Ortiz, P. A., Carr‐Schmid, A., Nissen, P., Kinzy, T. G., & Andersen, G. R. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb923 · Cited by 164 · see citing works

Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA

Bauer, G. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh125 · Cited by 163 · see citing works

FUCIDIN

Godtfredsen, W. O., Roholt, K., & Tybring, L. (1962) · The Lancet · doi:10.1016/s0140-6736(62)91968-2 · Cited by 162 · see citing works

The Structural Basis of Large Ribosomal Subunit Function

Moore, P. B., & Steitz, T. A. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.110601.135450 · Cited by 162 · see citing works

Dissecting the Ribosomal Inhibition Mechanisms of Edeine and Pactamycin

Dinos, G. P., Wilson, D. N., Teraoka, Y., et al. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00002-4 · Cited by 161 · see citing works

Formation of the ribosome-G factor-GDP complex in the presence of fusidic acid

Bodley, J. W., Zieve, F. J., Lin, L., et al. (1969) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(69)90934-6 · Cited by 158 · see citing works

A steric block in translation caused by the antibiotic spectinomycin.

Borovinskaya, M. A., Shoji, S., Holton, J., Fredrick, K., & Cate, J. (2007) · ACS Chemical Biology · doi:10.1021/cb700100n · Cited by 157 · see citing works

Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection

Bergeron, J., Ammirati, M., Danley, D., James, L., Norcia, M., Retsema, J., Strick, C. A., Su, W. G., Sutcliffe, J., & Wondrack, L. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.9.2226 · Cited by 157 · see citing works

Three‐dimensional cryo‐electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 Å resolution

Gómez-Lorenzo, M. G., Spahn, C. M. T., Agrawal, R. K., Grassucci, R. A., Penczek, P. A., Chakraburtty, K., Ballesta, J. P. G., Lavandera, J. L., Garcia-Bustos, J., & Frank, J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2710 · Cited by 156 · see citing works

Throwing a spanner in the works: antibiotics and the translation apparatus

Spahn, C. M. T., & Prescott, C. D. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050044 · Cited by 154 · see citing works

Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes

Menninger, J. R., & Otto, D. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.21.5.811 · Cited by 153 · see citing works

Fine Structure of the Peptidyl Transferase Centre on 23 S-like rRNAs Deduced from Chemical Probing of Antibiotic-Ribosome Complexes

Rodriguez-Fonseca, C., Amils, R., & Garrett, R. A. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.0135 · Cited by 153 · see citing works

What are antibiotics? Archaic functions for modern activities

DAVIES, J. E. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb00701.x · Cited by 153 · see citing works

Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: An analysis of x‐ray crystal structures

Vicens, Q., & Westhof, É. (2003) · Biopolymers · doi:10.1002/bip.10414 · Cited by 151 · see citing works

Nucleoside antibiotics

Suhadolnik, R. J., Chassy, B. M., & Waller, G. R. (1969) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(69)90035-5 · Cited by 148 · see citing works

Cross-linking in the Living Cell Locates the Site of Action of Oxazolidinone Antibiotics

Colca, J. R., McDonald, W. G., Waldon, D. J., Thomasco, L. M., Gadwood, R. C., Lund, E. T., Cavey, G. S., Mathews, W. R., Adams, L. D., Cecil, E. T., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302109200 · Cited by 148 · see citing works

Substrate‐and Antibiotic‐Binding Sites at the Peptidyl‐Transferase Centre of Escherichia coli Ribosomes

Fernández-Muñoz, R., Monro, R. E., Vázquez, D., et al. (1971) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1971.tb01607.x · Cited by 147 · see citing works

New developments in tetracycline antibiotics: Glycylcyclines and tetracycline efflux pump inhibitors

Chopra, I. (2002) · Drug Resistance Updates · doi:10.1016/s1368-7646(02)00051-1 · Cited by 143 · see citing works

Structural basis for hygromycin B inhibition of protein biosynthesis.

Borovinskaya, M. A., Shoji, S., Fredrick, K., & Cate, J. (2008) · RNA: A publication of the RNA Society · doi:10.1261/rna.1076908 · Cited by 143 · see citing works

Blasticidin S, a new antibiotic.

