Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Correspondence - Tranexamic acid for traumatic brain injury

(2005) · London School of Economics and Political Science Theses Online (London School of Economics and Political Science) · doi:10.1016/s0140-6736 · Cited by 11,894

Science

(2023) · doi:10.1126/science · Cited by 6,063

Global prevalence of dementia: a Delphi consensus study

Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336

American Journal of Pathology

(2015) · American Journal Of Pathology · doi:10.2353/ajpath · Cited by 4,961

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744

Network pharmacology: the next paradigm in drug discovery

Hopkins, A. L. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.118 · Cited by 4,622

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

Sussman, J. L., Harel, M., Frolow, F., Oefner, C., Goldman, A., Toker, L., & Silman, I. (1991) · Science · doi:10.1126/science.1678899 · Cited by 2,740

New Approaches in the Design and Development of Cannabinoid Receptor Ligands: Multifunctional and Bivalent Compounds

Nimczick, M., & Decker, M. W. (2015) · ChemMedChem · doi:10.1002/cmdc.201500041 · Cited by 28

Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

Markowicz-Piasecka, M., Huttunen, K. M., & Sikora, J. (2018) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1499627 · Cited by 27

Design, synthesis and evaluation of resveratrol-indazole hybrids as novel monoamine oxidases inhibitors with amyloid- β aggregation inhibition

Lan, J., Liu, Y., Hou, J., Yang, J. L., Zhang, X., Zhao, Y. Q., Xie, S., Ding, Y., & Zhang, T. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.11.009 · Cited by 27

Pharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer’s disease

Sagar, S. R., Singh, D. P., Das, R. D., Panchal, N. B., Sudarsanam, V., Nivsarkar, M., & Vasu, K. K. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.102992 · Cited by 27

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's Disease Therapy

Dgachi, Y., Ismaïli, L., Knez, D., Benchekroun, M., Martin, H., Szałaj, N., Wehle, S., Bautista‐Aguilera, Ó. M., Luzet, V., Bonnet, A., et al. (2016) · ChemMedChem · doi:10.1002/cmdc.201500539 · Cited by 26

Melatonin as a Versatile Molecule to Design Novel Multitarget Hybrids Against Neurodegeneration

Ramos, E., Egea, J., Rı́os, C. D. L., Marco, J. L., & Romero, A. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0014 · Cited by 26

Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Sang, Z., Wang, K., Wang, H., Wang, H., Ma, Q., Han, X., Ye, M., Yu, L., & Liu, W. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.09.057 · Cited by 26

Synthesis and cholinesterase inhibition of cativic acid derivatives

Alza, N. P., Richmond, V., Baier, C. J., Freire, E., Baggio, R., & Murray, A. P. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.06.030 · Cited by 24

Evaluation of the Key Structural Features of Various Butyrylcholinesterase Inhibitors Using Simple Molecular Descriptors

Miličević, A., & Šinko, G. (2022) · Molecules · doi:10.3390/molecules27206894 · Cited by 23

Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?

Carradori, S., Fantacuzzi, M., Ammazzalorso, A., Angeli, A., Filippis, B. D., Galati, S., Petzer, A., Petzer, J. P., Poli, G., Tuccinardi, T., et al. (2022) · Molecules · doi:10.3390/molecules27227816 · Cited by 23

Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase

Menéndez, C. A., Biscussi, B., Accordino, S. R., Murray, A. P., Gerbino, D. C., & Appignanesi, G. A. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.09.012 · Cited by 23

Synthesis and Evaluation of Thiazolyl-indole-2-carboxamide Derivatives as Potent Multitarget Anticancer Agents

Saadan, N. M., Ahmed, W. U., Kadi, A. A., Almutairi, M. S., Al-Wabli, R. I., & Rahman, A. F. M. M. (2024) · ACS Omega · doi:10.1021/acsomega.4c06889 · Cited by 22

