The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Opioid Receptors and their Ligands
Abstract
This review gives a historical perspective, summarizing approximately 25 years of research on opioids. The “typical” opioid peptides produced in the brain, “atypical” opioids encrypted in milk protein or hemoglobin sequences, and extremely potent and selective opioids of amphibian origin are described. The main focus is on the structure-activity relationship studies of peptide ligands for three main opioid receptor types (μ, δ, κ), their selectivities and pharmacological activities in vitro. Chemical modifications that led to obtaining potent and selective agonists and antagonists for these receptors are discussed. Keywords: Opioid peptides, opioid agonists and antagonists, structure-activity relationships, opioid receptor selectivity, receptor binding assay
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Dynorphin-(1-13), an extraordinarily potent opioid peptide.
Goldstein, A., Tachibana, S., Lowney, L. I., Hunkapiller, M., & Hood, L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6666 · Cited by 882 · cited 1×
“Systematic truncation of Dyn A at the C-terminus revealed that the shorter Dyn A(1-13) and Dyn A(1-11) and their corresponding analogs with a C-terminal carboxamide function have a in vitro activity profile similar to that of the parent peptide [153-155].”
Background
Cited by
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390
EEG delta oscillations as a correlate of basic homeostatic and motivational processes
Knyazev, G. G. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.002 · Cited by 776
Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa
Zaborina, O., Lepine, F., Xiao, G., Valuckaite, V., Chen, Y., Li, T., Ciancio, M., Zaborin, A., Petroff, E., Turner, J. R., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030035 · Cited by 207
IL-10 Is Associated with Increased Mu-Opioid Receptor Levels in Major Depressive Disorder
Al-Fadhel, S. Z., Al-Hakeim, H. K., Al-Dujaili, A. H., & Maes, M. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2018.10.001 · Cited by 44
Chen, P., Lin, D., Giesler, J., & Li, C. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22620 · Cited by 39
Metadata
- Authors
- Janecka, A., Fichna, J., & Janecki, T.
- Venue
- Current Topics in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2004-01-01
- Volume
- 4
- Issue
- 1
- Pages
- 1-17
- ISSN
- 1568-0266 (ISSN-L)
- OpenAlex
- W2104930749
- Cited by
- 311
- References
- 2
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