Takeuchi, S., Hirayama, K., UEDA, K., et al. (1958) · PubMed · Cited by 143 · see citing works

Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome

Myasnikov, A. G., Marzi, S., Simonetti, A., et al. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1012 · Cited by 142 · see citing works

Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site 1 1Edited by I. A. Wilson

Laurberg, M., Kristensen, O., Martemyanov, K. A., Gudkov, A. T., Нагаев, И. Ю., Hughes, D., & Liljas, A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4168 · Cited by 141 · see citing works

The antibiotic viomycin traps the ribosome in an intermediate state of translocation

Ermolenko, D. N., Spiegel, P. C., Majumdar, Z. K., et al. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1243 · Cited by 140 · see citing works

The Molecular Basis for A‐Site Mutations Conferring Aminoglycoside Resistance: Relationship between Ribosomal Susceptibility and X‐ray Crystal Structures

Pfister, P., Hobbie, S. N., Vicens, Q., Böttger, E. C., & Westhof, É. (2003) · ChemBioChem · doi:10.1002/cbic.200300657 · Cited by 140 · see citing works

Erythromycin Resistance Mutations in Ribosomal Proteins L22 and L4 Perturb the Higher Order Structure of 23 S Ribosomal RNA

Gregory, S. T., & Dahĺberg, A. E. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2839 · Cited by 139 · see citing works

Translation and Protein Synthesis: Macrolides

Katz, L., & Ashley, G. W. (2005) · ChemInform · doi:10.1002/chin.200524271 · Cited by 139 · see citing works

Tertiary interactions within the ribosomal exit tunnel

Kosolapov, A., & DEUTSCH, C. J. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1571 · Cited by 138 · see citing works

The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation

Schluenzen, F., Takemoto, C., Wilson, D. N., Kaminishi, T., Harms, J. M., Hanawa‐Suetsugu, K., Szaflarski, W., Kawazoe, M., Shirouzu, M., Nierhaus, K. H., et al. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1145 · Cited by 138 · see citing works

Catalysis of Ribosomal Translocation by Sparsomycin

Fredrick, K., & Noller, H. (2003) · Science · doi:10.1126/science.1084571 · Cited by 138 · see citing works

16S rRNA Mutation-Mediated Tetracycline Resistance in <i>Helicobacter pylori</i>

Gerrits, M. M., de Zoete, M. R., Arents, N. L. A., Kuipers, E. J., & Kusters, J. G. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.9.2996-3000.2002 · Cited by 137 · see citing works

Elongation factor G stabilizes the hybrid-state conformation of the 70S ribosome

Spiegel, P. C., Ermolenko, D. N., & Noller, H. F. (2007) · RNA · doi:10.1261/rna.601507 · Cited by 137 · see citing works

Structural analysis of kasugamycin inhibition of translation

Schuwirth, B., Day, J., Hau, C. W., Janssen, G. R., Dahĺberg, A. E., Cate, J. H. D., & Vila-Sanjurjo, A. (2006) · Nature Structural &Molecular Biology · doi:10.1038/nsmb1150 · Cited by 135 · see citing works

Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli

Chittum, H. S., & Champney, W. S. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.20.6192-6198.1994 · Cited by 134 · see citing works

Total Synthesis of Thiostrepton. Retrosynthetic Analysis and Construction of Key Building Blocks

Nicolaou, K. C., Safina, B. S., Zak, M., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0529337 · Cited by 134 · see citing works

Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes

Celma, M. L., Monro, R. E., & Vázquez, D. (1970) · FEBS Letters · doi:10.1016/0014-5793(70)80076-x · Cited by 132 · see citing works

Distinct functions of elongation factor G in ribosome recycling and translocation

Savelsbergh, A., Rodnina, M. V., & Wintermeyer, W. (2009) · RNA · doi:10.1261/rna.1592509 · Cited by 129 · see citing works

Oxazolidinone Antibiotics Target the P Site onEscherichiacoliRibosomes

Aoki, H., Ke, L., Poppe, S. M., et al. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.4.1080-1085.2002 · Cited by 129 · see citing works