Thiazolyl-thiadiazines as Beta Site Amyloid Precursor Protein Cleaving Enzyme-1 (BACE-1) Inhibitors and Anti-inflammatory Agents: Multitarget-Directed Ligands for the Efficient Management of Alzheimer’s Disease

Sagar, S. R., Singh, D. P., Panchal, N. B., Das, R. D., Pandya, D. H., Sudarsanam, V., Nivsarkar, M., & Vasu, K. K. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00063 · Cited by 22

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy

Dgachi, Y., Martin, H., Malek, R. S., Jun, D., Janočková, J., Šepsová, V., Soukup, O., Iriepa, I., Moraleda, I., Maalej, E., et al. (2018) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1538136 · Cited by 21

The battle of Alzheimer’s Disease – the beginning of the future Unleashing the potential of academic discoveries

Lundkvist, J., Halldin, M. M., Sandin, J., Nordvall, G., Forsell, P. K. A. L., Svensson, S., Jansson, L., Johansson, G., Winblad, B. G., & Ekstrand, J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00102 · Cited by 21

New semicarbazones as gorge-spanning ligands of acetylcholinesterase and potential new drugs against Alzheimer’s disease: Synthesis, molecular modeling, NMR, and biological evaluation

Neto, D. C. F., Lima, J. A., de Almeida, J. S. F. D., França, T. C. C., do Nascimento, C. J., & Figueroa‐Villar, J. D. (2017) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2017.1407676 · Cited by 20

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

Pachón-Angona, I., Daniel, S., Martin, H., Bonet, A., Wnorowski, A., Maj, M., Jóźwiak, K., Silva, T., Refouvelet, B., Borges, F., et al. (2020) · Molecules · doi:10.3390/molecules25061329 · Cited by 20

Ang (1–7)/Mas receptor-axis activation promotes amyloid beta-induced altered mitochondrial bioenergetics in discrete brain regions of Alzheimer's disease-like rats

Varshney, V., & Garabadu, D. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102122 · Cited by 20

Current Approaches and Tools Used in Drug Development against Parkinson’s Disease

Koszła, O., Stępnicki, P., Zięba, A., Grudzińska, A., Matosiuk, D., & Kaczor, A. A. (2021) · Biomolecules · doi:10.3390/biom11060897 · Cited by 25

Citronellal as a Promising Candidate for Alzheimer’s Disease Treatment: A Comprehensive Study on In Silico and In Vivo Anti-Acetylcholine Esterase Activity

Pavani, K., Prasanth, D., Shadakshara, M. K. R., Ahmad, S. F., Seemaladinne, R., Rudrapal, M., & Pasala, P. K. (2023) · Metabolites · doi:10.3390/metabo13111133 · Cited by 20

Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease

Semenov, V. E., Zueva, I. V., Mukhamedyarov, M. A., Lushchekina, S. V., Petukhova, E. O., Gubaidullina, L. M., Krylova, E. S., Saifina, L. F., Lenina, O. A., & Petrov, K. A. (2020) · Molecules · doi:10.3390/molecules25184191 · Cited by 19

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

Jourdan, J., Since, M., Kihel, L. E., Lecoutey, C., Corvaisier, S., Legay, R., Santos, J. S. O., Cresteil, T., Malzert‐Fréon, A., Rochais, C., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.03.023 · Cited by 20

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy

Zribi, L., Pachón-Angona, I., Bautista‐Aguilera, Ó. M., Diez‐Iriepa, D., Marco, J. L., Ismaïli, L., Iriepa, I., & Chabchoub, F. (2020) · Molecules · doi:10.3390/molecules25143190 · Cited by 16

New Multifunctional Agents for Potential Alzheimer’s Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones

Elkina, N. А., Grishchenko, M. V., Shchegolkov, E. V., Махаева, Г. Ф., Ковалева, Н. В., Рудакова, Е. В., Boltneva, N. P., Lushchekina, S. V., Astakhova, T. Y., Radchenko, E. V., et al. (2022) · Biomolecules · doi:10.3390/biom12111551 · Cited by 16