Mutation in 23S rRNA Responsible for Resistance to 16-Membered Macrolides and Streptogramins in Streptococcus pneumoniae

Depardieu, F., & Courvalin, P. M. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.319-323.2001 · Cited by 128 · see citing works

The Inhibition of Ribosomal Translocation by Viomycin

MODOLFLL, J., & Vázquez, D. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11974.x · Cited by 122 · see citing works

Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin

Poulsen, S. M., Kofoed, C. B., & Vester, B. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4229 · Cited by 121 · see citing works

Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates

Pringle, M., Poehlsgaard, J., Vester, B., & Long, K. S. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04373.x · Cited by 120 · see citing works

Molecular analysis of fusidic acid resistance in Staphylococcus aureus

Besier, S. M., Ludwig, A., Brade, V., et al. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03307.x · Cited by 118 · see citing works

Dissociation Rate of Cognate Peptidyl‐tRNA from the A‐Site of Hyper‐Accurate and Error‐Prone Ribosomes

Karimi, R., & Ehrenberg, M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb20059.x · Cited by 118 · see citing works

Mechanism of action of DuP 721: inhibition of an early event during initiation of protein synthesis

Eustice, D. C., Feldman, P., Zajac, I., & Slee, A. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.8.1218 · Cited by 118 · see citing works

Inhibition of Protein Synthesis by Spectinomycin

DAVIES, J. E., Anderson, P. W., & Davis, B. D. (1965) · Science · doi:10.1126/science.149.3688.1096 · Cited by 117 · see citing works

Post‐termination complex disassembly by ribosome recycling factor, a functional tRNA mimic

Hirokawa, G., Kiel, M. C., Muto, A., Selmer, M., Raj, V. S., Liljas, A., Igarashi, K., Kaji, H., & Kaji, A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.9.2272 · Cited by 117 · see citing works

Conformational Change of Elongation Factor Tu (EF-Tu) Induced by Antibiotic Binding

Vogeley, L., Palm, G. J., Mesters, J. R., & Hilgenfeld, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100017200 · Cited by 116 · see citing works

Cooperative and Antagonistic Interactions of Peptidyl‐tRNA and Antibiotics with Bacterial Ribosomes

Contreras, A., & Vázquez, D. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11422.x · Cited by 116 · see citing works

Streptomycin interferes with conformational coupling between codon recognition and GTPase activation on the ribosome

Gromadski, K. B., & Rodnina, M. V. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb742 · Cited by 116 · see citing works

The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A

Rosendahl, G., & Douthwaite, S. R. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.3.357 · Cited by 114 · see citing works

The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre

Porse, B. T., Leviev, I., Mankin, A. S., & Garrett, R. A. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1541 · Cited by 114 · see citing works

Inhibition of ribosomal translocation by aminoglycoside antibiotics

Cabañas, M. J., Vázquez, D., & Modolell, J. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91493-6 · Cited by 114 · see citing works

Action of Sparsomycin on Ribosome-catalysed Peptidyl Transfer

Monro, R. E., Celma, M. L., & Vázquez, D. (1969) · Nature · doi:10.1038/222356a0 · Cited by 114 · see citing works

Reverse Translocation of tRNA in the Ribosome

Shoji, S., Walker, S. E., & Fredrick, K. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.025 · Cited by 113 · see citing works

Multidrug resistant to extensively drug resistant tuberculosis: What is next?

Jain, A., & Dixit, P. (2008) · Journal of Biosciences · doi:10.1007/s12038-008-0078-8 · Cited by 112 · see citing works

An Unexpected Type of Ribosomes Induced by Kasugamycin: A Look into Ancestral Times of Protein Synthesis?

Kaberdina, A. C., Szaflarski, W., Nierhaus, K. H., & Moll, I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.014 · Cited by 111 · see citing works

Structure of an EF-Tu Complex with a Thiazolyl Peptide Antibiotic Determined at 2.35 Å Resolution: Atomic Basis for GE2270A Inhibition of EF-Tu ,

Heffron, S. E., & JURNAK, F. A. (1999) · Biochemistry · doi:10.1021/bi9913597 · Cited by 109 · see citing works

Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation

Agrawal, R. K., Linde, J., Sengupta, J., Nierhaus, K. H., & Frank, J. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4907 · Cited by 109 · see citing works

Quinupristin/Dalfopristin

Lamb, H. M., Figgitt, D. P., & Faulds, D. M. (1999) · Drugs · doi:10.2165/00003495-199958060-00008 · Cited by 109 · see citing works

Alteration of a 30S Ribosomal Protein Accompanying the ram Mutation in Escherichia coli

Zimmermann, R. A., Garvin, R. T., & Gorini, L. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2263 · Cited by 103 · see citing works

Cooperative Interactions of RNA and Thiostrepton Antibiotic with Two Domains of Ribosomal Protein L11

Xing, Y., & Draper, D. E. (1996) · Biochemistry · doi:10.1021/bi952132o · Cited by 103 · see citing works

The Protein Synthesis Inhibitors, Oxazolidinones and Chloramphenicol, Cause Extensive Translational Inaccuracy in Vivo

Thompson, J., O'Connor, M., Mills, J. A., et al. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00784-2 · Cited by 102 · see citing works

The allosteric three-site model for the ribosomal elongation cycle. New insights into the inhibition mechanisms of aminoglycosides, thiostrepton, and viomycin.

Hausner, T. P., Geigenmüller, U., & Nierhaus, K. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37677-4 · Cited by 101 · see citing works

Limitations of translational accuracy

Cg, K., Hughes, D., & Ehrenberg, M. (1996) · Cited by 100 · see citing works

A novel site of antibiotic action in the ribosome: Interaction of evernimicin with the large ribosomal subunit

Belova, L., Tenson, T., Xiong, L., McNicholas, P. M., & Mankin, A. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071527498 · Cited by 98 · see citing works

The Antibiotic Micrococcin Is a Potent Inhibitor of Growth and Protein Synthesis in the Malaria Parasite

Rogers, M. J., Cundliffe, E., & McCutchan, T. F. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.3.715 · Cited by 97 · see citing works

Comparison of X-Ray Crystal Structure of the 30S Subunit-Antibiotic Complex with NMR Structure of Decoding Site Oligonucleotide-Paromomycin Complex

Lynch, S. R., Gonzalez, R. L., & Puglisi, J. D. (2003) · Structure · doi:10.1016/s0969-2126(02)00934-6 · Cited by 97 · see citing works

The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits

Hirokawa, G., Nijman, R., Raj, V. S., et al. (2005) · RNA · doi:10.1261/rna.2520405 · Cited by 97 · see citing works

Biochemical characterization of resistance determinants cloned from antibiotic-producing streptomycetes

Thompson, C. J., Skinner, R. H., Thompson, J., et al. (1982) · Journal of Bacteriology · doi:10.1128/jb.151.2.678-685.1982 · Cited by 96 · see citing works

Elongation factor Tu‐targeted antibiotics: Four different structures, two mechanisms of action

Parmeggiani, A., & Nissen, P. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.039 · Cited by 96 · see citing works

Ribosomal RNA and protein mutants resistant to spectinomycin.

Bilgin, N., Richter, A. A., Ehrenberg, M., et al. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08167.x · Cited by 95 · see citing works

Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation

Misumi, M., Nishimura, T., Komai, T., & Tanaka, N. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)90178-x · Cited by 95 · see citing works

Total Synthesis of Thiostrepton. Assembly of Key Building Blocks and Completion of the Synthesis

Nicolaou, K. C., Zak, M., Safina, B. S., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja052934z · Cited by 95 · see citing works

Binding of Thiostrepton to a Complex of 23‐S rRNA with Ribosomal Protein L11

Thompson, J., Cundliffe, E., & Stark, M. J. R. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb13184.x · Cited by 94 · see citing works

Methylation of the nucleobases in RNA oligonucleotides mediates duplex–hairpin conversion

Micura, R., Pils, W., Höbartner, C., Grubmayr, K., Ebert, M., & Jaun, B. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.19.3997 · Cited by 94 · see citing works