Aminoadamantane conjugates with carbazole derivatives as potential multitarget agents for the treatment of Alzheimer’s disease. Effect of the spacer structure

Махаева, Г. Ф., Shevtsova, E. F., Ковалева, Н. В., Рудакова, Е. В., Евгеньевна, Н. М., Dubova, L. G., Shevtsov, P. N., Aksinenko, A. Y., Sokolov, V. B., & Бачурин, С. О. (2018) · Russian Chemical Bulletin · doi:10.1007/s11172-018-2338-6 · Cited by 16

Design, synthesis and biological evaluation of new multi-target scutellarein hybrids for treatment of Alzheimer’s disease

Luo, K., Chen, J., Li, H., Wu, D., Du, Y., Zhao, S., Liu, T., Li, L., Dai, Z., Li, Y., et al. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106596 · Cited by 15

Multifunctional Inhibitors of Cholinesterases for the Therapy of Alzheimer’s Disease (A Review)

Махаева, Г. Ф., & Бачурин, С. О. (2023) · Russian Journal of General Chemistry · doi:10.1134/s1070363223150161 · Cited by 15

The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer’s disease

Zhu, G., Wang, K., Shi, J., Zhang, P., Yang, D., Fan, X., Zhang, Z., Liu, W., & Sang, Z. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126625 · Cited by 15

Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer's disease

Montero, J. M. S., Agís-Torres, Á., Solano, D., Söllhuber, M. M., Fernandez, M., Villaro, W., Gómez‐Cañas, M., Garcı́a-Arencibia, M., Fernández‐Ruíz, J., Egea, J., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173875 · Cited by 14

Donepezil–melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments

Łozińska, I., Świerczyńska, A., Molęda, Z., Hartman, A. M., Hirsch, A. K. H., & Czarnocki, Z. (2018) · Archiv der Pharmazie · doi:10.1002/ardp.201800194 · Cited by 13

Plant extracts and phytochemicals targeting Alzheimer’s through acetylcholinesterase inhibition

Deepa, A. K., & Thomas, T. D. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.100697 · Cited by 13

Multifunctional agents against Alzheimer’s disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions

Wei, W., Jing, L., Tian, Y., Więckowska, A., Kang, D., Meng, B., Panek, D., Godyń, J., Góral, I., Song, Y., et al. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117535 · Cited by 12

Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy

Barré, A., Azzouz, R., Gembus, V., Papamicaël, C. A., & Levacher, V. (2019) · Molecules · doi:10.3390/molecules24071264 · Cited by 12

3‐Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety as Multi‐Target‐Directed Ligands against Alzheimer's Disease

Abdshahzadeh, H., Golshani, M., Nadri, H., Kia, I. S., Abdolahi, Z., Forootanfar, H., Ameri, A., Küçükkılınç, T. T., Ayazgök, B., Jalili‐Baleh, L., et al. (2019) · Chemistry & Biodiversity · doi:10.1002/cbdv.201800436 · Cited by 12

Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer’s Disease

Hayden, M. R., & Tyagi, N. (2024) · Pharmaceuticals · doi:10.3390/ph17121741 · Cited by 11

Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

Pirolla, N. F. F., Batista, V. S., Viegas, F. P. D., Gontijo, V. S., McCarthy, C. R., Viegas, C., & Nascimento-Júnior, N. M. (2020) · Current Drug Targets · doi:10.2174/1389450121999200819144544 · Cited by 11

Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation

Falkenstein, M., Reiner‐Link, D., Živković, A., Gering, I., Willbold, D., & Stark, H. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116462 · Cited by 12

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Thakur, A., Rana, M., Vanjani, S., Liou, K.-C., Taliyan, R., Nepali, K., & Yang, C. (2026) · Medicinal Research Reviews · doi:10.1002/med.70047 · Cited by 10

Recent Applications of the MultiTarget Directed Ligands Approach for the Treatment of Alzheimer's Disease

Dias, K. S. T., de Paula, C. T., Riquiel, M. M., do Lago, S. T. L., Costa, K. C. M., Vaz, S. M., Machado, R. P., de Lima, L. M. S., & Viegas, C. (2015) · Revista Virtual de Química · doi:10.5935/1984-6835.20150027 · Cited by 12

Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer’s Disease Therapy

Malek, R. S., Refouvelet, B., Benchekroun, M., Iriepa, I., Moraleda, I., Andrýs, R., Musílek, K., Marco, J. L., & Ismaïli, L. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666191011112624 · Cited by 9

Investigating the multifunctionality of fluorinated donepezil derivatives for Alzheimer’s disease

Swain, S., Sen, A., & Metya, A. K. (2024) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2024.125500 · Cited by 8

Scutellarein derivatives with histamine H3 receptor antagonism and cholinesterase inhibitory potency as multi target-directed ligands for possible Alzheimer’s disease therapy

Chen, J., Zhu, H., Luo, K., Luo, Q., Wang, Y., Liu, T., Li, L., Dai, Z., Yang, S., Li, Y., et al. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107704 · Cited by 8

Novel Stem Cell Strategies with mTOR

Maiese, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00020-7 · Cited by 8

Synthesis, Molecular Modeling and Cholinesterase Inhibitory Effects of 2-Indolinone-Based Hydrazinecarbothioamides

Demir-Yazıcı, K., Apaydın, Ç. B., Eter, Ö. S., Özsoy, N., & Karalı, N. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0018 · Cited by 8

1-(7-Chloroquinolin-4-yl)-N-(4-Methoxybenzyl)-5-Methyl-1H-1,2, 3-Triazole-4- carboxamide Reduces Aβ Formation and Tau Phosphorylation in Cellular Models of Alzheimer’s Disease

Fronza, M. G., Sacramento, M., Alves, D. A. C., Praticò, D., & Savegnago, L. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03514-8 · Cited by 8

Bis-γ-carbolines as new potential multitarget agents for Alzheimer’s disease

Махаева, Г. Ф., Shevtsova, E. F., Aksinenko, A. Y., Ковалева, Н. В., Boltneva, N. P., Lushchekina, S. V., Рудакова, Е. В., Pushkareva, E. A., Serkova, T. P., Dubova, L. G., et al. (2020) · Pure and Applied Chemistry · doi:10.1515/pac-2019-1206 · Cited by 8

Genetics and Epigenetics of Alzheimer’s Disease: Understanding Pathogenesis and Exploring Therapeutic Potential

Tiwari, P., Dwivedi, R., Kaushik, M., Tripathi, M., & Dada, R. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02363-2 · Cited by 8

Exploring the therapeutic potential of steroidal alkaloids in managing Alzheimer’s disease

Pandey, P. P., & Kumar, M. S. (2024) · Steroids · doi:10.1016/j.steroids.2024.109468 · Cited by 7

Alkaloids from Caliphruria subedentata (Amaryllidaceae) as Regulators of AChE, BuChE, NMDA and GSK3 Activity: An In Vitro and In Silico Approach for Mimicking Alzheimer´s Disease

Ordoñez, W. O. C., Palomino, N. V., Varela, P. E. V., Martinez, I., Alves, L. B., & Giuliatti, S. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04354-6 · Cited by 7

Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice

Bae, M., Han, S. Y., Kim, E. S., You, B. H., Kim, Y., Cho, J., Chin, Y., & Choi, Y. H. (2021) · Molecules · doi:10.3390/molecules26175246 · Cited by 7

Influence of the γ-carboline and carbazole pharmacophore moieties on anticholinesterase and antiradical activity of multifunctional agents for the treatment of neurodegenerative diseases