Ribosomal and non‐ribosomal resistance to oxazolidinones: species‐specific idiosyncrasy of ribosomal alterations

Sander, P., Belova, L., Kidan, Y. G., et al. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03242.x · Cited by 94 · see citing works

Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center

Long, K. S., Hansen, L. H., Jakobsen, L. A., et al. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.4.1458-1462.2006 · Cited by 93 · see citing works

QUINUPRISTIN/DALFOPRISTIN

Shear, N., & Litt, J. Z. (2004) · CRC Press eBooks · doi:10.3109/9780203492079-157 · Cited by 93 · see citing works

Mutation proximal to the tRNA binding region of the Nicotiana plastid 16S rRNA confers resistance to spectinomycin

Sváb, Z., & Maliga, P. (1991) · Molecular and General Genetics MGG · doi:10.1007/bf00282483 · Cited by 92 · see citing works

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

Wilson, D. N. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3155 · Cited by 1,054 · see citing works

Revisiting the structures of several antibiotics bound to the bacterial ribosome

Bulkley, D., Innis, C. A., Blaha, G., & Steitz, T. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008685107 · Cited by 308 · see citing works

The bacterial translation stress response.

Starosta, A. L., Lassak, J., Jung, K., & Wilson, D. N. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12083 · Cited by 210 · see citing works

Structural basis for TetM-mediated tetracycline resistance

Dönhöfer, A., Franckenberg, S., Wickles, S., Berninghausen, O., Beckmann, R., & Wilson, D. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208037109 · Cited by 217 · see citing works

Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome

Meydan, S., Marks, J., Klepacki, D., Sharma, V., Baranov, P. V., Firth, A. E., Margus, T., Kefi, A., Vázquez-Laslop, N., & Mankin, A. S. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.017 · Cited by 184 · see citing works

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

Jenner, L., Starosta, A. L., Terry, D. S., Mikolajka, A., Filonava, L., Yusupov, M., Blanchard, S. C., Wilson, D. N., & Yusupova, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216691110 · Cited by 204 · see citing works

Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center

Marks, J., Kannan, K., Roncase, E. J., Klepacki, D., Kefi, A., Orelle, C., Vázquez-Laslop, N., & Mankin, A. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613055113 · Cited by 159 · see citing works

Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic

Grossman, T. H., Starosta, A. L., Fyfe, C., O'Brien, W., Rothstein, D. M., Mikolajka, A., Wilson, D. N., & Sutcliffe, J. A. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06187-11 · Cited by 162 · see citing works

Structural conservation of antibiotic interaction with ribosomes

Paternoga, H., Crowe-McAuliffe, C., Bock, L. V., Koller, T. O., Morici, M., Beckert, B., Myasnikov, A. G., Grubmüller, H., Nováček, J., & Wilson, D. N. (2023) · Nature Structural &amp; Molecular Biology · doi:10.1038/s41594-023-01047-y · Cited by 94 · see citing works

Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii

Zhang, Z., Morgan, C. E., Bonomo, R. A., & Yu, E. W. (2021) · mBio · doi:10.1128/mbio.01031-21 · Cited by 58 · see citing works

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

Polikanov, Y. S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T. A., Vázquez-Laslop, N., & Mankin, A. S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.021 · Cited by 57 · see citing works

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors

Cocozaki, A. I., Altman, R. B., Huang, J., Buurman, E. T., Kazmirski, S. L., Doig, P., Prince, D. B., Blanchard, S. C., Cate, J. H. D., & Ferguson, A. D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605127113 · Cited by 56 · see citing works

Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance

Rudra, P., Hurst-Hess, K. R., Cotten, K. L., Partida-Miranda, A., & Ghosh, P. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906748117 · Cited by 53 · see citing works

Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline

Li, X., Wang, M., Denk, T., Buschauer, R., Li, Y., Beckmann, R., & Cheng, J. (2024) · Nature Communications · doi:10.1038/s41467-024-49797-7 · Cited by 21 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS

Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41 · see citing works

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint

Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 127 · see citing works

Anthoxanthum Mosaic Virus

Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6 · see citing works