Махаева, Г. Ф., Boltneva, N. P., Ковалева, Н. В., Рудакова, Е. В., Lushchekina, S. V., Aksinenko, A. Y., & Sokolov, V. B. (2018) · Russian Chemical Bulletin · doi:10.1007/s11172-018-2282-5 · Cited by 7

Regioselective synthesis, biological evaluation, and molecular docking of dihydropyrimidin‐4‐ols as acetylcholinesterase inhibitors

da Silva, A. M. P. W., da Silva, F. M., Nogara, P. A., Dutra, E. J. M., Serres, J. D. D. S., Saraiva, R. D. A., Piccoli, B. C., Oliveira, C. S., Schetinger, M. R. C., Morsch, V. M., et al. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13036 · Cited by 6

Probing the Immune System Dynamics of the COVID-19 Disease for Vaccine Designing and Drug Repurposing Using Bioinformatics Tools

Yadav, D., Agarwal, S., Pancham, P., Jindal, D., Agarwal, V., Dubey, P. K., Jha, S. K., Mani, S., Rachana, R., Dey, A., et al. (2022) · Immuno · doi:10.3390/immuno2020022 · Cited by 7

A safe alternative synthesis of primary carbamates from alcohols;in vitroandin silicoassessments as an alternative acetylcholinesterase inhibitors

Atmaca, U., Aksoy, M., & Öztekіn, A. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2134209 · Cited by 6

Huprines — an insight into the synthesis and biological properties

Mezeiová, E., Soukup, O., & Korábečný, J. (2020) · Russian Chemical Reviews · doi:10.1070/rcr4938 · Cited by 7

Multiple Ligands in Neurodegenerative Diseases

Lalut, J., Rochais, C., & Dallemagne, P. (2017) · Methods and principles in medicinal chemistry · doi:10.1002/9783527674381.ch16 · Cited by 6

Targeting Amyloid-β Proteins as Potential Alzheimer’s Disease Therapeutics: Anti-Amyloid Drug Discovery, Emerging Therapeutics, Clinical Trials and Implications for Public Health

Abduljawad, A. A., Alkinani, K. B., Zaakan, A., AlGhamdi, A. S., Hamdoon, A. A. E., Alshanbari, B. H., Alshehri, A. A., Alluhaybi, B. B., Alqashi, S. O. I., & Abduljawad, R. A. (2025) · Pharmaceuticals · doi:10.3390/ph18111731 · Cited by 7

Integrating artificial intelligence with small molecule therapeutics and precision medicine for neurochemical understanding of Alzheimer’s diseases

Alshehri, Z. S. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.08.055 · Cited by 5

Development of potent cholinesterase inhibitors based on a marine pharmacophore

Elumalai, V., Trobec, T., Grundner, M., Labrière, C., Frangež, R., Sepčić, K., Hansen, J. H., & Svenson, J. (2022) · Organic & Biomolecular Chemistry · doi:10.1039/d2ob01064j · Cited by 5

In silico and in vitro assessment of the anti-β-amyloid aggregation and anti-cholinesterase activities of Ptaeroxylon obliquum and Bauhinia bowkeri extracts

Ojo, M. C., Mosa, R. A., Osunsanmi, F. O., Revaprasadu, N., & Opoku, A. R. (2023) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2023.11.004 · Cited by 5

Chemo‐Biocatalytic Oxidative Condensation of Natural Arylpropene with 2‐Aminobenzothiazole into Schiff‐Bases as Potent Anti‐Amyloid Agents: Studies Employing Transgenic C. elegans

Saima, S., Kumar, L., Lavekar, A. G., Sharma, T., Shamsuzzama, S., Equbal, D., Siddiqi, M. I., Sinha, A. K., & Nazir, A. (2018) · ChemistrySelect · doi:10.1002/slct.201800243 · Cited by 5

Fundamentals of Polyphenols : Nomenclature, Classification and Properties

Subhan, S., Zeeshan, M., Rahman, A. U., & Yaseen, M. (2024) · Wiley eBooks · doi:10.1002/9781394203932.ch1 · Cited by 8

Synthesis, biological evaluation, and in silico studies of pyridoxal-amiridine hybrids as multitargeting anti-Alzheimer's disease agents.

Makhaeva, G., Grishchenko, M. V., Rudakova, E., Kovaleva, N., Boltneva, N., Skornyakova, T. S., Khudina, O. G., Shchegolkov, E., Zhilina, E. F., Astakhova, T., et al. (2025) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2025.118397 · Cited by 4

Inhibition of β-amyloid Aggregation of Ugni molinae Extracts

Jara-Moreno, D., Riveros, A. L., Barriga, A., Kogan, M. J., & Delporte, C. L. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200113160840 · Cited by 4

Donepezil-Squaric Acid Hybrid: Synthesis, Characterization and Investigation of Anticholinesterase Inhibitory, DNA Binding and Antioxidant Properties

Kılıçaslan, D. (2024) · Cumhuriyet Science Journal · doi:10.17776/csj.1414168 · Cited by 3

Edaravone N-benzyl pyridinium derivatives: BACE-1 inhibition, kinetics and in silico binding pose determination

Zondagh, L. S., Malan, S. F., & Joubert, J. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106869 · Cited by 3

Multicomponent Synthesis of Multi-Target Quinazolines Modulating Cholinesterase, Oxidative Stress, and Amyloid Aggregation Activities for the Therapy of Alzheimer’s Disease

Chakhari, S., Marco, J. L., Iriepa, I., Carreiras, M. C., Chabchoub, F., Ismaïli, L., & Refouvelet, B. (2025) · Molecules · doi:10.3390/molecules30193930 · Cited by 3

Polynitrogen-containing compounds as multi-target sEH/FAAH inhibitors: Structure-activity relationship and pharmacological studies

Tsang, A., Yuan, C., Berumen, M., Duong, L., Gomez, K., Seely, S., Salgado, A., Rai, A., Vistosa, J., Munoz, E. M., et al. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118495 · Cited by 3

Flavonoid-Based Derivatives for Modulating Various Targets of Alzheimer’s Disease

Pandey, J. (2023) · Springer eBooks · doi:10.1007/978-981-99-6038-5_11 · Cited by 3

Discovery of small molecules for the treatment of Alzheimer’s disease

Rao, P. P. N., Pham, A. T., & Shakeri, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818349-6.00011-x · Cited by 3

Computer-Aided Multi-Target Management of Emergent Alzheimer’s Disease

Kim, H., & Han, H. W. (2018) · Bioinformation · doi:10.6026/97320630014167 · Cited by 3

Tacrine Derivatives Containing an Antioxidant Moiety

Serkov, I. V., Proshin, A. N., Ковалева, Н. В., Boltneva, N. P., Рудакова, Е. В., Махаева, Г. Ф., & Бачурин, С. О. (2022) · Doklady Chemistry · doi:10.1134/s0012500822700094 · Cited by 3

Atividade antioxidante, anticolinesterásica e perfil metabolômico de diferentes tipos de pimentas: Implicações na doença de Alzheimer

Biazotto, F. D. O. (2014) · doi:10.11606/d.11.2014.tde-10112014-112458 · Cited by 3

Biological activity of some thiazolyl‐thiadiazines as BACE‐1 inhibitors for Alzheimer's disease in the light of density functional theory based quantum descriptors

Roy, S. M., Mehta, B. R., Trivedi, S. J., Sharma, B. K., & Roy, D. R. (2022) · Journal of Physical Organic Chemistry · doi:10.1002/poc.4444 · Cited by 2

Synthesis of novel benzylpiperazine derivatives as potential anti-Alzheimer agents: biological evaluation, cytotoxicity assessment, molecular docking, and molecular dynamics simulations

Osmani̇ye, D., Hıdır, A., Özkay, Y., & Kaplancıklı, Z. A. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.143769 · Cited by 2

Toxicity Profiles of Kleeb Bua Daeng Formula, a Traditional Thai Medicine, and Its Protective Effects on Memory Impairment in Animals

Waiwut, P., Kengkoom, K., Pannangrong, W., Musigavong, N., Chheng, C., Plekratoke, K., Taklomthong, P., Nillert, N., Pitiporn, S., Kwankhao, P., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15080988 · Cited by 2

Design, Synthesis and Biological Evaluation of Novel Indanones Derivatives As Potent Acetylcholinesterase/Monoamine Oxidase B Inhibitors

Hu, Z., Zhou, S., Li, J., Li, X., Zhou, Y., Zhu, Z., Xu, J., & Liu, J. (2023) · Future Medicinal Chemistry · doi:10.4155/fmc-2023-0206 · Cited by 1

Inhibition of Human Amylin Aggregation: In Silico and In Vitro Studies

Mizgalska, K., Al-Aani, U., Jaidah, Y. A., Panek, D., Châari, A., & Bajda, M. (2025) · ACS Omega · doi:10.1021/acsomega.5c02443 · Cited by 2

Theranostic advances in Alzheimer's disease: structure-guided design of near-infrared fluorescent probes targeting amyloid-β and cholinergic dysfunction

Mandloi, U., Giri, N., Kumar, S., & Modi, G. P. (2026) · RSC Medicinal Chemistry · doi:10.1039/d5md00713e · Cited by 1

Modulation of the Kynurenine Pathway: A New Approach for Treating Neurodegeneration

Banaszkiewicz, J. K., Kukiełka, A., Kudyk, E., Walczak, Ł. J., Wicha-Komsta, K., Herbet, M., Piątkowska‐Chmiel, I., Nowicki, G., Mielnik, C. E., & Kocki, T. (2026) · Life · doi:10.3390/life16020266 · Cited by 4

Evolution of Multitarget Strategies for Alzheimer’s Disease: From Cholinergic Inhibition to Network-Oriented Therapeutic Design (2006–2025)

Mella, J., Vega-Muñoz, A., Soto, M., Moraga, D., Campanini-Salinas, J., Sandoval-Obando, E., Contreras-Barraza, N., Salazar-Sepúlveda, G., Salas, N., Carabantes-Silva, R., et al. (2026) · Pharmaceuticals · doi:10.3390/ph19071024 · Cited by 1

Tea Polyphenolics and their Effect on Neurodegenerative Disorders-A Review

Bagchi, A., Swain, D. K., Bera, N., & Mitra, A. (2016) · Cited by 1

Computational Studies of Multi-Target Directed Ligands Against Acetylcholinesterase, Butyrylcholinesterase and Amyloid Beta as Potential Anti-Alzheimer’s Agents

Maurya, N. S., Gaddam, M., & Sharma, A. (2023) · Journal of Computational Biophysics and Chemistry · doi:10.1142/s2737416523500667 · Cited by 1

A Dft Study of the Chemical Reactivity Properties of Alzheimer's Disease MedicationsPreprint

Nuha, D., Berber, H., & Karaburun, A. Ç. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4113642 · Cited by 1

Drugs development and fragile X syndrome translational success story

Budimirovic, D. B., & Protic, D. D. (2016) · Medicinski podmladak · doi:10.5937/mp67-12697

Avaliação dos efeitos neuroprotetores do extrato etanólico de Caliphruria subedentata e o fármaco galantamina em células indiferenciadas SH-SY5Y expostas ao peptídeo beta-amiloide(1-42)

Ordoñez, W. O. C. (2017) · doi:10.11606/t.17.2017.tde-06062017-164343

Computer-Aided Design of Ligands at Multiple Protein Targets for Multifactorial Diseases

Kalash, L. N. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.38293

Búsqueda racional de alcaloides isoquinolínicos del género Zanthoxylum (Rutaceae) como posibles agentes multifuncionales para el tratamiento del Alzheimer

González, P., & González, E. A. P. (2020)

Identificación de inhibidores polifuncionales contra blancos moleculares usados en el tratamiento de obesidad y diabetes

Murillo, O., & Alberto, L. (2020)

Design and synthesis of new anilide and benzylamide derivatives as potential multifunctional ligands with procognitive and antidepressant activity

Jankowska, A., & Chłoń‐Rzepa, G. (2022) · Postępy Polskiej Medycyny i Farmacji · doi:10.5604/01.3001.0015.7725

Research Progress of Chemical Synthesis Drugs and Biotechnology Drugs for Alzheimer’s Disease

陈, 学. (2024) · Open Journal of Natural Science · doi:10.12677/ojns.2024.122051

Synthesis and evaluation of HFIP bearing triazolo-amides as amyloid-β aggregation inhibitors and suppressors of aggregation induced neuroinflammation

Dewangan, B., Swain, P., Patra, S., Bodhe, P. R., Kulkarni, N., & Sahu, B. (2025) · RSC Medicinal Chemistry · doi:10.1039/d5md00481k

Computational insights into the chemical reactivity of Alzheimer’s therapeutics: a DFT-based study

Nuha, D., Berber, H., & Karaburun, A. Ç. (2025) · European Journal of Life Sciences · doi:10.55971/ejls.1705320 · Cited by 1

AI-based prediction and validation in zebrafish model elucidates potential bioactivity of novel thiazolone derivative

Cheng, J., Zheng, T., Lin, T.-Y., Zhang, Z., Zheng, K., Li, X., Wu, X., Zhongquan, L. I., Wu, X., & Liu, B. (2026) · Chinese Journal of Analytical Chemistry · doi:10.1016/j.cjac.2026.100713

Etude du complexe récepteur 5-HT4/ADAM10/APP et recherche de protéines associées à l’ADAM10 : de nouveaux acteurs favorisant la voie non-amyloïdogénique dans le contexte de la maladie d'Alzheimer

Donneger, R. (2014) · theses.fr (ABES) · doi:10.70675/46774734zb996z4960z95d2ze286ee7dbbe3

Membranes biomimétiques pour la caractérisation de nouveaux agents thérapeutiques : application à la maladie d'Alzheimer

Smeralda, W. (2019) · theses.fr (ABES) · doi:10.70675/16bb8ffez6612z4ceeza7e1zccb78a0024e8

Current Research on Alzheimer’s Disease-Associated Cognitive Disabilities Management and Future Perspectives

Das, S., Ganguly, S. C., & Kundu, M. (2026) · SpringerBriefs in modern perspectives on disability research. · doi:10.1007/978-981-95-7121-5_4

Computational exploration of phycobiliproteins-derived peptides: in-silico gastrointestinal digestion and multi-target molecular docking against Alzheimer’s disease-related enzymes

Lijassi, I., Mansouri, Z., Rhazi, L., & Wahby, I. (2026) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2026.2723004

Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer’s disease. Curr. Neuropharmacol. 12, 2–36. doi: 10.2174/1570159X113116660047 Alzheimer’s Association

Agis-torres, A., Söllhuber, M. M., Fern, M., & Sanchez-montero, J. M. (2014)

Multi-Target-Directed Ligands in Alzheimer’s Disease Therapy

Nepovimová, E., & Kuča, K. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93269 · Cited by 5

Multi-Target-Directed Ligands in Alzheimer’s Disease Therapy

Kuca, K. (2018) · BiblioBoard Library Catalog (Open Research Library)

Multi Target Directed Ligand for Alzheimer’s Disease: A Review of Therapeutic Strategies and Advances

Kumar, S., Sharma, V., Happy, & Verma, D. K. K. (2026) · Current Pharmaceutical Research · doi:10.63785/cpr.2026.2.2.292310

Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer’s Disease

Kumar, R., Kumar, V., Kumar, B., Thakur, A., & Dwivedi, A. R. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210512005508 · Cited by 55